DE60100186D1 - Orale pharmazeutische formulierungen von benzimidazolderivaten und verfahren zu ihrer herstellung - Google Patents
Orale pharmazeutische formulierungen von benzimidazolderivaten und verfahren zu ihrer herstellungInfo
- Publication number
- DE60100186D1 DE60100186D1 DE60100186T DE60100186T DE60100186D1 DE 60100186 D1 DE60100186 D1 DE 60100186D1 DE 60100186 T DE60100186 T DE 60100186T DE 60100186 T DE60100186 T DE 60100186T DE 60100186 D1 DE60100186 D1 DE 60100186D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- pharmaceutical formulations
- oral pharmaceutical
- benzimidazole derivatives
- benzimidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000008203 oral pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US488406 | 2000-01-19 | ||
| US09/488,406 US6228400B1 (en) | 1999-09-28 | 2000-01-19 | Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same |
| PCT/US2001/000817 WO2001052816A2 (en) | 2000-01-19 | 2001-01-11 | Orally administered pharmaceutical formulations of benzimidazole derivatives and the method of preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60100186D1 true DE60100186D1 (de) | 2003-05-22 |
| DE60100186T2 DE60100186T2 (de) | 2004-01-08 |
Family
ID=23939604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60100186T Expired - Fee Related DE60100186T2 (de) | 2000-01-19 | 2001-01-11 | Orale pharmazeutische formulierungen von benzimidazolderivaten und verfahren zu ihrer herstellung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6228400B1 (de) |
| EP (1) | EP1185254B1 (de) |
| JP (1) | JP4293750B2 (de) |
| KR (1) | KR100740218B1 (de) |
| CN (1) | CN1212833C (de) |
| AU (1) | AU2001230892A1 (de) |
| DE (1) | DE60100186T2 (de) |
| WO (1) | WO2001052816A2 (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070231402A1 (en) | 1994-08-02 | 2007-10-04 | Immunopath Profile, Inc. | Therapeutic stem cell composition and stimulant, facilitator, accelerator, and synergizer thereof, growth factor, anti-inflammatory composition and uses thereof |
| ZA9810765B (en) * | 1998-05-28 | 1999-08-06 | Ranbaxy Lab Ltd | Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole. |
| IL130602A0 (en) * | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
| US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| MXPA02009587A (es) * | 2000-03-28 | 2003-05-14 | Biochemie Gmbh | Particulas granuladas con sabor enmascarado. |
| WO2002041891A2 (en) * | 2000-11-01 | 2002-05-30 | The Procter & Gamble Company | Hiv treatment with benzimidazoles |
| US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
| US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
| AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
| CA2448195A1 (en) * | 2001-05-15 | 2002-11-21 | Taisho Pharmaceutical Co., Ltd. | Minoxidil-containing liquid composition |
| US20030050620A1 (en) * | 2001-09-07 | 2003-03-13 | Isa Odidi | Combinatorial type controlled release drug delivery device |
| US8309118B2 (en) * | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
| KR100479637B1 (ko) * | 2002-02-01 | 2005-03-31 | 한국화학연구원 | 란소프라졸을 함유하는 경구제제 및 그의 제조방법 |
| JP2005521712A (ja) | 2002-03-26 | 2005-07-21 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | 弱塩基の可溶化 |
| DE10235475B4 (de) * | 2002-08-02 | 2006-04-27 | Ratiopharm Gmbh | Arzneimittel mit einer Benzimidazolverbindung im Gemisch mit mikrokristalliner Cellulose und Verfahren zu deren Herstellung |
| US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
| EP1524967B1 (de) | 2002-08-02 | 2008-03-12 | Ratiopharm GmbH | Pharmazeutische zusammensetzung enthaltend ein benzimidazol-derivat gemischt mit mikrokristalliner cellulose |
