DK0738262T3 - Hidtil ukendte heterocykliske forbindelser - Google Patents

Hidtil ukendte heterocykliske forbindelser

Info

Publication number: DK0738262T3
Authority: DK; Denmark
Prior art keywords: heterocyclic compounds; new heterocyclic; substituted; hyperalgesic; painful
Prior art date: 1994-01-04

Application number

DK95904409T

Other languages

English (en)

Inventor

Hans Petersen

Ursula Sonnewald

Knud Erik Andersen

Uffe Bang Olsen

Frederik Christian Gronvald

Tine Krogh Jorgensen

Henrik Sune Andersen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-04

Filing date

1995-01-03

Publication date

2000-09-04

1995-01-03 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2000-09-04 Application granted granted Critical

2000-09-04 Publication of DK0738262T3 publication Critical patent/DK0738262T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Indole Compounds (AREA)

DK95904409T 1994-01-04 1995-01-03 Hidtil ukendte heterocykliske forbindelser DK0738262T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK1994		1994-01-04
DK129094		1994-11-09
PCT/DK1995/000002 WO1995018793A1 (en)	1994-01-04	1995-01-03	Novel heterocyclic compounds

Publications (1)

Publication Number	Publication Date
DK0738262T3 true DK0738262T3 (da)	2000-09-04

Family

ID=26063135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95904409T DK0738262T3 (da)	1994-01-04	1995-01-03	Hidtil ukendte heterocykliske forbindelser

Country Status (31)

Country	Link
US (8)	US5595989A (da)
EP (1)	EP0738262B1 (da)
JP (1)	JP2944221B2 (da)
KR (1)	KR100329450B1 (da)
CN (1)	CN1083431C (da)
AT (1)	ATE191909T1 (da)
AU (1)	AU691858B2 (da)
BG (1)	BG100692A (da)
BR (1)	BR9506452A (da)
CA (1)	CA2180238A1 (da)
CZ (1)	CZ286109B6 (da)
DE (1)	DE69516394T2 (da)
DK (1)	DK0738262T3 (da)
ES (1)	ES2147837T3 (da)
FI (1)	FI114025B (da)
GR (1)	GR3033967T3 (da)
HU (1)	HUT75878A (da)
IL (1)	IL112222A (da)
MY (1)	MY113463A (da)
NO (1)	NO306295B1 (da)
NZ (1)	NZ277763A (da)
PE (1)	PE45095A1 (da)
PL (1)	PL180209B1 (da)
PT (1)	PT738262E (da)
RU (1)	RU2167152C2 (da)
SG (1)	SG50602A1 (da)
SI (1)	SI9520023A (da)
SK (1)	SK88196A3 (da)
TW (1)	TW300887B (da)
UA (1)	UA47396C2 (da)
WO (1)	WO1995018793A1 (da)

