DE60316709D1 - Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren - Google Patents

Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren

Info

Publication number: DE60316709D1
Authority: DE; Germany
Prior art keywords: gluccokinase; carbonateaureamides; activators; indole
Prior art date: 2002-10-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60316709T

Other languages

English (en)

Other versions

DE60316709T2 (de

Inventor

Wendy Lea Corbett

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-03

Filing date

2003-09-26

Publication date

2007-11-15

2003-09-26 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2007-11-15 Publication of DE60316709D1 publication Critical patent/DE60316709D1/de

2008-07-17 Application granted granted Critical

2008-07-17 Publication of DE60316709T2 publication Critical patent/DE60316709T2/de

2023-09-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60316709T 2002-10-03 2003-09-26 Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren Expired - Lifetime DE60316709T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US41573702P	2002-10-03	2002-10-03
US415737P		2002-10-03
PCT/EP2003/010776 WO2004031179A1 (en)	2002-10-03	2003-09-26	Indole-3-carboxamides as glucokinase (gk) activators

Publications (2)

Publication Number	Publication Date
DE60316709D1 true DE60316709D1 (de)	2007-11-15
DE60316709T2 DE60316709T2 (de)	2008-07-17

Family

ID=32069904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60316709T Expired - Lifetime DE60316709T2 (de)	2002-10-03	2003-09-26	Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren

Country Status (28)

Country	Link
US (1)	US6881844B2 (de)
EP (1)	EP1549638B1 (de)
JP (1)	JP4390704B2 (de)
KR (1)	KR100646486B1 (de)
CN (1)	CN100348596C (de)
AR (1)	AR041467A1 (de)
AT (1)	ATE374768T1 (de)
AU (1)	AU2003270285B2 (de)
BR (1)	BR0315047A (de)
CA (1)	CA2499329C (de)
DE (1)	DE60316709T2 (de)
DK (1)	DK1549638T3 (de)
ES (1)	ES2293005T3 (de)
HR (1)	HRP20050287A2 (de)
MX (1)	MXPA05003391A (de)
MY (1)	MY136764A (de)
NO (1)	NO20051103L (de)
NZ (1)	NZ538466A (de)
PA (1)	PA8584001A1 (de)
PE (1)	PE20050090A1 (de)
PL (1)	PL375149A1 (de)
PT (1)	PT1549638E (de)
RU (1)	RU2309956C2 (de)
SI (1)	SI1549638T1 (de)
TW (1)	TW200413364A (de)
UY (1)	UY28005A1 (de)
WO (1)	WO2004031179A1 (de)
ZA (1)	ZA200502619B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0102299D0 (sv)	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
US7812167B2 (en) *	2002-10-03	2010-10-12	Novartis, Ag	Substituted (thiazol-2-yl)-amides or sulfonamides as glucokinase activators useful in the treatment of type 2 diabetes
GB0226930D0 (en) *	2002-11-19	2002-12-24	Astrazeneca Ab	Chemical compounds
GB0226931D0 (en)	2002-11-19	2002-12-24	Astrazeneca Ab	Chemical compounds
EP1532980A1 (de) *	2003-11-24	2005-05-25	Novo Nordisk A/S	N-Heteroaryl Indol-Carboxamide und deren analoga zur Vewendung als glucokinase Aktivatoren zur Behandlung von Diabetes
PT1735322E (pt)	2004-04-02	2012-01-12	Novartis Ag	Derivados de sulfonamido-tiazolopiridina como activadores de glucoquinase úteis para o tratamento de diabetes de tipo 2
US7781451B2 (en)	2004-04-02	2010-08-24	Novartis Ag	Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
WO2006112549A1 (ja)	2005-04-20	2006-10-26	Takeda Pharmaceutical Company Limited	縮合複素環化合物
EP2301935A1 (de)	2005-07-09	2011-03-30	AstraZeneca AB (Publ)	Heteroarylbenzamid-Derivat zur Verwendung als GLK Aktivator zur Behandlung von Diabetes
US7622492B2 (en)	2005-08-31	2009-11-24	Hoffmann-La Roche Inc.	Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
JP2007063225A (ja)	2005-09-01	2007-03-15	Takeda Chem Ind Ltd	イミダゾピリジン化合物
AU2006299091A1 (en)	2005-09-29	2007-04-12	Sanofi-Aventis	Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
US7799820B2 (en)	2005-09-30	2010-09-21	Banyu Pharmaceutical Co., Ltd.	2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions
GT200600429A (es) *	2005-09-30	2007-04-30		Compuestos organicos
GT200600428A (es) *	2005-09-30	2007-05-21		Compuestos organicos
JP2009013065A (ja) *	2005-10-14	2009-01-22	Astellas Pharma Inc	縮合へテロ環化合物
WO2007061923A2 (en) *	2005-11-18	2007-05-31	Takeda San Diego, Inc.	Glucokinase activators
US7351706B2 (en) *	2006-01-05	2008-04-01	Hoffmann-La Roche Inc.	Indol-3-yl-carbonyl-spiro-piperidine derivatives
JP5302012B2 (ja)	2006-03-08	2013-10-02	タケダカリフォルニアインコーポレイテッド	グルコキナーゼ活性剤
EP1849785A1 (de) *	2006-04-28	2007-10-31	Neuropharma, S.A.	N-(2-Thiazolyl)-Amid-Derivative als GSK-3 Inhibitoren
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
EP2049518B1 (de) *	2006-05-31	2011-08-31	Takeda San Diego, Inc.	Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
CN101573357B (zh)	2006-10-19	2013-01-23	武田药品工业株式会社	吲哚化合物
WO2008079787A2 (en)	2006-12-20	2008-07-03	Takeda San Diego, Inc.	Glucokinase activators
WO2008074694A1 (en) *	2006-12-20	2008-06-26	F. Hoffmann-La Roche Ag	Crystallization of glucokinase activators
US8173645B2 (en)	2007-03-21	2012-05-08	Takeda San Diego, Inc.	Glucokinase activators
CN101778850A (zh) *	2007-08-10	2010-07-14	H.隆德贝克有限公司	杂芳基酰胺类似物
UY31830A (es)	2008-05-16	2010-01-05	Takeda Pharmaceutical	Activadores de glucoquinasa
WO2010107736A2 (en) *	2009-03-20	2010-09-23	University Of Virginia Patent Foundation	Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
JP2011006366A (ja)	2009-06-26	2011-01-13	Sanwa Kagaku Kenkyusho Co Ltd	新規チオフェンカルボキサミド誘導体及びその医薬用途
US9333193B2 (en)	2010-09-20	2016-05-10	University Of Virginia Patent Foundation	Compositions and methods for treating tuberculosis
CN103044310B (zh) *	2013-01-18	2015-02-04	贵阳医学院	二氢吲哚-3-乙酸衍生物、其制备方法以及在药物中的应用
CN118265698A (zh) *	2021-10-20	2024-06-28	科学与工业研究会(按照印度社会团体注册法案(1860年第21号法案)设立的注册机构)	用于制备吲哚-3-羧酸衍生物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2716194B1 (fr) *	1994-02-14	1996-05-31	Sanofi Elf	Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR2740686B1 (fr)	1995-11-03	1998-01-16	Sanofi Sa	Formulation pharmaceutique lyophilisee stable
FR2763337B1 (fr) *	1997-05-13	1999-08-20	Sanofi Sa	Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant
US6262096B1 (en)	1997-11-12	2001-07-17	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
US6040321A (en)	1997-11-12	2000-03-21	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
JP5278983B2 (ja)	1999-11-17	2013-09-04	塩野義製薬株式会社	アミド化合物の新規用途
DE60117059T2 (de)	2000-12-06	2006-10-26	F. Hoffmann-La Roche Ag	Kondensierte heteroaromatische glucokinaseaktivatoren
US6433188B1 (en)	2000-12-06	2002-08-13	Wendy Lea Corbett	Fused heteroaromatic glucokinase activators
US6482951B2 (en)	2000-12-13	2002-11-19	Hoffmann-La Roche Inc.	Isoindolin-1-one glucokinase activators
RU2290403C2 (ru) *	2000-12-28	2006-12-27	Дайити Фармасьютикал Ко., Лтд.	Ингибиторы vla-4
UA77303C2 (en) *	2002-06-14	2006-11-15	Pfizer	Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use

