[go: up one dir, main page]

DE60321450D1 - Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung - Google Patents

Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung

Info

Publication number
DE60321450D1
DE60321450D1 DE60321450T DE60321450T DE60321450D1 DE 60321450 D1 DE60321450 D1 DE 60321450D1 DE 60321450 T DE60321450 T DE 60321450T DE 60321450 T DE60321450 T DE 60321450T DE 60321450 D1 DE60321450 D1 DE 60321450D1
Authority
DE
Germany
Prior art keywords
preparation
pharmaceutical preparations
antineoplastic agents
particular temozolomide
temozolomide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60321450T
Other languages
English (en)
Inventor
Sydney Ugwu
Vinay Radhakrishnan
Peter M Ihnat
Leonore C Witchey-Lakshmanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27766051&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60321450(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE60321450D1 publication Critical patent/DE60321450D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60321450T 2002-02-22 2003-02-20 Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung Expired - Lifetime DE60321450D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35919802P 2002-02-22 2002-02-22
PCT/US2003/005018 WO2003072082A1 (en) 2002-02-22 2003-02-20 Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same

Publications (1)

Publication Number Publication Date
DE60321450D1 true DE60321450D1 (de) 2008-07-17

Family

ID=27766051

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60321450T Expired - Lifetime DE60321450D1 (de) 2002-02-22 2003-02-20 Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung

Country Status (23)

