[go: up one dir, main page]

DE07797600T1 - Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren - Google Patents

Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren Download PDF

Info

Publication number
DE07797600T1
DE07797600T1 DE07797600T DE07797600T DE07797600T1 DE 07797600 T1 DE07797600 T1 DE 07797600T1 DE 07797600 T DE07797600 T DE 07797600T DE 07797600 T DE07797600 T DE 07797600T DE 07797600 T1 DE07797600 T1 DE 07797600T1
Authority
DE
Germany
Prior art keywords
foam
composition
foamable
blowing agent
hfo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE07797600T
Other languages
English (en)
Inventor
Paul J. Champaign Hergenrother
Vitaliy Rantoul Nesterenko
Karson S. Champaign Putt
Rahul Champaign Palchaudhuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois at Urbana Champaign
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Publication of DE07797600T1 publication Critical patent/DE07797600T1/de
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/54Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings
    • C07C13/573Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings with three six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/54Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings
    • C07C13/573Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings with three six-membered rings
    • C07C13/58Completely or partially hydrogenated anthracenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075Esters with hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/42Halides thereof
    • C07F9/425Acid or estermonohalides thereof, e.g. RP(=X)(YR)(Hal) (X, Y = O, S; R = H, or hydrocarbon group)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Verwendung einer 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassenden Zusammensetzung als Blähmittel.

Claims (13)

  1. Verwendung einer 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassenden Zusammensetzung als Blähmittel.
  2. Verwendung nach Anspruch 1, wobei die Zusammensetzung mindestens etwa 5 Gew.-% und vorzugsweise mindestens etwa 15 Gew.-% HFO 1234ze umfaßt.
  3. Verschäumbare Zusammensetzung, umfassend ein Polyol und ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel.
  4. Verschäumbare Zusammensetzung nach Anspruch 3, die zu einem unter Polyurethan- und Polyisocyanurat-Schaumstoffen ausgewählten Schaumstoff verschäumbar ist.
  5. Verschäumbare Zusammensetzung, die zu einem thermoplastischen Schaumstoff verschäumbar ist und als Blähmittel 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfaßt.
  6. Verschäumbare Zusammensetzung nach Anspruch 5, bei der der thermoplastische Schaumstoff unter Polystyrol- und Polyethylen-Schaumstoffen ausgewählt ist.
  7. Schaumstoff, umfassend eine Polymerschaumstoffzusammensetzung, die ein Blähmittel enthält, wobei das Blähmittel 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfaßt.
  8. Schaumstoff nach Anspruch 7, bei dem es sich um einen geschlossenzelligen Schaumstoff handelt.
  9. Schaumstoff nach Anspruch 7, bei der die Polymerschaumstoffzusammensetzung unter Polyurethan-Schaumstoffen, Polyisocyanurat-Schaumstoffen und thermoplastischen Schaumstoffen ausgewählt ist.
  10. Vorgemischte Zusammensetzung, umfassend: (A) eine erste Komponente, die ein Isocyanat umfaßt; und (B) eine zweite Komponente, die ein Polyol oder eine Polyolmischung, ein Tensid, Katalysatoren, Blähmittel und ein Flammschutzmittel umfaßt.
  11. Verfahren zur Bildung eines Schaumstoffs, bei dem man: 1) ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel bereitstellt; 2) das Blähmittel zu einer verschäumbaren Zusammensetzung gibt und 3) die verschäumbare Zusammensetzung unter zur Bildung eines Schaumstoffs oder einer zelligen Struktur effektiven Bedingungen zur Reaktion bringt.
  12. Verfahren zur Bildung eines Polyurethan- oder Polyisocyanurat-Schaumstoffs durch Zusammenmischen der ersten und zweiten Komponente gemäß Anspruch 10.
  13. Verfahren zur Bildung eines Polyurethan- oder Polyisocyanurat-Schaumstoffs, bei dem man ein Isocyanat; ein Polyol oder eine Polyolmischung; ein 1,3,3,3-Tetrafluorpropen (HFO 1234ze) umfassendes Blähmittel und andere, mindestens unter Katalysatoren und Tensiden ausgewählte Substanzen vereinigt.
DE07797600T 2006-05-19 2007-05-18 Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren Pending DE07797600T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74774706P 2006-05-19 2006-05-19
US747747P 2006-05-19
PCT/US2007/069307 WO2007137200A2 (en) 2006-05-19 2007-05-18 Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers

Publications (1)

Publication Number Publication Date
DE07797600T1 true DE07797600T1 (de) 2009-08-13