| WO2004089333A2 (en) * | 2003-02-28 | 2004-10-21 | Cadila Healthcare Limited | A stable benzimidazole formulation |
| WO2004103338A1 (en) * | 2003-05-19 | 2004-12-02 | Bioprogress Plc | Adhesives and film modifying compositions |
| US8802139B2 (en) * | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| US7312439B1 (en) | 2003-08-18 | 2007-12-25 | Rad Elec Inc. | Radon progeny monitor |
| KR20060109915A (ko) * | 2003-11-19 | 2006-10-23 | 벡타 리미티드 | 엔도퍼옥사이드 브리지 함유 화합물을 이용하여 헬리코박터파일로리 연관 질병의 치료를 위한 방법 및 조성물 |
| US20050175696A1 (en) * | 2003-12-29 | 2005-08-11 | David Edgren | Drug granule coatings that impart smear resistance during mechanical compression |
| EP1721604A4 (de) * | 2004-03-04 | 2008-04-30 | Takeda Pharmaceutical | Stabiles kapselpräparat |
| MXPA06011765A (es) * | 2004-04-12 | 2006-12-15 | Pfizer Prod Inc | Farmacos de sabor enmascarado en multiparticulados que se rompen. |
| US8394409B2 (en) * | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| US7981908B2 (en) * | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| EP1785135A1 (de) * | 2005-11-10 | 2007-05-16 | Laboratorios Del Dr. Esteve, S.A. | Neue Lanzoprazol enthaltende stabilisierte galenische Formulierungen und ihre Herstellung |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| KR100771426B1 (ko) * | 2006-02-03 | 2007-10-30 | 한국유나이티드제약 주식회사 | 마이크로펠렛을 이용한 약물학적 조성물 및 그의 제조방법 |
| CN104825397A (zh) * | 2006-04-03 | 2015-08-12 | 伊萨·奥迪迪 | 含有机溶胶涂层的受控释放递送物件 |
| CH698658B1 (de) * | 2006-04-24 | 2009-09-30 | Mepha Ag | Orale pharmazeutische Formulierung mit schneller Freisetzung für Pyridylmethylsulfinyl-Benzimidazole. |
| WO2007125397A2 (en) * | 2006-04-27 | 2007-11-08 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acidity using endoperoxide bridge-containing compounds |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| US20100297226A1 (en) * | 2006-06-01 | 2010-11-25 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
| PL2046334T3 (pl) * | 2006-07-25 | 2015-02-27 | Vecta Ltd | Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI |
| US9095512B2 (en) * | 2006-08-11 | 2015-08-04 | Asahi Kasei Chemicals Corporation | Method for producing spherical base granules comprising hardly water-soluble drug |
| CA2667039A1 (en) * | 2006-10-17 | 2008-04-24 | Ranbaxy Laboratories Limited | Multiple unit tablet compositions of benzimidazole compounds |
| US11116728B2 (en) | 2006-11-30 | 2021-09-14 | Bend Research, Inc. | Multiparticulates of spray-coated drug and polymer on a meltable core |
| US20080131563A1 (en) * | 2006-11-30 | 2008-06-05 | Vladek Kasperchik | Food-compatible laser-imageable coatings |
| EP2091519B1 (de) * | 2006-11-30 | 2015-06-24 | Bend Research, Inc | Multiteilchen eines spray-überzogenen arzneimittels und polymer auf einem schmelzbaren kern |
| WO2009006299A2 (en) * | 2007-06-29 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Multi-particulate systems |
| US20110038933A1 (en) * | 2008-05-06 | 2011-02-17 | Dexcell Ltd. | Stable benzimidazole formulation |
| WO2010018593A2 (en) * | 2008-07-03 | 2010-02-18 | Torrent Pharmaceuticals Ltd. | Gastric acid resistant benzimidazole multiple unit tablet composition |
| CL2008002267A1 (es) * | 2008-07-31 | 2009-07-03 | Servicios Cientificos Neuroinnovation Ltda | Uso de compuestos derivados de pirinmetilsulfinilbencimadazol y piperidinilaminobencimidazol como marcadores especificos para enfermedades neurodegenerativas y patologias tau; y como metodo de diagnostico de enfermedad de alzheimer, y formulacion farmaceutica que comprende dichos compuestos marcados radiactivamente o con fluorescencia. |
| DE102008045339A1 (de) * | 2008-09-01 | 2010-03-04 | Stada Arzneimittel Ag | Pharmazeutisches Pellet |
