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MX2020001422A - Metodos para el tratamiento de hcv. - Google Patents

Metodos para el tratamiento de hcv.

Info

Publication number
MX2020001422A
MX2020001422A MX2020001422A MX2020001422A MX2020001422A MX 2020001422 A MX2020001422 A MX 2020001422A MX 2020001422 A MX2020001422 A MX 2020001422A MX 2020001422 A MX2020001422 A MX 2020001422A MX 2020001422 A MX2020001422 A MX 2020001422A
Authority
MX
Mexico
Prior art keywords
treatment
methods
weeks
compound
pharmaceutically acceptable
Prior art date
Application number
MX2020001422A
Other languages
English (en)
Inventor
Matthew Kosloski
Bo Fu
Christine Collins
Abhishek Gulati
Jens Kort
Yang Lei
Chih - Wei Lin
Ran Liu
Federico Mensa
Iok Chan Ng
Tami Pilot-Matias
David Pugatch
Nancy S Shulman
Roger Trinh
Rolando M Viani
Stanley Wang
Zhenzhen Zhang
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/667,212 external-priority patent/US20200368229A9/en
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2020001422A publication Critical patent/MX2020001422A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención presenta tratamientos sin interferón para el tratamiento de HCV. Preferentemente, el tratamiento tiene una duración de tratamiento más corta, tal como de no más de 12 semanas. En un aspecto, el tratamiento comprende administrar al menos dos agentes antivirales de acción directa a un sujeto con infección por HCV, en donde el tratamiento dura 12 semanas y no incluye la administración de interferón o ribavirina, y dichos al menos dos agentes antivirales de acción directa comprenden (a) el Compuesto 1 o una sal aceptable desde el punto de vista farmacéutico de este y (b) el Compuesto 2 o una sal aceptable desde el punto de vista farmacéutico de este.
MX2020001422A 2017-08-02 2018-07-20 Metodos para el tratamiento de hcv. MX2020001422A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/667,212 US20200368229A9 (en) 2013-03-14 2017-08-02 Methods for Treating HCV
PCT/US2018/042992 WO2019027694A1 (en) 2017-08-02 2018-07-20 METHODS OF TREATING HCV

Publications (1)

Publication Number Publication Date
MX2020001422A true MX2020001422A (es) 2020-08-06

Family

ID=60190576

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020001422A MX2020001422A (es) 2017-08-02 2018-07-20 Metodos para el tratamiento de hcv.

Country Status (15)

Country Link
US (1) US20200222397A1 (es)
EP (1) EP3437643A1 (es)
JP (1) JP2019026633A (es)
KR (1) KR20200047552A (es)
CN (1) CN111163779A (es)
AU (2) AU2017248487A1 (es)
BR (2) BR102017022849A8 (es)
CA (2) CA2981993A1 (es)
EA (1) EA202090412A1 (es)
IL (1) IL272420A (es)
MX (1) MX2020001422A (es)
SG (1) SG11202000948QA (es)
TW (1) TW201909897A (es)
WO (1) WO2019027694A1 (es)
ZA (1) ZA202000943B (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8937150B2 (en) * 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
KR102163902B1 (ko) 2010-09-21 2020-10-12 이난타 파마슈티칼스, 인코포레이티드 매크로사이클릭 프롤린 유도된 ｈｃｖ 세린 프로테아제 억제제
CN104436197A (zh) 2011-10-21 2015-03-25 艾伯维公司 至少两种直接作用抗病毒剂的组合产品
WO2014099908A1 (en) * 2012-12-17 2014-06-26 Genentech, Inc. Methods for inhibiting viral infection in transplant patients
PT2968302T (pt) * 2013-03-14 2018-01-03 Abbvie Inc Combinação de agentes antivirais de ação direta e ribavirina para tratar pacientes com vhc
HUE033010T2 (en) * 2013-03-14 2017-11-28 Abbvie Inc Combination of two antivirals for treating hepatitis c
CA2942823C (en) * 2014-04-02 2023-01-03 Abbvie Inc. Methods for treating hcv
CA2943054A1 (en) * 2014-04-02 2015-10-08 Abbvie Inc. Methods for treating hcv
BR112018000383A2 (pt) * 2015-07-08 2018-09-18 Abbvie Inc métodos para tratar hcv

Also Published As

Publication number Publication date
BR102017022849A8 (pt) 2022-09-20
US20200222397A1 (en) 2020-07-16
EA202090412A1 (ru) 2020-05-27
ZA202000943B (en) 2022-10-26
AU2018311684A1 (en) 2020-02-27
SG11202000948QA (en) 2020-02-27
IL272420A (en) 2020-03-31
TW201909897A (zh) 2019-03-16
CA3072026A1 (en) 2019-02-07
BR112020002308A2 (pt) 2020-08-04
CA2981993A1 (en) 2019-02-02
BR102017022849A2 (pt) 2019-03-19
CN111163779A (zh) 2020-05-15
JP2019026633A (ja) 2019-02-21
WO2019027694A1 (en) 2019-02-07
AU2017248487A1 (en) 2019-02-21
KR20200047552A (ko) 2020-05-07
EP3437643A1 (en) 2019-02-06

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