DE10123952A1 - Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel - Google Patents
Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als ArzneimittelInfo
- Publication number
- DE10123952A1 DE10123952A1 DE10123952A DE10123952A DE10123952A1 DE 10123952 A1 DE10123952 A1 DE 10123952A1 DE 10123952 A DE10123952 A DE 10123952A DE 10123952 A DE10123952 A DE 10123952A DE 10123952 A1 DE10123952 A1 DE 10123952A1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- group
- different
- optionally
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 108090000078 AMPA Receptors Proteins 0.000 title abstract description 6
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- 206010015037 epilepsy Diseases 0.000 title 1
- 239000004090 neuroprotective agent Substances 0.000 title 1
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- 238000000034 method Methods 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims description 56
- 125000005843 halogen group Chemical group 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 32
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- 239000001257 hydrogen Substances 0.000 claims description 25
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 23
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
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- -1 1-methylpropylene, 2-methylpropylene, 1,1-dimethylethylene, 1,2-dimethylethylene Chemical group 0.000 description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123952A DE10123952A1 (de) | 2001-05-17 | 2001-05-17 | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US10/141,208 US20030100552A1 (en) | 2001-05-17 | 2002-05-08 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions |
| BR0209796-6A BR0209796A (pt) | 2001-05-17 | 2002-05-15 | Moduladores de receptor ampa alostérico naftotiazina positivos (paarm) |
| YU90403A YU90403A (sh) | 2001-05-17 | 2002-05-15 | Naftotiazinski pozitivno alosterični modulatori ampa receptora (paarm) |
| KR10-2003-7014965A KR20040007572A (ko) | 2001-05-17 | 2002-05-15 | 나프토티아진 양성 알로스테릭 ａｍｐａ 수용체변조인자(ｐａａｒｍ) |
| CNA028100832A CN1533278A (zh) | 2001-05-17 | 2002-05-15 | 萘并噻嗪正变构的ampa受体调节物(paarm) |
| PL02364053A PL364053A1 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
| EP02750931A EP1404340A1 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
| PCT/EP2002/005338 WO2002100411A1 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
| JP2003503232A JP2004529980A (ja) | 2001-05-17 | 2002-05-15 | 正のアロステリックａｍｐａレセプターモジュレーター（ｐａａｒｍ）であるナフトチアジン化合物 |
| EEP200300566A EE200300566A (et) | 2001-05-17 | 2002-05-15 | AMPA retseptori allosteerilised positiivsed naftotiasiin-modulaatorid |
| MXPA03010373A MXPA03010373A (es) | 2001-05-17 | 2002-05-15 | Moduladores de receptores ampa alostericos naftotiazina positivos. |
| CZ20033112A CZ20033112A3 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
| EA200301167A EA006608B1 (ru) | 2001-05-17 | 2002-05-15 | Нафтотиазиновые позитивные аллостерические модуляторы амра-рецепторов |
| NZ530154A NZ530154A (en) | 2001-05-17 | 2002-05-15 | Naphthothiazine positive allosteric AMPA receptor modulators ( PAARM ) |
| HR20030933A HRP20030933A2 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
| CA002449189A CA2449189A1 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
| SK1422-2003A SK14222003A3 (sk) | 2001-05-17 | 2002-05-15 | Naftotiazíny, farmaceutický prostriedok s ich obsahom a ich použitie |
| UY27290A UY27290A1 (es) | 2001-05-17 | 2002-05-15 | Nuevos moduladores de receptores ampa alostéricos positivos (paarm), procedimientos para su preparación y su empleo como medicamentos |
| HU0401273A HUP0401273A3 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators, their use and pharmaceutical compositions containing them |
| IL15864202A IL158642A0 (en) | 2001-05-17 | 2002-05-15 | Naphthothiazine positive allosteric ampa receptor modulators (paarm) |
| ARP020101827A AR036332A1 (es) | 2001-05-17 | 2002-05-17 | Derivados sustituidos de nafto[1,8-de]-[1,3]tiazin-1,1-dioxido, procedimientos para su preparacion, su empleo para la preparacion de un medicamento , y los preparados farmaceuticos que contienen dichos compuestos en calidad de sustancias activas |
| ZA200308466A ZA200308466B (en) | 2001-05-17 | 2003-10-30 | Naphtothiazine positive allosteric ampa receptor modulators (PAARM). |
| US10/699,374 US7026475B2 (en) | 2001-05-17 | 2003-10-31 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions |
| US10/699,168 US20040122003A1 (en) | 2001-05-17 | 2003-10-31 | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions |
| BG108324A BG108324A (bg) | 2001-05-17 | 2003-11-07 | Нафтотиазин положителни алостерични модулатори на амра - рецептор |
| NO20035088A NO20035088L (no) | 2001-05-17 | 2003-11-14 | Naftotiazin positive allosteriske AMPA reseptor modulatorer (PAARM) |
| EC2003004852A ECSP034852A (es) | 2001-05-17 | 2003-11-17 | Moduladores de receptores ampa alostéricos naftotiazina-positivos (paarm) |
| CO03105591A CO5550460A2 (es) | 2001-05-17 | 2003-12-01 | Moduladores de receptores ampa alostericos naftotiazina positivos (paarm) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123952A DE10123952A1 (de) | 2001-05-17 | 2001-05-17 | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10123952A1 true DE10123952A1 (de) | 2002-11-21 |
Family
ID=7685080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10123952A Withdrawn DE10123952A1 (de) | 2001-05-17 | 2001-05-17 | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1404340A1 (xx) |
| JP (1) | JP2004529980A (xx) |
| KR (1) | KR20040007572A (xx) |
| CN (1) | CN1533278A (xx) |
| AR (1) | AR036332A1 (xx) |
| BG (1) | BG108324A (xx) |
| BR (1) | BR0209796A (xx) |
| CA (1) | CA2449189A1 (xx) |
| CO (1) | CO5550460A2 (xx) |
| CZ (1) | CZ20033112A3 (xx) |
| DE (1) | DE10123952A1 (xx) |
| EA (1) | EA006608B1 (xx) |
| EC (1) | ECSP034852A (xx) |
| EE (1) | EE200300566A (xx) |
| HR (1) | HRP20030933A2 (xx) |
| HU (1) | HUP0401273A3 (xx) |
| IL (1) | IL158642A0 (xx) |
| MX (1) | MXPA03010373A (xx) |
| NO (1) | NO20035088L (xx) |
| NZ (1) | NZ530154A (xx) |
| PL (1) | PL364053A1 (xx) |
| SK (1) | SK14222003A3 (xx) |
| UY (1) | UY27290A1 (xx) |
| WO (1) | WO2002100411A1 (xx) |
| YU (1) | YU90403A (xx) |
| ZA (1) | ZA200308466B (xx) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8039468B2 (en) * | 2006-08-31 | 2011-10-18 | The Governors Of The University Of Alberta | Method of inhibition of respiratory depression using positive allosteric AMPA receptor modulators |
| CN111518058B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种噁噻嗪类化合物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| US6346526B1 (en) * | 1998-06-25 | 2002-02-12 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
-
2001
- 2001-05-17 DE DE10123952A patent/DE10123952A1/de not_active Withdrawn
-
2002
- 2002-05-15 IL IL15864202A patent/IL158642A0/xx unknown
- 2002-05-15 MX MXPA03010373A patent/MXPA03010373A/es unknown
- 2002-05-15 NZ NZ530154A patent/NZ530154A/en unknown
- 2002-05-15 PL PL02364053A patent/PL364053A1/xx not_active Application Discontinuation
- 2002-05-15 BR BR0209796-6A patent/BR0209796A/pt not_active IP Right Cessation
- 2002-05-15 CZ CZ20033112A patent/CZ20033112A3/cs unknown
- 2002-05-15 CA CA002449189A patent/CA2449189A1/en not_active Abandoned
- 2002-05-15 KR KR10-2003-7014965A patent/KR20040007572A/ko not_active Withdrawn
- 2002-05-15 EP EP02750931A patent/EP1404340A1/en not_active Withdrawn
- 2002-05-15 YU YU90403A patent/YU90403A/sh unknown
- 2002-05-15 EA EA200301167A patent/EA006608B1/ru not_active IP Right Cessation
- 2002-05-15 JP JP2003503232A patent/JP2004529980A/ja not_active Abandoned
- 2002-05-15 WO PCT/EP2002/005338 patent/WO2002100411A1/en not_active Ceased
- 2002-05-15 EE EEP200300566A patent/EE200300566A/xx unknown
- 2002-05-15 HR HR20030933A patent/HRP20030933A2/xx not_active Application Discontinuation
- 2002-05-15 CN CNA028100832A patent/CN1533278A/zh active Pending
- 2002-05-15 HU HU0401273A patent/HUP0401273A3/hu unknown
- 2002-05-15 SK SK1422-2003A patent/SK14222003A3/sk unknown
- 2002-05-15 UY UY27290A patent/UY27290A1/es not_active Application Discontinuation
- 2002-05-17 AR ARP020101827A patent/AR036332A1/es unknown
-
2003
- 2003-10-30 ZA ZA200308466A patent/ZA200308466B/en unknown
- 2003-11-07 BG BG108324A patent/BG108324A/bg unknown
- 2003-11-14 NO NO20035088A patent/NO20035088L/no not_active Application Discontinuation
- 2003-11-17 EC EC2003004852A patent/ECSP034852A/es unknown
- 2003-12-01 CO CO03105591A patent/CO5550460A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20035088D0 (no) | 2003-11-14 |
| KR20040007572A (ko) | 2004-01-24 |
| YU90403A (sh) | 2006-05-25 |
| WO2002100411A1 (en) | 2002-12-19 |
| HUP0401273A3 (en) | 2006-11-28 |
| EA200301167A1 (ru) | 2004-06-24 |
| NO20035088L (no) | 2003-11-14 |
| ZA200308466B (en) | 2004-05-24 |
| HUP0401273A2 (hu) | 2004-10-28 |
| SK14222003A3 (sk) | 2004-05-04 |
| BR0209796A (pt) | 2004-06-01 |
| CZ20033112A3 (en) | 2004-03-17 |
| JP2004529980A (ja) | 2004-09-30 |
| CA2449189A1 (en) | 2002-12-19 |
| EA006608B1 (ru) | 2006-02-24 |
| EP1404340A1 (en) | 2004-04-07 |
| BG108324A (bg) | 2004-12-30 |
| HRP20030933A2 (en) | 2004-04-30 |
| CN1533278A (zh) | 2004-09-29 |
| MXPA03010373A (es) | 2004-03-16 |
| CO5550460A2 (es) | 2005-08-31 |
| UY27290A1 (es) | 2002-12-31 |
| IL158642A0 (en) | 2004-05-12 |
| EE200300566A (et) | 2004-02-16 |
| AR036332A1 (es) | 2004-09-01 |
| NZ530154A (en) | 2005-09-30 |
| PL364053A1 (en) | 2004-12-13 |
| ECSP034852A (es) | 2003-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG, 55218 IN |
|
| 8139 | Disposal/non-payment of the annual fee |