DK0991658T3 - Dolastatin 15-derivater - Google Patents

Dolastatin 15-derivater

Info

Publication number: DK0991658T3
Authority: DK; Denmark
Prior art keywords: dolastatin; derivatives
Prior art date: 1997-07-18

Application number

DK98935531T

Other languages

English (en)

Inventor

Bernd Janssen

Thomas Zierke

Andreas Kling

Teresa Barlozzari

Andreas Haupt

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-18

Filing date

1998-07-07

Publication date

2006-05-15

1998-07-07 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2006-05-15 Application granted granted Critical

2006-05-15 Publication of DK0991658T3 publication Critical patent/DK0991658T3/da

Links

LQKSHSFQQRCAFW-CCVNJFHASA-N [(2s)-1-[(2s)-2-benzyl-3-methoxy-5-oxo-2h-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2s)-1-[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxyl Chemical class C([C@@H]1N(C(=O)C=C1OC)C(=O)[C@@H](OC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)C1=CC=CC=C1 LQKSHSFQQRCAFW-CCVNJFHASA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Hematology (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

DK98935531T 1997-07-18 1998-07-07 Dolastatin 15-derivater DK0991658T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/896,394 US6143721A (en)	1997-07-18	1997-07-18	Dolastatin 15 derivatives

Publications (1)

Publication Number	Publication Date
DK0991658T3 true DK0991658T3 (da)	2006-05-15

Family

ID=25406130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98935531T DK0991658T3 (da)	1997-07-18	1998-07-07	Dolastatin 15-derivater

Country Status (32)

Country	Link
US (6)	US6143721A (da)
EP (1)	EP0991658B1 (da)
JP (4)	JP4508413B2 (da)
KR (1)	KR100579748B1 (da)
CN (1)	CN1268636C (da)
AR (1)	AR018501A1 (da)
AT (1)	ATE314387T1 (da)
AU (1)	AU750120B2 (da)
BG (1)	BG65212B1 (da)
BR (1)	BR9810911A (da)
CA (1)	CA2296036C (da)
CO (1)	CO4990967A1 (da)
CY (1)	CY1107047T1 (da)
CZ (1)	CZ303045B6 (da)
DE (1)	DE69832982T2 (da)
DK (1)	DK0991658T3 (da)
ES (1)	ES2258819T3 (da)
HR (1)	HRP980397A2 (da)
HU (1)	HU228996B1 (da)
ID (1)	ID24669A (da)
IL (1)	IL133784A (da)
MY (1)	MY135057A (da)
NO (1)	NO326827B1 (da)
NZ (1)	NZ502296A (da)
PL (1)	PL197884B1 (da)
PT (1)	PT991658E (da)
RU (1)	RU2195462C2 (da)
SK (1)	SK286581B6 (da)
TR (2)	TR200000132T2 (da)
TW (1)	TW533217B (da)
WO (1)	WO1999003879A1 (da)
ZA (1)	ZA986358B (da)