Country Link
US (9) US6987108B2 (de)
EP (1) EP1478339B9 (de)
JP (2) JP4077794B2 (de)
KR (1) KR100970528B1 (de)
CN (2) CN100346784C (de)
AR (3) AR038535A1 (de)
AT (1) ATE397440T1 (de)
AU (1) AU2003213142B2 (de)
BR (1) BRPI0307802B8 (de)
CA (2) CA2476494C (de)
CY (1) CY1108291T1 (de)
DE (1) DE60321450D1 (de)
DK (1) DK1478339T3 (de)
ES (1) ES2307905T3 (de)
MX (1) MXPA04008133A (de)
NO (1) NO335045B1 (de)
NZ (1) NZ534378A (de)
PL (1) PL205936B1 (de)
PT (1) PT1478339E (de)
SG (1) SG161101A1 (de)
SI (1) SI1478339T1 (de)
WO (1) WO2003072082A1 (de)
ZA (1) ZA200406632B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0307802B8 (pt) * 2002-02-22 2021-05-25 Merck Sharp & Dohme formulação farmacêutica compreendendo temozolomida, processo para a produção da mesma, bem como artigo fabricado contendo pó liofilizado compreendendo temozolomida
US8188067B2 (en) 2004-04-01 2012-05-29 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
WO2005099666A2 (en) * 2004-04-01 2005-10-27 Teva Pharmaceutical Industries Ltd. Delayed release formulations of 6-mercaptopurine
WO2006060464A1 (en) * 2004-12-02 2006-06-08 Schering Corporation Methods of using temozolomide formulation intrathecally in the treatment of cancers
JP2009538317A (ja) * 2006-05-26 2009-11-05 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌治療のための置換ジアリールウレアを用いた薬物の組み合わせ
AU2007325838B2 (en) 2006-11-22 2013-09-19 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
US20100119592A1 (en) * 2006-12-08 2010-05-13 Bruce Michael Frankel Cytarabine for treatment of glioma
FR2910812B1 (fr) 2006-12-29 2009-03-20 Pierre Fabre Medicament Sa Compositions pharmaceutiques injectables lyophilisees de derives hemi-synthetiques d'alcaloide de vinca stables a temperature ambiante
CN101678002A (zh) * 2007-05-08 2010-03-24 先灵公司 使用含有替莫唑胺的静脉注射用配制剂的治疗方法
US20080319039A1 (en) * 2007-06-25 2008-12-25 Jacqueline Rose Bersch Unit dosage forms of temozolomide
CN101467967B (zh) * 2007-12-29 2012-05-23 北京京卫燕康药物研究所有限公司 用于静脉和脑内注射的两元溶液型制剂
CN102007145A (zh) 2008-02-14 2011-04-06 百时美施贵宝公司 基于结合egfr的工程化蛋白质的靶向治疗剂
CN101559037B (zh) * 2008-04-16 2013-01-30 北京京卫燕康药物研究所有限公司 用于静脉和脑内注射的两元溶液型制剂
EP2110130A1 (de) * 2008-04-18 2009-10-21 Teva Pharmaceutical Industries Ltd. Pharmazeutische Verwendung von 6-Mercaptopurin
AR071874A1 (es) 2008-05-22 2010-07-21 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
AR066943A1 (es) * 2008-06-10 2009-09-23 Eriochem Sa Una composicion farmaceutica de melfalano
CN102149379A (zh) 2008-07-10 2011-08-10 安吉翁生物医药有限公司 调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物
MX393894B (es) 2008-09-30 2025-03-24 Shaw Ind Group Inc Composiciones de tereftalato de polietileno reciclado, fibras y artículos producidos a partir de las mismas, y métodos para producirlas.
CA2681244C (en) 2008-09-30 2015-03-17 Shaw Industries Group, Inc. Recycled polyethylene terephthalate compositions, fibers and articles produced therefrom, and methods for producing same
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US20100210511A1 (en) * 2009-02-11 2010-08-19 Bristol-Myers Squibb Company Combination VEGFR2 Therapy with Temozolomide
WO2011036676A2 (en) 2009-09-23 2011-03-31 Ashwini Nangia Stable cocrystals of temozolomide
EP3091028A1 (de) 2010-05-26 2016-11-09 Bristol-Myers Squibb Company Auf fibronectin basierende gerüstproteine mit erhöhter stabilität
CN101869551B (zh) * 2010-06-28 2012-04-18 江苏奥赛康药业股份有限公司 一种替莫唑胺冻干制剂
CN102342931B (zh) * 2010-07-29 2014-04-23 江苏恒瑞医药股份有限公司 替莫唑胺的可注射的胃肠外用药物制剂及其制备方法
CN101984968A (zh) * 2010-10-29 2011-03-16 北京润德康医药技术有限公司 抗肿瘤剂替莫唑胺的药物制剂制备方法
CN102659789B (zh) * 2011-04-27 2014-10-15 四川科瑞德凯华制药有限公司 一锅法制备替莫唑胺的方法及替莫唑胺的精制方法
AU2012247545B2 (en) * 2011-04-28 2016-08-11 Oncopeptides Innovation Ab Lyophilized preparation of cytotoxic dipeptides
CN102178676B (zh) * 2011-04-29 2012-07-25 山东大学 一种治疗脑胶质瘤的药物组合物
CN102949351B (zh) * 2011-08-16 2015-05-13 上海汇伦生命科技有限公司 一种替莫唑胺冻干制剂的制备方法
CN102688202B (zh) * 2012-06-07 2013-08-14 北京莱瑞森医药科技有限公司 一种替莫唑胺冻干制剂
US8974811B2 (en) * 2013-03-14 2015-03-10 Hikma Pharmaceuticals Stabilized pharmaceutical formulations comprising antineoplastic compounds
CN104274412A (zh) * 2013-07-01 2015-01-14 北京恒瑞康达医药科技发展有限公司 一种含有替莫唑胺、其药学上可接受的盐或其他衍生物的药物制剂
CN103432085A (zh) * 2013-08-19 2013-12-11 南京海纳医药科技有限公司 一种含氨基酸增溶剂的替莫唑胺冻干制剂及其制备方法
PL2865391T3 (pl) 2013-10-22 2018-01-31 Medac Ges Fuer Klinische Spezialpraeparate Mbh Sposób wytwarzania liofilizowanej kompozycji farmaceutycznej zawierającej mitomycynę C
WO2015193477A1 (en) * 2014-06-20 2015-12-23 Syddansk Universitet Auger electron therapy for glioblastoma
JP6825764B2 (ja) * 2014-08-14 2021-02-03 エル．イー．エー．エフ． ホールディングス グループ エルエルシーＬ．Ｅ．Ａ．Ｆ． Ｈｏｌｄｉｎｇｓ Ｇｒｏｕｐ Ｌｌｃ リポソームカプセル化親和性薬物
WO2016114818A1 (en) 2015-01-14 2016-07-21 The Medicines Company Pharmaceutical formulations comprising high purity cangrelor and methods for preparing and using the same
EP3362053A4 (de) 2015-10-16 2019-04-17 Hadasit Medical Research Services and Development Ltd. Behandlung von nicht alkoholbedingter fettleber oder nicht alkoholbedingter steatohepatitis mit 6-mercaptopurin mit verzögerter freisetzung
BR112018072603B1 (pt) * 2016-05-02 2023-12-26 Double Bond Pharmaceutical AB Composição farmacêutica tendo atividade antineoplásica, métodos para preparar a referida composição, formulações farmacêuticas, hidrogel compreendendo a referida composição, uso da composição e do hidrogel
JP6706988B2 (ja) * 2016-07-20 2020-06-10 日本化薬株式会社 ボルテゾミブを含有する医薬組成物
JOP20190204A1 (ar) * 2017-03-08 2019-09-05 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على سيليكسيباغ
CN107213123A (zh) * 2017-07-23 2017-09-29 南京正宽医药科技有限公司 一种注射用盐酸氨溴索及其制备方法
US20190216823A1 (en) * 2018-01-12 2019-07-18 Hyloris Developments Sa Methylprednisolone pharmaceutical suspension
MX2021012250A (es) 2019-04-11 2022-01-18 Angion Biomedica Corp Formas solidas de (e)-3-[2-(2-tienil)vinil]-1h-pirazol.
WO2021108601A1 (en) * 2019-11-25 2021-06-03 The Johns Hopkins University Formulations of terameprocol and temozolomide and their use in stimulation of humoral immunity in tumors
WO2021229442A1 (en) 2020-05-12 2021-11-18 Shorla Pharma Ltd Stable formulations of temozolomide for oral administration
WO2024071464A1 (ko) * 2022-09-27 2024-04-04 (주)바이오솔릭스 말레이트 금속염을 포함하는 항암용 조성물
AU2024290762A1 (en) 2023-07-06 2026-01-22 Shorla Pharma Ltd Oral compositions comprising temozolomide or lenalidomide