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* Cited by examiner, † Cited by third party
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MY113463A (en) *	1994-01-04	2002-03-30	Novo Nordisk As	Novel heterocyclic compounds
US6110913A (en) *	1994-01-04	2000-08-29	Novo Nordisk A/S	N-substituted azaheterocyclic carboxylic acids and esters thereof
US6239148B1 (en)	1994-01-04	2001-05-29	Novo Nordisk A/S	N-substituted azaheterocyclic carboxylic acids and esters thereof
US5698551A (en) *	1995-04-07	1997-12-16	Novo Nordisk A/S	Heterocyclic compounds
US5962449A (en)	1995-04-07	1999-10-05	Novo Nordisk A/S	Tricyclic compounds in treating hyperalgesic conditions and NIDDM
US5716949A (en) *	1995-04-07	1998-02-10	Novo Nordisk A/S	Heterocyclic compounds
UA54385C2 (uk) *	1995-04-07	2003-03-17	Ново Нордіск А/С	N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування
US5952352A (en) *	1995-04-07	1999-09-14	Novo Nordisk A/S	Heterocyclic compounds
HUP9901652A3 (en) *	1995-12-15	2000-04-28	Novo Nordisk As	Use of piperidine-carboxylic acid derivatives for producing pharmaceutical compositions suitable for reducing blood glucose
US6323206B1 (en)	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
WO1998015548A1 (en) *	1996-10-04	1998-04-16	Novo Nordisk A/S	1,4-disubstituted piperazines
ZA978792B (en) *	1996-10-04	1998-04-06	Novo Nordisk As	N-substituted azaheterocyclic compounds.
BR9712202A (pt) *	1996-10-04	1999-08-31	Novo Nordisk As	Composto, processo para preparar o mesmo, composicão farmacêutica, processo para o tratamento de inflamacão neurogênica em um indivíduo em necessidade deste tratamento, e, uso do composto.
US6040318A (en) *	1997-06-25	2000-03-21	Novo Nordisk A/S	Tricycle substituted with azaheterocyclic carboxylic acids
BR9812772A (pt)	1997-10-27	2000-10-10	Reddy Research Foundation	"compostos tricìclicos inéditos e o seu emprego na medicina;processo para a sua preparação e composições farmacêuticas contendo os mesmos"
CA2318088A1 (en) *	1998-01-21	1999-07-29	Yoshisuke Nakasato	Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
ES2251176T3 (es)	1998-01-21	2006-04-16	Millennium Pharmaceuticals, Inc.	Antagonistas del receptor de quimioquina y procedimientos de uso de los mismos.
ES2137136B1 (es) *	1998-05-18	2000-07-01	Esteve Labor Dr	Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica.
US7271176B2 (en) *	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US6468996B1 (en) *	1998-10-21	2002-10-22	Novo Nordisk A/S	Substituted hetero-polycyclic compounds as PPARα and PPARγ activators
US6207682B1 (en)	1998-12-22	2001-03-27	Novo Nordisk A/S	Modified release formulations containing (R)-1-(10,11-dihydro-5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1propyl)-3-piperidinecarboxylic acid
EP1140084A1 (en) *	1998-12-22	2001-10-10	Novo Nordisk A/S	Novel formulation
US7355042B2 (en) *	2001-10-16	2008-04-08	Hypnion, Inc.	Treatment of CNS disorders using CNS target modulators
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US20040087642A1 (en) *	2002-10-24	2004-05-06	Zeldis Jerome B.	Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor
US20070066570A1 (en) *	2003-06-16	2007-03-22	Michael Solomon	Methods for treating sleep disorders
EP2061788A4 (en) *	2006-09-01	2010-10-06	Immune Control Inc	NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH ACTIVATED LYMPHOCYTES
TW201711999A (zh)	2015-09-03	2017-04-01	佛瑪治療公司	﹝６，６﹞稠合雙環組蛋白脫乙醯基酶８（ｈｄａｃ８）抑制劑
CN110996932A (zh)	2017-07-13	2020-04-10	托尼克斯医药控股公司	环苯扎林和阿米替林的类似物
CN115850232B (zh) *	2023-02-16	2023-05-26	广州佳途科技股份有限公司	一种氟哌噻吨ep杂质h的制备方法及其应用

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MY113463A (en) *	1994-01-04	2002-03-30	Novo Nordisk As	Novel heterocyclic compounds

1994
- 1994-12-30 MY MYPI94003583A patent/MY113463A/en unknown
1995
- 1995-01-02 IL IL11222295A patent/IL112222A/xx not_active IP Right Cessation
- 1995-01-03 SK SK881-96A patent/SK88196A3/sk unknown
- 1995-01-03 ES ES95904409T patent/ES2147837T3/es not_active Expired - Lifetime
- 1995-01-03 EP EP95904409A patent/EP0738262B1/en not_active Expired - Lifetime
- 1995-01-03 JP JP7518275A patent/JP2944221B2/ja not_active Expired - Fee Related
- 1995-01-03 BR BR9506452A patent/BR9506452A/pt not_active IP Right Cessation
- 1995-01-03 CN CN95191845A patent/CN1083431C/zh not_active Expired - Fee Related
- 1995-01-03 AT AT95904409T patent/ATE191909T1/de not_active IP Right Cessation
- 1995-01-03 UA UA96072659A patent/UA47396C2/uk unknown
- 1995-01-03 SG SG1996006195A patent/SG50602A1/en unknown
- 1995-01-03 RU RU96116134/04A patent/RU2167152C2/ru not_active IP Right Cessation
- 1995-01-03 AU AU13110/95A patent/AU691858B2/en not_active Ceased
- 1995-01-03 DE DE69516394T patent/DE69516394T2/de not_active Expired - Fee Related
- 1995-01-03 PT PT95904409T patent/PT738262E/pt unknown
- 1995-01-03 HU HU9601842A patent/HUT75878A/hu unknown
- 1995-01-03 NZ NZ277763A patent/NZ277763A/en unknown
- 1995-01-03 US US08/367,648 patent/US5595989A/en not_active Expired - Fee Related
- 1995-01-03 SI SI9520023A patent/SI9520023A/sl unknown
- 1995-01-03 DK DK95904409T patent/DK0738262T3/da active
- 1995-01-03 WO PCT/DK1995/000002 patent/WO1995018793A1/en not_active Ceased
- 1995-01-03 KR KR1019960703605A patent/KR100329450B1/ko not_active Expired - Fee Related
- 1995-01-03 CA CA002180238A patent/CA2180238A1/en not_active Abandoned
- 1995-01-03 PL PL95315294A patent/PL180209B1/pl not_active IP Right Cessation
- 1995-01-03 CZ CZ19961921A patent/CZ286109B6/cs unknown
- 1995-01-04 PE PE1995258527A patent/PE45095A1/es not_active Application Discontinuation
- 1995-02-22 TW TW084101613A patent/TW300887B/zh active
- 1995-05-18 US US08/444,140 patent/US5688788A/en not_active Expired - Fee Related
- 1995-10-18 US US08/544,682 patent/US5795888A/en not_active Expired - Fee Related
- 1995-10-18 US US08/544,502 patent/US5693649A/en not_active Expired - Fee Related
- 1995-10-18 US US08/544,905 patent/US5712292A/en not_active Expired - Fee Related
- 1995-10-18 US US08/544,500 patent/US5721254A/en not_active Expired - Fee Related
1996
- 1996-03-27 US US08/626,745 patent/US5668129A/en not_active Expired - Fee Related
- 1996-07-02 BG BG100692A patent/BG100692A/xx unknown
- 1996-07-03 NO NO962811A patent/NO306295B1/no not_active IP Right Cessation
- 1996-07-04 FI FI962749A patent/FI114025B/fi active
1998
- 1998-01-23 US US09/012,918 patent/US6043239A/en not_active Expired - Fee Related
2000
- 2000-07-17 GR GR20000401652T patent/GR3033967T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
SI9520023A (en)	1997-04-30
SG50602A1 (en)	1998-07-20
US5688788A (en)	1997-11-18
JP2944221B2 (ja)	1999-08-30
US6043239A (en)	2000-03-28
HU9601842D0 (en)	1996-09-30
HUT75878A (en)	1997-05-28
TW300887B (da)	1997-03-21
CN1142226A (zh)	1997-02-05
FI962749A0 (fi)	1996-07-04
IL112222A0 (en)	1995-03-30
ATE191909T1 (de)	2000-05-15
KR100329450B1 (ko)	2002-10-04
JPH09507239A (ja)	1997-07-22
US5693649A (en)	1997-12-02
CN1083431C (zh)	2002-04-24
PT738262E (pt)	2000-10-31
CZ286109B6 (cs)	2000-01-12
US5712292A (en)	1998-01-27
ES2147837T3 (es)	2000-10-01
CZ192196A3 (en)	1997-05-14
CA2180238A1 (en)	1995-07-13
NO306295B1 (no)	1999-10-18
NO962811L (no)	1996-09-04
UA47396C2 (uk)	2002-07-15
DE69516394T2 (de)	2000-10-26
MY113463A (en)	2002-03-30
WO1995018793A1 (en)	1995-07-13
NO962811D0 (no)	1996-07-03
FI962749L (fi)	1996-09-04
US5795888A (en)	1998-08-18
US5668129A (en)	1997-09-16
IL112222A (en)	1999-12-31
PE45095A1 (es)	1995-12-18
US5595989A (en)	1997-01-21
AU1311095A (en)	1995-08-01
PL180209B1 (pl)	2001-01-31
RU2167152C2 (ru)	2001-05-20
AU691858B2 (en)	1998-05-28
BR9506452A (pt)	1997-09-02
GR3033967T3 (en)	2000-11-30
SK88196A3 (en)	1997-06-04
EP0738262B1 (en)	2000-04-19
BG100692A (en)	1997-09-30
EP0738262A1 (en)	1996-10-23
NZ277763A (en)	2001-11-30
FI114025B (fi)	2004-07-30
US5721254A (en)	1998-02-24
DE69516394D1 (de)	2000-05-25

Publication	Publication Date	Title
DK0738262T3 (da)	2000-09-04	Hidtil ukendte heterocykliske forbindelser
MX9707531A (es)	1997-11-29	Nuevos compuestos heterociclicos.
EA200201271A1 (ru)	2003-04-24	Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
EA200100971A1 (ru)	2002-02-28	Новые соединения и композиции в качестве ингибиторов протеазы
EA200400944A1 (ru)	2005-04-28	Замещенные производные тетрациклина, фармацевтическая композиция и способ лечения субъекта с их использованием
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