DE60331559D1 - Pyrrolidonderivate als mao-b hemmer - Google Patents

Pyrrolidonderivate als mao-b hemmer

Info

Publication number: DE60331559D1
Authority: DE; Germany
Prior art keywords: hemmer; mao; pyrrolidone derivatives; pyrrolidone; derivatives
Prior art date: 2002-09-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60331559T

Other languages

English (en)

Inventor

Hans Iding

Synese Jolidon

Daniela Krummenacher

Sarmiento Rosa Maria Rodriguez

Andrew William Thomas

Beat Wirz

Wolfgang Wostl

Rene Wyler

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-20

Filing date

2003-09-18

Publication date

2010-04-15

2003-09-18 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2010-04-15 Application granted granted Critical

2010-04-15 Publication of DE60331559D1 publication Critical patent/DE60331559D1/de

2023-09-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DE60331559T 2002-09-20 2003-09-18 Pyrrolidonderivate als mao-b hemmer Expired - Lifetime DE60331559D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02021319		2002-09-20
PCT/EP2003/010384 WO2004026827A1 (en)	2002-09-20	2003-09-18	Pyrrolidone derivatives as maob inhibitors

Publications (1)

Publication Number	Publication Date
DE60331559D1 true DE60331559D1 (de)	2010-04-15

Family

ID=32010924

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60333202T Expired - Lifetime DE60333202D1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer
DE60331559T Expired - Lifetime DE60331559D1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60333202T Expired - Lifetime DE60333202D1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer

Country Status (31)

