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DE69828614D1 - Behandlung von Nierenfibrose durch Antikörper gegen integrin alpha-v-beta 6 - Google Patents

Behandlung von Nierenfibrose durch Antikörper gegen integrin alpha-v-beta 6

Info

Publication number
DE69828614D1
DE69828614D1 DE69828614T DE69828614T DE69828614D1 DE 69828614 D1 DE69828614 D1 DE 69828614D1 DE 69828614 T DE69828614 T DE 69828614T DE 69828614 T DE69828614 T DE 69828614T DE 69828614 D1 DE69828614 D1 DE 69828614D1
Authority
DE
Germany
Prior art keywords
antibodies
beta
treatment
renal fibrosis
integrin alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69828614T
Other languages
English (en)
Other versions
DE69828614T2 (de
Inventor
Xiaozhu Huang
Dean Sheppard
Robert Pytela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Original Assignee
University of California
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, University of California Berkeley filed Critical University of California
Publication of DE69828614D1 publication Critical patent/DE69828614D1/de
Application granted granted Critical
Publication of DE69828614T2 publication Critical patent/DE69828614T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69828614T 1997-08-08 1998-08-07 Behandlung von Nierenfibrose durch Antikörper gegen integrin alpha-v-beta 6 Expired - Lifetime DE69828614T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5506097P 1997-08-08 1997-08-08
US55060P 1997-08-08
PCT/US1998/016439 WO1999007405A1 (en) 1997-08-08 1998-08-07 TREATMENT OF ACUTE LUNG INJURY AND FIBROSIS WITH ANTAGONISTS OF αvβ6

Publications (2)

Publication Number Publication Date
DE69828614D1 true DE69828614D1 (de) 2005-02-17
DE69828614T2 DE69828614T2 (de) 2006-02-09

Family

ID=21995323

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69828614T Expired - Lifetime DE69828614T2 (de) 1997-08-08 1998-08-07 Behandlung von Nierenfibrose durch Antikörper gegen integrin alpha-v-beta 6
DE69840113T Expired - Lifetime DE69840113D1 (de) 1997-08-08 1998-08-07 Behandlung von Leberfibrose mit Anti-alpha V beta 6 Integrin Antikörpern

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69840113T Expired - Lifetime DE69840113D1 (de) 1997-08-08 1998-08-07 Behandlung von Leberfibrose mit Anti-alpha V beta 6 Integrin Antikörpern

Country Status (23)

Country Link
US (5) US20020004482A1 (de)
EP (3) EP0996460B1 (de)
JP (2) JP2001513333A (de)
KR (1) KR100586202B1 (de)
CN (1) CN1267224A (de)
AT (3) ATE511850T1 (de)
AU (1) AU739283B2 (de)
BR (1) BR9814040A (de)
CA (1) CA2297736A1 (de)
CY (2) CY1110462T1 (de)
CZ (1) CZ299768B6 (de)
DE (2) DE69828614T2 (de)
DK (2) DK1504764T3 (de)
EE (1) EE04752B1 (de)
ES (3) ES2235350T3 (de)
HU (1) HU228900B1 (de)
IL (2) IL134288A0 (de)
NZ (2) NZ502546A (de)
PL (2) PL199014B1 (de)
PT (3) PT1504764E (de)
RU (1) RU2221589C2 (de)
TR (2) TR200000374T2 (de)
WO (1) WO1999007405A1 (de)