2003
- 2003-09-26 DE DE60316709T patent/DE60316709T2/de not_active Expired - Lifetime
- 2003-09-26 SI SI200331008T patent/SI1549638T1/sl unknown
- 2003-09-26 DK DK03750648T patent/DK1549638T3/da active
- 2003-09-26 WO PCT/EP2003/010776 patent/WO2004031179A1/en not_active Ceased
- 2003-09-26 NZ NZ538466A patent/NZ538466A/en unknown
- 2003-09-26 EP EP03750648A patent/EP1549638B1/de not_active Expired - Lifetime
- 2003-09-26 ES ES03750648T patent/ES2293005T3/es not_active Expired - Lifetime
- 2003-09-26 BR BR0315047-0A patent/BR0315047A/pt not_active IP Right Cessation
- 2003-09-26 AT AT03750648T patent/ATE374768T1/de not_active IP Right Cessation
- 2003-09-26 PT PT03750648T patent/PT1549638E/pt unknown
- 2003-09-26 CN CNB038236796A patent/CN100348596C/zh not_active Expired - Fee Related
- 2003-09-26 CA CA002499329A patent/CA2499329C/en not_active Expired - Fee Related
- 2003-09-26 RU RU2005113719/04A patent/RU2309956C2/ru not_active IP Right Cessation
- 2003-09-26 JP JP2004540731A patent/JP4390704B2/ja not_active Expired - Fee Related
- 2003-09-26 MX MXPA05003391A patent/MXPA05003391A/es active IP Right Grant
- 2003-09-26 PL PL03375149A patent/PL375149A1/xx not_active Application Discontinuation
- 2003-09-26 KR KR1020057005669A patent/KR100646486B1/ko not_active Expired - Fee Related
- 2003-09-26 AU AU2003270285A patent/AU2003270285B2/en not_active Ceased
- 2003-09-26 HR HR20050287A patent/HRP20050287A2/xx not_active Application Discontinuation
- 2003-09-30 PA PA20038584001A patent/PA8584001A1/es unknown
- 2003-09-30 TW TW092127030A patent/TW200413364A/zh unknown
- 2003-09-30 PE PE2003000988A patent/PE20050090A1/es not_active Application Discontinuation
- 2003-09-30 US US10/674,481 patent/US6881844B2/en not_active Expired - Fee Related
- 2003-10-01 UY UY28005A patent/UY28005A1/es not_active Application Discontinuation
- 2003-10-01 MY MYPI20033742A patent/MY136764A/en unknown
- 2003-10-01 AR ARP030103589A patent/AR041467A1/es unknown
2005
- 2005-03-01 NO NO20051103A patent/NO20051103L/no not_active Application Discontinuation
2006
- 2006-01-19 ZA ZA200502619A patent/ZA200502619B/en unknown

