DE07797600T1 - Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren - Google Patents
Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren Download PDFInfo
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- DE07797600T1 DE07797600T1 DE07797600T DE07797600T DE07797600T1 DE 07797600 T1 DE07797600 T1 DE 07797600T1 DE 07797600 T DE07797600 T DE 07797600T DE 07797600 T DE07797600 T DE 07797600T DE 07797600 T1 DE07797600 T1 DE 07797600T1
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- foam
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- blowing agent
- hfo
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- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000001441 melanoma Diseases 0.000 title 1
- 150000003018 phosphorus compounds Chemical class 0.000 title 1
- OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical class C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 12
- 239000004604 Blowing Agent Substances 0.000 claims abstract 10
- CDOOAUSHHFGWSA-OWOJBTEDSA-N (e)-1,3,3,3-tetrafluoroprop-1-ene Chemical compound F\C=C\C(F)(F)F CDOOAUSHHFGWSA-OWOJBTEDSA-N 0.000 claims abstract 7
- 239000006260 foam Substances 0.000 claims 17
- 229920000582 polyisocyanurate Polymers 0.000 claims 4
- 239000011495 polyisocyanurate Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- 150000003077 polyols Chemical class 0.000 claims 3
- 229920002635 polyurethane Polymers 0.000 claims 3
- 239000004814 polyurethane Substances 0.000 claims 3
- 229920001169 thermoplastic Polymers 0.000 claims 3
- 239000004416 thermosoftening plastic Substances 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 2
- 239000012948 isocyanate Substances 0.000 claims 2
- 150000002513 isocyanates Chemical class 0.000 claims 2
- 229920005903 polyol mixture Polymers 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- RNFJDJUURJAICM-UHFFFAOYSA-N 2,2,4,4,6,6-hexaphenoxy-1,3,5-triaza-2$l^{5},4$l^{5},6$l^{5}-triphosphacyclohexa-1,3,5-triene Chemical compound N=1P(OC=2C=CC=CC=2)(OC=2C=CC=CC=2)=NP(OC=2C=CC=CC=2)(OC=2C=CC=CC=2)=NP=1(OC=1C=CC=CC=1)OC1=CC=CC=C1 RNFJDJUURJAICM-UHFFFAOYSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 229920005830 Polyurethane Foam Polymers 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000003850 cellular structure Anatomy 0.000 claims 1
- 239000003063 flame retardant Substances 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 239000011496 polyurethane foam Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
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- C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
- C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
- C07C13/54—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings
- C07C13/573—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings with three six-membered rings
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- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A61P35/00—Antineoplastic agents
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- C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
- C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
- C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
- C07C13/54—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings
- C07C13/573—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings with three six-membered rings
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- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
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- C07F9/42—Halides thereof
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- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
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Abstract
Verwendung einer 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassenden Zusammensetzung als Blähmittel.
Claims (13)
- Verwendung einer 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassenden Zusammensetzung als Blähmittel.
- Verwendung nach Anspruch 1, wobei die Zusammensetzung mindestens etwa 5 Gew.-% und vorzugsweise mindestens etwa 15 Gew.-% HFO 1234ze umfaßt.
- Verschäumbare Zusammensetzung, umfassend ein Polyol und ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel.
- Verschäumbare Zusammensetzung nach Anspruch 3, die zu einem unter Polyurethan- und Polyisocyanurat-Schaumstoffen ausgewählten Schaumstoff verschäumbar ist.
- Verschäumbare Zusammensetzung, die zu einem thermoplastischen Schaumstoff verschäumbar ist und als Blähmittel 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfaßt.
- Verschäumbare Zusammensetzung nach Anspruch 5, bei der der thermoplastische Schaumstoff unter Polystyrol- und Polyethylen-Schaumstoffen ausgewählt ist.
- Schaumstoff, umfassend eine Polymerschaumstoffzusammensetzung, die ein Blähmittel enthält, wobei das Blähmittel 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfaßt.
- Schaumstoff nach Anspruch 7, bei dem es sich um einen geschlossenzelligen Schaumstoff handelt.
- Schaumstoff nach Anspruch 7, bei der die Polymerschaumstoffzusammensetzung unter Polyurethan-Schaumstoffen, Polyisocyanurat-Schaumstoffen und thermoplastischen Schaumstoffen ausgewählt ist.
- Vorgemischte Zusammensetzung, umfassend: (A) eine erste Komponente, die ein Isocyanat umfaßt; und (B) eine zweite Komponente, die ein Polyol oder eine Polyolmischung, ein Tensid, Katalysatoren, Blähmittel und ein Flammschutzmittel umfaßt.
- Verfahren zur Bildung eines Schaumstoffs, bei dem man: 1) ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel bereitstellt; 2) das Blähmittel zu einer verschäumbaren Zusammensetzung gibt und 3) die verschäumbare Zusammensetzung unter zur Bildung eines Schaumstoffs oder einer zelligen Struktur effektiven Bedingungen zur Reaktion bringt.
- Verfahren zur Bildung eines Polyurethan- oder Polyisocyanurat-Schaumstoffs durch Zusammenmischen der ersten und zweiten Komponente gemäß Anspruch 10.
- Verfahren zur Bildung eines Polyurethan- oder Polyisocyanurat-Schaumstoffs, bei dem man ein Isocyanat; ein Polyol oder eine Polyolmischung; ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel und andere, mindestens unter Katalysatoren und Tensiden ausgewählte Substanzen vereinigt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74774706P | 2006-05-19 | 2006-05-19 | |
| US747747P | 2006-05-19 | ||
| PCT/US2007/069307 WO2007137200A2 (en) | 2006-05-19 | 2007-05-18 | Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE07797600T1 true DE07797600T1 (de) | 2009-08-13 |
Family
ID=38724052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE07797600T Pending DE07797600T1 (de) | 2006-05-19 | 2007-05-18 | Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7709465B2 (de) |
| EP (1) | EP2034828A4 (de) |
| JP (1) | JP2009537636A (de) |
| KR (1) | KR20090020585A (de) |
| CN (1) | CN101489380A (de) |
| AU (1) | AU2007253753A1 (de) |
| BR (1) | BRPI0711769A2 (de) |
| CA (1) | CA2651395A1 (de) |
| DE (1) | DE07797600T1 (de) |
| IL (1) | IL194906A0 (de) |
| MX (1) | MX2008014712A (de) |
| NO (1) | NO20084635L (de) |
| RU (1) | RU2008149461A (de) |
| WO (1) | WO2007137200A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013230985B2 (en) | 2012-03-06 | 2016-05-12 | The Board Of Trustees Of The University Of Illinois | Procaspase combination therapy for glioblastoma |
| RU2659936C2 (ru) | 2012-03-06 | 2018-07-04 | Зэ Борд оф Трастиз оф зэ Юниверсити оф Иллинойс | Активация прокаспазы-3 с помощью комбинированной терапии |
| US10113131B2 (en) * | 2017-01-11 | 2018-10-30 | The Boeing Company | Phosphono paraffins |
| JP7349155B2 (ja) | 2017-11-17 | 2023-09-22 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ | 二元的なmekシグナル伝達の低減によるがん治療 |
| JP7591283B2 (ja) | 2018-10-05 | 2024-11-28 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ | ブドウ膜黒色腫の治療のための併用療法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3847866A (en) | 1965-07-12 | 1974-11-12 | H Bredereck | Bis-(p-hydroxyphenyl)alkylphosphonic acid esters |
| DE1263001B (de) | 1965-07-12 | 1968-03-14 | Dr Miltiadis Ioannu Hiopulos | Verfahren zur Herstellung von 1, 1-Bis-(p-hydroxyphenyl)-alkan-1-phosphonsaeure-diestern |
| US3360432A (en) | 1965-11-12 | 1967-12-26 | Allied Chem | Chlorophenylcyclopropanecar-boxamide mite ovicides |
| US3879498A (en) | 1971-08-31 | 1975-04-22 | Miltiadis I Iliopulos | Dialkyl 1-acryloyloxy-2-alkenyl-1-phosphonates and dialkyl 1-methacryloxy-2-alkenyl-1-phosphonates |
| DE3222571A1 (de) | 1982-06-16 | 1983-12-22 | Röhm GmbH, 6100 Darmstadt | Phosphorhaltige polyarylenester und verfahren zu ihrer herstellung |
| US5569673A (en) | 1994-05-24 | 1996-10-29 | Purdue Research Foundation | Capsacinoid compounds as proliferation inhibitors |
| US5665713A (en) * | 1995-04-12 | 1997-09-09 | Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| CA2246734A1 (en) | 1996-02-20 | 1997-08-21 | Sloan-Kettering Institute For Cancer Research | Combinations of pkc inhibitors and therapeutic agents for treating cancers |
| US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| AU762756B2 (en) | 1998-05-18 | 2003-07-03 | Apoptosis Technology, Inc. | Compounds, screening methods, and uses involving anti-apoptotic genes and gene products |
| WO2000012494A1 (en) | 1998-08-31 | 2000-03-09 | Kyowa Hakko Kogyo Co., Ltd. | Apoptosis inducing agents |
| US6489476B1 (en) | 1998-09-09 | 2002-12-03 | Metabasis Therapeutics, Inc. | Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase |
| US6777433B2 (en) * | 1999-12-22 | 2004-08-17 | Merck Frosst Canada & Co. | Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates |
| US6605589B1 (en) | 2000-03-31 | 2003-08-12 | Parker Hughes Institute | Cathepsin inhibitors in cancer treatment |
| US6608026B1 (en) | 2000-08-23 | 2003-08-19 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
| JP3576953B2 (ja) | 2000-10-18 | 2004-10-13 | シャープ株式会社 | 電子写真感光体、それに用いるベンゾフラン−スチリル化合物、およびその製造方法 |
| CA2438932A1 (en) | 2001-02-21 | 2002-09-06 | Rutgers, The State University Of New Jersey | Compositions and methods for cancer prevention and treatment derived from inula britannica |
| US7053071B2 (en) | 2001-11-30 | 2006-05-30 | The Burnham Institute | Induction of apoptosis in cancer cells |
| DE60322019D1 (de) * | 2002-01-04 | 2008-08-21 | Neurosearch As | Kaliumkanal-modulatoren |
| US20030148966A1 (en) | 2002-01-30 | 2003-08-07 | Hiremagalur Jayaram | Method and composition for inducing apoptosis in cells |
| US7632972B2 (en) | 2003-10-30 | 2009-12-15 | The Board Of Trustees Of The University Of Illionis | Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells |
| WO2005090370A1 (en) | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| US7435841B2 (en) * | 2004-03-10 | 2008-10-14 | Rhodia Inc. | Preparation of halohydrocarbyl phosphonic acid diesters |
| WO2005114197A2 (en) * | 2004-04-15 | 2005-12-01 | Albert Einstein College Of Medicine Of Yeshiva University | Activity-based probes for protein tyrosine phosphatases |
-
2007
- 2007-05-18 JP JP2009512237A patent/JP2009537636A/ja not_active Withdrawn
- 2007-05-18 MX MX2008014712A patent/MX2008014712A/es not_active Application Discontinuation
- 2007-05-18 CN CNA2007800271834A patent/CN101489380A/zh active Pending
- 2007-05-18 DE DE07797600T patent/DE07797600T1/de active Pending
- 2007-05-18 RU RU2008149461/04A patent/RU2008149461A/ru not_active Application Discontinuation
- 2007-05-18 BR BRPI0711769-8A patent/BRPI0711769A2/pt not_active IP Right Cessation
- 2007-05-18 EP EP07797600A patent/EP2034828A4/de not_active Withdrawn
- 2007-05-18 WO PCT/US2007/069307 patent/WO2007137200A2/en not_active Ceased
- 2007-05-18 AU AU2007253753A patent/AU2007253753A1/en not_active Abandoned
- 2007-05-18 KR KR1020087029000A patent/KR20090020585A/ko not_active Withdrawn
- 2007-05-18 US US11/750,952 patent/US7709465B2/en not_active Expired - Fee Related
- 2007-05-18 CA CA002651395A patent/CA2651395A1/en not_active Abandoned
-
2008
- 2008-10-26 IL IL194906A patent/IL194906A0/en unknown
- 2008-11-04 NO NO20084635A patent/NO20084635L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20084635L (no) | 2008-12-12 |
| US20090004293A1 (en) | 2009-01-01 |
| RU2008149461A (ru) | 2010-06-27 |
| AU2007253753A1 (en) | 2007-11-29 |
| CA2651395A1 (en) | 2007-11-29 |
| CN101489380A (zh) | 2009-07-22 |
| BRPI0711769A2 (pt) | 2011-12-13 |
| EP2034828A4 (de) | 2011-04-06 |
| MX2008014712A (es) | 2009-03-20 |
| IL194906A0 (en) | 2009-08-03 |
| KR20090020585A (ko) | 2009-02-26 |
| WO2007137200A2 (en) | 2007-11-29 |
| JP2009537636A (ja) | 2009-10-29 |
| US7709465B2 (en) | 2010-05-04 |
| EP2034828A2 (de) | 2009-03-18 |
| WO2007137200A3 (en) | 2008-03-13 |
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