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IL133784A - Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer - Google Patents

Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer

Info

Publication number
IL133784A
IL133784A IL13378498A IL13378498A IL133784A IL 133784 A IL133784 A IL 133784A IL 13378498 A IL13378498 A IL 13378498A IL 13378498 A IL13378498 A IL 13378498A IL 133784 A IL133784 A IL 133784A
Authority
IL
Israel
Prior art keywords
dolastatin
medicaments
derivatives
pharmaceutical compositions
treating cancer
Prior art date
Application number
IL13378498A
Other languages
English (en)
Other versions
IL133784A0 (en
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of IL133784A0 publication Critical patent/IL133784A0/xx
Publication of IL133784A publication Critical patent/IL133784A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13378498A 1997-07-18 1998-07-07 Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer IL133784A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives
PCT/US1998/013901 WO1999003879A1 (en) 1997-07-18 1998-07-07 Dolastatin 15 derivatives

Publications (2)

Publication Number Publication Date
IL133784A0 IL133784A0 (en) 2001-04-30
IL133784A true IL133784A (en) 2005-09-25

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13378498A IL133784A (en) 1997-07-18 1998-07-07 Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer

Country Status (32)

Country Link
US (6) US6143721A (da)
EP (1) EP0991658B1 (da)
JP (4) JP4508413B2 (da)
KR (1) KR100579748B1 (da)
CN (1) CN1268636C (da)
AR (1) AR018501A1 (da)
AT (1) ATE314387T1 (da)
AU (1) AU750120B2 (da)
BG (1) BG65212B1 (da)
BR (1) BR9810911A (da)
CA (1) CA2296036C (da)
CO (1) CO4990967A1 (da)
CY (1) CY1107047T1 (da)
CZ (1) CZ303045B6 (da)
DE (1) DE69832982T2 (da)
DK (1) DK0991658T3 (da)
ES (1) ES2258819T3 (da)
HR (1) HRP980397A2 (da)
HU (1) HU228996B1 (da)
ID (1) ID24669A (da)
IL (1) IL133784A (da)
MY (1) MY135057A (da)
NO (1) NO326827B1 (da)
NZ (1) NZ502296A (da)
PL (1) PL197884B1 (da)
PT (1) PT991658E (da)
RU (1) RU2195462C2 (da)
SK (1) SK286581B6 (da)
TR (2) TR200000132T2 (da)
TW (1) TW533217B (da)
WO (1) WO1999003879A1 (da)
ZA (1) ZA986358B (da)

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US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686336B2 (en) 2000-02-08 2004-02-03 Federal Government As Represented By The Department Of Veterans Affaires N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
NZ555951A (en) 2002-03-22 2009-01-31 Eisai Co Ltd Hemiasterlin derivatives and uses thereof
PT2357006E (pt) 2002-07-31 2016-01-22 Seattle Genetics Inc Conjugados de fármacos e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infeciosa
PT1725249E (pt) 2003-11-06 2014-04-10 Seattle Genetics Inc Compostos de monometilvalina capazes de conjugação a ligandos
JP2008522624A (ja) * 2004-12-09 2008-07-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘミアスタリン（ｈｅｍｉａｓｔｅｒｌｉｎ）アナログを使用する癌治療におけるチューブリンのアイソタイプのスクリーニング
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
SG171682A1 (en) 2006-05-16 2011-06-29 Aegera Therapeutics Inc Iap bir domain binding compounds
NZ583318A (en) 2007-07-16 2012-07-27 Genentech Inc Humanized anti-cd79b antibodies and immunoconjugates and methods of use
CN111499748A (zh) 2007-07-16 2020-08-07 健泰科生物技术公司 抗cd79b抗体和免疫偶联物及使用方法
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
ES2587392T3 (es) 2008-01-31 2016-10-24 Genentech, Inc. Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso
KR20120118008A (ko) 2009-12-18 2012-10-25 아이데닉스 파마슈티칼스, 인코포레이티드 5,5-융합 아릴렌 또는 헤테로아릴렌 간염 ｃ 바이러스 억제제
MX341687B (es) 2010-02-10 2016-08-30 Immunogen Inc "anticuerpos cd20 y su utilización".
KR20120140658A (ko) 2010-02-12 2012-12-31 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
CN105849086B (zh) 2012-11-24 2018-07-31 杭州多禧生物科技有限公司 亲水性链接体及其在药物分子和细胞结合分子共轭反应上的应用
CN114262344A (zh) 2014-02-28 2022-04-01 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
RS60349B8 (sr) 2014-09-23 2022-10-31 Hoffmann La Roche Postupak upotrebe anti-cd79b imunokonjugata
AU2015242210A1 (en) 2015-06-15 2017-12-07 Hangzhou Dac Biotech Co., Ltd Hydrophilic linkers for conjugation
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
NZ752394A (en) 2016-11-14 2021-07-30 Hangzhou Dac Biotech Co Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
KR20240051956A (ko) 2021-09-03 2024-04-22 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
KR20240095442A (ko) 2021-11-03 2024-06-25 항저우 디에이씨 바이오테크 씨오, 엘티디 항체의 특이적 접합

