DE602005006757D1 - Als muscarinrezeptorantagonisten geeignete biphenylverbindungen - Google Patents

Als muscarinrezeptorantagonisten geeignete biphenylverbindungen

Info

Publication number: DE602005006757D1
Authority: DE; Germany
Prior art keywords: receptor antagonists; compounds suitable; biphenyl compounds; muscarin receptor; muscarin
Prior art date: 2004-03-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE602005006757T

Other languages

English (en)

Inventor

Mathai Mammen

Yu-Hua Ji

Yongqi Mu

Craig Husfeld

Li Li

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Innoviva Inc

Original Assignee

Theravance Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-11

Filing date

2005-03-10

Publication date

2008-06-26

2005-03-10 Application filed by Theravance Inc filed Critical Theravance Inc

2008-06-26 Publication of DE602005006757D1 publication Critical patent/DE602005006757D1/de

2025-03-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dispersion Chemistry (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Psychology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE602005006757T 2004-03-11 2005-03-10 Als muscarinrezeptorantagonisten geeignete biphenylverbindungen Expired - Lifetime DE602005006757D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55244304P	2004-03-11	2004-03-11
PCT/US2005/007988 WO2005087738A1 (en)	2004-03-11	2005-03-10	Biphenyl compounds useful as muscarinic receptor antagonists

Publications (1)

Publication Number	Publication Date
DE602005006757D1 true DE602005006757D1 (de)	2008-06-26

Family

ID=34963910

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE602005006757T Expired - Lifetime DE602005006757D1 (de)	2004-03-11	2005-03-10	Als muscarinrezeptorantagonisten geeignete biphenylverbindungen
DE602005021258T Expired - Lifetime DE602005021258D1 (de)	2004-03-11	2005-03-10	Biphenylverbindungen geeignet für die Synthese von Muscarinrezeptorantagonisten

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE602005021258T Expired - Lifetime DE602005021258D1 (de)	2004-03-11	2005-03-10	Biphenylverbindungen geeignet für die Synthese von Muscarinrezeptorantagonisten

Country Status (27)

Country	Link
US (22)	US7288657B2 (de)
EP (2)	EP1930323B1 (de)
JP (1)	JP4837653B2 (de)
KR (1)	KR101174740B1 (de)
CN (1)	CN1930125B (de)
AR (2)	AR048032A1 (de)
AT (2)	ATE467617T1 (de)
AU (1)	AU2005222411B2 (de)
BR (1)	BRPI0508622B8 (de)
CA (1)	CA2557479C (de)
CY (1)	CY1109015T1 (de)
DE (2)	DE602005006757D1 (de)
DK (1)	DK1723114T3 (de)
ES (2)	ES2306125T3 (de)
HR (1)	HRP20080301T3 (de)
IL (1)	IL177359A (de)
MA (1)	MA28524B1 (de)
MY (1)	MY144482A (de)
NO (1)	NO338941B1 (de)
NZ (1)	NZ549472A (de)
PL (1)	PL1723114T3 (de)
PT (1)	PT1723114E (de)
RU (1)	RU2366656C2 (de)
SI (1)	SI1723114T1 (de)
TW (1)	TWI341836B (de)
WO (1)	WO2005087738A1 (de)
ZA (1)	ZA200607099B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1723112A1 (de) *	2004-03-11	2006-11-22	Theravance, Inc.	Als antagonisten für den muscarinrezeptor geeignete biphenylverbindungen
TWI341836B (en)	2004-03-11	2011-05-11	Theravance Inc	Biphenyl compounds useful as muscarinic receptor antagonists
EP1723113A1 (de) *	2004-03-11	2006-11-22	Theravance, Inc.	Als antagonisten des muscarinrezeptors geeignete biphenylverbindungen
TW200538095A (en) *	2004-03-11	2005-12-01	Theravance Inc	Biphenyl compounds useful as muscarinic receptor antagonists
JP2007528416A (ja) *	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
WO2005087737A1 (en)	2004-03-11	2005-09-22	Theravance, Inc.	Biphenyl compounds useful as muscarinic receptor antagonists
JP2007528412A (ja) *	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとして有用なビフェニル化合物
GB0501956D0 (en) *	2005-01-31	2005-03-09	Arrow Internat	Nebulizer formulation
TW200714587A (en) *	2005-03-10	2007-04-16	Theravance Inc	Biphenyl compounds useful as muscarinic receptor antagonists
JP2008537931A (ja) *	2005-03-10	2008-10-02	セラヴァンス，インコーポレーテッド	ムスカリン性レセプターアンタゴニストとして有用なビフェニル化合物
US7659403B2 (en) *	2005-03-10	2010-02-09	Theravance, Inc.	Biphenyl compounds useful as muscarinic receptor antagonists
JP2008533028A (ja) *	2005-03-10	2008-08-21	セラヴァンス，インコーポレーテッド	ムスカリン性受容体アンタゴニストとして有用なビフェニル化合物
EP1866284A1 (de) *	2005-03-10	2007-12-19	Theravance, Inc.	Biphenylverbindungen als muskarinrezeptorantagonisten
TWI372749B (en)	2005-03-10	2012-09-21	Theravance Inc	Crystalline forms of a biphenyl compound
US7728144B2 (en)	2005-06-13	2010-06-01	Theravance, Inc	Biphenyl compounds useful as muscarinic receptor antagonists
PL2599778T3 (pl)	2009-04-23	2018-01-31	Theravance Respiratory Co Llc	Związki diamidowe mających działanie antagonisty receptora muskarynowego i agonisty receptora adrenergicznego beta 2
BR112012000890A2 (pt)	2009-07-15	2017-10-31	Theravance Inc	formas de base livre cristalina de um composto bifenil
JP5959117B2 (ja)	2010-07-13	2016-08-02	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	ビフェニル−２−イルカルバミン酸を調製するためのプロセス
US10092552B2 (en) *	2011-01-31	2018-10-09	Avalyn Pharma Inc.	Aerosol pirfenidone and pyridone analog compounds and uses thereof
US9679336B2 (en) *	2011-10-19	2017-06-13	Facebook, Inc.	Social ad hoc networking protocol and presentation layer
US12226407B2 (en)	2012-07-24	2025-02-18	Avalyn Pharma Inc.	Aerosol pirfenidone and pyridone analog compounds and uses thereof
CN107074816B (zh) *	2015-03-27	2020-07-17	四川海思科制药有限公司	一种杂环衍生物及其制备方法和在医药上的用途
WO2017054702A1 (zh) *	2015-09-28	2017-04-06	四川海思科制药有限公司	一种联苯衍生物及其制备方法和在医药上的用途
WO2017063564A1 (zh) *	2015-10-13	2017-04-20	四川海思科制药有限公司	一种八氢环戊二烯并[c]吡咯衍生物及其制备方法和在医药上的用途
WO2020047225A1 (en)	2018-08-30	2020-03-05	Theravance Biopharma R&D Ip, Llc	Methods for treating chronic obstructive pulmonary disease
US11591323B2 (en) *	2019-03-06	2023-02-28	Barry university	Muscarinic agonists as non-steroidal and non-opioid analgesics and methods of use thereof
CN110526859B (zh) *	2019-08-07	2021-03-12	山东百诺医药股份有限公司	一种瑞维那新中间体及其制备方法和瑞维那新的制备方法
CN112694434B (zh) *	2020-12-29	2023-06-16	浙江和泽医药科技股份有限公司	一种雷芬那辛新中间体及其活性亲电砌块和雷芬那辛的新制备方法
WO2023017404A1 (en) *	2021-08-13	2023-02-16	Begum Dr M Sasthaa	A device, a compound, for inhalation of an anti-viral agent
WO2023104920A1 (en)	2021-12-09	2023-06-15	Medichem, S.A.	Crystalline acetone solvate of revefenacin
CN116496206A (zh) *	2023-04-21	2023-07-28	斯坦德药典标准物质研发(湖北)有限公司	一种雷芬那辛杂质ii及其制备方法
CN116640088A (zh) *	2023-05-29	2023-08-25	新领先(重庆)医药科技有限公司	一种高纯度雷芬那辛的制备方法
CN117263848A (zh) *	2023-09-19	2023-12-22	山东京卫制药有限公司	一种雷芬那辛的吸入喷雾剂

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US747952A (en) *	1903-03-02	1903-12-29	Harry Cauley Dillon	Ironing-board.
BR8007911A (pt)	1979-12-06	1981-06-16	Glaxo Group Ltd	Inalador aperfeicoado
ATE23272T1 (de)	1981-07-08	1986-11-15	Draco Ab	Pulverinhalator.
SE8603252L (sv)	1985-07-30	1987-01-31	Glaxo Group Ltd	Anordning for att tillfora lekemedel till patienter
US5225183A (en)	1988-12-06	1993-07-06	Riker Laboratories, Inc.	Medicinal aerosol formulations
US6006745A (en)	1990-12-21	1999-12-28	Minnesota Mining And Manufacturing Company	Device for delivering an aerosol
US5874063A (en)	1991-04-11	1999-02-23	Astra Aktiebolag	Pharmaceutical formulation
AU2178392A (en)	1991-06-12	1993-01-12	Minnesota Mining And Manufacturing Company	Albuterol sulfate suspension aerosol formulations
US5337740A (en)	1991-08-01	1994-08-16	New England Pharmaceuticals, Inc.	Inhalation devices
US5658549A (en)	1991-12-12	1997-08-19	Glaxo Group Limited	Aerosol formulations containing propellant 134a and fluticasone propionate
PT613371E (pt)	1991-12-18	2002-07-31	Astrazeneca Ab	Nova combinacao de formoterol e budesonido
ATE204743T1 (de)	1991-12-18	2001-09-15	Minnesota Mining & Mfg	Aerosolzusammensetzungen für arzneimittelsuspensionen
GB9206989D0 (en)	1992-03-31	1992-05-13	Glaxo Group Ltd	Chemical compounds
US5239993A (en)	1992-08-26	1993-08-31	Glaxo Inc.	Dosage inhalator providing optimized compound inhalation trajectory
AU7545894A (en)	1993-09-02	1995-03-22	Yamanouchi Pharmaceutical Co., Ltd.	Carbamate derivative and medicine containing the same
US5415162A (en)	1994-01-18	1995-05-16	Glaxo Inc.	Multi-dose dry powder inhalation device
EP0747355A4 (de)	1994-02-10	1997-04-09	Yamanouchi Pharma Co Ltd	Neue carbamate und diese enthaltende arzneimittel
US5983956A (en)	1994-10-03	1999-11-16	Astra Aktiebolag	Formulation for inhalation
RU2126001C1 (ru) *	1995-01-10	1999-02-10	Самдзин Фармасьютикал Ко., Лтд	Производные пиперазина и фармацевтическая композиция на их основе
SE9501384D0 (sv)	1995-04-13	1995-04-13	Astra Ab	Process for the preparation of respirable particles
RO119116B1 (ro)	1995-04-14	2004-04-30	Glaxo Wellcome Inc.	Inhalator pentru dozarea salmeterolului
US6464979B1 (en) *	1996-09-12	2002-10-15	Aventis Pasteur Limited	Chlamydial vaccines and methods of preparation thereof
US6040344A (en)	1996-11-11	2000-03-21	Sepracor Inc.	Formoterol process
AU9281298A (en)	1997-10-01	1999-04-23	Kyowa Hakko Kogyo Co. Ltd.	Benzodioxole derivatives
JP2002506856A (ja)	1998-03-14	2002-03-05	ビイクグルデンロンベルクヒエーミツシエフアブリークゲゼルシヤフトミツトベシユレンクテルハフツング	フタラジノンｐｄｅｉｉｉ／ｉｖ阻害剤
AU755066B2 (en)	1998-04-18	2002-12-05	Glaxo Group Limited	Pharmaceutical aerosol formulation
GB9808802D0 (en)	1998-04-24	1998-06-24	Glaxo Group Ltd	Pharmaceutical formulations
WO1999064043A1 (en)	1998-06-08	1999-12-16	Advanced Medicine, Inc.	Muscarinic receptor antagonists
SE9804000D0 (sv)	1998-11-23	1998-11-23	Astra Ab	New composition of matter
US6693202B1 (en) *	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
PT1169019E (pt)	1999-04-14	2003-07-31	Glaxo Group Ltd	Formulacao farmaceutica em aerossol
DE19933926A1 (de)	1999-07-20	2001-01-25	Boehringer Ingelheim Pharma	Biphenylderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
US6510182B1 (en) *	1999-10-25	2003-01-21	Freesystems Pte. Ltd.	Wireless infrared digital audio system
EP1235802B1 (de)	1999-12-07	2005-07-13	Theravance, Inc.	Carbamat-derivate als muscarin-rezeptor antonisten
UA73543C2 (uk) *	1999-12-07	2005-08-15	Тераванс, Інк.	Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
UA73965C2 (en)	1999-12-08	2005-10-17	Theravance Inc	b2 ADRENERGIC RECEPTOR ANTAGONISTS
ATE305468T1 (de)	2000-12-22	2005-10-15	Almirall Prodesfarma Ag	Chinuclidincarbamat derivate und deren verwendung als m3 antagonisten
US6656694B2 (en)	2001-01-11	2003-12-02	Theravance, Inc.	Method for identifying a ligand for a biological substrate
GB0103630D0 (en)	2001-02-14	2001-03-28	Glaxo Group Ltd	Chemical compounds
JP2004526720A (ja)	2001-03-08	2004-09-02	グラクソ　グループ　リミテッド	βアドレナリン受容体のアゴニスト
ATE381537T1 (de)	2001-03-22	2008-01-15	Glaxo Group Ltd	Formanilid-derivative als beta2-adrenorezeptor- agonisten
US20030018019A1 (en)	2001-06-23	2003-01-23	Boehringer Ingelheim Pharma Kg	Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
AU2002326026B2 (en)	2001-09-14	2005-04-28	Glaxo Group Limited	Phenethanolamine derivatives for treatment of respiratory diseases
WO2003042160A1 (en)	2001-11-13	2003-05-22	Theravance, Inc.	Aryl aniline beta-2 adrenergic receptor agonists
AU2003258507A1 (en)	2002-07-30	2004-02-23	Unilever Plc	Abrasive hard surface cleaning compositions
UY27927A1 (es)	2002-08-06	2003-12-31	Glaxo Group Ltd	Antagonistas del receptor muscarínico m3 de acetilcolina
PE20040950A1 (es)	2003-02-14	2005-01-01	Theravance Inc	DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP4851937B2 (ja) *	2003-11-21	2012-01-11	セラヴァンス，インコーポレーテッド	β２アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物
TW200538095A (en) *	2004-03-11	2005-12-01	Theravance Inc	Biphenyl compounds useful as muscarinic receptor antagonists
TWI341836B (en)	2004-03-11	2011-05-11	Theravance Inc	Biphenyl compounds useful as muscarinic receptor antagonists
EP1723112A1 (de)	2004-03-11	2006-11-22	Theravance, Inc.	Als antagonisten für den muscarinrezeptor geeignete biphenylverbindungen
EP1723113A1 (de) *	2004-03-11	2006-11-22	Theravance, Inc.	Als antagonisten des muscarinrezeptors geeignete biphenylverbindungen
WO2005087737A1 (en)	2004-03-11	2005-09-22	Theravance, Inc.	Biphenyl compounds useful as muscarinic receptor antagonists
JP2007528416A (ja)	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
JP2007528412A (ja) *	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとして有用なビフェニル化合物
EP1723109A1 (de)	2004-03-11	2006-11-22	Theravance, Inc.	Als antagonisten des muscarinrezeptors geeignete biphenylverbindungen
JP2008537931A (ja)	2005-03-10	2008-10-02	セラヴァンス，インコーポレーテッド	ムスカリン性レセプターアンタゴニストとして有用なビフェニル化合物
TW200714587A (en)	2005-03-10	2007-04-16	Theravance Inc	Biphenyl compounds useful as muscarinic receptor antagonists
US7659403B2 (en)	2005-03-10	2010-02-09	Theravance, Inc.	Biphenyl compounds useful as muscarinic receptor antagonists
EP1866284A1 (de)	2005-03-10	2007-12-19	Theravance, Inc.	Biphenylverbindungen als muskarinrezeptorantagonisten
JP2008533028A (ja)	2005-03-10	2008-08-21	セラヴァンス，インコーポレーテッド	ムスカリン性受容体アンタゴニストとして有用なビフェニル化合物
TWI372749B (en)	2005-03-10	2012-09-21	Theravance Inc	Crystalline forms of a biphenyl compound
US7728144B2 (en)	2005-06-13	2010-06-01	Theravance, Inc	Biphenyl compounds useful as muscarinic receptor antagonists
US20070029346A1 (en) *	2005-08-03	2007-02-08	Fu-Tian Hung	Pneumatic greaser
TW200811105A (en)	2006-04-25	2008-03-01	Theravance Inc	Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
JP2009535462A (ja) *	2006-04-27	2009-10-01	インテザインテクノロジーズ，インコーポレイテッド	化学的に異なる末端基を含むポリ（エチレングリコール）
BR112012000890A2 (pt)	2009-07-15	2017-10-31	Theravance Inc	formas de base livre cristalina de um composto bifenil
JP5959117B2 (ja)	2010-07-13	2016-08-02	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	ビフェニル−２−イルカルバミン酸を調製するためのプロセス

2005
- 2005-02-15 TW TW094104354A patent/TWI341836B/zh not_active IP Right Cessation
- 2005-03-10 EP EP08151157A patent/EP1930323B1/de not_active Expired - Lifetime
- 2005-03-10 AT AT08151157T patent/ATE467617T1/de not_active IP Right Cessation
- 2005-03-10 AR ARP050100927A patent/AR048032A1/es active IP Right Grant
- 2005-03-10 MY MYPI20051008A patent/MY144482A/en unknown
- 2005-03-10 RU RU2006135927/04A patent/RU2366656C2/ru active
- 2005-03-10 HR HR20080301T patent/HRP20080301T3/xx unknown
- 2005-03-10 EP EP05730087A patent/EP1723114B1/de not_active Expired - Lifetime
- 2005-03-10 US US11/077,433 patent/US7288657B2/en active Active
- 2005-03-10 CN CN2005800076368A patent/CN1930125B/zh not_active Expired - Lifetime
- 2005-03-10 SI SI200530283T patent/SI1723114T1/sl unknown
- 2005-03-10 PL PL05730087T patent/PL1723114T3/pl unknown
- 2005-03-10 ES ES05730087T patent/ES2306125T3/es not_active Expired - Lifetime
- 2005-03-10 DE DE602005006757T patent/DE602005006757D1/de not_active Expired - Lifetime
- 2005-03-10 CA CA2557479A patent/CA2557479C/en not_active Expired - Lifetime
- 2005-03-10 AU AU2005222411A patent/AU2005222411B2/en not_active Expired
- 2005-03-10 PT PT05730087T patent/PT1723114E/pt unknown
- 2005-03-10 WO PCT/US2005/007988 patent/WO2005087738A1/en not_active Ceased
- 2005-03-10 ES ES08151157T patent/ES2345640T3/es not_active Expired - Lifetime
- 2005-03-10 DE DE602005021258T patent/DE602005021258D1/de not_active Expired - Lifetime
- 2005-03-10 NZ NZ549472A patent/NZ549472A/en not_active IP Right Cessation
- 2005-03-10 AT AT05730087T patent/ATE395335T1/de active
- 2005-03-10 JP JP2007503012A patent/JP4837653B2/ja not_active Expired - Lifetime
- 2005-03-10 DK DK05730087T patent/DK1723114T3/da active
- 2005-03-10 BR BRPI0508622A patent/BRPI0508622B8/pt not_active IP Right Cessation
2006
- 2006-08-08 IL IL177359A patent/IL177359A/en active IP Right Grant
- 2006-08-24 ZA ZA200607099A patent/ZA200607099B/xx unknown
- 2006-10-09 NO NO20064579A patent/NO338941B1/no unknown
- 2006-10-10 KR KR1020067021073A patent/KR101174740B1/ko not_active Expired - Lifetime
- 2006-10-11 MA MA29377A patent/MA28524B1/fr unknown
2007
- 2007-07-19 US US11/879,835 patent/US7910608B2/en active Active
- 2007-07-19 US US11/880,002 patent/US7550595B2/en not_active Expired - Lifetime
- 2007-07-19 US US11/879,996 patent/US7585879B2/en not_active Expired - Lifetime
- 2007-07-19 US US11/880,007 patent/US7491736B2/en not_active Expired - Lifetime
- 2007-09-05 US US11/899,181 patent/US8017783B2/en active Active
- 2007-10-12 US US11/974,318 patent/US7521041B2/en not_active Expired - Lifetime
2008
- 2008-06-19 CY CY20081100652T patent/CY1109015T1/el unknown
2009
- 2009-05-08 US US12/437,766 patent/US7803812B2/en not_active Expired - Lifetime
2010
- 2010-06-14 US US12/814,629 patent/US8034946B2/en not_active Expired - Lifetime
2011
- 2011-02-10 US US13/024,532 patent/US8053448B2/en not_active Expired - Lifetime
- 2011-09-07 US US13/226,677 patent/US8173815B2/en not_active Expired - Lifetime
2012
- 2012-04-03 US US13/438,105 patent/US8273894B2/en not_active Expired - Lifetime
- 2012-08-23 US US13/592,713 patent/US8557997B2/en not_active Expired - Lifetime
2013
- 2013-09-11 US US14/023,794 patent/US8912334B2/en not_active Expired - Lifetime
2014
- 2014-11-12 US US14/539,550 patent/US9283183B2/en not_active Expired - Lifetime
2016
- 2016-02-05 US US15/016,528 patent/US9452161B2/en not_active Expired - Lifetime
- 2016-04-28 AR ARP160101213A patent/AR104444A2/es active IP Right Grant
- 2016-08-30 US US15/251,144 patent/US9926272B2/en not_active Expired - Lifetime
2018
- 2018-01-22 US US15/876,525 patent/US10106503B2/en not_active Expired - Lifetime
- 2018-09-13 US US16/130,076 patent/US10343995B2/en not_active Expired - Lifetime
2019
- 2019-05-23 US US16/420,421 patent/US10570092B2/en not_active Expired - Lifetime
2020
- 2020-01-16 US US16/744,565 patent/US11247969B2/en not_active Expired - Lifetime
2022
- 2022-01-05 US US17/569,255 patent/US12258316B2/en active Active