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US5962643A (en) * 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
US20020004482A1 (en) * 1997-08-08 2002-01-10 Xiaozhu Huang Treatment of acute lung injury and fibrosis with antagonists of avbeta6
DE60020955T2 (de) * 1999-04-22 2006-05-11 Biogen Idec Ma Inc., Cambridge Verfahren zur behandlung einer fibrose unter verwendung eines antagonisten der integrin alpha-4 untereinheit
DE19929410A1 (de) * 1999-06-26 2000-12-28 Merck Patent Gmbh Inhibitoren des Integrins avß6
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
AUPR230500A0 (en) * 2000-12-22 2001-01-25 University Of Newcastle Research Associates Limited, The A method of modulating map kinase mediated cellular activity and agents useful in same
ATE409047T1 (de) * 2001-04-30 2008-10-15 Lilly Co Eli Humanisierte antikörper
EA011853B1 (ru) * 2002-03-13 2009-06-30 Байоджен Айдек Ма Инк. АНТИТЕЛА ПРОТИВ αβ
CA2481922A1 (en) * 2002-04-12 2003-10-23 Raven Biotechnologies, Inc. Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
EP2394662B1 (de) * 2004-04-02 2018-03-21 The Regents of The University of California Verfahren und zusammensetzungen für die behandlung und vorbeugung von mit alpha v beta 5-integrin assoziierten krankheiten
CN104072614B (zh) 2005-07-08 2017-04-26 生物基因Ma公司 抗-αvβ6 抗体及其用途
US8795668B2 (en) * 2005-12-23 2014-08-05 The Regents Of The University Of Michigan Methods for treating pulmonary fibrosis
KR20090027241A (ko) 2006-07-10 2009-03-16 바이오겐 아이덱 엠에이 인코포레이티드 Ｓｍａｄ４-결핍 암의 성장을 억제하기 위한 조성물 및 방법
BRPI0715141A2 (pt) * 2006-08-03 2013-06-04 Astrazeneca Ab agente de ligaÇço alvejante, anticorpo isolado, fragmento de anticorpo isolado, molÉcula de Ácido nucleico, vetor, cÉlula hospedeira, mÉtodos para produzir um agente de ligaÇço alvejado, para produzir um anticorpo, para produzir um fragmento de anticorpo, para tratar um tumor maligno em um animal, para tratar inflamaÇço, e para inibir a interaÇço de alfabeta6 com seu ligando, e, conjugado
EP2087008A1 (de) * 2006-10-19 2009-08-12 The Regents of the University of California BEHANDLUNG UND PRÄVENTION VON CHRONISCHEM ASTHMA MIT INTEGRIN-alphaVbeta6-ANTAGONISTEN
DK2182981T3 (en) 2007-08-02 2013-04-02 Gilead Biologics Inc Methods and compositions for treatment and diagnosis of fibrosis.
KR101046317B1 (ko) * 2008-07-04 2011-07-05 이종대 조력발전 방법 및 그 장치
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US10087252B2 (en) 2009-07-24 2018-10-02 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with αvβ5 integrin
NZ598464A (en) * 2009-08-21 2014-07-25 Gilead Biologics Inc Methods and compositions for treatment of pulmonary fibrotic disorders
BR112012008054A2 (pt) 2009-08-21 2017-05-23 Gilead Biologics Inc domínios catalíticos de lisil oxidase e loxl2
KR20130008021A (ko) * 2010-02-04 2013-01-21 길리아드 바이오로직스, 인크. 리실 산화효소-유사 2 (ｌｏｘｌ2)에 결합하는 항체, 및 그를 위한 사용 방법
US9493566B2 (en) 2012-02-17 2016-11-15 Seattle Genetics, Inc. Antibodies to integrin AVB6 and use of same to treat cancer
US10035860B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014144466A1 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
EP2784511A1 (de) 2013-03-27 2014-10-01 Universität Zürich Integrin-alpha-v-beta 6 zur Diagnose/Prognose von Kolorektalkarzinomen
JP6104312B2 (ja) * 2014-06-19 2017-03-29 日東電工株式会社 組織再生促進剤
JP7034914B2 (ja) * 2015-11-23 2022-03-14 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 線維症および／または線維性疾患の治療のための抗α－ｖインテグリン抗体
CA3073286A1 (en) 2017-08-22 2019-02-28 Biogen Ma Inc. Pharmaceutical compositions and dosage regimens containing anti-alpha(v)beta(6) antibodies
WO2021113697A1 (en) 2019-12-05 2021-06-10 Seagen Inc. Anti-avb6 antibodies and antibody-drug conjugates
CA3173761A1 (en) * 2020-05-07 2021-11-11 Eric Lefebvre Treatment of respiratory diseases with amino acid compounds
CN120960406A (zh) * 2024-05-16 2025-11-18 浙江大学 靶向整合素αVβ6的CAR-免疫细胞在预防和/或治疗纤维化疾病中的应用

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US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
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US5962643A (en) 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
US6492332B1 (en) * 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
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US20020004482A1 (en) * 1997-08-08 2002-01-10 Xiaozhu Huang Treatment of acute lung injury and fibrosis with antagonists of avbeta6

Also Published As

Publication number Publication date
US7150871B2 (en) 2006-12-19
DK1930022T3 (da) 2011-07-25
ES2311131T3 (es) 2009-02-01
IL134288A (en) 2008-07-08
US6692741B2 (en) 2004-02-17
IL134288A0 (en) 2001-04-30
CY1110462T1 (el) 2015-04-29
PL341029A1 (en) 2001-03-26
NZ515955A (en) 2003-04-29
TR200000374T2 (tr) 2000-09-21
AU739283B2 (en) 2001-10-11
HU228900B1 (en) 2013-06-28
KR20010022740A (ko) 2001-03-26
EP0996460A4 (de) 2001-03-07
DE69840113D1 (de) 2008-11-20
CZ299768B6 (cs) 2008-11-19
EP1504764A1 (de) 2005-02-09
NZ502546A (en) 2002-02-01
WO1999007405A1 (en) 1999-02-18
PT996460E (pt) 2005-04-29
CY1111792T1 (el) 2015-10-07
US7544358B2 (en) 2009-06-09
JP2009001587A (ja) 2009-01-08
CN1267224A (zh) 2000-09-20
EP1504764B1 (de) 2008-10-08
KR100586202B1 (ko) 2006-06-07
PL201716B1 (pl) 2009-05-29
PL199014B1 (pl) 2008-08-29
ATE286742T1 (de) 2005-01-15
HUP0003547A2 (hu) 2001-02-28
RU2221589C2 (ru) 2004-01-20
US20010056076A1 (en) 2001-12-27
CA2297736A1 (en) 1999-02-18
AU8774398A (en) 1999-03-01
JP2001513333A (ja) 2001-09-04
ATE410179T1 (de) 2008-10-15
US20020004482A1 (en) 2002-01-10
US6316601B1 (en) 2001-11-13
CZ2000413A3 (cs) 2000-11-15
ATE511850T1 (de) 2011-06-15
US20040208878A1 (en) 2004-10-21
ES2235350T3 (es) 2005-07-01
PT1504764E (pt) 2009-01-14
EP0996460B1 (de) 2005-01-12
EP1930022A1 (de) 2008-06-11
PT1930022E (pt) 2011-08-01
HUP0003547A3 (en) 2002-05-28
EE200000068A (et) 2000-10-16
BR9814040A (pt) 2000-10-03
EP1930022B1 (de) 2011-06-08
ES2364703T3 (es) 2011-09-12
EP0996460A1 (de) 2000-05-03
DE69828614T2 (de) 2006-02-09
EE04752B1 (et) 2006-12-15
US20070148173A1 (en) 2007-06-28
TR200202323T2 (tr) 2002-12-23
DK1504764T3 (da) 2008-11-17

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