DE60333201D1 - Verfahren zur herstellung von proteinen - Google Patents
Verfahren zur herstellung von proteinenInfo
- Publication number
- DE60333201D1 DE60333201D1 DE60333201T DE60333201T DE60333201D1 DE 60333201 D1 DE60333201 D1 DE 60333201D1 DE 60333201 T DE60333201 T DE 60333201T DE 60333201 T DE60333201 T DE 60333201T DE 60333201 D1 DE60333201 D1 DE 60333201D1
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- production
- transient expression
- secreted protein
- protein therefrom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000003306 harvesting Methods 0.000 abstract 1
- 210000001938 protoplast Anatomy 0.000 abstract 1
- 230000010474 transient expression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020020382 EP1398383A1 (de) | 2002-09-12 | 2002-09-12 | Verfahren zur Herstellung von Proteinen |
| EP03015881 | 2003-07-11 | ||
| PCT/EP2003/009959 WO2004024927A1 (en) | 2002-09-12 | 2003-09-08 | Protein production method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60333201D1 true DE60333201D1 (de) | 2010-08-12 |
Family
ID=31995519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60333201T Expired - Lifetime DE60333201D1 (de) | 2002-09-12 | 2003-09-08 | Verfahren zur herstellung von proteinen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1539966B1 (de) |
| AT (1) | ATE472604T1 (de) |
| AU (1) | AU2003270152A1 (de) |
| DE (1) | DE60333201D1 (de) |
| DK (1) | DK1539966T3 (de) |
| ES (1) | ES2347325T3 (de) |
| PT (1) | PT1539966E (de) |
| SI (1) | SI1539966T1 (de) |
| WO (1) | WO2004024927A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101364902B1 (ko) | 2003-11-05 | 2014-02-21 | 로슈 글리카트 아게 | 증가된 ｆｃ 수용체 결합 친화성 및 효과기 기능을 가진 ｃｄ20 항체 |
| PT1871805T (pt) | 2005-02-07 | 2019-12-02 | Roche Glycart Ag | Moléculas de ligação a antigénios que se ligam ao rfce, vetores que as codificam e as suas utilizações |
| JP5373396B2 (ja) | 2005-08-26 | 2013-12-18 | ロシュ グリクアート アクチェンゲゼルシャフト | 改変された細胞シグナル活性有する改変抗原結合分子 |
| SE529610C2 (sv) | 2006-02-13 | 2007-10-02 | Alfa Laval Corp Ab | Centrifugalseparator |
| AR062223A1 (es) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| MX339608B (es) | 2009-08-31 | 2016-05-31 | Roche Glycart Ag | Anticuerpos del antigeno carcinoembrionario (cea). |
| US20110200595A1 (en) | 2010-02-18 | 2011-08-18 | Roche Glycart | TREATMENT WITH A HUMANIZED IgG CLASS ANTI EGFR ANTIBODY AND AN ANTIBODY AGAINST INSULIN LIKE GROWTH FACTOR 1 RECEPTOR |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| JP5841149B2 (ja) | 2010-08-13 | 2016-01-13 | ロシュ グリクアート アーゲー | 抗テネイシンｃａ２抗体及び使用の方法 |
| MA34519B1 (fr) | 2010-08-13 | 2013-09-02 | Roche Glycart Ag | Anticorps anti-fap et procédés d'utilisation |
| MX2013009151A (es) | 2011-02-10 | 2013-08-29 | Roche Glycart Ag | Inmunoterapia mejorada. |
| US20140088019A1 (en) | 2011-02-11 | 2014-03-27 | Zyngenia, Inc. | Monovalent and Multivalent Multispecific Complexes and Uses Thereof |
| MX347590B (es) | 2011-03-02 | 2017-05-03 | Roche Glycart Ag | Anticuerpos del cea. |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| CA2837169C (en) | 2011-05-24 | 2021-11-09 | Zyngenia, Inc. | Multispecific complexes comprising angiopoietin-2-binding peptide and their uses |
| RU2014109038A (ru) | 2011-08-23 | 2015-09-27 | Рош Гликарт Аг | Антитела к хондроитинсульфат протеогликану меланомы |
| MY171038A (en) | 2011-08-23 | 2019-09-23 | Roche Glycart Ag | Bispecific antigen binding molecules |
| NZ702241A (en) | 2012-08-07 | 2018-04-27 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
| CN104936987A (zh) | 2013-02-26 | 2015-09-23 | 罗切格利卡特公司 | 抗mcsp抗体 |
| KR102788389B1 (ko) | 2015-04-06 | 2025-03-31 | 서브도메인, 엘엘씨 | 드 노보 결합 도메인 함유 폴리펩티드 및 그의 용도 |
| KR20180083313A (ko) | 2015-09-24 | 2018-07-20 | 에이비비트로, 엘엘씨 | Hiv 항체 조성물 및 사용 방법 |
| EP3178848A1 (de) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antikörper zur verringerung der bildung von antikörpern gegen medikamente |