| WO2010030667A2 (en) * | 2008-09-09 | 2010-03-18 | Cima Labs Inc. | Dosage forms for weakly ionizable compounds |
| US11304960B2 (en) * | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| EP2319504A1 (de) | 2009-11-07 | 2011-05-11 | Laboratorios Del. Dr. Esteve, S.A. | Feste pharmazeutische Dosierform |
| BR112013000978A2 (pt) * | 2010-07-22 | 2017-07-11 | Lupin Ltd | composição de tablete de unidade múltipla |
| CN101953802B (zh) * | 2010-09-14 | 2012-05-09 | 陈敏伟 | 一种兰索拉唑肠溶制剂及其制备方法 |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| KR102060738B1 (ko) * | 2012-12-13 | 2019-12-30 | 한미약품 주식회사 | 에스오메프라졸 유리염기 또는 그의 알칼리염을 포함하는 고미가 차폐된 약학 제제 및 이의 제조방법 |
| CN103386133A (zh) * | 2013-07-09 | 2013-11-13 | 重庆莱美药业股份有限公司 | 一种质子泵抑制剂的口腔速溶制剂及其制备方法 |
| WO2015057191A1 (en) | 2013-10-15 | 2015-04-23 | General Electric Company | Methods and compositions for improving oil recovery in corn processing |
| WO2016033556A1 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS |
| WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| MX378262B (es) * | 2015-03-31 | 2025-03-10 | Laboratorios Bago S A | Procedimiento de elaboración de pellets entéricos que contienen un inhibidor de la bomba protónica y composiciones farmacéuticas multiparticuladas que los contienen. |
| EP3288556A4 (de) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Oral zerfallende zusammensetzungen |
| US20160331689A1 (en) * | 2015-05-12 | 2016-11-17 | SE Tylose USA, Inc. | Aqueous enteric coating composition |
| US20160361322A1 (en) | 2015-06-15 | 2016-12-15 | Lipocine Inc. | Composition and method for oral delivery of androgen prodrugs |
| US9714398B2 (en) | 2015-07-31 | 2017-07-25 | General Electric Company | Method for improving corn oil extraction using alkyl polyglycosides |
| US11286446B2 (en) | 2016-02-18 | 2022-03-29 | Bl Technologies, Inc. | Stillage solids concentration |
| WO2017145146A1 (en) | 2016-02-25 | 2017-08-31 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| CA3078723A1 (en) | 2016-11-28 | 2018-05-31 | Nachiappan Chidambaram | Oral testosterone undecanoate therapy |
| EP3824296A4 (de) | 2018-07-20 | 2022-04-27 | Lipocine Inc. | Lebererkrankung |
| KR102555956B1 (ko) | 2021-03-09 | 2023-07-18 | 주식회사한국파마 | 안정성이 향상된 라베프라졸을 유효성분으로 포함하는 경구용 속방형 제제 및 이의 제조방법 |
| WO2024228542A1 (ko) * | 2023-05-04 | 2024-11-07 | 풍림무약주식회사 | 장용성 코팅용 조성물 및 이를 이용한 정제의 제조 방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| SE8301182D0 (sv) | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| US5026560A (en) | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
| US5232706A (en) * | 1990-12-31 | 1993-08-03 | Esteve Quimica, S.A. | Oral pharmaceutical preparation containing omeprazol |
| JPH05194225A (ja) * | 1991-11-07 | 1993-08-03 | Yoshitomi Pharmaceut Ind Ltd | 安定化された抗潰瘍剤含有製剤 |
| FR2692146B1 (fr) | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
| JPH0733659A (ja) * | 1992-07-17 | 1995-02-03 | Yoshitomi Pharmaceut Ind Ltd | 抗潰瘍剤含有製剤 |
| DE69424487T2 (de) * | 1993-09-09 | 2001-01-18 | Takeda Chemical Industries, Ltd. | Formulierung enthaltend einen antibakteriellen und einen Antiulcus Wirkstoff |
| DE4439452A1 (de) * | 1994-11-04 | 1996-05-09 | Boehringer Mannheim Gmbh | Antikörperklassenspezifisches Entstörungsreagenz |
| SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
| ES2137862B1 (es) * | 1997-07-31 | 2000-09-16 | Intexim S A | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion. |
-
2000
- 2000-01-19 US US09/488,406 patent/US6228400B1/en not_active Expired - Fee Related
-
2001
- 2001-01-11 EP EP01903019A patent/EP1185254B1/de not_active Expired - Lifetime
- 2001-01-11 AU AU2001230892A patent/AU2001230892A1/en not_active Abandoned
