PT1318987E - Processo de resolucao do 2-amino-6-propilamino-4,5,6,7-tetra-hidrobenzotiazole e compostos para esse fim - Google Patents
Processo de resolucao do 2-amino-6-propilamino-4,5,6,7-tetra-hidrobenzotiazole e compostos para esse fimInfo
- Publication number
- PT1318987E PT1318987E PT01981155T PT01981155T PT1318987E PT 1318987 E PT1318987 E PT 1318987E PT 01981155 T PT01981155 T PT 01981155T PT 01981155 T PT01981155 T PT 01981155T PT 1318987 E PT1318987 E PT 1318987E
- Authority
- PT
- Portugal
- Prior art keywords
- compounds
- tetrahydrobenzotiazole
- propylamino
- resolution
- amino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 abstract 1
- 229960003089 pramipexole Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200002262A ES2187249B1 (es) | 2000-09-18 | 2000-09-18 | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1318987E true PT1318987E (pt) | 2005-10-31 |
Family
ID=8494959
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01979066T PT1318986E (pt) | 2000-09-18 | 2001-09-14 | Processo para preparacao de 2-amino -6-(alquil) amino-4,5,6,7 tetra-hidrobenzotiazoles |
| PT01981155T PT1318987E (pt) | 2000-09-18 | 2001-09-18 | Processo de resolucao do 2-amino-6-propilamino-4,5,6,7-tetra-hidrobenzotiazole e compostos para esse fim |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01979066T PT1318986E (pt) | 2000-09-18 | 2001-09-14 | Processo para preparacao de 2-amino -6-(alquil) amino-4,5,6,7 tetra-hidrobenzotiazoles |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6770761B2 (pt) |
| EP (2) | EP1318986B1 (pt) |
| AT (2) | ATE327985T1 (pt) |
| AU (2) | AU2002211055A1 (pt) |
| DE (1) | DE60120197T2 (pt) |
| DK (2) | DK1318986T3 (pt) |
| ES (3) | ES2187249B1 (pt) |
| PT (2) | PT1318986E (pt) |
| SI (1) | SI1318986T1 (pt) |
| WO (2) | WO2002022590A1 (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2241118A (en) * | 1990-02-15 | 1991-08-21 | Ibm | Electrical apparatus with forced air cooling |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| EP2305252A1 (en) * | 2001-12-11 | 2011-04-06 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| MY142204A (en) * | 2002-07-25 | 2010-10-29 | Pharmacia Corp | Pramipexole once-daily dosage form |
| US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| GB0221513D0 (en) * | 2002-09-17 | 2002-10-23 | Generics Uk Ltd | Novel compounds and processes |
| GB2394951A (en) * | 2002-11-04 | 2004-05-12 | Cipla Ltd | One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole |
| US7365086B2 (en) * | 2003-07-25 | 2008-04-29 | Synthon Ip Inc. | Pramipexole acid addition salts |
| CA2560128A1 (en) | 2004-03-19 | 2005-10-06 | Dipharma S.P.A. | Intermediates for the preparation of pramipexole |
| WO2006003471A2 (en) * | 2004-07-03 | 2006-01-12 | Generics [Uk] Limited | Process for the preparation of pramipexole by chiral chromatography |
| KR20070050081A (ko) * | 2004-08-13 | 2007-05-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 프라미펙솔 또는 약제학적으로 허용되는 이의 염을포함하는 연장 방출형 펠렛 제형, 이의 제조방법 및 이의용도 |
| RS52057B2 (sr) * | 2004-08-13 | 2018-03-30 | Boehringer Ingelheim Int | Formulacija tablete sa produženim oslobađanjem koja sadrži pramipeksol ili njegovu farmaceutski prihvatljivu so |
| US20060069263A1 (en) * | 2004-09-30 | 2006-03-30 | Irina Gribun | Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole |
| US20060148866A1 (en) * | 2004-12-30 | 2006-07-06 | Chemagis Ltd. | Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride |
| CN1834092B (zh) * | 2005-03-15 | 2010-04-28 | 姜能桥 | 盐酸普拉克索的制备方法 |
| US20090062549A1 (en) * | 2005-05-03 | 2009-03-05 | Seema Kanwar | Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride |
| ES2264378B1 (es) | 2005-05-09 | 2007-11-01 | Ragactives, S.L. | Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios. |
| JP2009504748A (ja) * | 2005-08-15 | 2009-02-05 | ユニバーシティ オブ バージニア パテント ファウンデーション | Ｒ（＋）プラミペキソールを用いた神経回復 |
| WO2007040474A1 (en) * | 2005-09-21 | 2007-04-12 | Chemagis Ltd. | Novel polymorphs of (s)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole monotartrate and methods of producing and using the same |
| WO2007054970A2 (en) * | 2005-10-25 | 2007-05-18 | Alembic Limited | Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole |
| PL378587A1 (pl) * | 2005-12-29 | 2007-07-09 | Instytut Farmaceutyczny | Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli |
| ITMI20060044A1 (it) * | 2006-01-13 | 2007-07-14 | Dipharma Spa | Sintesi di intermedi pr la preparazione di pramipexolo |
| WO2007090883A1 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Extended release formulation |
| US20090041844A1 (en) * | 2006-02-10 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Modified Release Formulation |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| KR20090021169A (ko) * | 2006-05-16 | 2009-02-27 | 크놉 뉴로사이언시스 인코포레이티드 | Ｒ(+) 및 ｓ(-) 프라미펙솔을 포함하는 조성물 및 이의 사용 방법 |
| ATE405554T1 (de) * | 2006-06-26 | 2008-09-15 | Helm Ag | Verfahren zur herstellung von pramipexole |
| WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| JP2010521496A (ja) * | 2007-03-14 | 2010-06-24 | ノップ ニューロサイエンシーズ、インク． | キラル精製置換ベンゾチアゾールジアミンの合成 |
| US20100312010A1 (en) * | 2007-12-18 | 2010-12-09 | Watson Pharma Private Limited | Process for the Preparation of (S)-Pregabalin |
| US20110190356A1 (en) * | 2008-08-19 | 2011-08-04 | Knopp Neurosciences Inc. | Compositions and Methods of Using (R)- Pramipexole |
| WO2010148409A1 (en) * | 2009-06-19 | 2010-12-23 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| ITMI20101998A1 (it) * | 2010-10-27 | 2012-04-28 | Dipharma Francis Srl | Procedimento per la racemizzazione di acidi carbossilici |
| US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| CN104072442B (zh) * | 2013-03-28 | 2016-09-28 | 成都弘达药业有限公司 | 一种化合物及其制备方法 |
| ES3043076T3 (en) | 2013-07-12 | 2025-11-24 | Areteia Therapeutics Inc | Treating elevated levels of eosinophils and/or basophils |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| EP3038467B1 (en) | 2013-08-13 | 2020-07-29 | Knopp Biosciences LLC | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| US9763918B2 (en) | 2013-08-13 | 2017-09-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| CN108084115B (zh) * | 2017-12-28 | 2020-03-17 | 上海博志研新药物技术有限公司 | 盐酸普拉克索及其中间体的制备方法 |
| CN110669024A (zh) * | 2019-10-30 | 2020-01-10 | 福建福瑞明德药业有限公司 | 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法 |
| CN116178304B (zh) * | 2023-03-10 | 2024-10-25 | 中国药科大学 | 一种盐酸普拉克索的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0186087B1 (de) * | 1984-12-22 | 1989-08-23 | Dr. Karl Thomae GmbH | Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel |
| EP0207696A1 (en) * | 1985-06-24 | 1987-01-07 | Eli Lilly And Company | Dialkylaminotetrahydrobenzothiazoles and oxazoles |
| DE3620813A1 (de) * | 1986-06-21 | 1987-12-23 | Boehringer Ingelheim Kg | Neue tetrahydro-benzothiazole, ihre herstellung und verwendung |
-
2000
- 2000-09-18 ES ES200002262A patent/ES2187249B1/es not_active Expired - Fee Related
-
2001
- 2001-09-14 DK DK01979066T patent/DK1318986T3/da active
- 2001-09-14 AT AT01979066T patent/ATE327985T1/de not_active IP Right Cessation
- 2001-09-14 PT PT01979066T patent/PT1318986E/pt unknown
- 2001-09-14 WO PCT/NL2001/000680 patent/WO2002022590A1/en not_active Ceased
- 2001-09-14 US US10/380,758 patent/US6770761B2/en not_active Expired - Fee Related
- 2001-09-14 AU AU2002211055A patent/AU2002211055A1/en not_active Abandoned
- 2001-09-14 SI SI200130558T patent/SI1318986T1/sl unknown
- 2001-09-14 ES ES01979066T patent/ES2260296T3/es not_active Expired - Lifetime
- 2001-09-14 EP EP01979066A patent/EP1318986B1/en not_active Expired - Lifetime
- 2001-09-14 DE DE60120197T patent/DE60120197T2/de not_active Expired - Fee Related
- 2001-09-18 US US09/953,870 patent/US6727367B2/en not_active Expired - Fee Related
- 2001-09-18 WO PCT/NL2001/000691 patent/WO2002022591A1/en not_active Ceased
- 2001-09-18 EP EP01981155A patent/EP1318987B1/en not_active Expired - Lifetime
- 2001-09-18 DK DK01981155T patent/DK1318987T3/da active
- 2001-09-18 AU AU2002212815A patent/AU2002212815A1/en not_active Abandoned
- 2001-09-18 AT AT01981155T patent/ATE301646T1/de not_active IP Right Cessation
- 2001-09-18 PT PT01981155T patent/PT1318987E/pt unknown
- 2001-09-18 ES ES01981155T patent/ES2242778T3/es not_active Expired - Lifetime
-
2003
- 2003-10-06 US US10/678,081 patent/US20040068119A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1318986A1 (en) | 2003-06-18 |
| EP1318987A1 (en) | 2003-06-18 |
| ES2187249A1 (es) | 2003-05-16 |
| US6727367B2 (en) | 2004-04-27 |
| AU2002211055A1 (en) | 2002-03-26 |
| DE60120197T2 (de) | 2007-03-15 |
| PT1318986E (pt) | 2006-10-31 |
| US20020103240A1 (en) | 2002-08-01 |
| ES2242778T3 (es) | 2005-11-16 |
| ATE301646T1 (de) | 2005-08-15 |
| AU2002212815A1 (en) | 2002-03-26 |
| ES2187249B1 (es) | 2004-09-16 |
| US20040029936A1 (en) | 2004-02-12 |
| ES2260296T3 (es) | 2006-11-01 |
| ATE327985T1 (de) | 2006-06-15 |
| WO2002022590A1 (en) | 2002-03-21 |
| US6770761B2 (en) | 2004-08-03 |
| SI1318986T1 (sl) | 2006-10-31 |
| DE60120197D1 (de) | 2006-07-06 |
| US20040068119A1 (en) | 2004-04-08 |
| WO2002022591A1 (en) | 2002-03-21 |
| EP1318987B1 (en) | 2005-08-10 |
| EP1318986B1 (en) | 2006-05-31 |
| DK1318987T3 (da) | 2005-12-12 |
| DK1318986T3 (da) | 2006-10-02 |
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