Country	Link
US (4)	US7037935B2 (de)
EP (3)	EP1542971A1 (de)
JP (3)	JP4335141B2 (de)
KR (3)	KR100676014B1 (de)
CN (3)	CN100383118C (de)
AR (3)	AR041299A1 (de)
AT (2)	ATE459601T1 (de)
AU (3)	AU2003267381B2 (de)
BR (4)	BRPI0314631B1 (de)
CA (3)	CA2496756C (de)
CY (1)	CY1110745T1 (de)
DE (2)	DE60333202D1 (de)
DK (1)	DK1542970T3 (de)
ES (2)	ES2344557T3 (de)
GT (3)	GT200300206A (de)
HR (3)	HRP20050262A2 (de)
JO (2)	JO2604B1 (de)
MX (3)	MXPA05002880A (de)
MY (3)	MY134480A (de)
NO (3)	NO330012B1 (de)
NZ (3)	NZ538049A (de)
PA (3)	PA8583001A1 (de)
PE (3)	PE20050077A1 (de)
PL (3)	PL376019A1 (de)
PT (1)	PT1542970E (de)
RU (3)	RU2323209C2 (de)
SI (1)	SI1542970T1 (de)
TW (3)	TWI286132B (de)
UY (3)	UY27990A1 (de)
WO (3)	WO2004026827A1 (de)
ZA (3)	ZA200501137B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20050077A1 (es) *	2002-09-20	2005-03-01	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil-eter
GB0314373D0 (en) *	2003-06-19	2003-07-23	Glaxo Group Ltd	Chemical compounds
KR100845366B1 (ko) *	2004-08-02	2008-07-09	에프. 호프만-라 로슈 아게	모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
MX2007001169A (es)	2004-08-02	2007-03-12	Hoffmann La Roche	Derivados de benciloxi como inhibidores de la oxidasa de monoamina b.
WO2006089674A2 (en)	2005-02-25	2006-08-31	F.Hoffmann-La Roche Ag	Tablets with improved drug substance dispersibility
ES2314877T3 (es) *	2005-03-15	2009-03-16	F. Hoffmann-La Roche Ag	Metodo para preparar derivados de eter-4-pirrolidino-fenilbencilico enantiomericamente puros.
US7501528B2 (en) *	2005-03-15	2009-03-10	Hoffmann-La Roche Inc.	Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
WO2007042250A1 (en) *	2005-10-10	2007-04-19	Glaxo Group Limited	Prolinamide derivatives as sodium channel modulators
TW200730494A (en)	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
TW200728258A (en) *	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
WO2008121407A1 (en) *	2007-03-30	2008-10-09	The Regents Of The University Of California	In vivo imaging of sulfotransferases
KR101220182B1 (ko) *	2009-02-25	2013-01-11	에스케이바이오팜 주식회사	치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) *	2011-08-22	2013-09-04	Farmak, A. S.	Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) *	2013-02-28	2019-09-05	삼성디스플레이 주식회사	박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
BR112015022202A2 (pt)	2013-03-14	2017-07-18	Dart Neuroscience Cayman Ltd	compostos substituídos de naftiridina e quinolina como inibidores da mao
CZ305213B6 (cs) *	2013-04-29	2015-06-10	Farmak, A. S.	Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
RU2016118748A (ru)	2013-10-29	2017-12-05	Ф. Хоффманн-Ля Рош Аг	Кристаллические формы производного пирролидона, полезные при лечении болезни альцгеймера, и их получение
EP3237379B1 (de)	2014-12-23	2022-04-06	Convergence Pharmaceuticals Limited	Verfahren zur herstellung von alpha-carboxamid-pyrrolidinderivaten
EP3273946A1 (de) *	2015-03-27	2018-01-31	F. Hoffmann-La Roche AG	Pharmazeutische formulierung mit sembragilin
WO2019065794A1 (ja)	2017-09-27	2019-04-04	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた鎮痛薬
CA3076823A1 (en)	2017-10-05	2019-04-11	Biogen Inc.	Process for preparing alpha-carboxamide pyrrolidine derivatives
CN108299272B (zh) *	2018-01-31	2019-10-18	福州大学	一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
CN110240557B (zh) *	2018-03-08	2023-05-09	广东东阳光药业有限公司	吡咯烷酰胺衍生物及其用途
US20220184081A1 (en)	2019-02-27	2022-06-16	Kagoshima University	Antipruritic agent using pac1 receptor antagonist
JP7049637B1 (ja)	2020-05-08	2022-04-07	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた抗うつ・抗不安薬
CN112851561A (zh) *	2021-01-29	2021-05-28	南京艾美斐生物医药科技有限公司	一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de)	2021-06-21	2022-12-29	Bayer Aktiengesellschaft	Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4348393A (en) *	1978-06-09	1982-09-07	Delalande S.A.	N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2500831A1 (fr) *	1981-02-27	1982-09-03	Delalande Sa	Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
JP2657324B2 (ja)	1989-04-19	1997-09-24	大塚製薬株式会社	ヘテロ環を有するフェニルカルボン酸誘導体
HU221138B1 (en) *	1994-08-30	2002-08-28	Sankyo Co	Condensed isoxazolyloxy- and -thioalkylamine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5679715A (en)	1995-06-07	1997-10-21	Harris; Richard Y.	Method for treating multiple sclerosis
CA2244253C (en)	1996-03-15	2002-11-12	Somerset Pharmaceuticals, Inc.	Method for preventing and treating peripheral neuropathy by administering selegiline
US5683404A (en) *	1996-06-05	1997-11-04	Metagen, Llc	Clamp and method for its use
DE19841895A1 (de)	1998-09-11	2000-03-23	Degussa	Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
EP1165546A2 (de) *	1999-04-02	2002-01-02	Du Pont Pharmaceuticals Company	Lactamverbindungen als metalloprotease, tnf-alpha und aggrecanase inhibitoren
WO2001034172A2 (en)	1999-11-05	2001-05-17	Vela Pharmaceuticals Inc.	Methods and compositions for treating reward deficiency syndrome
WO2001058388A1 (en) *	2000-02-10	2001-08-16	Potencia Medical Ag	Urinary incontinence treatment with wireless energy supply
US7442165B2 (en) *	2000-02-14	2008-10-28	Obtech Medical Ag	Penile prosthesis
PE20050077A1 (es) *	2002-09-20	2005-03-01	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil-eter
US20040267292A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with transverse attachment mechanism
US20040267291A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with non-mechanical attachment mechanism

2003
- 2003-09-17 PE PE2003000952A patent/PE20050077A1/es not_active Application Discontinuation
- 2003-09-17 MY MYPI20033545A patent/MY134480A/en unknown
- 2003-09-17 TW TW092125618A patent/TWI286132B/zh not_active IP Right Cessation
- 2003-09-17 PA PA20038583001A patent/PA8583001A1/es unknown
- 2003-09-18 PL PL03376019A patent/PL376019A1/xx not_active Application Discontinuation
- 2003-09-18 EP EP03757866A patent/EP1542971A1/de not_active Withdrawn
- 2003-09-18 GT GT200300206A patent/GT200300206A/es unknown
- 2003-09-18 CA CA2496756A patent/CA2496756C/en not_active Expired - Fee Related
- 2003-09-18 PL PL376021A patent/PL216030B1/pl unknown
- 2003-09-18 CA CA2498785A patent/CA2498785C/en not_active Expired - Fee Related
- 2003-09-18 SI SI200331830T patent/SI1542970T1/sl unknown
- 2003-09-18 UY UY27990A patent/UY27990A1/es not_active Application Discontinuation
- 2003-09-18 MX MXPA05002880A patent/MXPA05002880A/es active IP Right Grant
- 2003-09-18 ES ES03750564T patent/ES2344557T3/es not_active Expired - Lifetime
- 2003-09-18 US US10/667,088 patent/US7037935B2/en not_active Expired - Fee Related
- 2003-09-18 CA CA002498335A patent/CA2498335A1/en not_active Abandoned
- 2003-09-18 MY MYPI20033558A patent/MY133332A/en unknown
- 2003-09-18 GT GT200300205A patent/GT200300205A/es unknown
- 2003-09-18 BR BRPI0314631-6A patent/BRPI0314631B1/pt unknown
- 2003-09-18 HR HR20050262A patent/HRP20050262A2/xx not_active Application Discontinuation
- 2003-09-18 BR BR0314314-7A patent/BR0314314A/pt not_active IP Right Cessation
- 2003-09-18 PA PA20038583501A patent/PA8583501A1/es unknown
- 2003-09-18 EP EP03748052A patent/EP1542969B1/de not_active Expired - Lifetime
- 2003-09-18 NZ NZ538049A patent/NZ538049A/en unknown
- 2003-09-18 BR BR0314299-0A patent/BR0314299A/pt active Search and Examination
- 2003-09-18 NZ NZ538046A patent/NZ538046A/en not_active IP Right Cessation
- 2003-09-18 GT GT200300204A patent/GT200300204A/es unknown
- 2003-09-18 RU RU2005111969/04A patent/RU2323209C2/ru not_active IP Right Cessation
- 2003-09-18 AU AU2003267381A patent/AU2003267381B2/en not_active Ceased
- 2003-09-18 AR ARP030103385A patent/AR041299A1/es not_active Application Discontinuation
- 2003-09-18 KR KR1020057004718A patent/KR100676014B1/ko not_active Expired - Fee Related
- 2003-09-18 TW TW092125746A patent/TWI331994B/zh not_active IP Right Cessation
- 2003-09-18 DE DE60333202T patent/DE60333202D1/de not_active Expired - Lifetime
- 2003-09-18 AT AT03748052T patent/ATE459601T1/de active
- 2003-09-18 MX MXPA05002881A patent/MXPA05002881A/es active IP Right Grant
- 2003-09-18 KR KR1020057004683A patent/KR100676015B1/ko not_active Expired - Fee Related
- 2003-09-18 EP EP03750564A patent/EP1542970B1/de not_active Expired - Lifetime
- 2003-09-18 US US10/666,594 patent/US7235581B2/en not_active Expired - Fee Related
- 2003-09-18 PL PL03376018A patent/PL376018A1/xx not_active Application Discontinuation
- 2003-09-18 ES ES03748052T patent/ES2338646T3/es not_active Expired - Lifetime
- 2003-09-18 NZ NZ538048A patent/NZ538048A/en not_active IP Right Cessation
- 2003-09-18 WO PCT/EP2003/010384 patent/WO2004026827A1/en not_active Ceased
- 2003-09-18 WO PCT/EP2003/010356 patent/WO2004026825A1/en not_active Ceased
- 2003-09-18 AU AU2003270213A patent/AU2003270213B8/en not_active Ceased
- 2003-09-18 CN CNB038219522A patent/CN100383118C/zh not_active Expired - Fee Related
- 2003-09-18 JP JP2004537120A patent/JP4335141B2/ja not_active Expired - Fee Related
- 2003-09-18 JP JP2004537121A patent/JP4335142B2/ja not_active Expired - Fee Related
- 2003-09-18 PE PE2003000958A patent/PE20050079A1/es active IP Right Grant
- 2003-09-18 JO JO2003115A patent/JO2604B1/en active
- 2003-09-18 TW TW092125735A patent/TWI337604B/zh not_active IP Right Cessation
- 2003-09-18 PA PA20038583601A patent/PA8583601A1/es unknown
- 2003-09-18 MY MYPI20033559A patent/MY135696A/en unknown
- 2003-09-18 AU AU2003273901A patent/AU2003273901B2/en not_active Ceased
- 2003-09-18 AR ARP030103383A patent/AR041297A1/es unknown
- 2003-09-18 CN CNB038212560A patent/CN100503562C/zh not_active Expired - Fee Related
- 2003-09-18 HR HRP20050263AA patent/HRP20050263B1/hr not_active IP Right Cessation
- 2003-09-18 AR ARP030103384A patent/AR041298A1/es unknown
- 2003-09-18 HR HR20050261A patent/HRP20050261A2/hr not_active Application Discontinuation
- 2003-09-18 WO PCT/EP2003/010383 patent/WO2004026826A1/en not_active Ceased
- 2003-09-18 AT AT03750564T patent/ATE472530T1/de active
- 2003-09-18 PT PT03750564T patent/PT1542970E/pt unknown
- 2003-09-18 UY UY27991A patent/UY27991A1/es not_active Application Discontinuation
- 2003-09-18 BR BR0314631-6A patent/BR0314631A/pt not_active IP Right Cessation
- 2003-09-18 US US10/667,087 patent/US7151111B2/en not_active Expired - Lifetime
- 2003-09-18 DK DK03750564.1T patent/DK1542970T3/da active
- 2003-09-18 JP JP2004537119A patent/JP4335140B2/ja not_active Expired - Fee Related
- 2003-09-18 RU RU2005111974/04A patent/RU2336267C2/ru not_active IP Right Cessation
- 2003-09-18 JO JO2003116A patent/JO2605B1/en active
- 2003-09-18 DE DE60331559T patent/DE60331559D1/de not_active Expired - Lifetime
- 2003-09-18 RU RU2005111968/04A patent/RU2336268C2/ru not_active IP Right Cessation
- 2003-09-18 KR KR1020057004699A patent/KR100681586B1/ko not_active Expired - Fee Related
- 2003-09-18 MX MXPA05002878A patent/MXPA05002878A/es active IP Right Grant
- 2003-09-18 CN CNB038217678A patent/CN100400509C/zh not_active Expired - Fee Related
- 2003-09-18 PE PE2003000956A patent/PE20050078A1/es not_active Application Discontinuation
- 2003-09-19 UY UY27993A patent/UY27993A1/es not_active Application Discontinuation
2005
- 2005-02-08 NO NO20050665A patent/NO330012B1/no not_active IP Right Cessation
- 2005-02-08 ZA ZA200501137A patent/ZA200501137B/xx unknown
- 2005-02-08 NO NO20050652A patent/NO329754B1/no not_active IP Right Cessation
- 2005-02-09 NO NO20050701A patent/NO20050701L/no not_active Application Discontinuation
- 2005-02-14 ZA ZA200501311A patent/ZA200501311B/en unknown
- 2005-02-22 ZA ZA200501557A patent/ZA200501557B/xx unknown
2006
- 2006-01-05 US US11/325,747 patent/US7122562B2/en not_active Expired - Fee Related
2010
- 2010-08-20 CY CY20101100770T patent/CY1110745T1/el unknown