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US20010009901A1 (en) *	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US6143721A (en) *	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
AU2001227375A1 (en) *	2000-02-08	2001-08-20	Herbert T. Nagasawa	N-terminal d(-)-penicillamine peptides as aldehyde sequestration agents
US6884869B2 (en) *	2001-04-30	2005-04-26	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US7256257B2 (en) *	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
US7064211B2 (en) *	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
RU2342399C2 (ru) *	2002-03-22	2008-12-27	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Производные гемиастерлина и их применение при лечении рака
AU2003263964C1 (en)	2002-07-31	2010-08-19	Seagen Inc.	Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
NZ547633A (en)	2003-11-06	2010-08-27	Seattle Genetics Inc	Monomethylvaline compounds capable of conjugation to ligands
JP2008522624A (ja) *	2004-12-09	2008-07-03	エーザイ・アール・アンド・ディー・マネジメント株式会社	ヘミアスタリン（ｈｅｍｉａｓｔｅｒｌｉｎ）アナログを使用する癌治療におけるチューブリンのアイソタイプのスクリーニング
CA2607940C (en)	2005-05-18	2009-12-15	Aegera Therapeutics Inc.	Bir domain binding compounds
AU2007250443B2 (en)	2006-05-16	2013-06-13	Pharmascience Inc.	IAP BIR domain binding compounds
TWI392503B (zh)	2007-07-16	2013-04-11	建南德克公司	抗－ｃｄ７９ｂ抗體及免疫共軛物及使用方法
PE20090481A1 (es)	2007-07-16	2009-05-18	Genentech Inc	Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso
DE102007039706A1 (de)	2007-08-22	2009-02-26	Erhard Prof. Dr.-Ing. Kohn	Chemischer Sensor auf Diamantschichten
CN101981055B (zh)	2008-01-31	2016-03-09	健泰科生物技术公司	抗cd79b抗体和免疫偶联物及使用方法
TW201136942A (en)	2009-12-18	2011-11-01	Idenix Pharmaceuticals Inc	5,5-fused arylene or heteroarylene hepatitis C virus inhibitors
BR112012020102A2 (pt)	2010-02-10	2016-11-29	Immunogen Inc	anticorpos cd20 e usos dos mesmos.
EP2534170B1 (en)	2010-02-12	2017-04-19	Pharmascience Inc.	Iap bir domain binding compounds
CA2891280C (en)	2012-11-24	2018-03-20	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US10464955B2 (en)	2014-02-28	2019-11-05	Hangzhou Dac Biotech Co., Ltd.	Charged linkers and their uses for conjugation
CA3069221C (en)	2014-09-23	2023-04-04	Genentech, Inc.	Methods of using anti-cd79b immunoconjugates
CN112125929A (zh)	2015-06-15	2020-12-25	杭州多禧生物科技有限公司	用于偶联的亲水链接体
EP4678240A2 (en)	2015-07-12	2026-01-14	Hangzhou Dac Biotech Co., Ltd.	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
MX2019005583A (es)	2016-11-14	2019-10-21	Hangzhou Dac Biotech Co Ltd	Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes.
CA3230737A1 (en)	2021-09-03	2023-03-09	Toray Industries, Inc.	Pharmaceutical composition for cancer treatment and/or prevention
EP4426727A2 (en)	2021-11-03	2024-09-11	Hangzhou Dac Biotech Co., Ltd.	Specific conjugation of an antibody

