DE602005009355D1 - Gehinderte himbacinanaloga als thrombinrezeptorantagonisten - Google Patents

Gehinderte himbacinanaloga als thrombinrezeptorantagonisten

Info

Publication number: DE602005009355D1
Authority: DE; Germany
Prior art keywords: himbacinanaloga; disabled; receptor antagonists; thrombin receptor; thrombin
Prior art date: 2004-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE602005009355T

Other languages

English (en)

Inventor

Mariappan V Chelliah

Samuel Chackalamannil

Yan Xia

Martin C Clasby

William J Greenlee

Yuguang Wang

Enrico P Veltri

Wenxue Wu

Michael P Graziano

Teddy Kosoglou

Madhu Chintala

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-28

Filing date

2005-05-25

Publication date

2008-10-09

2005-05-25 Application filed by Schering Corp filed Critical Schering Corp

2008-10-09 Publication of DE602005009355D1 publication Critical patent/DE602005009355D1/de

2025-05-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Hematology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Psychiatry (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)

DE602005009355T 2004-05-28 2005-05-25 Gehinderte himbacinanaloga als thrombinrezeptorantagonisten Expired - Lifetime DE602005009355D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57511504P	2004-05-28	2004-05-28
PCT/US2005/018372 WO2005118576A1 (en)	2004-05-28	2005-05-25	Constrained himbacine analogs as thrombin receptor antagonists

Publications (1)

Publication Number	Publication Date
DE602005009355D1 true DE602005009355D1 (de)	2008-10-09

Family

ID=35058111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602005009355T Expired - Lifetime DE602005009355D1 (de)	2004-05-28	2005-05-25	Gehinderte himbacinanaloga als thrombinrezeptorantagonisten

Country Status (13)

Country	Link
US (1)	US7442712B2 (de)
EP (1)	EP1751144B1 (de)
JP (1)	JP4558788B2 (de)
CN (1)	CN1984905B (de)
AR (1)	AR049429A1 (de)
AT (1)	ATE406366T1 (de)
CA (1)	CA2567981C (de)
DE (1)	DE602005009355D1 (de)
ES (1)	ES2311996T3 (de)
MX (1)	MXPA06013903A (de)
MY (1)	MY143987A (de)
TW (1)	TWI357326B (de)
WO (1)	WO2005118576A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7488742B2 (en) *	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
CN102757423B (zh) *	2005-01-14	2016-04-20	先灵公司	喜巴辛类似物的外型和非对映立体选择合成
AR060354A1 (es) *	2006-04-06	2008-06-11	Schering Corp	Terapias de combinacion antagonistas receptor trombina (tra)
AR061664A1 (es)	2006-06-29	2008-09-10	Schering Corp	Derivados de himbacina como antagonistas del receptor de trombina biciclicos y triciclicos sustituidos. composiciones farmaceuticas.
AR061727A1 (es) *	2006-06-30	2008-09-17	Schering Corp	Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
US8227412B2 (en) *	2007-03-29	2012-07-24	Tsopanoglou Nikos E	Bioactive parstatin peptides and methods of use
WO2008128038A2 (en) *	2007-04-13	2008-10-23	The Scripps Research Institute	Methods and compositions for treating cardiac dysfunctions
PL2558462T3 (pl)	2010-04-16	2015-03-31	Sanofi Sa	Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
ES2532902T3 (es)	2010-04-16	2015-04-01	Sanofi	Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
KR101303348B1 (ko) *	2010-06-25	2013-09-03	한국화학연구원	트롬빈 수용체 길항제인 ［6＋5］접합 바이사이클, 그의 제조방법 및 그를 포함하는 약제학적 조성물
EP2822557B1 (de)	2012-03-06	2017-08-23	Merck Sharp & Dohme Corp.	Herstellung und verwendung bicyclischer himbacinderivate als par-rezeptor-antagonisten
WO2015026685A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives
EP3035929B1 (de)	2013-08-22	2024-07-03	Merck Sharp & Dohme LLC	7a-amid-substituierte bicyclische 6,6-difluorhimbacinderivate
US9808473B2 (en)	2013-08-22	2017-11-07	Merck Sharp & Dohme Corp.	Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
ITUB20160876A1 (it)	2016-02-19	2017-08-19	Dambrosio Enzo Maria	Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo
CN116640058B (zh) *	2023-04-08	2026-01-27	郑州大学	一种有机炔酸酯的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL106197A (en) *	1992-07-30	1999-11-30	Cor Therapeutics Inc	Agagonists for the rhombin receptors and pharmaceutical preparations containing them
US6063847A (en) *	1997-11-25	2000-05-16	Schering Corporation	Thrombin receptor antagonists
KR100393492B1 (ko) *	1997-11-25	2003-08-02	쉐링 코포레이션	트롬빈 수용체 길항제
ES2291323T3 (es) *	2000-06-15	2008-03-01	Schering Corporation	Antagonistas de receptores de trombina.
US7488742B2 (en)	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
MXPA04003610A (es)	2001-10-18	2004-07-27	Schering Corp	Analogos de himbacina como antagonistas del receptor de trombina.
JP4558331B2 (ja)	2002-04-16	2010-10-06	シェーリングコーポレイション	三環式トロンビンレセプターアンタゴニスト

2005
- 2005-05-25 CA CA2567981A patent/CA2567981C/en not_active Expired - Fee Related
- 2005-05-25 MY MYPI20052380A patent/MY143987A/en unknown
- 2005-05-25 MX MXPA06013903A patent/MXPA06013903A/es active IP Right Grant
- 2005-05-25 ES ES05755642T patent/ES2311996T3/es not_active Expired - Lifetime
- 2005-05-25 DE DE602005009355T patent/DE602005009355D1/de not_active Expired - Lifetime
- 2005-05-25 EP EP05755642A patent/EP1751144B1/de not_active Expired - Lifetime
- 2005-05-25 JP JP2007515301A patent/JP4558788B2/ja not_active Expired - Fee Related
- 2005-05-25 WO PCT/US2005/018372 patent/WO2005118576A1/en not_active Ceased
- 2005-05-25 US US11/137,283 patent/US7442712B2/en not_active Expired - Lifetime
- 2005-05-25 CN CN2005800232506A patent/CN1984905B/zh not_active Expired - Fee Related
- 2005-05-25 AT AT05755642T patent/ATE406366T1/de not_active IP Right Cessation
- 2005-05-26 TW TW094117273A patent/TWI357326B/zh not_active IP Right Cessation
- 2005-05-26 AR ARP050102170A patent/AR049429A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2008500360A (ja)	2008-01-10
JP4558788B2 (ja)	2010-10-06
HK1100667A1 (en)	2007-09-28
MXPA06013903A (es)	2007-01-26
WO2005118576A1 (en)	2005-12-15
MY143987A (en)	2011-07-29
US7442712B2 (en)	2008-10-28
CN1984905A (zh)	2007-06-20
CA2567981C (en)	2010-08-31
AR049429A1 (es)	2006-08-02
EP1751144B1 (de)	2008-08-27
EP1751144A1 (de)	2007-02-14
TWI357326B (en)	2012-02-01
US20050267155A1 (en)	2005-12-01
CA2567981A1 (en)	2005-12-15
TW200602024A (en)	2006-01-16
ATE406366T1 (de)	2008-09-15
ES2311996T3 (es)	2009-02-16
CN1984905B (zh)	2011-06-22

Publication	Publication Date	Title
ATE413400T1 (de)	2008-11-15	Cgrp-rezeptorantagonisten
DK1720859T3 (da)	2010-04-26	Chemokinreceptorantagonister
ATE505467T1 (de)	2011-04-15	2-aza-bicycloä3.1.0ühexanderivate als orexin- rezeptorantagonisten
DE602006015607D1 (de)	2010-09-02	Thiazol-4-carboxamid-derivate als mglur5-antagonisten
ATE481405T1 (de)	2010-10-15	Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors
DK1682142T3 (da)	2012-10-15	M3-muscarin-acetylcholin-receptor-antagonister
DK2653465T3 (da)	2016-08-22	Opioid-receptormodulatorer
EP1765805A4 (de)	2009-08-26	Cgrp-rezeptorantagonisten
ATE395335T1 (de)	2008-05-15	Als muscarinrezeptorantagonisten geeignete biphenylverbindungen
ZA200702790B (en)	2008-09-25	Thrombin receptor antagonists
ATE555111T1 (de)	2012-05-15	Chinuclidinol-derivate als muscarinrezeptor- antagonisten
ATE382034T1 (de)	2008-01-15	Hydroisoindolin-tachykininrezeptorantagonisten
ATE394391T1 (de)	2008-05-15	Indolderivate als histaminrezeptorantagonisten
ATE477243T1 (de)	2010-08-15	2-aminochinoline als 5-ht(5a)- rezeptorantagonisten
DE602005009355D1 (de)	2008-10-09	Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
DK1973886T3 (da)	2013-03-18	Prokineticin-1-receptor-antagonister
ATE421511T1 (de)	2009-02-15	Indol-3-carbonyl-spiro-piperidinderivate als antagonisten des v1a-rezeptors
ATE377008T1 (de)	2007-11-15	Imidazolderivate als glutamatrezeptorantagonisten
EP1799672A4 (de)	2011-01-19	Cgrp-rezeptorantagonisten
EP1819342A4 (de)	2008-12-17	Chinolin-tachykininrezeptor-antagonisten
NL2000241A1 (nl)	2007-03-22	Carboxamidederivaten als muscarine-receptorantagonisten.
ATE462688T1 (de)	2010-04-15	Diarylsulfone als 5-ht2a-antagonisten
DE602006003666D1 (de)	2008-12-24	Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten
ATE469900T1 (de)	2010-06-15	Spiropiperidinderivate als antagonisten des via- rezeptors
DE602006018334D1 (de)	2010-12-30	Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten

Legal Events

Date	Code	Title	Description
2009-09-17	8364	No opposition during term of opposition