Also Published As

Publication number	Publication date
JO2604B1 (en)	2011-11-01
US20060122235A1 (en)	2006-06-08
JO2605B1 (en)	2011-11-01
CA2496756C (en)	2012-01-10
BR0314314A (pt)	2005-07-26
EP1542969A1 (de)	2005-06-22
PL376019A1 (en)	2005-12-12
PT1542970E (pt)	2010-07-19
PE20050077A1 (es)	2005-03-01
HRP20050263A2 (en)	2006-12-31
TWI337604B (en)	2011-02-21
AU2003273901A1 (en)	2004-04-08
MXPA05002878A (es)	2005-05-27
UY27990A1 (es)	2004-03-31
US7037935B2 (en)	2006-05-02
CA2498335A1 (en)	2004-04-01
ATE472530T1 (de)	2010-07-15
CA2498785A1 (en)	2004-04-01
NO329754B1 (no)	2010-12-13
RU2005111974A (ru)	2006-01-20
EP1542969B1 (de)	2010-03-03
EP1542970A1 (de)	2005-06-22
KR100676014B1 (ko)	2007-01-30
GT200300205A (es)	2004-04-29
BR0314299A (pt)	2005-12-13
KR100676015B1 (ko)	2007-01-30
AR041299A1 (es)	2005-05-11
NO330012B1 (no)	2011-02-07
US20040097578A1 (en)	2004-05-20
CA2496756A1 (en)	2004-04-01
PA8583601A1 (es)	2004-09-16
EP1542971A1 (de)	2005-06-22
NZ538046A (en)	2007-08-31
TW200413350A (en)	2004-08-01
CN100503562C (zh)	2009-06-24
KR20050057450A (ko)	2005-06-16
ZA200501137B (en)	2006-12-27
MY133332A (en)	2007-11-30
HK1084383A1 (en)	2006-07-28
RU2005111968A (ru)	2006-11-10
MXPA05002880A (es)	2005-05-27
AU2003270213B2 (en)	2009-02-12
NO20050652L (no)	2005-03-08
NO20050701L (no)	2005-03-02
UY27991A1 (es)	2004-03-31
US7235581B2 (en)	2007-06-26
RU2323209C2 (ru)	2008-04-27
WO2004026825A1 (en)	2004-04-01
HK1083498A1 (zh)	2006-07-07
JP4335141B2 (ja)	2009-09-30
US7151111B2 (en)	2006-12-19
ES2344557T3 (es)	2010-08-31
PA8583501A1 (es)	2004-04-23
PL376021A1 (en)	2005-12-12
RU2005111969A (ru)	2006-01-20
ATE459601T1 (de)	2010-03-15
HK1083499A1 (zh)	2006-07-07
SI1542970T1 (sl)	2010-08-31
DK1542970T3 (da)	2010-08-02
MY134480A (en)	2007-12-31
HRP20050262A2 (en)	2006-06-30
CN100400509C (zh)	2008-07-09
JP2006503834A (ja)	2006-02-02
JP2006510596A (ja)	2006-03-30
WO2004026827A1 (en)	2004-04-01
BR0314631A (pt)	2005-08-02
UY27993A1 (es)	2004-03-31
GT200300206A (es)	2004-04-29
PE20050079A1 (es)	2005-03-01
AU2003267381B2 (en)	2009-08-27
MXPA05002881A (es)	2005-05-27
PL216030B1 (pl)	2014-02-28
KR20050057456A (ko)	2005-06-16
TW200410935A (en)	2004-07-01
AU2003270213B8 (en)	2009-03-05
JP4335142B2 (ja)	2009-09-30
PA8583001A1 (es)	2004-04-23
TWI331994B (en)	2010-10-21
US20040106650A1 (en)	2004-06-03
RU2336267C2 (ru)	2008-10-20
ZA200501311B (en)	2006-10-25
CY1110745T1 (el)	2015-06-10
WO2004026826A1 (en)	2004-04-01
CN1681778A (zh)	2005-10-12
ZA200501557B (en)	2005-09-08
TWI286132B (en)	2007-09-01
KR100681586B1 (ko)	2007-02-09
DE60333202D1 (de)	2010-08-12
EP1542970B1 (de)	2010-06-30
MY135696A (en)	2008-06-30
NO20050665L (no)	2005-04-18
AR041298A1 (es)	2005-05-11
CN1681777A (zh)	2005-10-12
BRPI0314631B1 (pt)	2018-04-17
HRP20050261A2 (en)	2006-05-31
CA2498785C (en)	2011-07-26
PE20050078A1 (es)	2005-02-28
RU2336268C2 (ru)	2008-10-20
JP2006503833A (ja)	2006-02-02
US20040116707A1 (en)	2004-06-17
CN1681779A (zh)	2005-10-12
JP4335140B2 (ja)	2009-09-30
PL376018A1 (en)	2005-12-12
AR041297A1 (es)	2005-05-11
CN100383118C (zh)	2008-04-23
ES2338646T3 (es)	2010-05-11
HRP20050263B1 (hr)	2013-09-30
AU2003273901B2 (en)	2008-07-10
US7122562B2 (en)	2006-10-17
NZ538049A (en)	2007-05-31
AU2003267381A1 (en)	2004-04-08
KR20050057466A (ko)	2005-06-16
GT200300204A (es)	2004-04-29
TW200408624A (en)	2004-06-01
NZ538048A (en)	2007-05-31
AU2003270213A1 (en)	2004-04-08

