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NO20051103L - Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer - Google Patents

Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer

Info

Publication number
NO20051103L
NO20051103L NO20051103A NO20051103A NO20051103L NO 20051103 L NO20051103 L NO 20051103L NO 20051103 A NO20051103 A NO 20051103A NO 20051103 A NO20051103 A NO 20051103A NO 20051103 L NO20051103 L NO 20051103L
Authority
NO
Norway
Prior art keywords
activators
glucokinase
carboxamides
indole
glucokinase activators
Prior art date
Application number
NO20051103A
Other languages
English (en)
Inventor
Wendy Lea Corbett
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20051103L publication Critical patent/NO20051103L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer glukokinase-aktivatorer med formel I: hvor R1, R2 og R3 er definert i beskrivelsen. Glukokinase-aktivatorer er anvendelige for å øke insulinsekresjonen ved behandling av type II diabetes.
NO20051103A 2002-10-03 2005-03-01 Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer NO20051103L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41573702P 2002-10-03 2002-10-03
PCT/EP2003/010776 WO2004031179A1 (en) 2002-10-03 2003-09-26 Indole-3-carboxamides as glucokinase (gk) activators

Publications (1)

Publication Number Publication Date
NO20051103L true NO20051103L (no) 2005-04-08

Family

ID=32069904

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051103A NO20051103L (no) 2002-10-03 2005-03-01 Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer

Country Status (28)

Country Link
US (1) US6881844B2 (no)
EP (1) EP1549638B1 (no)
JP (1) JP4390704B2 (no)
KR (1) KR100646486B1 (no)
CN (1) CN100348596C (no)
AR (1) AR041467A1 (no)
AT (1) ATE374768T1 (no)
AU (1) AU2003270285B2 (no)
BR (1) BR0315047A (no)
CA (1) CA2499329C (no)
DE (1) DE60316709T2 (no)
DK (1) DK1549638T3 (no)
ES (1) ES2293005T3 (no)
HR (1) HRP20050287A2 (no)
MX (1) MXPA05003391A (no)
MY (1) MY136764A (no)
NO (1) NO20051103L (no)
NZ (1) NZ538466A (no)
PA (1) PA8584001A1 (no)
PE (1) PE20050090A1 (no)
PL (1) PL375149A1 (no)
PT (1) PT1549638E (no)
RU (1) RU2309956C2 (no)
SI (1) SI1549638T1 (no)
TW (1) TW200413364A (no)
UY (1) UY28005A1 (no)
WO (1) WO2004031179A1 (no)
ZA (1) ZA200502619B (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7812167B2 (en) * 2002-10-03 2010-10-12 Novartis, Ag Substituted (thiazol-2-yl)-amides or sulfonamides as glucokinase activators useful in the treatment of type 2 diabetes
GB0226930D0 (en) * 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
EP1532980A1 (en) * 2003-11-24 2005-05-25 Novo Nordisk A/S N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
PT1735322E (pt) 2004-04-02 2012-01-12 Novartis Ag Derivados de sulfonamido-tiazolopiridina como activadores de glucoquinase úteis para o tratamento de diabetes de tipo 2
US7781451B2 (en) 2004-04-02 2010-08-24 Novartis Ag Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
WO2006112549A1 (ja) 2005-04-20 2006-10-26 Takeda Pharmaceutical Company Limited 縮合複素環化合物
EP2301935A1 (en) 2005-07-09 2011-03-30 AstraZeneca AB (Publ) Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
AU2006299091A1 (en) 2005-09-29 2007-04-12 Sanofi-Aventis Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
US7799820B2 (en) 2005-09-30 2010-09-21 Banyu Pharmaceutical Co., Ltd. 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
JP2009013065A (ja) * 2005-10-14 2009-01-22 Astellas Pharma Inc 縮合へテロ環化合物
WO2007061923A2 (en) * 2005-11-18 2007-05-31 Takeda San Diego, Inc. Glucokinase activators
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
JP5302012B2 (ja) 2006-03-08 2013-10-02 タケダ カリフォルニア インコーポレイテッド グルコキナーゼ活性剤
EP1849785A1 (en) * 2006-04-28 2007-10-31 Neuropharma, S.A. N-(2-Thiazolyl)-amide derivatives as GSK-3 inhibitors
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2049518B1 (en) * 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
CN101573357B (zh) 2006-10-19 2013-01-23 武田药品工业株式会社 吲哚化合物
WO2008079787A2 (en) 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
WO2008074694A1 (en) * 2006-12-20 2008-06-26 F. Hoffmann-La Roche Ag Crystallization of glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
CN101778850A (zh) * 2007-08-10 2010-07-14 H.隆德贝克有限公司 杂芳基酰胺类似物
UY31830A (es) 2008-05-16 2010-01-05 Takeda Pharmaceutical Activadores de glucoquinasa
WO2010107736A2 (en) * 2009-03-20 2010-09-23 University Of Virginia Patent Foundation Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
JP2011006366A (ja) 2009-06-26 2011-01-13 Sanwa Kagaku Kenkyusho Co Ltd 新規チオフェンカルボキサミド誘導体及びその医薬用途
US9333193B2 (en) 2010-09-20 2016-05-10 University Of Virginia Patent Foundation Compositions and methods for treating tuberculosis
CN103044310B (zh) * 2013-01-18 2015-02-04 贵阳医学院 二氢吲哚-3-乙酸衍生物、其制备方法以及在药物中的应用
CN118265698A (zh) * 2021-10-20 2024-06-28 科学与工业研究会(按照印度社会团体注册法案(1860年第21号法案)设立的注册机构) 用于制备吲哚-3-羧酸衍生物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716194B1 (fr) * 1994-02-14 1996-05-31 Sanofi Elf Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant
US6262096B1 (en) 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6040321A (en) 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
JP5278983B2 (ja) 1999-11-17 2013-09-04 塩野義製薬株式会社 アミド化合物の新規用途
DE60117059T2 (de) 2000-12-06 2006-10-26 F. Hoffmann-La Roche Ag Kondensierte heteroaromatische glucokinaseaktivatoren
US6433188B1 (en) 2000-12-06 2002-08-13 Wendy Lea Corbett Fused heteroaromatic glucokinase activators
US6482951B2 (en) 2000-12-13 2002-11-19 Hoffmann-La Roche Inc. Isoindolin-1-one glucokinase activators
RU2290403C2 (ru) * 2000-12-28 2006-12-27 Дайити Фармасьютикал Ко., Лтд. Ингибиторы vla-4
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use

Also Published As

Publication number Publication date
MXPA05003391A (es) 2005-06-22
AR041467A1 (es) 2005-05-18
ES2293005T3 (es) 2008-03-16
SI1549638T1 (sl) 2008-02-29
JP2006504707A (ja) 2006-02-09
HRP20050287A2 (en) 2006-12-31
MY136764A (en) 2008-11-28
BR0315047A (pt) 2005-08-23
EP1549638B1 (en) 2007-10-03
PA8584001A1 (es) 2004-11-02
HK1083098A1 (en) 2006-06-23
WO2004031179A1 (en) 2004-04-15
KR20050046817A (ko) 2005-05-18
US20040067939A1 (en) 2004-04-08
KR100646486B1 (ko) 2006-11-15
RU2005113719A (ru) 2006-02-27
RU2309956C2 (ru) 2007-11-10
CN100348596C (zh) 2007-11-14
CA2499329A1 (en) 2004-04-15
AU2003270285A1 (en) 2004-04-23
PT1549638E (pt) 2007-12-11
DE60316709D1 (de) 2007-11-15
ZA200502619B (en) 2006-03-29
NZ538466A (en) 2007-05-31
CA2499329C (en) 2009-04-21
DE60316709T2 (de) 2008-07-17
TW200413364A (en) 2004-08-01
AU2003270285B2 (en) 2007-04-26
PE20050090A1 (es) 2005-02-28
US6881844B2 (en) 2005-04-19
PL375149A1 (en) 2005-11-28
UY28005A1 (es) 2004-04-30
ATE374768T1 (de) 2007-10-15
DK1549638T3 (da) 2008-01-21
EP1549638A1 (en) 2005-07-06
CN1688574A (zh) 2005-10-26
JP4390704B2 (ja) 2009-12-24

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Legal Events

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