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DE60024651D1 - Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten - Google Patents

Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten

Info

Publication number
DE60024651D1
DE60024651D1 DE60024651T DE60024651T DE60024651D1 DE 60024651 D1 DE60024651 D1 DE 60024651D1 DE 60024651 T DE60024651 T DE 60024651T DE 60024651 T DE60024651 T DE 60024651T DE 60024651 D1 DE60024651 D1 DE 60024651D1
Authority
DE
Germany
Prior art keywords
optionally substituted
chain
substituted
active
denotes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60024651T
Other languages
English (en)
Other versions
DE60024651T2 (de
Inventor
Toshimi Okada
Nobuyuki Kurusu
Keigo Tanaka
Kazuki Miyazaki
Daisuke Shinmyo
Hiroyuki Sugumi
Hironori Ikuta
Hironobu Hiyoshi
Takao Saeki
Mamoru Yanagimachi
Masashi Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DE60024651D1 publication Critical patent/DE60024651D1/de
Publication of DE60024651T2 publication Critical patent/DE60024651T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60024651T 1999-09-28 2000-09-27 Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten Expired - Lifetime DE60024651T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP27390599 1999-09-28
JP27390599 1999-09-28
JP2000179352 2000-06-15
JP2000179352 2000-06-15
PCT/JP2000/006665 WO2001023383A1 (en) 1999-09-28 2000-09-27 Quinuclidine compounds and drugs containing the same as the active ingredient

Publications (2)

Publication Number Publication Date
DE60024651D1 true DE60024651D1 (de) 2006-01-12
DE60024651T2 DE60024651T2 (de) 2006-09-28

Family

ID=26550809

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60024651T Expired - Lifetime DE60024651T2 (de) 1999-09-28 2000-09-27 Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten

Country Status (20)

Country Link
US (1) US6599917B1 (de)
EP (1) EP1217001B1 (de)
JP (1) JP4206212B2 (de)
KR (1) KR100694687B1 (de)
CN (1) CN100334085C (de)
AT (1) ATE312100T1 (de)
AU (1) AU782114B2 (de)
BR (1) BR0014331A (de)
CA (1) CA2385995C (de)
DE (1) DE60024651T2 (de)
DK (1) DK1217001T3 (de)
ES (1) ES2252063T3 (de)
HU (1) HUP0203514A3 (de)
IL (2) IL148631A0 (de)
MX (1) MXPA02003167A (de)
NO (1) NO328218B1 (de)
NZ (1) NZ517788A (de)
RU (1) RU2266905C2 (de)
TW (1) TWI282794B (de)
WO (1) WO2001023383A1 (de)

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US7361671B2 (en) * 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
DE10225537A1 (de) * 2002-06-10 2003-12-18 Bayer Ag N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
CZ2005252A3 (cs) 2002-09-25 2005-11-16 Memory Pharmaceuticals Corporation Indazoly, benzothiazoly a benzoisothiazoly jejich příprava a použití
DE10334724A1 (de) * 2003-07-30 2005-02-24 Bayer Healthcare Ag N-Biarylamide
WO2005046683A1 (en) * 2003-10-07 2005-05-26 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP1735306A2 (de) 2004-03-25 2006-12-27 Memory Pharmaceuticals Corporation Indazole, benzothiazole, benzoisothiazole, benzisoxazole und deren herstellung und verwendungen
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
JP2010519328A (ja) 2007-02-26 2010-06-03 ファイザー・プロダクツ・インク Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンｄ２が媒介する疾患の治療のためのそれらの使用
TW201111385A (en) 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
BR112012029994A2 (pt) 2010-05-28 2019-09-24 Biocryst Pharm Inc composto heterocíclicos como inibidores de janus quinase
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
PE20181519A1 (es) 2011-12-28 2018-09-21 Global Blood Therapeutics Inc Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
WO2014067962A1 (de) 2012-10-31 2014-05-08 Bayer Cropscience Ag Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
BR112015021985B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos ou sais farmaceuticamente aceitáveis dos mesmos, respectivos usos e composição
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
JP6463327B2 (ja) 2013-03-15 2019-01-30 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
JP6809681B2 (ja) 2014-02-07 2021-01-06 グローバル ブラッド セラピューティクス インコーポレイテッド ２−ヒドロキシ−６−（（２−（１−イソプロピル−１ｈ−ピラゾール−５−イル）ピリジン−３−イル）メトキシ）ベンズアルデヒドの遊離塩基の結晶多形
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
RU2712633C1 (ru) 2015-06-03 2020-01-30 Ф. Хоффманн-Ля Рош Аг Этинильные производные
US11020382B2 (en) 2015-12-04 2021-06-01 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
BR112021005082A2 (pt) 2018-09-18 2021-06-08 Nikang Therapeutics, Inc. derivados de anel tricíclico fundido como inibidores de src homologia-2 fosfatase
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin

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WO1992015579A1 (en) * 1991-03-08 1992-09-17 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
GB9127279D0 (en) 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
JPH05310732A (ja) 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
GB9207961D0 (en) * 1992-04-10 1992-05-27 Ici Plc Heterocyclic derivatives
GB9218334D0 (en) 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
AU7394394A (en) 1992-10-13 1995-12-05 Rhone-Poulenc Rorer Pharmaceuticals Inc. 3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
GB9226573D0 (en) 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
IL109451A0 (en) 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
GB9412145D0 (en) * 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
JPH08134067A (ja) * 1994-11-11 1996-05-28 Yamanouchi Pharmaceut Co Ltd キヌクリジン誘導体
JPH08269056A (ja) * 1995-03-29 1996-10-15 Chugai Pharmaceut Co Ltd スクアレンシンセターゼ阻害作用を有するキヌクリジン誘導体
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
WO1997044339A1 (en) 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Also Published As

Publication number Publication date
DE60024651T2 (de) 2006-09-28
KR20020034197A (ko) 2002-05-08
EP1217001A4 (de) 2002-12-18
CN1377349A (zh) 2002-10-30
NO20021528D0 (no) 2002-03-26
BR0014331A (pt) 2003-06-10
CA2385995C (en) 2009-06-16
NO20021528L (no) 2002-05-28
WO2001023383A1 (en) 2001-04-05
NZ517788A (en) 2003-11-28
AU7446400A (en) 2001-04-30
JP4206212B2 (ja) 2009-01-07
NO328218B1 (no) 2010-01-11
TWI282794B (en) 2007-06-21
AU782114B2 (en) 2005-07-07
ES2252063T3 (es) 2006-05-16
HUP0203514A2 (hu) 2003-03-28
IL148631A0 (en) 2002-09-12
HUP0203514A3 (en) 2004-01-28
EP1217001B1 (de) 2005-12-07
CN100334085C (zh) 2007-08-29
ATE312100T1 (de) 2005-12-15
DK1217001T3 (da) 2006-03-20
MXPA02003167A (es) 2003-10-06
RU2266905C2 (ru) 2005-12-27
KR100694687B1 (ko) 2007-03-13
IL148631A (en) 2010-04-29
US6599917B1 (en) 2003-07-29
CA2385995A1 (en) 2001-04-05
EP1217001A1 (de) 2002-06-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP