DE69628643T2 - System dispersibler partikel zur desensibilisierung der zähne - Google Patents

System dispersibler partikel zur desensibilisierung der zähne Download PDF

Info

Publication number: DE69628643T2
Authority: DE; Germany
Prior art keywords: clay; use according; toothpaste; sodium; laponite
Prior art date: 1995-04-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69628643T

Other languages

German (de)

English (en)

Other versions

DE69628643D1 (de

Inventor

Kenneth Markowitz

Y. Mikhail GELFER

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Block Drug Co Inc

Original Assignee

Block Drug Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-11

Filing date

1996-04-10

Publication date

2004-04-29

1996-04-10 Application filed by Block Drug Co Inc filed Critical Block Drug Co Inc

2003-07-17 Publication of DE69628643D1 publication Critical patent/DE69628643D1/de

2004-04-29 Application granted granted Critical

2004-04-29 Publication of DE69628643T2 publication Critical patent/DE69628643T2/de

2016-04-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000002245 particle Substances 0.000 title description 4
239000000606 toothpaste Substances 0.000 claims description 37
239000004927 clay Substances 0.000 claims description 32
239000000203 mixture Substances 0.000 claims description 28
KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims description 17
229910000271 hectorite Inorganic materials 0.000 claims description 17
239000000499 gel Substances 0.000 claims description 14
206010020751 Hypersensitivity Diseases 0.000 claims description 13
150000003839 salts Chemical group 0.000 claims description 10
239000002270 dispersing agent Substances 0.000 claims description 9
229920002678 cellulose Polymers 0.000 claims description 6
239000001913 cellulose Substances 0.000 claims description 6
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 5
238000011282 treatment Methods 0.000 claims description 5
159000000008 strontium salts Chemical class 0.000 claims description 3
AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical compound [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 2
150000001447 alkali salts Chemical class 0.000 claims 2
150000001875 compounds Chemical class 0.000 claims 2
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
150000001860 citric acid derivatives Chemical class 0.000 claims 1
235000011180 diphosphates Nutrition 0.000 claims 1
150000004820 halides Chemical class 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
150000002823 nitrates Chemical class 0.000 claims 1
229940034610 toothpaste Drugs 0.000 description 25
XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 23
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
229940094522 laponite Drugs 0.000 description 20
239000004615 ingredient Substances 0.000 description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
210000004268 dentin Anatomy 0.000 description 15
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 14
210000005239 tubule Anatomy 0.000 description 14
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 13
239000011734 sodium Substances 0.000 description 13
229910052708 sodium Inorganic materials 0.000 description 13
210000005036 nerve Anatomy 0.000 description 12
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 11
239000002562 thickening agent Substances 0.000 description 11
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 9
239000012530 fluid Substances 0.000 description 9
239000008213 purified water Substances 0.000 description 9
239000000600 sorbitol Substances 0.000 description 9
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 8
238000009472 formulation Methods 0.000 description 8
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 7
239000001768 carboxy methyl cellulose Substances 0.000 description 7
239000011737 fluorine Substances 0.000 description 7
229910052731 fluorine Inorganic materials 0.000 description 7
235000011187 glycerol Nutrition 0.000 description 7
238000000034 method Methods 0.000 description 7
239000000377 silicon dioxide Substances 0.000 description 7
239000011775 sodium fluoride Substances 0.000 description 7
235000013024 sodium fluoride Nutrition 0.000 description 7
229920002134 Carboxymethyl cellulose Polymers 0.000 description 6
229940090898 Desensitizer Drugs 0.000 description 6
208000026935 allergic disease Diseases 0.000 description 6
235000010948 carboxy methyl cellulose Nutrition 0.000 description 6
239000008112 carboxymethyl-cellulose Substances 0.000 description 6
230000009610 hypersensitivity Effects 0.000 description 6
230000009467 reduction Effects 0.000 description 6
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 5
150000001768 cations Chemical class 0.000 description 5
239000006185 dispersion Substances 0.000 description 5
239000010410 layer Substances 0.000 description 5
229910052710 silicon Inorganic materials 0.000 description 5
239000010703 silicon Substances 0.000 description 5
239000004408 titanium dioxide Substances 0.000 description 5
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
229920002125 Sokalan® Polymers 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000000463 material Substances 0.000 description 4
229920000642 polymer Polymers 0.000 description 4
239000001103 potassium chloride Substances 0.000 description 4
235000011164 potassium chloride Nutrition 0.000 description 4
FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
239000001488 sodium phosphate Substances 0.000 description 4
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 4
235000019801 trisodium phosphate Nutrition 0.000 description 4
229910000406 trisodium phosphate Inorganic materials 0.000 description 4
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
229910052586 apatite Inorganic materials 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
230000001680 brushing effect Effects 0.000 description 3