Publication	Publication Date	Title
ATE459601T1 (de)	2010-03-15	Pyrrolidonderivate als mao-b hemmer
DE50304983D1 (de)	2006-10-19	Heteroaryloxy-substituierte phenylaminopyrimidine als rho-kinaseinhibitoren
DE60330694D1 (de)	2010-02-04	Pyrimidopyrimidone als kinaseinhibitoren
DE602004015724D1 (de)	2008-09-25	Diazepinoindolderivate als kinaseinhibitoren
DE602004024420D1 (de)	2010-01-14	Chinazolinderivate als antitumormittel
ATE460418T1 (de)	2010-03-15	Heterocyclocarboxamidderivate
ATE450506T1 (de)	2009-12-15	Indol-3-schwefelderivate
ATE467631T1 (de)	2010-05-15	Chinuclidinamidderivate
ATE438644T1 (de)	2009-08-15	Chinazolinderivate
IS7720A (is)	2005-03-01	Píperidín-N-oxíð-afleiður
DK1474408T3 (da)	2012-06-25	N-Phenyl-2-pyrimidinaminderivater
DE60226775D1 (de)	2008-07-03	Azaindolylalkylaminderivate als 5-hydroxytryptamin-6-liganden
DK1492934T3 (da)	2010-10-04	Dørenhed
ATE335729T1 (de)	2006-09-15	3h-chinazoline -4-on derivaten
DE602004004295D1 (de)	2007-02-22	6-ä(substituiertes)phenylütriazolopyrimidine als antikrebsmittel
ATE423771T1 (de)	2009-03-15	Tetrahydrochinolinderivate
ATE394372T1 (de)	2008-05-15	G-lactamderivate als prostaglandinagonisten
DE60214138D1 (de)	2006-10-05	Isoxazolin-derivate als antidepressiva
NO20041958L (no)	2004-11-16	Stovtett plagg
DE60201463D1 (de)	2004-11-11	Indanon-Derivate als Duftstoffe
BR0311793B1 (pt)	2013-12-31	Projétil de neblina
NO20023047D0 (no)	2002-06-21	Kompenseringsanordning
DE50306277D1 (de)	2007-02-22	4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate
DE602004017206D1 (de)	2008-11-27	Benzazepin-derivate als mao-b-hemmer
DE60336338D1 (de)	2011-04-21	Sulfonylaminopyrazole als pestizide

Legal Events

Date	Code	Title	Description
2011-03-24	8364	No opposition during term of opposition