Also Published As

Publication number	Publication date
EP1930323B1 (de)	2010-05-12
MY144482A (en)	2011-09-30
US20090226379A1 (en)	2009-09-10
RU2006135927A (ru)	2008-04-20
CA2557479C (en)	2013-05-07
PT1723114E (pt)	2008-07-17
US8173815B2 (en)	2012-05-08
IL177359A (en)	2012-04-30
EP1930323A1 (de)	2008-06-11
US20070292357A1 (en)	2007-12-20
US10570092B2 (en)	2020-02-25
BRPI0508622B8 (pt)	2021-05-25
US8053448B2 (en)	2011-11-08
US8557997B2 (en)	2013-10-15
US8912334B2 (en)	2014-12-16
DK1723114T3 (da)	2008-07-28
SI1723114T1 (sl)	2008-08-31
ATE467617T1 (de)	2010-05-15
US12258316B2 (en)	2025-03-25
US20110130422A1 (en)	2011-06-02
AU2005222411B2 (en)	2011-04-21
JP2008532922A (ja)	2008-08-21
US20190047957A1 (en)	2019-02-14
CA2557479A1 (en)	2005-09-22
ATE395335T1 (de)	2008-05-15
NO338941B1 (no)	2016-10-31
AU2005222411A1 (en)	2005-09-22
US20100249421A1 (en)	2010-09-30
DE602005021258D1 (de)	2010-06-24
NO20064579L (no)	2006-11-08
CN1930125A (zh)	2007-03-14
EP1723114B1 (de)	2008-05-14
US7585879B2 (en)	2009-09-08
US8273894B2 (en)	2012-09-25
BRPI0508622B1 (pt)	2018-05-22
US20180179161A1 (en)	2018-06-28
US20090018165A1 (en)	2009-01-15
US7910608B2 (en)	2011-03-22
HK1119672A1 (en)	2009-03-13
US20070292356A1 (en)	2007-12-20
ES2345640T3 (es)	2010-09-28
US20130172301A1 (en)	2013-07-04
TWI341836B (en)	2011-05-11
US20190359570A1 (en)	2019-11-28
MA28524B1 (fr)	2007-04-03
EP1723114A1 (de)	2006-11-22
US20160220551A1 (en)	2016-08-04
JP4837653B2 (ja)	2011-12-14
US20200290966A1 (en)	2020-09-17
US20080095708A1 (en)	2008-04-24
KR101174740B1 (ko)	2012-08-17
US20110319625A1 (en)	2011-12-29
US20220306579A1 (en)	2022-09-29
US10106503B2 (en)	2018-10-23
WO2005087738A1 (en)	2005-09-22
PL1723114T3 (pl)	2008-10-31
RU2366656C2 (ru)	2009-09-10
US8034946B2 (en)	2011-10-11
US20050203133A1 (en)	2005-09-15
US20170204061A1 (en)	2017-07-20
HK1097537A1 (en)	2007-06-29
ES2306125T3 (es)	2008-11-01
CY1109015T1 (el)	2014-07-02
US20120190657A1 (en)	2012-07-26
AR048032A1 (es)	2006-03-22
NZ549472A (en)	2010-06-25
US20070265305A1 (en)	2007-11-15
KR20070011370A (ko)	2007-01-24
US20140171397A1 (en)	2014-06-19
US10343995B2 (en)	2019-07-09
BRPI0508622A (pt)	2007-07-31
US8017783B2 (en)	2011-09-13
TW200538438A (en)	2005-12-01
CN1930125B (zh)	2010-07-21
US20150164795A1 (en)	2015-06-18
US20080071088A1 (en)	2008-03-20
HRP20080301T3 (en)	2008-09-30
US9926272B2 (en)	2018-03-27
US9283183B2 (en)	2016-03-15
US9452161B2 (en)	2016-09-27
US7803812B2 (en)	2010-09-28
US7491736B2 (en)	2009-02-17
US7288657B2 (en)	2007-10-30
AR104444A2 (es)	2017-07-19
US7550595B2 (en)	2009-06-23
IL177359A0 (en)	2006-12-10
ZA200607099B (en)	2008-09-25
US7521041B2 (en)	2009-04-21
US11247969B2 (en)	2022-02-15

Publication	Publication Date	Title
ATE395335T1 (de)	2008-05-15	Als muscarinrezeptorantagonisten geeignete biphenylverbindungen
CY2017008I2 (el)	2017-11-14	Νεες ενωσεις ως διαμορφωτες υποδοχεα οπιοειδων
DK1740177T3 (da)	2012-10-29	Antagonister til muskarinfølsomme acetylcholinreceptorer
ATE537151T1 (de)	2011-12-15	Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten
DK2089382T3 (da)	2013-02-04	Substituerede diazepan-forbindelser som orexin-receptor-antagonister
ATE413400T1 (de)	2008-11-15	Cgrp-rezeptorantagonisten
DK1682142T3 (da)	2012-10-15	M3-muscarin-acetylcholin-receptor-antagonister
ATE509928T1 (de)	2011-06-15	8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten
NL1028624A1 (nl)	2005-10-03	Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten.
DK2094709T3 (da)	2010-12-06	Thiazol-pyrazolopyrimidiner som CRF1-receptorantagonister
DK2009992T3 (da)	2012-08-13	Il-8 receptor-antagonister
ATE420088T1 (de)	2009-01-15	Chinolinoncarbonsäureamidverbindungen als 5-ht4- rezeptoragonisten
ATE545633T1 (de)	2012-03-15	Als vasopressinantagonisten geeignete benzazepinderivate
DK1711465T3 (da)	2008-03-31	Hydroisoindolin-tachykinikreceptorantagonister
ATE517100T1 (de)	2011-08-15	Pyrrolidinarylether als nk3-rezeptorantagonisten
ATE519738T1 (de)	2011-08-15	Pyrrolidinarylether als nk3-rezeptorantagonisten
ATE477243T1 (de)	2010-08-15	2-aminochinoline als 5-ht(5a)- rezeptorantagonisten
DK1973886T3 (da)	2013-03-18	Prokineticin-1-receptor-antagonister
DE602005009355D1 (de)	2008-10-09	Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
ATE429428T1 (de)	2009-05-15	Indanderivate als antagonisten des mch-rezeptors
EP1799672A4 (de)	2011-01-19	Cgrp-rezeptorantagonisten
EP1812008A4 (de)	2008-10-29	Il-8-rezeptorantagonisten
DE602006003666D1 (de)	2008-12-24	Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten
DE602006018334D1 (de)	2010-12-30	Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten
ATE528291T1 (de)	2011-10-15	Cyclopropylderivate als nk3 rezeptor-antagonisten

Legal Events

Date	Code	Title	Description
2009-06-04	8364	No opposition during term of opposition