229960001631 carbomer Drugs 0.000 description 3
201000002170 dentin sensitivity Diseases 0.000 description 3
238000000586 desensitisation Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000000796 flavoring agent Substances 0.000 description 3
150000002222 fluorine compounds Chemical class 0.000 description 3
229910052744 lithium Inorganic materials 0.000 description 3
239000011777 magnesium Substances 0.000 description 3
229910052749 magnesium Inorganic materials 0.000 description 3
239000006072 paste Substances 0.000 description 3
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
239000011591 potassium Substances 0.000 description 3
229910052700 potassium Inorganic materials 0.000 description 3
229960003975 potassium Drugs 0.000 description 3
239000011736 potassium bicarbonate Substances 0.000 description 3
235000015497 potassium bicarbonate Nutrition 0.000 description 3
229910000028 potassium bicarbonate Inorganic materials 0.000 description 3
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
229960003500 triclosan Drugs 0.000 description 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
239000000654 additive Substances 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
239000002981 blocking agent Substances 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
230000006378 damage Effects 0.000 description 2
239000003599 detergent Substances 0.000 description 2
GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical class [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 2
239000000975 dye Substances 0.000 description 2
239000003792 electrolyte Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
239000003349 gelling agent Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000003906 humectant Substances 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
238000011835 investigation Methods 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
239000011707 mineral Substances 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
238000005498 polishing Methods 0.000 description 2
235000010333 potassium nitrate Nutrition 0.000 description 2
239000004323 potassium nitrate Substances 0.000 description 2
159000000001 potassium salts Chemical class 0.000 description 2
230000001603 reducing effect Effects 0.000 description 2
238000011160 research Methods 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
229960001866 silicon dioxide Drugs 0.000 description 2
235000019333 sodium laurylsulphate Nutrition 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
229940013553 strontium chloride Drugs 0.000 description 2
229910001631 strontium chloride Inorganic materials 0.000 description 2
AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
208000006558 Dental Calculus Diseases 0.000 description 1
206010013911 Dysgeusia Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical class [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
208000002599 Smear Layer Diseases 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
239000003082 abrasive agent Substances 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
238000013459 approach Methods 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
229940105329 carboxymethylcellulose Drugs 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
239000011247 coating layer Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000004040 coloring Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
210000003298 dental enamel Anatomy 0.000 description 1
239000003975 dentin desensitizing agent Substances 0.000 description 1
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
235000019820 disodium diphosphate Nutrition 0.000 description 1
229940038485 disodium pyrophosphate Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012025 fluorinating agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
239000007789 gas Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229920000591 gum Polymers 0.000 description 1
SNXYIOIMZXSIDC-UHFFFAOYSA-A hexadecasodium;phosphonato phosphate Chemical class [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O SNXYIOIMZXSIDC-UHFFFAOYSA-A 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
238000010874 in vitro model Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000004941 influx Effects 0.000 description 1
208000014674 injury Diseases 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
239000002324 mouth wash Substances 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000007686 potassium Nutrition 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
230000008569 process Effects 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
230000004044 response Effects 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229940047908 strontium chloride hexahydrate Drugs 0.000 description 1
AMGRXJSJSONEEG-UHFFFAOYSA-L strontium dichloride hexahydrate Chemical compound O.O.O.O.O.O.Cl[Sr]Cl AMGRXJSJSONEEG-UHFFFAOYSA-L 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000010998 test method Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Birds (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cosmetics (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Fodder In General (AREA)

DE69628643T 1995-04-11 1996-04-10 System dispersibler partikel zur desensibilisierung der zähne Expired - Lifetime DE69628643T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/419,816 US5589159A (en)	1995-04-11	1995-04-11	Dispersible particulate system for desensitizing teeth
US419816		1995-04-11
PCT/US1996/004852 WO1996032090A1 (en)	1995-04-11	1996-04-10	Dispersible particulate system for desensitizing teeth

Publications (2)

Publication Number	Publication Date
DE69628643D1 DE69628643D1 (de)	2003-07-17
DE69628643T2 true DE69628643T2 (de)	2004-04-29

Family

ID=23663881

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69628643T Expired - Lifetime DE69628643T2 (de)	1995-04-11	1996-04-10	System dispersibler partikel zur desensibilisierung der zähne

Country Status (23)

Country	Link
US (1)	US5589159A (es)
EP (1)	EP0820270B1 (es)
JP (1)	JPH11509518A (es)
KR (1)	KR19980703780A (es)
CN (1)	CN1102379C (es)
AR (1)	AR004171A1 (es)
AT (1)	ATE242624T1 (es)
AU (1)	AU717149B2 (es)
BG (1)	BG101949A (es)
BR (1)	BR9604959A (es)
CA (1)	CA2217861A1 (es)
CZ (1)	CZ288829B6 (es)
DE (1)	DE69628643T2 (es)
DK (1)	DK0820270T3 (es)
ES (1)	ES2201180T3 (es)
HU (1)	HUP9801702A3 (es)
NZ (1)	NZ305772A (es)
PL (1)	PL184327B1 (es)
PT (1)	PT820270E (es)
RU (1)	RU2163798C2 (es)
SK (1)	SK137697A3 (es)
UA (1)	UA48965C2 (es)
WO (1)	WO1996032090A1 (es)

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US5885551A (en) *	1997-08-01	1999-03-23	Smetana; Alfred J.	Treatment for dentinal hypersensitivity
US6241972B1 (en) *	1999-02-19	2001-06-05	Block Drug Company, Inc.	Oral care formulation for the treatment of sensitivity teeth
MXPA00002509A (es)	1999-03-12	2014-04-30	Pfizer	Composiciones que comprenden un ingrediente activo a base de una sal de potasio, incluyendo composiciones orales para reducir la sensibilidad del nervio dental y, la dentina que comprende un aromatizante distinto del mentol..
US6685920B2 (en) *	1999-11-12	2004-02-03	The Procter & Gamble Company	Method of protecting teeth against erosion
EP1731132B1 (en)	2000-10-13	2008-12-10	Block Drug Company, Inc.	Dental compositions for hypersensitive teeth
US6447756B1 (en) *	2000-11-08	2002-09-10	Colgate Palmolive Company	Desensitizing dual component dentifrice
US6416745B1 (en)	2001-05-03	2002-07-09	Block Drug Company, Inc.	Dental composition for treating hypersensitive teeth
BR0313249B1 (pt) *	2002-08-05	2014-04-22	Colgate Palmolive Co	Composição dentária para eliminar ou reduzir o desconforto e a dor associados com a hipersensibilidade dentinária
WO2006014365A2 (en) *	2004-07-02	2006-02-09	Discus Dental Impressions, Inc.	Dental compositions with sensitivity relief
WO2006100071A1 (en)	2005-03-21	2006-09-28	Glaxo Group Limited	Alkyl sulfate free and orthophosphate free dentifrice compostion comprising a fluoride source and a silica dental abrasive
US20070140992A1 (en) *	2005-12-21	2007-06-21	Lynn Schick	Taste masking of essential oils using a hydrocolloid
US20080268001A1 (en) *	2007-04-30	2008-10-30	Lynette Zaidel	Oral care composition to reduce or eliminate dental sensitivity
MX2010005542A (es) *	2008-02-08	2010-06-22	Colgate Palmolive Co	Producto para el cuidado oral y metodos de uso y fabricacion del mismo.
US20100047742A1 (en) *	2008-08-25	2010-02-25	Pitcock Jr William Henry	Tubule-blocking silica materials for dentifrices
AR076178A1 (es)	2009-04-01	2011-05-26	Colgate Palmolive Co	Composiciones dentifricas de accion doble para prevenir la hipersensibilidad y promover la remineralizacion
US20110206749A1 (en) *	2010-02-19	2011-08-25	J.M. Huber Corporation	Silica materials for reducing oral malador
US8658139B1 (en)	2010-02-27	2014-02-25	Squigle, Inc.	Prevention and treatment of oral diseases
US20110236444A1 (en) *	2010-03-25	2011-09-29	Darsillo Michael S	Antimicrobial Silica Composites
CN102946841A (zh)	2010-06-23	2013-02-27	高露洁-棕榄公司	治疗用口腔组合物
MX338600B (es)	2010-11-12	2016-04-22	Colgate Palmolive Co	Producto para el cuidado bucal asi como metodos para el uso y manufactura del mismo.
US9408794B2 (en)	2010-11-12	2016-08-09	Colgate-Palmolive Company	Oral care product and methods of use and manufacture thereof
CN107714495A (zh) *	2010-12-07	2018-02-23	高露洁-棕榄公司	含硅酸钙的洁齿剂组合物
US9717929B2 (en) *	2010-12-07	2017-08-01	Colgate-Palmolive Company	Dentifrice compositions containing calcium silicate and a basic amino acid
JP5720416B2 (ja) *	2011-05-19	2015-05-20	ライオン株式会社	ゲル状口腔用組成物及びその製造方法
HK1203385A1 (en) *	2011-12-21	2015-10-30	Colgate-Palmolive Company	Oral care compositions
AU2013408427B2 (en) *	2013-12-16	2017-02-02	Colgate-Palmolive Company	Oral care compositions comprising calcium carbonate and a clay
AU2013408426B2 (en) *	2013-12-16	2017-02-02	Colgate-Palmolive Company	Oral care compositions comprising calcium carbonate and talc
WO2021078685A1 (en)	2019-10-23	2021-04-29	Unilever Ip Holdings B.V.	Method of reducing dental hypersensitivity
EP4021585A1 (en)	2020-03-27	2022-07-06	Colgate-Palmolive Company	Oral care compositions and methods of use
CN115297824B (zh)	2020-03-27	2024-07-19	高露洁-棕榄公司	口腔护理组合物及使用方法
EP4387741A1 (en)	2021-09-23	2024-06-26	Colgate-Palmolive Company	Oral care compositions and methods of use

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JPS5257339A (en) *	1975-11-07	1977-05-11	Kao Corp	Tooth paste composition
US4474750A (en) *	1976-12-27	1984-10-02	Colgate-Palmolive Company	Anticalculus oral composition
US4418053A (en) *	1980-03-17	1983-11-29	Indiana University Foundation	Dental prophylaxis compositions and their use
US4634589A (en) *	1984-05-18	1987-01-06	Wurttembergische Parfumerie-Fabrik Gmbh	Dentifrice for hypersensitive teeth
JPH0742219B2 (ja) *	1984-07-26	1995-05-10	ライオン株式会社	口腔用組成物
US4992258A (en) *	1989-10-23	1991-02-12	Colgate-Palmolive Company	Dentrifice composition
US5328682A (en) *	1990-10-25	1994-07-12	Boots Company Plc	Mouthwash
GB9115154D0 (en) *	1991-07-12	1991-08-28	Patel Bipin C M	Sol-gel composition for producing glassy coatings
GB9115153D0 (en) *	1991-07-12	1991-08-28	Patel Bipin C M	Sol-gel composition for producing glassy coatings
US5250288A (en) *	1991-09-13	1993-10-05	Gillette Canada, Inc.	Method for desensitizing teeth
US5211939A (en) *	1991-09-13	1993-05-18	Gillette Canada	Method for desensitizing teeth
US5374417A (en) *	1991-10-17	1994-12-20	Colgate Palmolive Company	Desensitizing dentifrice
US5240697A (en) *	1991-10-17	1993-08-31	Colgate-Palmolive Company	Desensitizing anti-tartar dentifrice
US5270031A (en) *	1991-12-20	1993-12-14	Block Drug Company Inc.	Dentinal desensitizing compositions

1995
- 1995-04-11 US US08/419,816 patent/US5589159A/en not_active Expired - Lifetime
1996
- 1996-04-10 DK DK96910786T patent/DK0820270T3/da active
- 1996-04-10 BR BR9604959A patent/BR9604959A/pt not_active Application Discontinuation
- 1996-04-10 AT AT96910786T patent/ATE242624T1/de not_active IP Right Cessation
- 1996-04-10 ES ES96910786T patent/ES2201180T3/es not_active Expired - Lifetime
- 1996-04-10 CA CA002217861A patent/CA2217861A1/en not_active Abandoned
- 1996-04-10 PT PT96910786T patent/PT820270E/pt unknown
- 1996-04-10 KR KR1019970707180A patent/KR19980703780A/ko not_active Abandoned
- 1996-04-10 RU RU97118435/14A patent/RU2163798C2/ru not_active IP Right Cessation
- 1996-04-10 CZ CZ19973210A patent/CZ288829B6/cs not_active IP Right Cessation
- 1996-04-10 HU HU9801702A patent/HUP9801702A3/hu unknown
- 1996-04-10 PL PL96322719A patent/PL184327B1/pl unknown
- 1996-04-10 EP EP96910786A patent/EP0820270B1/en not_active Expired - Lifetime
- 1996-04-10 UA UA97115406A patent/UA48965C2/uk unknown
- 1996-04-10 JP JP8531103A patent/JPH11509518A/ja active Pending
- 1996-04-10 AU AU53885/96A patent/AU717149B2/en not_active Ceased
- 1996-04-10 CN CN96194361A patent/CN1102379C/zh not_active Expired - Fee Related
- 1996-04-10 NZ NZ305772A patent/NZ305772A/xx unknown
- 1996-04-10 WO PCT/US1996/004852 patent/WO1996032090A1/en not_active Ceased
- 1996-04-10 DE DE69628643T patent/DE69628643T2/de not_active Expired - Lifetime
- 1996-04-10 SK SK1376-97A patent/SK137697A3/sk unknown
- 1996-04-11 AR ARP960102155A patent/AR004171A1/es unknown
1997
- 1997-10-08 BG BG101949A patent/BG101949A/xx unknown

Also Published As

Publication number	Publication date
PL184327B1 (pl)	2002-10-31
ATE242624T1 (de)	2003-06-15
EP0820270A1 (en)	1998-01-28
AU5388596A (en)	1996-10-30
BR9604959A (pt)	1998-07-14
DE69628643D1 (de)	2003-07-17
CZ321097A3 (cs)	1998-03-18
JPH11509518A (ja)	1999-08-24
CZ288829B6 (cs)	2001-09-12
EP0820270B1 (en)	2003-06-11
KR19980703780A (ko)	1998-12-05
CN1186426A (zh)	1998-07-01
PT820270E (pt)	2003-10-31
BG101949A (en)	1998-05-29
US5589159A (en)	1996-12-31
UA48965C2 (uk)	2002-09-16
HUP9801702A3 (en)	1998-12-28
EP0820270A4 (en)	1999-06-23
PL322719A1 (en)	1998-02-16
WO1996032090A1 (en)	1996-10-17
CA2217861A1 (en)	1996-10-17
CN1102379C (zh)	2003-03-05
AR004171A1 (es)	1998-11-04
DK0820270T3 (da)	2003-09-29
NZ305772A (en)	1999-02-25
ES2201180T3 (es)	2004-03-16
SK137697A3 (en)	1998-05-06
HUP9801702A2 (hu)	1998-11-30
RU2163798C2 (ru)	2001-03-10
HK1004108A1 (en)	1998-11-20
AU717149B2 (en)	2000-03-16

Publication	Publication Date	Title
DE69628643T2 (de)	2004-04-29	System dispersibler partikel zur desensibilisierung der zähne
DE60037319T2 (de)	2008-11-27	Zusammensetzung zur behandlung von dentin hypersensitivität
DE3921133C2 (de)	1999-09-30	Wasserstoffperoxid freisetzende Zahnpasta
DE69530727T2 (de)	2004-04-29	Zweikomponenten Zahnpflegemittel zur Behandlung von Dentinhyperempfindlichkeit
DE69011560T2 (de)	1994-12-08	Oralmittel zur Behandlung von Überempfindlichkeit der Zähne.
DE69618786T2 (de)	2002-11-07	Wärmeerzeugende zahnpasta
DE3786754T2 (de)	1994-03-17	Granulatzusammensetzung und ihre Verwendung in Zahnpasten.
DE69518331T2 (de)	2000-12-14	Orale zubereitungen
DE10066408B4 (de)	2010-03-18	Verwendung feinkörniger Pulver für supragingivales Pulverstrahlen
DE3619867A1 (de)	1987-01-08	Zahnpasta mit hydrogenkarbonat
DE202007019713U1 (de)	2016-07-15	Mundpflegezusammensetzungen
AT390731B (de)	1990-06-25	Zahncreme
DE3241017C1 (de)	1983-12-15	Zahn- und Mundpflegemittel
EP0291747A1 (de)	1988-11-23	Zahnpasta
DE69714485T3 (de)	2007-10-31	Amorphe Kieselsäuren und orale Zusammensetzungen
DE69828043T2 (de)	2005-11-10	Fluoridfreie zahnremineralisierung
DE3874071T2 (de)	1993-01-14	Zahnsteinverhindernde zusammensetzung.
WO2019149889A1 (de)	2019-08-08	Hydroxylapatit
DE3545985A1 (de)	1986-07-10	Oral anzuwendendes mittel
DE69313635T2 (de)	1998-02-19	Mundwasser zur behandlung der dentinhyperempfindlichkeit
DE2146224A1 (de)	1972-03-23	Zahnpflegemittel
CH655239A5 (de)	1986-04-15	Zahnpflegemittel.
DE102017009626A1 (de)	2019-04-18	Oralzusammensetzung mit Zitrusextrakt und Hydroxylapatit
DE2347787A1 (de)	1974-04-11	Zahnpasta
CH624297A5 (en)	1981-07-31	Toothpaste

Legal Events

Date	Code	Title	Description
2004-07-08	8364	No opposition during term of opposition