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US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4879278A (en) *	1989-05-16	1989-11-07	Arizona Board Of Regents	Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
WO1993003054A1 (fr) *	1991-08-09	1993-02-18	Teikoku Hormone Mfg. Co., Ltd.	Nouveau derive de tetrapeptide
US5533097A (en) *	1992-02-26	1996-07-02	Motorola, Inc.	Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5448045A (en)	1992-02-26	1995-09-05	Clark; Paul C.	System for protecting computers via intelligent tokens or smart cards
US5831002A (en) *	1992-05-20	1998-11-03	Basf Aktiengesellschaft	Antitumor peptides
JP3523253B2 (ja) *	1992-05-20	2004-04-26	アボットゲーエムベーハーウントカンパニーカーゲー	ドラスタチン誘導体
CZ286752B6 (en) *	1992-12-16	2000-06-14	Basf Ag	Peptide and pharmaceutical preparation containing thereof
US5554993A (en)	1994-01-04	1996-09-10	Panasonic Technologies, Inc.	Global position determining system and method
US5530097A (en) *	1994-08-01	1996-06-25	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory peptide amides
US5504191A (en) *	1994-08-01	1996-04-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) *	1994-09-14	1996-09-10	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Synthesis of dolastatin 15
US5663149A (en) *	1994-12-13	1997-09-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en)	1995-03-23	1997-04-08	Martin; John R.	Dual mode gaming device methods and systems
US5970143A (en)	1995-11-22	1999-10-19	Walker Asset Management Lp	Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
TW474946B (en) *	1995-12-15	2002-02-01	Basf Ag	Novel compounds, the preparation and use thereof
CA2287379C (en)	1997-01-10	2005-10-04	Silicon Gaming-Nevada	Method and apparatus for providing authenticated, secure on-line communication between remote locations
US6143721A (en) *	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6554705B1 (en)	1997-08-22	2003-04-29	Blake Cumbers	Passive biometric customer identification and tracking system
US6629591B1 (en)	2001-01-12	2003-10-07	Igt	Smart token
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1997
- 1997-07-18 US US08/896,394 patent/US6143721A/en not_active Expired - Lifetime
1998
- 1998-07-07 WO PCT/US1998/013901 patent/WO1999003879A1/en not_active Ceased
- 1998-07-07 KR KR1020007000565A patent/KR100579748B1/ko not_active Expired - Fee Related
- 1998-07-07 ES ES98935531T patent/ES2258819T3/es not_active Expired - Lifetime
- 1998-07-07 JP JP2000503101A patent/JP4508413B2/ja not_active Expired - Fee Related
- 1998-07-07 DK DK98935531T patent/DK0991658T3/da active
- 1998-07-07 HU HU0004234A patent/HU228996B1/hu not_active IP Right Cessation
- 1998-07-07 IL IL13378498A patent/IL133784A/xx not_active IP Right Cessation
- 1998-07-07 DE DE69832982T patent/DE69832982T2/de not_active Expired - Lifetime
- 1998-07-07 NZ NZ502296A patent/NZ502296A/en not_active IP Right Cessation
- 1998-07-07 CN CNB988073595A patent/CN1268636C/zh not_active Expired - Fee Related
- 1998-07-07 CA CA002296036A patent/CA2296036C/en not_active Expired - Fee Related
- 1998-07-07 BR BR9810911-1A patent/BR9810911A/pt not_active Application Discontinuation
- 1998-07-07 AU AU84758/98A patent/AU750120B2/en not_active Ceased
- 1998-07-07 AT AT98935531T patent/ATE314387T1/de active
- 1998-07-07 PT PT98935531T patent/PT991658E/pt unknown
- 1998-07-07 SK SK1879-99A patent/SK286581B6/sk not_active IP Right Cessation
- 1998-07-07 PL PL338144A patent/PL197884B1/pl unknown
- 1998-07-07 TR TR2000/00132T patent/TR200000132T2/xx unknown
- 1998-07-07 TR TR2001/03545T patent/TR200103545T2/xx unknown
- 1998-07-07 CZ CZ20000176A patent/CZ303045B6/cs not_active IP Right Cessation
- 1998-07-07 EP EP98935531A patent/EP0991658B1/en not_active Expired - Lifetime
- 1998-07-07 RU RU2000103960/04A patent/RU2195462C2/ru not_active IP Right Cessation
- 1998-07-07 ID IDW20000322A patent/ID24669A/id unknown
- 1998-07-15 AR ARP980103445A patent/AR018501A1/es active IP Right Grant
- 1998-07-16 HR HR08/896,394A patent/HRP980397A2/hr not_active Application Discontinuation
- 1998-07-17 ZA ZA9806358A patent/ZA986358B/xx unknown
- 1998-07-17 CO CO98040961A patent/CO4990967A1/es unknown
- 1998-07-18 TW TW087111729A patent/TW533217B/zh active
- 1998-07-18 MY MYPI98003298A patent/MY135057A/en unknown
2000
- 2000-01-17 NO NO20000231A patent/NO326827B1/no not_active IP Right Cessation
- 2000-01-17 BG BG104089A patent/BG65212B1/bg unknown
- 2000-07-18 US US09/618,694 patent/US6458765B1/en not_active Expired - Lifetime
2002
- 2002-09-25 US US10/255,118 patent/US7084110B2/en not_active Expired - Lifetime
2006
- 2006-03-13 CY CY20061100348T patent/CY1107047T1/el unknown
- 2006-04-18 US US11/406,512 patent/US7662786B2/en not_active Expired - Fee Related
2008
- 2008-12-11 JP JP2008315263A patent/JP5122429B2/ja not_active Expired - Fee Related
- 2008-12-11 JP JP2008315269A patent/JP5047935B2/ja not_active Expired - Fee Related
2009
- 2009-12-29 US US12/648,446 patent/US8163698B2/en not_active Expired - Fee Related
2012
- 2012-04-16 US US13/447,529 patent/US20130046077A1/en not_active Abandoned
- 2012-06-20 JP JP2012138485A patent/JP2012211164A/ja active Pending

Also Published As

Publication number	Publication date
BG104089A (en)	2000-12-29
TR200103545T2 (tr)	2002-06-21
US20030153505A1 (en)	2003-08-14
US8163698B2 (en)	2012-04-24
CA2296036A1 (en)	1999-01-28
PL197884B1 (pl)	2008-05-30
CN1264388A (zh)	2000-08-23
TW533217B (en)	2003-05-21
US6143721A (en)	2000-11-07
EP0991658A1 (en)	2000-04-12
US7084110B2 (en)	2006-08-01
BR9810911A (pt)	2000-08-01
DE69832982T2 (de)	2006-08-24
NO20000231D0 (no)	2000-01-17
JP5122429B2 (ja)	2013-01-16
US20100099843A1 (en)	2010-04-22
JP2001515010A (ja)	2001-09-18
JP2009137968A (ja)	2009-06-25
WO1999003879A1 (en)	1999-01-28
AU750120B2 (en)	2002-07-11
IL133784A (en)	2005-09-25
TR200000132T2 (tr)	2000-05-22
MY135057A (en)	2008-01-31
ZA986358B (en)	2000-01-17
HUP0004234A3 (en)	2001-08-28
AU8475898A (en)	1999-02-10
SK286581B6 (sk)	2009-01-07
HRP980397A2 (en)	1999-04-30
DE69832982D1 (de)	2006-02-02
HUP0004234A2 (hu)	2001-05-28
JP5047935B2 (ja)	2012-10-10
US7662786B2 (en)	2010-02-16
NO326827B1 (no)	2009-02-23
US20060270606A1 (en)	2006-11-30
ES2258819T3 (es)	2006-09-01
JP2012211164A (ja)	2012-11-01
CO4990967A1 (es)	2000-12-26
HU228996B1 (hu)	2013-07-29
CY1107047T1 (el)	2012-09-26
CN1268636C (zh)	2006-08-09
US6458765B1 (en)	2002-10-01
ATE314387T1 (de)	2006-01-15
US20130046077A1 (en)	2013-02-21
KR20010021998A (ko)	2001-03-15
IL133784A0 (en)	2001-04-30
CA2296036C (en)	2007-05-01
CZ303045B6 (cs)	2012-03-07
JP2009137967A (ja)	2009-06-25
PL338144A1 (en)	2000-09-25
SK187999A3 (en)	2000-09-12
PT991658E (pt)	2006-05-31
EP0991658B1 (en)	2005-12-28
BG65212B1 (bg)	2007-07-31
KR100579748B1 (ko)	2006-05-15
JP4508413B2 (ja)	2010-07-21
NO20000231L (no)	2000-01-17
NZ502296A (en)	2002-02-01
HK1029125A1 (en)	2001-03-23
AR018501A1 (es)	2001-11-28
CZ2000176A3 (en)	2001-06-13
RU2195462C2 (ru)	2002-12-27
ID24669A (id)	2000-07-27

Publication	Publication Date	Title
DK0991658T3 (da)	2006-05-15	Dolastatin 15-derivater
NO983169L (no)	1998-09-09	Hetrosykel-kondenserte morfinoidderivater (31)
DE59605821D1 (de)	2000-10-05	l/4-SCALLABSORBER
DE69621528D1 (de)	2002-07-11	Anti-inflamatorische agenzien
NO996108D0 (no)	1999-12-10	9-oksinerytromycinderivater
PT828506E (pt)	2002-08-30	Agentes endoparasiticidas
FR2763953B1 (fr)	2005-01-07	Derives de 5'-desoxy-cytidine
DK0882066T3 (da)	2000-12-18	Peptidderivater
NO992059D0 (no)	1999-04-29	2-metoksyfenylpiperazinderivater
EP1046648A4 (en)	2002-09-11	3'-deoxyribonucleotide DERIVATIVES
NO961404D0 (no)	1996-04-09	4-indolylpiperazinyl-derivater
PT1060183E (pt)	2003-08-29	Derivados de 5'-desoxicitidina
NO960353L (no)	1996-07-29	4-aminobenzoylguanidinderivater
DE69926606D1 (de)	2005-09-15	Plazentaprotein 13
FI963568L (fi)	1996-11-07	Peptidijohdannaisia
BR9709521A (pt)	1999-08-10	"3-Cianoaril-pirazóis"
EP0850950A4 (en)	1999-05-19	Peptide derivatives
NO960392L (no)	1996-08-01	4-merkaptobenzoylguanidinderivater
DK1077984T3 (da)	2003-09-15	2'-Deoxyhygromycin derivater
DE69709802D1 (de)	2002-02-28	Amythiamicin Amid-Derivate
MA26481A1 (fr)	2004-12-20	Derives d'arylsecocholadiene
NO972978D0 (no)	1997-06-26	Tomrock 5000
SE9601982D0 (sv)	1996-05-24	Tifaret 6
SI0991658T1 (sl)	2006-06-30	Derivati dolastatina 15
KR970014100U (ko)	1997-04-28	무한 증폭기