Family

ID=38724052

Family Applications (1)

Application Number Title Priority Date Filing Date
DE07797600T Pending DE07797600T1 (de) 2006-05-19 2007-05-18 Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren

Country Status (14)

Country Link
US (1) US7709465B2 (de)
EP (1) EP2034828A4 (de)
JP (1) JP2009537636A (de)
KR (1) KR20090020585A (de)
CN (1) CN101489380A (de)
AU (1) AU2007253753A1 (de)
BR (1) BRPI0711769A2 (de)
CA (1) CA2651395A1 (de)
DE (1) DE07797600T1 (de)
IL (1) IL194906A0 (de)
MX (1) MX2008014712A (de)
NO (1) NO20084635L (de)
RU (1) RU2008149461A (de)
WO (1) WO2007137200A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013230985B2 (en) 2012-03-06 2016-05-12 The Board Of Trustees Of The University Of Illinois Procaspase combination therapy for glioblastoma
RU2659936C2 (ru) 2012-03-06 2018-07-04 Зэ Борд оф Трастиз оф зэ Юниверсити оф Иллинойс Активация прокаспазы-3 с помощью комбинированной терапии
US10113131B2 (en) * 2017-01-11 2018-10-30 The Boeing Company Phosphono paraffins
JP7349155B2 (ja) 2017-11-17 2023-09-22 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ 二元的なmekシグナル伝達の低減によるがん治療
JP7591283B2 (ja) 2018-10-05 2024-11-28 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ ブドウ膜黒色腫の治療のための併用療法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847866A (en) 1965-07-12 1974-11-12 H Bredereck Bis-(p-hydroxyphenyl)alkylphosphonic acid esters
DE1263001B (de) 1965-07-12 1968-03-14 Dr Miltiadis Ioannu Hiopulos Verfahren zur Herstellung von 1, 1-Bis-(p-hydroxyphenyl)-alkan-1-phosphonsaeure-diestern
US3360432A (en) 1965-11-12 1967-12-26 Allied Chem Chlorophenylcyclopropanecar-boxamide mite ovicides
US3879498A (en) 1971-08-31 1975-04-22 Miltiadis I Iliopulos Dialkyl 1-acryloyloxy-2-alkenyl-1-phosphonates and dialkyl 1-methacryloxy-2-alkenyl-1-phosphonates
DE3222571A1 (de) 1982-06-16 1983-12-22 Röhm GmbH, 6100 Darmstadt Phosphorhaltige polyarylenester und verfahren zu ihrer herstellung
US5569673A (en) 1994-05-24 1996-10-29 Purdue Research Foundation Capsacinoid compounds as proliferation inhibitors
US5665713A (en) * 1995-04-12 1997-09-09 Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
CA2246734A1 (en) 1996-02-20 1997-08-21 Sloan-Kettering Institute For Cancer Research Combinations of pkc inhibitors and therapeutic agents for treating cancers
US6312662B1 (en) * 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
AU762756B2 (en) 1998-05-18 2003-07-03 Apoptosis Technology, Inc. Compounds, screening methods, and uses involving anti-apoptotic genes and gene products
WO2000012494A1 (en) 1998-08-31 2000-03-09 Kyowa Hakko Kogyo Co., Ltd. Apoptosis inducing agents
US6489476B1 (en) 1998-09-09 2002-12-03 Metabasis Therapeutics, Inc. Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase
US6777433B2 (en) * 1999-12-22 2004-08-17 Merck Frosst Canada & Co. Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates
US6605589B1 (en) 2000-03-31 2003-08-12 Parker Hughes Institute Cathepsin inhibitors in cancer treatment
US6608026B1 (en) 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
JP3576953B2 (ja) 2000-10-18 2004-10-13 シャープ株式会社 電子写真感光体、それに用いるベンゾフラン−スチリル化合物、およびその製造方法
CA2438932A1 (en) 2001-02-21 2002-09-06 Rutgers, The State University Of New Jersey Compositions and methods for cancer prevention and treatment derived from inula britannica
US7053071B2 (en) 2001-11-30 2006-05-30 The Burnham Institute Induction of apoptosis in cancer cells
DE60322019D1 (de) * 2002-01-04 2008-08-21 Neurosearch As Kaliumkanal-modulatoren
US20030148966A1 (en) 2002-01-30 2003-08-07 Hiremagalur Jayaram Method and composition for inducing apoptosis in cells
US7632972B2 (en) 2003-10-30 2009-12-15 The Board Of Trustees Of The University Of Illionis Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
US7435841B2 (en) * 2004-03-10 2008-10-14 Rhodia Inc. Preparation of halohydrocarbyl phosphonic acid diesters
WO2005114197A2 (en) * 2004-04-15 2005-12-01 Albert Einstein College Of Medicine Of Yeshiva University Activity-based probes for protein tyrosine phosphatases

Also Published As

Publication number Publication date
NO20084635L (no) 2008-12-12
US20090004293A1 (en) 2009-01-01
RU2008149461A (ru) 2010-06-27
AU2007253753A1 (en) 2007-11-29
CA2651395A1 (en) 2007-11-29
CN101489380A (zh) 2009-07-22
BRPI0711769A2 (pt) 2011-12-13
EP2034828A4 (de) 2011-04-06
MX2008014712A (es) 2009-03-20
IL194906A0 (en) 2009-08-03
KR20090020585A (ko) 2009-02-26
WO2007137200A2 (en) 2007-11-29
JP2009537636A (ja) 2009-10-29
US7709465B2 (en) 2010-05-04
EP2034828A2 (de) 2009-03-18
WO2007137200A3 (en) 2008-03-13

Similar Documents

Publication Publication Date Title
DE13166417T1 (de) Schaumbildner und Zusammensetzungen mit fluorsubstituierten Olefinen sowie Schäumungsverfahren
DE2710901C2 (de) Verfahren zur Herstellung von Polyurethanen, gegebenenfalls Polyurethanschaumstoffen mit Integralhaut
EP2762509B1 (de) Zusammensetzung zur Verwendung bei der Herstellung von Polyurethansystemen
DE3819940C2 (de)
DE102010063241A1 (de) Siliconstabilisatoren für Polyurethan- oder Polyisocyanurat-Hartschaumstoffe
DE2454049C3 (de) Verfahren zur Herstellung von offenzelligen Polyurethan-Weichschaumstoffen
EP3538578A1 (de) Expandierte thermoplastische polyurethanpartikel, verfahren zu deren herstellung sowie verfahren zur herstellung eines formteils
DE07797600T1 (de) Phosphorhaltige verbindungen mit triphenylmethylphosphonatestern zur behandlung von melanomen oder anderen tumoren
EP2465892A1 (de) Siliconstabilisatoren für Polyurethan- oder Polyisocyanurat-Hartschaumstoffe
DE2911719C2 (de) Verfahren zur Herstellung von leichtgewichtigen Schaumstoffen aus thermoplastischen kristallinen Kunststoffen
WO2006108833A1 (de) Verfahren zur herstellung von polyurethan- und polyisocyanurat-hartschaumstoffen
EP4107214A1 (de) Polyurethan-isolierschaumstoffe und ihre herstellung
DE3700245A1 (de) Verfahren zur herstellung von leichten, flaechigen formteilen unter verwendung von waessrigen dispersionen oder emulsionen aus nco-gruppen aufweisenden organischen verbindungen sowie durch das verfahren hergestellte formteile
CH677235A5 (de)
DE60005454T2 (de) Katalysatorzusammensetzung zur Herstellung von Polyurethanharz und Verfahren zur Herstellung von Polyurethanharz
EP2614110A1 (de) Verfahren zur herstellung von verbundelementen auf basis von polyurethanschaum
DE2631167B2 (de) Verfahren zur Herstellung von massiven FormteUen
DE2451393A1 (de) Verfahren zur herstellung eines mit polyurethanschaum gebundenen aggregats niedriger dichte
WO2017202672A1 (de) Faserverstärkung von schaumstoffen
DE3687158T2 (de) Harter urethanmodifizierter polyisocyanuratschaumstoff.
DE1959921A1 (de) Verdichteter Polyurethanschaum und Verfahren zu seiner Herstellung
DE112013004958B4 (de) Verfahren zur Herstellung eines frei aufgeschäumten Polyurethan-Schaumstoffs mit niedriger Dichte sowie frei aufgeschäumter Polyurethan-Schaumstoff
EP0608023B1 (de) Verfahren zur Herstellung von Formteilen aus flexiblem Polyurethan-Integralschaumstoff
DE4344891A1 (de) Verfahren zur Herstellung eines umweltfreundlichen Werkstoffs, der bei dem Verfahren erhaltene Werkstoff und seine Verwendung
EP0377868A3 (de) Verfahren zur Herstellung von flammwidrigen, elastischen Polyurethan-Weichschaumstoffen unter Mitverwendung mindestens eines Polyoxyalkylenpolyamins und Melamin