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
US5731304A (en) * 1982-08-23 1998-03-24 Cancer Research Campaign Technology Potentiation of temozolomide in human tumour cells
JPS60243028A (ja) * 1984-04-28 1985-12-03 Kyowa Hakko Kogyo Co Ltd インタ−フエロンの可溶化方法
GB8426672D0 (en) 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US5204335A (en) 1986-10-31 1993-04-20 Asta Pharma Aktiengesellschaft Ifosfamide lyophilisate and process for its preparation
JPS63313721A (ja) * 1987-06-17 1988-12-21 Teisan Seiyaku Kk 速溶性の注射用組成物
SU1479049A1 (ru) * 1987-07-01 1989-05-15 Научно-производственное объединение "Биолар" Способ получени концентрата водорастворимых фосфолипидов
US5066647A (en) 1989-04-20 1991-11-19 Erbamont, Inc. Cyclophosphamide - alanine lyophilizates
JP2977236B2 (ja) * 1990-07-20 1999-11-15 株式会社東芝 音声合成装置
US5268368A (en) * 1991-05-17 1993-12-07 Erbamont, Inc. Cyclophosphamide--amino acid lyophilizates
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
AU5838494A (en) * 1993-01-14 1994-08-15 Cancer Research Campaign Technology Limited Potentiation of temozolomide in human tumour cells
DE4331147A1 (de) * 1993-09-14 1995-03-16 Nycomed Arzneimittel Gmbh Intravenös verabreichbare, wäßrige Lösung
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
CZ302005B6 (cs) 1998-03-26 2010-09-01 Schering Corporation Vodný prostredek PEG-interferon alfa konjugátu, jeho lyofilizát a výrobek jej obsahující
US6251886B1 (en) 1998-12-07 2001-06-26 Schering Corporation Methods of using temozolomide in the treatment of cancers
US5972912A (en) 1998-12-17 1999-10-26 S.P. Pharmaceuticals Method for lyophilizing ifosfamide
CN1434825A (zh) * 1999-12-24 2003-08-06 拜尔公司 咪唑并[1,3,5]三嗪酮及其应用
BRPI0307802B8 (pt) 2002-02-22 2021-05-25 Merck Sharp & Dohme formulação farmacêutica compreendendo temozolomida, processo para a produção da mesma, bem como artigo fabricado contendo pó liofilizado compreendendo temozolomida
CA2585446A1 (en) 2004-11-09 2006-05-18 Schering Corporation Improved dosing regimen of temozolomide for treating cancer based on the patient's mgmt level