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
CA2115355C (en) * 1991-08-09 2007-09-11 Kyoichi Sakakibara Novel tetrapeptide derivative
US5448045A (en) * 1992-02-26 1995-09-05 Clark; Paul C. System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
KR100286242B1 (ko) * 1992-05-20 2001-04-16 스타르크, 카르크 돌라스타틴 유도체
CZ286752B6 (en) * 1992-12-16 2000-06-14 Basf Ag Peptide and pharmaceutical preparation containing thereof
US5554993A (en) * 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) * 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) * 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
WO1998030297A1 (en) * 1997-01-10 1998-07-16 Silicon Gaming, Inc. Method and apparatus for providing authenticated, secure on-line communication between remote locations
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) * 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) * 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) * 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
NO20000231D0 (no) 2000-01-17
JP2001515010A (ja) 2001-09-18
CN1264388A (zh) 2000-08-23
NZ502296A (en) 2002-02-01
KR100579748B1 (ko) 2006-05-15
HU228996B1 (hu) 2013-07-29
US20060270606A1 (en) 2006-11-30
TR200103545T2 (tr) 2002-06-21
JP4508413B2 (ja) 2010-07-21
HUP0004234A2 (hu) 2001-05-28
TW533217B (en) 2003-05-21
NO20000231L (no) 2000-01-17
CO4990967A1 (es) 2000-12-26
ES2258819T3 (es) 2006-09-01
PL197884B1 (pl) 2008-05-30
CZ303045B6 (cs) 2012-03-07
AU8475898A (en) 1999-02-10
JP5047935B2 (ja) 2012-10-10
ID24669A (id) 2000-07-27
DE69832982T2 (de) 2006-08-24
AR018501A1 (es) 2001-11-28
RU2195462C2 (ru) 2002-12-27
SK286581B6 (sk) 2009-01-07
US20100099843A1 (en) 2010-04-22
US6143721A (en) 2000-11-07
NO326827B1 (no) 2009-02-23
BG65212B1 (bg) 2007-07-31
KR20010021998A (ko) 2001-03-15
HK1029125A1 (en) 2001-03-23
CN1268636C (zh) 2006-08-09
IL133784A0 (en) 2001-04-30
AU750120B2 (en) 2002-07-11
ATE314387T1 (de) 2006-01-15
BG104089A (en) 2000-12-29
EP0991658B1 (en) 2005-12-28
CA2296036C (en) 2007-05-01
JP2012211164A (ja) 2012-11-01
JP2009137968A (ja) 2009-06-25
DE69832982D1 (de) 2006-02-02
HRP980397A2 (en) 1999-04-30
EP0991658A1 (en) 2000-04-12
US6458765B1 (en) 2002-10-01
US7084110B2 (en) 2006-08-01
US20130046077A1 (en) 2013-02-21
DK0991658T3 (da) 2006-05-15
MY135057A (en) 2008-01-31
JP5122429B2 (ja) 2013-01-16
SK187999A3 (en) 2000-09-12
ZA986358B (en) 2000-01-17
BR9810911A (pt) 2000-08-01
US20030153505A1 (en) 2003-08-14
US7662786B2 (en) 2010-02-16
JP2009137967A (ja) 2009-06-25
CZ2000176A3 (en) 2001-06-13
HUP0004234A3 (en) 2001-08-28
WO1999003879A1 (en) 1999-01-28
PT991658E (pt) 2006-05-31
CA2296036A1 (en) 1999-01-28
PL338144A1 (en) 2000-09-25
CY1107047T1 (el) 2012-09-26
US8163698B2 (en) 2012-04-24
TR200000132T2 (tr) 2000-05-22

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Legal Events

Date Code Title Description
KB Patent renewed
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MM9K Patent not in force due to non-payment of renewal fees