DE60006213D1 - Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden - Google Patents

Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden

Info

Publication number: DE60006213D1
Authority: DE; Germany
Prior art keywords: diazabicyloderivatives; receptor ligands; acetyl choline; choline receptor; nicotine
Prior art date: 1999-01-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60006213T

Other languages

English (en)

Other versions

DE60006213T2 (de

Inventor

H Bunnelle

Barlocco Cristina

F Daanen

J Dart

D Meyer

B Ryther

R Schrimpf

B Sippy

B Toupence

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Laboratories

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-29

Filing date

2000-01-25

Publication date

2003-12-04

2000-01-25 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

2003-12-04 Publication of DE60006213D1 publication Critical patent/DE60006213D1/de

2004-07-29 Application granted granted Critical

2004-07-29 Publication of DE60006213T2 publication Critical patent/DE60006213T2/de

2020-01-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60006213T 1999-01-29 2000-01-25 Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden Expired - Lifetime DE60006213T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US23983899A	1999-01-29	1999-01-29
US239838		1999-01-29
PCT/US2000/001620 WO2000044755A1 (en)	1999-01-29	2000-01-25	Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands

Publications (2)

Publication Number	Publication Date
DE60006213D1 true DE60006213D1 (de)	2003-12-04
DE60006213T2 DE60006213T2 (de)	2004-07-29

Family

ID=22903947

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60038823T Expired - Lifetime DE60038823D1 (de)	1999-01-29	2000-01-25	Diazabicycloderivate als Nikotin-Acetylcholin-Rezeptorliganden
DE60006213T Expired - Lifetime DE60006213T2 (de)	1999-01-29	2000-01-25	Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60038823T Expired - Lifetime DE60038823D1 (de)	1999-01-29	2000-01-25	Diazabicycloderivate als Nikotin-Acetylcholin-Rezeptorliganden

Country Status (26)

Country	Link
EP (2)	EP1359152B1 (de)
JP (1)	JP4676062B2 (de)
KR (1)	KR20010101725A (de)
CN (2)	CN1345320A (de)
AR (1)	AR034538A1 (de)
AT (2)	ATE394401T1 (de)
AU (1)	AU773795B2 (de)
BG (1)	BG105836A (de)
BR (1)	BR0007664A (de)
CA (1)	CA2361525C (de)
CO (1)	CO5150231A1 (de)
CZ (1)	CZ20012716A3 (de)
DE (2)	DE60038823D1 (de)
DK (1)	DK1147112T3 (de)
ES (2)	ES2209825T3 (de)
HK (1)	HK1043116B (de)
HU (1)	HUP0200332A3 (de)
IL (1)	IL144340A0 (de)
NO (1)	NO20013731L (de)
NZ (1)	NZ512884A (de)
PT (1)	PT1147112E (de)
SK (1)	SK10692001A3 (de)
TR (1)	TR200102162T2 (de)
TW (1)	TW200300021A (de)
WO (1)	WO2000044755A1 (de)
ZA (1)	ZA200105835B (de)

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2000
- 2000-01-25 PT PT00906998T patent/PT1147112E/pt unknown
- 2000-01-25 CN CN00805544A patent/CN1345320A/zh active Pending
- 2000-01-25 CA CA002361525A patent/CA2361525C/en not_active Expired - Fee Related
- 2000-01-25 AU AU28569/00A patent/AU773795B2/en not_active Ceased
- 2000-01-25 JP JP2000596011A patent/JP4676062B2/ja not_active Expired - Fee Related
- 2000-01-25 ES ES00906998T patent/ES2209825T3/es not_active Expired - Lifetime
- 2000-01-25 KR KR1020017009420A patent/KR20010101725A/ko not_active Ceased
- 2000-01-25 WO PCT/US2000/001620 patent/WO2000044755A1/en not_active Ceased
- 2000-01-25 HK HK02102948.7A patent/HK1043116B/en not_active IP Right Cessation
- 2000-01-25 IL IL14434000A patent/IL144340A0/xx unknown
- 2000-01-25 CZ CZ20012716A patent/CZ20012716A3/cs unknown
- 2000-01-25 HU HU0200332A patent/HUP0200332A3/hu unknown
- 2000-01-25 EP EP03017562A patent/EP1359152B1/de not_active Expired - Lifetime
- 2000-01-25 DE DE60038823T patent/DE60038823D1/de not_active Expired - Lifetime
- 2000-01-25 ES ES03017562T patent/ES2305373T3/es not_active Expired - Lifetime
- 2000-01-25 DK DK00906998T patent/DK1147112T3/da active
- 2000-01-25 AT AT03017562T patent/ATE394401T1/de not_active IP Right Cessation
- 2000-01-25 SK SK1069-2001A patent/SK10692001A3/sk unknown
- 2000-01-25 AT AT00906998T patent/ATE253067T1/de active
- 2000-01-25 BR BR0007664-3A patent/BR0007664A/pt not_active IP Right Cessation
- 2000-01-25 CN CNA2004100974823A patent/CN1636996A/zh active Pending
- 2000-01-25 EP EP00906998A patent/EP1147112B1/de not_active Expired - Lifetime
- 2000-01-25 DE DE60006213T patent/DE60006213T2/de not_active Expired - Lifetime
- 2000-01-25 TR TR2001/02162T patent/TR200102162T2/xx unknown
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- 2000-01-26 CO CO00004294A patent/CO5150231A1/es unknown
- 2000-01-28 AR ARP000100393A patent/AR034538A1/es not_active Application Discontinuation
- 2000-03-01 TW TW091133012A patent/TW200300021A/zh unknown
2001
- 2001-07-16 ZA ZA200105835A patent/ZA200105835B/en unknown
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Publication number	Publication date
HUP0200332A3 (en)	2002-09-30
SK10692001A3 (sk)	2002-01-07
KR20010101725A (ko)	2001-11-14
ZA200105835B (en)	2002-10-16
HUP0200332A2 (en)	2002-06-29
ES2209825T3 (es)	2004-07-01
ATE394401T1 (de)	2008-05-15
AU2856900A (en)	2000-08-18
JP4676062B2 (ja)	2011-04-27
TW200300021A (en)	2003-05-01
PT1147112E (pt)	2004-03-31
CZ20012716A3 (cs)	2001-11-14
ATE253067T1 (de)	2003-11-15
WO2000044755A1 (en)	2000-08-03
CA2361525A1 (en)	2000-08-03
EP1359152A2 (de)	2003-11-05
CO5150231A1 (es)	2002-04-29
EP1359152B1 (de)	2008-05-07
AU773795B2 (en)	2004-06-03
IL144340A0 (en)	2002-05-23
BG105836A (en)	2002-03-29
DK1147112T3 (da)	2004-02-23
NZ512884A (en)	2004-03-26
BR0007664A (pt)	2002-05-07
EP1147112A1 (de)	2001-10-24
CA2361525C (en)	2009-12-08
JP2002535409A (ja)	2002-10-22
HK1043116A1 (en)	2002-09-06
CN1636996A (zh)	2005-07-13
NO20013731D0 (no)	2001-07-30
AR034538A1 (es)	2004-03-03
DE60006213T2 (de)	2004-07-29
EP1359152A3 (de)	2003-12-17
CN1345320A (zh)	2002-04-17
TR200102162T2 (tr)	2001-12-21
ES2305373T3 (es)	2008-11-01
DE60038823D1 (de)	2008-06-19
HK1043116B (en)	2004-10-15
NO20013731L (no)	2001-09-18
EP1147112B1 (de)	2003-10-29

Publication	Publication Date	Title
DE60006213D1 (de)	2003-12-04	Diazabicyloderivate als nikotin-acetylcholin-rezeptorliganden
ATE393783T1 (de)	2008-05-15	Melanocortinrezeptor-liganden
NO20015536L (no)	2002-01-10	FAP-aktiverte anti-tumor-forbindelser
DE50007721D1 (de)	2004-10-21	Trageinrichtung
EE200100502A (et)	2002-12-16	Ühendid
NO20015015D0 (no)	2001-10-15	Östrogenreseptor-beta-ligander
PT1202994E (pt)	2004-08-31	Novos compostos
NO20013954L (no)	2001-10-11	Understöttelsesanordning
DE60037233D1 (de)	2008-01-10	Hämofiltrationsvorrichtung
NO20013997L (no)	2001-10-17	Reseptoranalyse
EE200200204A (et)	2003-04-15	Asendatud bensimidasooli preparaat
DE69910997D1 (de)	2003-10-09	Azabzyclische 5ht1 rezeptor liganden
NO20014587D0 (no)	2001-09-21	Resorcinolderivater
NO20013769D0 (no)	2001-08-01	Kalsilytiske forbindelser
ATE281456T1 (de)	2004-11-15	Aminotriazolopyridinderivate als adenosinrezeptorliganden
NO20020466D0 (no)	2002-01-29	Kalsilytiske forbindelser
NO20014262D0 (no)	2001-09-03	Tiazoloindolinon-forbindelser
NO20021295D0 (no)	2002-03-15	Nikotinsyreacetylcholin-reseptor
DE60023981D1 (de)	2005-12-22	Vorverstärkerschaltung
NO20015380D0 (no)	2001-11-02	Tio-oksindolderivater
DE50003442D1 (de)	2003-10-02	Kleiderbügel
ID29984A (id)	2001-10-25	Senyawa-senyawa bis-stirilbifenil
DE50007117D1 (de)	2004-08-26	Doppelsiebformer
ES1045226Y (es)	2001-02-01	Soporte antivibrante mejorado
DK199900046U3 (da)	1999-10-08	Tilbehør til fondue

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