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DE69635424D1 - Zur hemming der g-protein-funktion und zur behandlung proliferativer krankheiten geeignete tricyclische amide - Google Patents

Zur hemming der g-protein-funktion und zur behandlung proliferativer krankheiten geeignete tricyclische amide

Info

Publication number
DE69635424D1
DE69635424D1 DE69635424T DE69635424T DE69635424D1 DE 69635424 D1 DE69635424 D1 DE 69635424D1 DE 69635424 T DE69635424 T DE 69635424T DE 69635424 T DE69635424 T DE 69635424T DE 69635424 D1 DE69635424 D1 DE 69635424D1
Authority
DE
Germany
Prior art keywords
amids
tricyclic
highlights
treatment
proliferative diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69635424T
Other languages
English (en)
Other versions
DE69635424T2 (de
Inventor
J Doll
M Kelly
George Njoroge
K Mallams
W Remiszewski
G Taveras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69635424D1 publication Critical patent/DE69635424D1/de
Publication of DE69635424T2 publication Critical patent/DE69635424T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
DE69635424T 1995-12-22 1996-12-19 Zur hemming der g-protein-funktion und zur behandlung proliferativer krankheiten geeignete tricyclische amide Expired - Lifetime DE69635424T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US57795195A 1995-12-22 1995-12-22
US577951 1995-12-22
US61576096A 1996-03-13 1996-03-13
US615760 1996-03-13
PCT/US1996/019603 WO1997023478A1 (en) 1995-12-22 1996-12-19 Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
DE69635424D1 true DE69635424D1 (de) 2005-12-15
DE69635424T2 DE69635424T2 (de) 2006-08-03

Family

ID=27077386

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69635424T Expired - Lifetime DE69635424T2 (de) 1995-12-22 1996-12-19 Zur hemming der g-protein-funktion und zur behandlung proliferativer krankheiten geeignete tricyclische amide

Country Status (23)

Country Link
EP (2) EP1019392B1 (de)
JP (1) JP3193725B2 (de)
KR (1) KR100295224B1 (de)
CN (1) CN1326847C (de)
AR (1) AR005152A1 (de)
AT (1) ATE309238T1 (de)
AU (1) AU730194B2 (de)
BR (1) BR9612203A (de)
CA (2) CA2358394C (de)
CZ (1) CZ292791B6 (de)
DE (1) DE69635424T2 (de)
DK (1) DK1019392T3 (de)
ES (1) ES2248826T3 (de)
HU (1) HU228352B1 (de)
IL (1) IL125062A (de)
MX (1) MX9804956A (de)
MY (1) MY119007A (de)
NO (1) NO318232B1 (de)
NZ (1) NZ326035A (de)
PL (1) PL185597B1 (de)
SK (1) SK86198A3 (de)
TW (1) TW350844B (de)
WO (1) WO1997023478A1 (de)

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HUT76066A (en) * 1993-10-15 1997-06-30 Schering Corp Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases, pharmaceutical compositions containing them and process for producing them
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IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

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WO1997023478A1 (en) 1997-07-03
AU1331197A (en) 1997-07-17
CA2358394C (en) 2006-05-02
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SK86198A3 (en) 1999-02-11
CA2240846C (en) 2002-07-16
JP3193725B2 (ja) 2001-07-30
ATE309238T1 (de) 2005-11-15
HUP9903705A2 (hu) 2000-05-28
MX9804956A (es) 1998-09-30
HK1025571A1 (en) 2000-11-17
KR100295224B1 (ko) 2001-09-17
CA2240846A1 (en) 1997-07-03
JPH11501671A (ja) 1999-02-09
PL185597B1 (pl) 2003-06-30
EP1019392A1 (de) 2000-07-19
AU730194B2 (en) 2001-03-01
IL125062A0 (en) 1999-01-26
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DE69635424T2 (de) 2006-08-03
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NZ326035A (en) 2000-01-28
CZ292791B6 (cs) 2003-12-17
CA2358394A1 (en) 1997-07-03
ES2248826T3 (es) 2006-03-16
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KR19990076655A (ko) 1999-10-15
EP1380581A1 (de) 2004-01-14
MY119007A (en) 2005-03-31
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AR005152A1 (es) 1999-04-14
CZ193898A3 (cs) 1998-10-14
NO318232B1 (no) 2005-02-21
CN1209127A (zh) 1999-02-24
HU228352B1 (en) 2013-03-28
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