Also Published As

Publication number	Publication date
MXPA05003391A (es)	2005-06-22
AR041467A1 (es)	2005-05-18
ES2293005T3 (es)	2008-03-16
SI1549638T1 (sl)	2008-02-29
JP2006504707A (ja)	2006-02-09
HRP20050287A2 (en)	2006-12-31
MY136764A (en)	2008-11-28
BR0315047A (pt)	2005-08-23
EP1549638B1 (de)	2007-10-03
PA8584001A1 (es)	2004-11-02
NO20051103L (no)	2005-04-08
HK1083098A1 (en)	2006-06-23
WO2004031179A1 (en)	2004-04-15
KR20050046817A (ko)	2005-05-18
US20040067939A1 (en)	2004-04-08
KR100646486B1 (ko)	2006-11-15
RU2005113719A (ru)	2006-02-27
RU2309956C2 (ru)	2007-11-10
CN100348596C (zh)	2007-11-14
CA2499329A1 (en)	2004-04-15
AU2003270285A1 (en)	2004-04-23
PT1549638E (pt)	2007-12-11
ZA200502619B (en)	2006-03-29
NZ538466A (en)	2007-05-31
CA2499329C (en)	2009-04-21
DE60316709T2 (de)	2008-07-17
TW200413364A (en)	2004-08-01
AU2003270285B2 (en)	2007-04-26
PE20050090A1 (es)	2005-02-28
US6881844B2 (en)	2005-04-19
PL375149A1 (en)	2005-11-28
UY28005A1 (es)	2004-04-30
ATE374768T1 (de)	2007-10-15
DK1549638T3 (da)	2008-01-21
EP1549638A1 (de)	2005-07-06
CN1688574A (zh)	2005-10-26
JP4390704B2 (ja)	2009-12-24

Publication	Publication Date	Title
DE60316709D1 (de)	2007-11-15	Indole-3-carbonsaüreamide als glucokinase (gk) aktivatoren
DK1572670T3 (da)	2007-12-17	5-substitueret-pyrazin eller -pyridin-glucokinaseaktivatorer
ATE297921T1 (de)	2005-07-15	Tetrazolylphenyl-acetamide als glukokinaseaktivatoren
DE50304983D1 (de)	2006-10-19	Heteroaryloxy-substituierte phenylaminopyrimidine als rho-kinaseinhibitoren
DE60330694D1 (de)	2010-02-04	Pyrimidopyrimidone als kinaseinhibitoren
DE60336538D1 (de)	2011-05-12	Stabilisiervorrichtung
NO20043116L (no)	2004-09-20	Amidderivater som GK-aktivatorer
DE60305903D1 (de)	2006-07-20	Tropanderivative als ccr5-modulatoren
NO20044046L (no)	2004-11-15	Substituerte hydroksyetylaminer
EP1559433A4 (de)	2009-11-04	Stabilisierte zusammensetzung
FI20022261A7 (fi)	2004-06-21	Puskurointijärjestely
DE60312863D1 (de)	2007-05-10	Fahrgestell
EP1578758A4 (de)	2009-09-30	Purinnukleoside
DE602004004295D1 (de)	2007-02-22	6-ä(substituiertes)phenylütriazolopyrimidine als antikrebsmittel
ATE496887T1 (de)	2011-02-15	Substituierte 5-aminomethyl-1h-pyrrol-2-carbons ureamide
FI20021743L (fi)	2004-04-02	Ohjausjärjestely
NO20023047D0 (no)	2002-06-21	Kompenseringsanordning
ITMI20020198A0 (it)	2002-02-05	(per)aloeteri
DE50310329D1 (de)	2008-09-25	Steuergerat
DE60217480D1 (de)	2007-02-22	17-METHYLEN-ANDROSTAN-3a-OL-ANALOGA ALS CRH- INHIBITOREN
DE60315020D1 (de)	2007-08-30	(2s)-2-ethylphenylpropionsäurederivat
DE60309612D1 (de)	2006-12-28	Steuergerät
DE50205540D1 (de)	2006-03-30	Steuergerät
DE60327250D1 (de)	2009-05-28	Modifizierte bace
ATE350379T1 (de)	2007-01-15	Substituierte benzdioxepine

Legal Events

Date	Code	Title	Description
2008-10-23	8364	No opposition during term of opposition