| EP4026848A1 (de) | 2015-12-09 | 2022-07-13 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antikörper zur reduktion des zytokin-freisetzungssyndroms |
| JP2019515874A (ja) | 2016-03-01 | 2019-06-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 改変された細胞死誘導を有するオビヌツズマブ変異体 |
| EP3455252B1 (de) | 2016-05-11 | 2022-02-23 | F. Hoffmann-La Roche AG | Modifizierte anti-tenascin-antikörper und verfahren zur verwendung |
| EP3252078A1 (de) | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Typ ii anti-cd20 antikörper und anti-cd20/cd3 bispecific antikörper zur behandlung von krebs |
| SG11201909395TA (en) | 2017-04-27 | 2019-11-28 | Tesaro Inc | Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof |
| MX2019014274A (es) | 2017-06-02 | 2020-01-23 | Hoffmann La Roche | Metodo de tratamiento. |
| AU2018369639C1 (en) | 2017-11-14 | 2025-04-03 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| IL274677B2 (en) | 2017-11-14 | 2025-01-01 | Arcellx Inc | Therapies with multifunctional immune system cells |
| EP3737692A4 (de) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | Calreticulin-bindende konstrukte und gentechnisch veränderte t-zellen zur behandlung von krankheiten |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| US11555071B2 (en) | 2018-06-03 | 2023-01-17 | Lamkap Bio Beta Ltd. | Bispecific antibodies against CEACAM5 and CD47 |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| CN109234284B (zh) * | 2018-09-14 | 2021-04-09 | 昆明理工大学 | 一种三七类甜蛋白基因PnTLP5及应用 |
| CN109295068B (zh) * | 2018-09-14 | 2021-04-09 | 昆明理工大学 | 一种三七类甜蛋白基因PnTLP2及应用 |
| CN119661722A (zh) | 2019-02-21 | 2025-03-21 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| AU2020224681A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| EP3831849A1 (de) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispezifische antikörper gegen ceacam5 und cd47 |
| WO2021138474A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| JP2023551353A (ja) | 2020-10-13 | 2023-12-08 | アヴィタイド エルエルシー | ３へリックスバンドルタンパク質の親和性リガンドライブラリー及びその使用 |
| WO2022081775A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Aav8 affinity agents |
| CN117241866A (zh) | 2021-02-19 | 2023-12-15 | 艾维泰有限责任公司 | Aav2亲和剂 |
| CN117425484A (zh) | 2021-03-26 | 2024-01-19 | 阿奇利克斯股份有限公司 | 多功能免疫细胞疗法 |
| EP4326271A1 (de) | 2021-04-23 | 2024-02-28 | F. Hoffmann-La Roche AG | Vorbeugung oder abschwächung von nebenwirkungen im zusammenhang mit nk-zell-aktivierenden mitteln |
| CN118984834A (zh) | 2021-12-24 | 2024-11-19 | 阿维泰德有限责任公司 | Ch1结构域亲和配体和试剂 |
| EP4562022A1 (de) | 2022-07-29 | 2025-06-04 | Repligen Corporation | Affinitätsagent mit einem ligand zur bindung von vce und mit seq id no: 1 |
| CN120187741A (zh) | 2022-09-09 | 2025-06-20 | 瑞普利金公司 | 亲和剂 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19947290A1 (de) * | 1999-10-01 | 2001-04-19 | Greenovation Pflanzenbiotechno | Verfahren zur Herstellung proteinöser Substanzen |
-
2003
- 2003-09-08 AT AT03750495T patent/ATE472604T1/de active
- 2003-09-08 ES ES03750495T patent/ES2347325T3/es not_active Expired - Lifetime
- 2003-09-08 PT PT03750495T patent/PT1539966E/pt unknown
- 2003-09-08 WO PCT/EP2003/009959 patent/WO2004024927A1/en not_active Ceased
- 2003-09-08 EP EP03750495A patent/EP1539966B1/de not_active Expired - Lifetime
- 2003-09-08 DK DK03750495.8T patent/DK1539966T3/da active
- 2003-09-08 DE DE60333201T patent/DE60333201D1/de not_active Expired - Lifetime
- 2003-09-08 SI SI200331863T patent/SI1539966T1/sl unknown
- 2003-09-08 AU AU2003270152A patent/AU2003270152A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2347325T3 (es) | 2010-10-28 |
| AU2003270152A1 (en) | 2004-04-30 |
| EP1539966A1 (de) | 2005-06-15 |
| ATE472604T1 (de) | 2010-07-15 |
| WO2004024927A1 (en) | 2004-03-25 |
| EP1539966B1 (de) | 2010-06-30 |
| SI1539966T1 (sl) | 2010-10-29 |
| DK1539966T3 (da) | 2010-10-04 |
| PT1539966E (pt) | 2010-09-14 |
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