Also Published As

Publication number Publication date
JP2005518434A (ja) 2005-06-23
PL372319A1 (en) 2005-07-11
AR084868A2 (es) 2013-07-10
DK1478339T3 (da) 2008-08-25
NZ534378A (en) 2006-10-27
MXPA04008133A (es) 2004-11-26
US20060122163A1 (en) 2006-06-08
KR100970528B1 (ko) 2010-07-16
EP1478339A1 (de) 2004-11-24
HK1066466A1 (en) 2005-03-24
WO2003072082A1 (en) 2003-09-04
US20040043001A1 (en) 2004-03-04
JP2008031186A (ja) 2008-02-14
US20090176852A1 (en) 2009-07-09
ZA200406632B (en) 2005-11-30
PT1478339E (pt) 2008-09-05
US7674790B2 (en) 2010-03-09
ES2307905T3 (es) 2008-12-01
JP4077794B2 (ja) 2008-04-23
US20120053219A1 (en) 2012-03-01
NO335045B1 (no) 2014-09-01
CN101172104A (zh) 2008-05-07
CY1108291T1 (el) 2014-02-12
US8076335B2 (en) 2011-12-13
US20140088166A1 (en) 2014-03-27
CA2476494A1 (en) 2003-09-04
US20100331382A1 (en) 2010-12-30
BRPI0307802B8 (pt) 2021-05-25
US20160082005A1 (en) 2016-03-24
AR064722A2 (es) 2009-04-22
CA2476494C (en) 2010-04-27
CN100346784C (zh) 2007-11-07
CN101172104B (zh) 2013-04-03
ATE397440T1 (de) 2008-06-15
CA2662899A1 (en) 2003-09-04
US7786118B2 (en) 2010-08-31
AU2003213142B2 (en) 2005-11-10
NO20043961L (no) 2004-09-21
US20190336495A1 (en) 2019-11-07
US6987108B2 (en) 2006-01-17
US8623868B2 (en) 2014-01-07
CN1635871A (zh) 2005-07-06
BRPI0307802B1 (pt) 2018-11-27
JP4785816B2 (ja) 2011-10-05
US20180078546A1 (en) 2018-03-22
EP1478339B1 (de) 2008-06-04
KR20040085196A (ko) 2004-10-07
SI1478339T1 (sl) 2008-10-31
PL205936B1 (pl) 2010-06-30
AU2003213142A1 (en) 2003-09-09
BR0307802A (pt) 2004-12-21
SG161101A1 (en) 2010-05-27
AR038535A1 (es) 2005-01-19
EP1478339B9 (de) 2009-08-19

Similar Documents

Publication Publication Date Title
DE60321450D1 (de) Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung
DE60100186D1 (de) Orale pharmazeutische formulierungen von benzimidazolderivaten und verfahren zu ihrer herstellung
DE50309807D1 (de) Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
ATE259805T1 (de) Als arzneimittel einsetzbare anticholinergika sowie verfahren zu deren herstellung
DE50207522D1 (de) Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE50213536D1 (de) Xanthinderivate Verwendung als Arzneimittel sowie deren Verfahren zur deren Herstellung
DE50212302D1 (de) 17alpha-alkyl-17beta-oxy-estratriene und zwischenprodukte zu deren herstellung, verwendung der 17alpha-alkyl-17beta-oxy-estratriene zur herstellung von arzneimitteln sowie pharmazeutische präparate
DE602004029236D1 (de) Cyclische harnstoffderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung als kinaseinhibitoren
ATE528288T1 (de) Anthranilsäureamide, verfahren zu ihrer herstellung, ihre verwendung als antiarrhythmika sowie pharmazeutische zubereitungen davon
DE50312949D1 (de) Acyl-4-carboxy-phenyl-harnstoffderivate, verfahren zu deren herstellung und deren verwendung
ATE252562T1 (de) Pyrazolcarbonsäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE344034T1 (de) N-adamantylmethyl-derivate und zwischenprodukte als pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung
ATE215951T1 (de) Tetracyclische campothecineanalogue, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen
DE50013167D1 (de) 2'-substituierte 1,1'-biphenyl-2-carboxamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen
DE60301570D1 (de) 1,2,3-substituierte indolizinderivate, fgf inhibitoren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE60318167D1 (de) Arzneiform und Verfahren zu ihrer Herstellung
DE60131331D1 (de) Fluoxetin-Arzneimittel in Form überzogener dispergierbarer Tabletten sowie Verfahren zu dessen Herstellung
ATE323092T1 (de) Pyridopyrimidinon-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE60307875D1 (de) Imidazopyrin-derivate, verfahren zu ihrer herstellung and sie enthaltende pharmazeutische zusamensetzungen
DE69934781D1 (de) Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
DE60033519D1 (de) Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
ATE290366T1 (de) Pharmazeutische formulierung mit überdecktem geschmack und verfahren zu ihrer herstellung
DE60022890D1 (de) Naphthyridine derivate, verfahren zu ihrer herstellung, deren anwendung und sie enthaltende pharmazeutische zusammensetzungen
ATE264837T1 (de) N-guanidinalkylamide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate
ATE222586T1 (de) Benzolsulfonamidderivate und verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen

Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings