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DE12189198T1 - Verfahren zur Behandlung von HCV mit wenigstens zwei direkt angreifenden viralen Mitteln, Ribavirin aber nicht Interferon. - Google Patents

Verfahren zur Behandlung von HCV mit wenigstens zwei direkt angreifenden viralen Mitteln, Ribavirin aber nicht Interferon. Download PDF

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Publication number
DE12189198T1
DE12189198T1 DE12189198.0T DE12189198T DE12189198T1 DE 12189198 T1 DE12189198 T1 DE 12189198T1 DE 12189198 T DE12189198 T DE 12189198T DE 12189198 T1 DE12189198 T1 DE 12189198T1
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Prior art keywords
treatment
combination
hcv
interferon
compound
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Pending
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DE12189198.0T
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Inventor
Walid M. Awni
Sandeep Dutta
Daniel E. Cohen
Thomas Podsadecki
Scott C. Brun
Sven MENSING
Cheri E. Klein
Emily O. Dumas
Barry M. Bernstein
Amit Khatri
Rajeev M. Menon
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AbbVie Inc
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AbbVie Inc
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Application filed by AbbVie Inc filed Critical AbbVie Inc
Priority claimed from EP12189198.0A external-priority patent/EP2583677A3/de
Publication of DE12189198T1 publication Critical patent/DE12189198T1/de
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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Abstract

Eine Kombination aus zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) zur Verwendung in der Behandlung von HCV, worin die Behandlung die Verabreichung von Ribavirin, aber nicht von Interferon umfasst und die Behandlung 8, 9, 10, 11 oder 12 Wochen andauert.

Claims (17)

  1. Eine Kombination aus zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) zur Verwendung in der Behandlung von HCV, worin die Behandlung die Verabreichung von Ribavirin, aber nicht von Interferon umfasst und die Behandlung 8, 9, 10, 11 oder 12 Wochen andauert.
  2. Die Kombination gemäß Anspruch 1, worin die Behandlung 12 Wochen andauert.
  3. Die Kombination gemäß Anspruch 2, worin die mindestens zwei DAAs BMS-790052 und BMS-650032 umfassen.
  4. Die Kombination gemäß Anspruch 3, worin die Behandlung für einen Behandlungs-naiven Patienten ist, der mit HCV-Genotyp 1 infiziert ist.
  5. Die Kombination gemäß Anspruch 2, worin die mindestens zwei DAAs PSI-7977 und TMC-435 umfassen.
  6. Die Kombination gemäß Anspruch 5, worin die Behandlung für einen Behandlungs-naiven Patienten ist, der mit HCV-Genotyp 1 infiziert ist.
  7. Die Kombination gemäß Anspruch 2, worin die mindestens zwei DAAs PSI-7977 und Daclatasvir umfassen.
  8. Die Kombination gemäß Anspruch 7, worin die Behandlung für einen Behandlungs-naiven Patienten ist, der mit HCV-Genotyp 1 infiziert ist.
  9. Die Kombination gemäß Anspruch 2, worin die mindestens zwei DAAs PSI-7977 und GS-5885 umfassen.
  10. Die Kombination gemäß Anspruch 9, worin die Behandlung für einen Behandlungs-naiven Patienten ist, der mit HCV-Genotyp 1 infiziert ist.
  11. Die Kombination gemäß Anspruch 2, worin die mindestens zwei DAAs Folgendes umfassen: Verbindung 1 oder ein pharmazeutisch verträgliches Salz davon, und Verbindung 4 oder ein pharmazeutisch verträgliches Salz davon, worin Verbindung 1 oder das Salz davon gemeinsam mit Ritonavir verabreicht wird.
  12. Die Kombination gemäß Anspruch 11, worin die Behandlung für einen Behandlungs-naiven Patienten ist, der mit HCV-Genotyp 1 infiziert ist.
  13. Die Kombination gemäß Anspruch 2, worin die mindestens zwei DAAs Folgendes umfassen: Verbindung 1 oder ein pharmazeutisch verträgliches Salz davon, Verbindung 2 oder ein pharmazeutisch verträgliches Salz davon, und Verbindung 4 oder ein pharmazeutisch verträgliches Salz davon, worin Verbindung 1 oder das Salz davon gemeinsam mit Ritonavir verabreicht wird.
  14. Die Kombination gemäß Anspruch 13, worin die Behandlung für einen Behandlungs-naiven Patienten ist, der mit HCV-Genotyp 1 infiziert ist.
  15. Die Kombination gemäß Anspruch 13, worin die Behandlung für einen Interferon-Nicht-Responder ist, der mit HCV-Genotyp 1 infiziert ist.
  16. PSI-7977 zur Verwendung in der Behandlung von HCV, worin die Behandlung die Verabreichung von Ribavirin, aber nicht Interferon umfasst und die Behandlung 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 oder 24 Wochen andauert.
  17. PSI-799 gemäß Anspruch 16, worin die Behandlung 12 Wochen andauert.
DE12189198.0T 2011-10-21 2012-10-19 Verfahren zur Behandlung von HCV mit wenigstens zwei direkt angreifenden viralen Mitteln, Ribavirin aber nicht Interferon. Pending DE12189198T1 (de)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201161550352P 2011-10-21 2011-10-21
US201161550352P 2011-10-21
US201161562181P 2011-11-21 2011-11-21
US201161562181P 2011-11-21
US201261587225P 2012-01-17 2012-01-17
US201261587225P 2012-01-17
US201261600276P 2012-02-17 2012-02-17
US201261600276P 2012-02-17
US201261619870P 2012-04-03 2012-04-03
US201261619870P 2012-04-03
US201261656251P 2012-06-06 2012-06-06
US201261656251P 2012-06-06
US201261711830P 2012-10-10 2012-10-10
US201261711830P 2012-10-10
EP12189198.0A EP2583677A3 (de) 2011-10-21 2012-10-19 Verfahren zur Behandlung von HCV mit wenigstens zwei direkt angreifenden viralen Mitteln, Ribavirin aber nicht Interferon.

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DE12189198T1 true DE12189198T1 (de) 2015-02-26

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DE12189198.0T Pending DE12189198T1 (de) 2011-10-21 2012-10-19 Verfahren zur Behandlung von HCV mit wenigstens zwei direkt angreifenden viralen Mitteln, Ribavirin aber nicht Interferon.

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US (4) US8466159B2 (de)
CN (1) CN105363035A (de)
CA (2) CA2851104C (de)
DE (1) DE12189198T1 (de)
GB (1) GB2511698A (de)

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