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DE60120197D1 - Verfahren zur herstellung von 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen - Google Patents

Verfahren zur herstellung von 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen

Info

Publication number
DE60120197D1
DE60120197D1 DE60120197T DE60120197T DE60120197D1 DE 60120197 D1 DE60120197 D1 DE 60120197D1 DE 60120197 T DE60120197 T DE 60120197T DE 60120197 T DE60120197 T DE 60120197T DE 60120197 D1 DE60120197 D1 DE 60120197D1
Authority
DE
Germany
Prior art keywords
amino
group
tetrahydrobenzothiazolene
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60120197T
Other languages
English (en)
Other versions
DE60120197T2 (de
Inventor
Karel Pospisilik
Jan Hoorn
Hendricus Peters
Maria Lemmens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthon BV
Original Assignee
Synthon BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon BV filed Critical Synthon BV
Publication of DE60120197D1 publication Critical patent/DE60120197D1/de
Application granted granted Critical
Publication of DE60120197T2 publication Critical patent/DE60120197T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60120197T 2000-09-18 2001-09-14 Verfahren zur herstellung von 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen Expired - Fee Related DE60120197T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200002262A ES2187249B1 (es) 2000-09-18 2000-09-18 Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
ES200002262 2000-09-18
PCT/NL2001/000680 WO2002022590A1 (en) 2000-09-18 2001-09-14 Process for preparation of 2-amino-6-(alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles

Publications (2)

Publication Number Publication Date
DE60120197D1 true DE60120197D1 (de) 2006-07-06
DE60120197T2 DE60120197T2 (de) 2007-03-15

Family

ID=8494959

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120197T Expired - Fee Related DE60120197T2 (de) 2000-09-18 2001-09-14 Verfahren zur herstellung von 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen

Country Status (10)

Country Link
US (3) US6770761B2 (de)
EP (2) EP1318986B1 (de)
AT (2) ATE327985T1 (de)
AU (2) AU2002211055A1 (de)
DE (1) DE60120197T2 (de)
DK (2) DK1318986T3 (de)
ES (3) ES2187249B1 (de)
PT (2) PT1318986E (de)
SI (1) SI1318986T1 (de)
WO (2) WO2002022590A1 (de)

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HUP0500001A3 (en) * 2001-12-11 2005-11-28 Univ Virginia Use of pramipexole to treat amyotrophic lateral sclerosis
PE20040134A1 (es) 2002-07-25 2004-03-06 Pharmacia Corp Forma de dosificacion de una vez al dia de pramipexol
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB0221513D0 (en) 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
ATE496036T1 (de) 2004-03-19 2011-02-15 Dipharma Francis Srl Zwischenprodukte für die herstellung von pramipexol
EP1773793A2 (de) * 2004-07-03 2007-04-18 Merck Generics (UK) Limited Verfahren zur herstellung von pramipexol durch chirale chromatographie
PT1789021E (pt) * 2004-08-13 2011-12-22 Boehringer Ingelheim Int Formulação de comprimidos de libertação prolongada contendo pramipexole ou um seu sal farmaceuticamente aceitável
UA97084C2 (ru) * 2004-08-13 2011-12-26 Бьорингер Ингельхайм Интернациональ Гмбх Пеллета пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, ее применение и капсула, которая содержит такие пеллеты
US20060069263A1 (en) * 2004-09-30 2006-03-30 Irina Gribun Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
JP2008526728A (ja) * 2004-12-30 2008-07-24 ケマジス・リミテッド ナトリウムトリアセトキシボロヒドリドを用いた還元による、プラミペキソール及びその光学異性体混合物の新規製造方法
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) * 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
EP1917014B1 (de) * 2005-08-15 2009-10-07 University Of Virginia Patent Foundation Neurorestauration mit r(+) pramipexol
WO2007040474A1 (en) * 2005-09-21 2007-04-12 Chemagis Ltd. Novel polymorphs of (s)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole monotartrate and methods of producing and using the same
WO2007054970A2 (en) * 2005-10-25 2007-05-18 Alembic Limited Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
WO2007090883A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Extended release formulation
EP1988875A2 (de) * 2006-02-10 2008-11-12 Boehringer Ingelheim International GmbH Modifizierte freisetzungsformulierung
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
DK2026803T3 (da) * 2006-05-16 2012-04-16 Knopp Neurosciences Inc Sammensætninger af R(+) og S(-) pramipexol og fremgangsmåder til anvendelse heraf
DE602006002385D1 (de) * 2006-06-26 2008-10-02 Helm Ag Verfahren zur Herstellung von Pramipexole
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
AU2008224844B2 (en) * 2007-03-14 2012-08-09 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
US20100312010A1 (en) * 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
CA2734491A1 (en) * 2008-08-19 2010-02-25 Knopp Neurosciences, Inc. Compositions and methods of using (r)-pramipexole
US20110009460A1 (en) * 2009-06-19 2011-01-13 Valentin Gribkoff Compositions and methods for treating amyotrophic lateral sclerosis
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
CN104072442B (zh) * 2013-03-28 2016-09-28 成都弘达药业有限公司 一种化合物及其制备方法
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
ES3043076T3 (en) 2013-07-12 2025-11-24 Areteia Therapeutics Inc Treating elevated levels of eosinophils and/or basophils
EP3033081B1 (de) 2013-08-13 2021-05-12 Knopp Biosciences LLC Zusammensetzungen und verfahren zur behandlung von chronischer nesselsucht
AU2014306683B2 (en) 2013-08-13 2017-10-12 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
CN108084115B (zh) * 2017-12-28 2020-03-17 上海博志研新药物技术有限公司 盐酸普拉克索及其中间体的制备方法
CN110669024A (zh) * 2019-10-30 2020-01-10 福建福瑞明德药业有限公司 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法
CN116178304B (zh) * 2023-03-10 2024-10-25 中国药科大学 一种盐酸普拉克索的合成方法

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ATE45735T1 (de) * 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
ZA864626B (en) * 1985-06-24 1988-02-24 Lilly Co Eli Dialkylaminotetrahydrobenzothiazoles and oxazoles
DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung

Also Published As

Publication number Publication date
DK1318987T3 (da) 2005-12-12
US6727367B2 (en) 2004-04-27
US20020103240A1 (en) 2002-08-01
WO2002022591A1 (en) 2002-03-21
ES2187249A1 (es) 2003-05-16
ES2187249B1 (es) 2004-09-16
PT1318986E (pt) 2006-10-31
WO2002022590A1 (en) 2002-03-21
DK1318986T3 (da) 2006-10-02
US6770761B2 (en) 2004-08-03
DE60120197T2 (de) 2007-03-15
AU2002211055A1 (en) 2002-03-26
AU2002212815A1 (en) 2002-03-26
ES2260296T3 (es) 2006-11-01
ES2242778T3 (es) 2005-11-16
EP1318987A1 (de) 2003-06-18
ATE327985T1 (de) 2006-06-15
SI1318986T1 (sl) 2006-10-31
US20040029936A1 (en) 2004-02-12
EP1318986B1 (de) 2006-05-31
US20040068119A1 (en) 2004-04-08
PT1318987E (pt) 2005-10-31
EP1318987B1 (de) 2005-08-10
EP1318986A1 (de) 2003-06-18
ATE301646T1 (de) 2005-08-15

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee