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DE60142971D1 - Expression biologisch aktiver polypeptide in wasserlinse - Google Patents

Expression biologisch aktiver polypeptide in wasserlinse

Info

Publication number
DE60142971D1
DE60142971D1 DE60142971T DE60142971T DE60142971D1 DE 60142971 D1 DE60142971 D1 DE 60142971D1 DE 60142971 T DE60142971 T DE 60142971T DE 60142971 T DE60142971 T DE 60142971T DE 60142971 D1 DE60142971 D1 DE 60142971D1
Authority
DE
Germany
Prior art keywords
expression
duckweed
biologically active
active polypeptides
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142971T
Other languages
English (en)
Inventor
Anne-Marie Stomp
Lynn Dickey
John Gasdaska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biolex Therapeutics Inc
Original Assignee
Biolex Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolex Therapeutics Inc filed Critical Biolex Therapeutics Inc
Application granted granted Critical
Publication of DE60142971D1 publication Critical patent/DE60142971D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE60142971T 2000-07-31 2001-07-26 Expression biologisch aktiver polypeptide in wasserlinse Expired - Lifetime DE60142971D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22170500P 2000-07-31 2000-07-31
US29333001P 2001-05-23 2001-05-23
PCT/US2001/023400 WO2002010414A2 (en) 2000-07-31 2001-07-26 Expression of biologically active polypeptides in duckweed

Publications (1)

Publication Number Publication Date
DE60142971D1 true DE60142971D1 (de) 2010-10-14

Family

ID=26916048

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60142971T Expired - Lifetime DE60142971D1 (de) 2000-07-31 2001-07-26 Expression biologisch aktiver polypeptide in wasserlinse

Country Status (13)

Country Link
US (4) US6815184B2 (de)
EP (1) EP1305437B1 (de)
JP (1) JP4795619B2 (de)
CN (2) CN1451048A (de)
AT (1) ATE479761T1 (de)
AU (2) AU2001288226B2 (de)
CA (1) CA2417415C (de)
CY (1) CY1110959T1 (de)
DE (1) DE60142971D1 (de)
DK (1) DK1305437T3 (de)
NZ (1) NZ523912A (de)
PT (1) PT1305437E (de)
WO (1) WO2002010414A2 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US7161064B2 (en) * 1997-08-12 2007-01-09 North Carolina State University Method for producing stably transformed duckweed using microprojectile bombardment
WO1999019497A1 (en) 1997-10-10 1999-04-22 Yeda Research And Development Co. Ltd. Transgenic lemnaceae
US8022270B2 (en) 2000-07-31 2011-09-20 Biolex Therapeutics, Inc. Expression of biologically active polypeptides in duckweed
US7959910B2 (en) * 2000-07-31 2011-06-14 Biolex Therapeutics, Inc. C-terminally truncated interferon alpha variants
US7632983B2 (en) * 2000-07-31 2009-12-15 Biolex Therapeutics, Inc. Expression of monoclonal antibodies in duckweed
US6815184B2 (en) * 2000-07-31 2004-11-09 Biolex, Inc. Expression of biologically active polypeptide in duckweed
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
EP1539960B1 (de) * 2002-09-09 2010-04-28 Hanall Pharmaceutical Co., Ltd. Protease-resistente modifizierte interferon alpha polypeptide
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
US7176024B2 (en) * 2003-05-30 2007-02-13 Biolex, Inc. Bioreactor for growing biological materials supported on a liquid surface
DK2380910T3 (en) * 2003-11-05 2015-10-19 Roche Glycart Ag Antigen binding molecules with increased Fc receptor binding affinity and effector function
US7659445B2 (en) * 2004-02-11 2010-02-09 Biolex Therapeutics, Inc. Expression of plasminogen and microplasminogen in duck weed
US7527947B2 (en) 2004-06-14 2009-05-05 Novozymes A/S Signal peptide for producing a polypeptide
WO2005121333A1 (en) * 2004-06-14 2005-12-22 Novozymes A/S Signal peptide for producing a polypeptide
US20060024272A1 (en) 2004-07-29 2006-02-02 Large Scale Biology Corporation C-terminally truncated interferon
RU2488597C2 (ru) 2005-02-07 2013-07-27 Гликарт Биотехнологи Аг Антигенсвязывающие молекулы, которые связывают egfr, кодирующие их векторы и их применение
AU2006226060A1 (en) * 2005-03-25 2006-09-28 Glycart Biotechnology Ag Antigen binding molecules directed to MCSP and having increased Fc receptor binding affinity and effector function
MX2007013924A (es) * 2005-05-09 2008-01-28 Glycart Biotechnology Ag Moleculas que unen antigeno que tienen regiones fc modificadas y union alterada a receptores fc.
AR055137A1 (es) 2005-08-26 2007-08-08 Glycart Biotechnology Ag Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada
US7622573B2 (en) * 2006-01-17 2009-11-24 Biolex, Inc. Expression control elements from the lemnaceae family
ES2396569T3 (es) * 2006-01-17 2013-02-22 Medarex, Inc. Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo y xilosilo
AR062223A1 (es) 2006-08-09 2008-10-22 Glycart Biotechnology Ag Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
CA2662350A1 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
DK2716301T3 (en) 2007-02-16 2017-07-31 Merrimack Pharmaceuticals Inc ANTIBODIES AGAINST ERBB3 AND APPLICATIONS THEREOF
JP2010525833A (ja) 2007-05-07 2010-07-29 プロタリクス リミテッド 大規模な使い捨て型バイオリアクター
WO2009015336A2 (en) * 2007-07-25 2009-01-29 Biolex Therapeutics, Inc. Controlled release interferon drug products and treatment of hcv infection using same
US9308257B2 (en) 2007-11-28 2016-04-12 Medimmune, Llc Protein formulation
EP3168307B1 (de) 2008-11-28 2020-07-15 Boehringer Ingelheim Animal Health USA Inc. Rekombinanter impfstoff gegen vogelgrippe und verwendungen davon
EP2398886A2 (de) * 2009-02-18 2011-12-28 Biolex Therapeutics, Inc. Aseptisches bioreaktorsystem zur verarbeitung biologischer materialien
US20120220015A1 (en) 2009-05-26 2012-08-30 Biolex Therapeutics Compositions and methods for production of aglycosylated plasminogen
US20120190004A1 (en) 2009-06-23 2012-07-26 Biolex Therapeutics, Inc. Methods and compositions for the cryopreservation of duckweed
CA2770174A1 (en) 2009-08-31 2011-03-03 Roche Glycart Ag Affinity-matured humanized anti cea monoclonal antibodies
KR20120101572A (ko) 2009-12-28 2012-09-13 메리얼 리미티드 재조합 ｎｄｖ 항원 및 이의 용도
AU2011224188B2 (en) 2010-03-12 2015-01-22 Boehringer Ingelheim Animal Health USA Inc. Bluetongue virus recombinant vaccines and uses thereof
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
WO2012009705A1 (en) 2010-07-15 2012-01-19 Zyngenia, Inc. Ang-2 binding complexes and uses thereof
US20140088019A1 (en) 2011-02-11 2014-03-27 Zyngenia, Inc. Monovalent and Multivalent Multispecific Complexes and Uses Thereof
PT2681244T (pt) 2011-03-02 2018-01-24 Roche Glycart Ag Anticorpos do cea
EP2714738B1 (de) 2011-05-24 2018-10-10 Zyngenia, Inc. Multivalente und monovalente multispezifische komplexe und ihre verwendungen
US9603906B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Inhalable liquid formulations of DNase I
CA2859490A1 (en) 2012-04-05 2013-10-10 Basf Plant Science Company Gmbh Fungal resistant plants expressing hydrophobin
US20160017021A1 (en) 2013-03-06 2016-01-21 Protalix Ltd. TNF alpha INHIBITOR POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, CELLS EXPRESSING SAME AND METHODS OF PRODUCING SAME
CN105121460A (zh) 2013-03-06 2015-12-02 波塔力克斯有限公司 表达TNFα多肽抑制的植物细胞在治疗中的用途
TWI463012B (zh) * 2013-04-01 2014-12-01 Lemnaceae Fermentation Inc 浮萍水解物及其用途
WO2014204988A2 (en) 2013-06-17 2014-12-24 Asana Biosciences, Llc 5t4-targeted immunofusion molecule and methods
AU2014308688A1 (en) * 2013-08-21 2016-04-07 Brookhaven Science Associates, Llc Transformation of duckweed and uses thereof
CN103609304B (zh) * 2013-11-22 2015-08-19 中国科学院成都生物研究所 一种快速提高浮萍淀粉含量的方法
CN107921090A (zh) 2015-04-06 2018-04-17 苏伯多曼有限责任公司 含有从头结合结构域的多肽及其用途
DK3383920T3 (da) 2015-11-30 2024-04-02 Univ California Levering af tumorspecifik nyttelast og immunaktivering ved hjælp af et humant antistof rettet mod et meget specifikt tumorcelleoverfladeantigen
JP2019515874A (ja) 2016-03-01 2019-06-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 改変された細胞死誘導を有するオビヌツズマブ変異体
IL245102A0 (en) 2016-04-13 2016-07-31 Yeda Res & Dev Cultivation of wolffia plants
US12049511B2 (en) 2016-11-10 2024-07-30 Fortis Therapeutics, Inc. Engineered CD46-specific effector cells and uses thereof in the treatment of cancer
AU2018369639C1 (en) 2017-11-14 2025-04-03 Arcellx, Inc. D-domain containing polypeptides and uses thereof
MX2020004935A (es) 2017-11-14 2020-09-25 Arcellx Inc Terapias con celulas inmunitarias multifuncionales.
JP2023534765A (ja) 2020-08-07 2023-08-10 フォーティス セラピューティクス，インク． 免疫複合体を標的とするｃｄ４６およびその使用方法
EP4229068A1 (de) 2020-10-13 2023-08-23 Avitide LLC Affinitätsligandbibliotheken von drei helixbündelproteinen und verwendungen davon
WO2022081775A1 (en) 2020-10-13 2022-04-21 Avitide LLC Aav8 affinity agents
CN117241866A (zh) 2021-02-19 2023-12-15 艾维泰有限责任公司 Aav2亲和剂
MX2023011110A (es) 2021-03-26 2023-11-23 Arcellx Inc Terapias de celulas inmunitarias multifuncionales.
CN118984834A (zh) 2021-12-24 2024-11-19 阿维泰德有限责任公司 Ch1结构域亲和配体和试剂
EP4562022A1 (de) 2022-07-29 2025-06-04 Repligen Corporation Affinitätsagent mit einem ligand zur bindung von vce und mit seq id no: 1
CA3266644A1 (en) 2022-09-09 2024-03-14 Repligen Corporation AFFINITY AGENTS

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8315980D0 (en) * 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
US4956282A (en) 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
US5256410A (en) * 1988-12-01 1993-10-26 Schering Corporation Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon
US5850032A (en) 1992-04-01 1998-12-15 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
US6288302B1 (en) * 1992-11-04 2001-09-11 National Science Council Of R.O.C. Application of α-amylase gene promoter and signal sequence in the production of recombinant proteins in transgenic plants and transgenic plant seeds
US5569828A (en) 1993-03-24 1996-10-29 Pioneer Hi-Bred International, Inc. Maize chlorotic dwarf virus and resistance thereto
US5780709A (en) * 1993-08-25 1998-07-14 Dekalb Genetics Corporation Transgenic maize with increased mannitol content
US5693506A (en) 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants
US6020169A (en) 1995-07-20 2000-02-01 Washington State University Research Foundation Production of secreted foreign polypeptides in plant cell culture
EP0981635A1 (de) 1997-02-13 2000-03-01 Applied Phytologics, Inc. Herstellung reifer proteine in pflanzen
US6066781A (en) 1997-02-13 2000-05-23 Applied Phytologics, Inc. Production of mature proteins in plants
CA2288895A1 (en) * 1997-08-12 1999-02-18 North Carolina State University Genetically engineered duckweed
US7161064B2 (en) * 1997-08-12 2007-01-09 North Carolina State University Method for producing stably transformed duckweed using microprojectile bombardment
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
WO1999019497A1 (en) 1997-10-10 1999-04-22 Yeda Research And Development Co. Ltd. Transgenic lemnaceae
US6095546A (en) * 1997-12-03 2000-08-01 Tekonsha Engineering Company Trailer hitch cover and accessory components
US6096546A (en) 1998-01-30 2000-08-01 Board Of Trustees, Rutgers, The State University Of New Jersey Methods for recovering polypeptides from plants and portions thereof
WO1999047678A2 (en) * 1998-03-19 1999-09-23 Valentis, Inc. Interferon alpha plasmids and delivery systems, and methods of making and using the same
US6815184B2 (en) * 2000-07-31 2004-11-09 Biolex, Inc. Expression of biologically active polypeptide in duckweed

Also Published As

Publication number Publication date
WO2002010414A3 (en) 2002-12-27
US20120258491A1 (en) 2012-10-11
ATE479761T1 (de) 2010-09-15
AU8822601A (en) 2002-02-13
CN101676400A (zh) 2010-03-24
US20050060776A1 (en) 2005-03-17
EP1305437B1 (de) 2010-09-01
US6815184B2 (en) 2004-11-09
JP2004504848A (ja) 2004-02-19
EP1305437A2 (de) 2003-05-02
US20090282584A1 (en) 2009-11-12
AU2001288226B2 (en) 2007-07-26
WO2002010414A9 (en) 2003-10-30
DK1305437T3 (da) 2010-12-13
HK1055317A1 (en) 2004-01-02
NZ523912A (en) 2005-03-24
WO2002010414A2 (en) 2002-02-07
US20020088027A1 (en) 2002-07-04
CA2417415C (en) 2012-10-09
CY1110959T1 (el) 2015-06-11
CN1451048A (zh) 2003-10-22
JP4795619B2 (ja) 2011-10-19
CA2417415A1 (en) 2002-02-07
PT1305437E (pt) 2010-11-12

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