- 2001-01-11 DE DE60100186T patent/DE60100186T2/de not_active Expired - Fee Related
- 2001-01-11 JP JP2001552864A patent/JP4293750B2/ja not_active Expired - Fee Related
- 2001-01-11 CN CNB018000819A patent/CN1212833C/zh not_active Expired - Fee Related
- 2001-01-11 KR KR1020017011825A patent/KR100740218B1/ko not_active Expired - Fee Related
- 2001-01-11 WO PCT/US2001/000817 patent/WO2001052816A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4293750B2 (ja) | 2009-07-08 |
| EP1185254B1 (de) | 2003-04-16 |
| DE60100186T2 (de) | 2004-01-08 |
| AU2001230892A1 (en) | 2001-07-31 |
| WO2001052816A2 (en) | 2001-07-26 |
| WO2001052816A3 (en) | 2001-12-20 |
| EP1185254A2 (de) | 2002-03-13 |
| CN1212833C (zh) | 2005-08-03 |
| JP2003520224A (ja) | 2003-07-02 |
| KR20010114225A (ko) | 2001-12-31 |
| CN1358089A (zh) | 2002-07-10 |
| KR100740218B1 (ko) | 2007-07-18 |
| US6228400B1 (en) | 2001-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60100186D1 (de) | Orale pharmazeutische formulierungen von benzimidazolderivaten und verfahren zu ihrer herstellung | |
| ATE252562T1 (de) | Pyrazolcarbonsäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen | |
| ATE263754T1 (de) | Substituierte sulfonylaminomethylbenzoesäure(derivate) und verfahren zu ihrer herstellung | |
| DE60215851D1 (de) | N-adamantylmethyl-derivate und zwischenprodukte als pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung | |
| DE60221201D1 (de) | Polyoxyalkylen-derivate und Verfahren zu ihrer Herstellung | |
| ATE317688T1 (de) | Orale pharmazeutische zusammensetzung enthaltend ein benzimidazolderivat mit antiulcus wirkung und verfahren zu seiner herstellung | |
| ATE259805T1 (de) | Als arzneimittel einsetzbare anticholinergika sowie verfahren zu deren herstellung | |
| ATE279392T1 (de) | Indol-verbindungen, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und ihre medizinische anwendung | |
| ATE296535T1 (de) | Wässerige formulierungen und verfahren zu ihrer herstellung | |
| ATE323092T1 (de) | Pyridopyrimidinon-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen | |
| DE60301570D1 (de) | 1,2,3-substituierte indolizinderivate, fgf inhibitoren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
| DE60318167D1 (de) | Arzneiform und Verfahren zu ihrer Herstellung | |
| ATE294175T1 (de) | 4-sulfonamid-piperidin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen | |
| ATE290366T1 (de) | Pharmazeutische formulierung mit überdecktem geschmack und verfahren zu ihrer herstellung | |
| DE69934781D1 (de) | Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen | |
| DE60033519D1 (de) | Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen | |
| ATE305471T1 (de) | Naphthyridine derivate, verfahren zu ihrer herstellung, deren anwendung und sie enthaltende pharmazeutische zusammensetzungen | |
| DE60010113D1 (de) | N-guanidinalkylamide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate | |
| ATE304534T1 (de) | Aminocarbonyl-substituierte benzimidazolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| ATE222586T1 (de) | Benzolsulfonamidderivate und verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen | |
| DE60012288D1 (de) | Antivirale pyrimidindion-derivate und verfahren zu ihrer herstellung | |
| ATE226082T1 (de) | Pharmazeutische zusammensetzungen aus dalfopristine und quinupristine und verfahren zu ihrer herstellung | |
| ATE244246T1 (de) | Pyridothienodiazepine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen | |
| DE60200023D1 (de) | Isoindoloindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltende pharmazeutische Zusammensetzungen | |
| ATE275136T1 (de) | Morpholinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |