DD211554A5 - Verfahren zur herstellung neuer dihydropyridine - Google Patents

Verfahren zur herstellung neuer dihydropyridine Download PDF

Info

Publication number: DD211554A5
Authority: DD; German Democratic Republic
Prior art keywords: compound; general formula; methyl; above meaning; oxygen
Prior art date: 1982-05-21

Application number

DD83251136A

Other languages

German (de)

English (en)

Inventor

Peder B Berntsson

Stig A I Carlsson

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-21

Filing date

1983-05-20

Publication date

1984-07-18

1983-05-20 Application filed by Haessle Ab filed Critical Haessle Ab

1984-07-18 Publication of DD211554A5 publication Critical patent/DD211554A5/de

Links

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150000001875 compounds Chemical class 0.000 claims abstract description 78
238000000034 method Methods 0.000 claims abstract description 29
238000002360 preparation method Methods 0.000 claims abstract description 24
125000001424 substituent group Chemical group 0.000 claims abstract description 5
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 16
239000001301 oxygen Substances 0.000 claims description 16
229910052760 oxygen Inorganic materials 0.000 claims description 16
-1 2,3-dichlorophenyl Chemical group 0.000 claims description 15
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 10
229910021529 ammonia Inorganic materials 0.000 claims description 5
125000000217 alkyl group Chemical group 0.000 claims description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
239000007858 starting material Substances 0.000 claims description 3
229910052717 sulfur Inorganic materials 0.000 claims description 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
239000011593 sulfur Substances 0.000 claims description 2
YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims 1
ZWJBVEXXAVYZQX-UHFFFAOYSA-N 4-(2,3-dichlorophenyl)-1,2-dimethyl-6-propylsulfanyl-4H-pyridine-3,5-dicarboxylic acid Chemical compound C(CC)SC=1N(C(=C(C(C=1C(=O)O)C1=C(C(=CC=C1)Cl)Cl)C(=O)O)C)C ZWJBVEXXAVYZQX-UHFFFAOYSA-N 0.000 claims 1
125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 abstract description 4
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)

DD83251136A 1982-05-21 1983-05-20 Verfahren zur herstellung neuer dihydropyridine DD211554A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8203177		1982-05-21

Publications (1)

Publication Number	Publication Date
DD211554A5 true DD211554A5 (de)	1984-07-18

Family

ID=20346868

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DD83264593A DD216454A5 (de)	1982-05-21	1983-05-20	Verfahren zur herstellung neuer dihydropyridine
DD83251136A DD211554A5 (de)	1982-05-21	1983-05-20	Verfahren zur herstellung neuer dihydropyridine

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DD83264593A DD216454A5 (de)	1982-05-21	1983-05-20	Verfahren zur herstellung neuer dihydropyridine

Country Status (19)

Country	Link
EP (1)	EP0095450A3 (ko)
JP (1)	JPS58210064A (ko)
KR (1)	KR900006116B1 (ko)
AU (1)	AU1464483A (ko)
CA (1)	CA1242201A (ko)
DD (2)	DD216454A5 (ko)
DK (1)	DK223783A (ko)
ES (4)	ES8600242A1 (ko)
FI (1)	FI79300C (ko)
GB (1)	GB2120251B (ko)
GR (1)	GR78849B (ko)
HU (2)	HU193785B (ko)
IL (1)	IL68604A0 (ko)
IS (1)	IS1380B6 (ko)
MW (1)	MW2083A1 (ko)
NO (1)	NO162515C (ko)
NZ (1)	NZ204284A (ko)
PT (1)	PT76734B (ko)
ZA (1)	ZA833264B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU199796B (en) *	1985-08-06	1990-03-28	Boehringer Biochemia Srl	Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds
IT1204421B (it) *	1986-06-27	1989-03-01	Boehringer Biochemia Srl	2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
IT1197012B (it) *	1986-07-29	1988-11-25	Boehringer Biochemia Srl	2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono
IT1213555B (it) *	1986-12-11	1989-12-20	Boehringer Biochemia Srl	2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
IT1213440B (it) *	1986-12-24	1989-12-20	Boehringer Biochemia Srl	2-ditioalchil-diidropiridine, un metodo per la loro preparazione e composizioni farmaceutiche chele contengono.
IT1204948B (it) *	1987-03-13	1989-03-10	Boheringer Biochemia Robin S P	2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono.
DE3741540A1 (de) *	1987-12-08	1989-06-22	Bayer Ag	Verfahren zur herstellung von unsymmetrischen dihydropyridinen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670827C3 (de) *	1967-03-20	1974-10-24	Bayer Ag, 5090 Leverkusen	4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2210672C3 (de) *	1972-03-06	1980-03-20	Bayer Ag, 5090 Leverkusen	N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
GB1552911A (en) *	1975-07-02	1979-09-19	Fujisawa Pharmaceutical Co	1,4 dihydropyridine derivatives and the preparation thereof
DE2740080A1 (de) *	1977-09-06	1979-03-15	Bayer Ag	2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
SE429652B (sv) *	1978-06-30	1983-09-19	Haessle Ab	2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
US4307103A (en) *	1978-09-08	1981-12-22	Fujisawa Pharmaceutical Co., Ltd.	Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
GB2050375B (en) *	1979-05-11	1983-02-23	Fujisawa Pharmaceutical Co	4-cyanophenyl-1,4-dihydropyridine compound processes for preparation thereof and pharmaceutical composition comprising the same
SE7910521L (sv) *	1979-12-20	1981-06-21	Haessle Ab	Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma

1983
- 1983-05-05 IL IL68604A patent/IL68604A0/xx unknown
- 1983-05-06 ZA ZA833264A patent/ZA833264B/xx unknown
- 1983-05-10 CA CA000427859A patent/CA1242201A/en not_active Expired
- 1983-05-13 EP EP83850126A patent/EP0095450A3/en not_active Withdrawn
- 1983-05-18 MW MW20/83A patent/MW2083A1/xx unknown
- 1983-05-18 NZ NZ204284A patent/NZ204284A/en unknown
- 1983-05-18 AU AU14644/83A patent/AU1464483A/en not_active Abandoned
- 1983-05-19 GR GR71399A patent/GR78849B/el unknown
- 1983-05-19 FI FI831779A patent/FI79300C/fi not_active IP Right Cessation
- 1983-05-19 DK DK223783A patent/DK223783A/da not_active Application Discontinuation
- 1983-05-20 IS IS2808A patent/IS1380B6/is unknown
- 1983-05-20 NO NO831807A patent/NO162515C/no unknown
- 1983-05-20 ES ES522573A patent/ES8600242A1/es not_active Expired
- 1983-05-20 DD DD83264593A patent/DD216454A5/de not_active IP Right Cessation
- 1983-05-20 DD DD83251136A patent/DD211554A5/de not_active IP Right Cessation
- 1983-05-20 HU HU852490A patent/HU193785B/hu unknown
- 1983-05-20 PT PT76734A patent/PT76734B/pt not_active IP Right Cessation
- 1983-05-20 GB GB08314021A patent/GB2120251B/en not_active Expired
- 1983-05-20 JP JP58087769A patent/JPS58210064A/ja active Pending
- 1983-05-20 HU HU831793A patent/HU188343B/hu not_active IP Right Cessation
- 1983-05-21 KR KR1019830002236A patent/KR900006116B1/ko not_active Expired
1985
- 1985-04-12 ES ES542185A patent/ES8603415A1/es not_active Expired
- 1985-04-12 ES ES542186A patent/ES542186A0/es active Granted
- 1985-04-12 ES ES542187A patent/ES8603417A1/es not_active Expired

Also Published As

Publication number	Publication date
EP0095450A2 (en)	1983-11-30
KR840004724A (ko)	1984-10-24
HU188343B (en)	1986-04-28
GB8314021D0 (en)	1983-06-29
IL68604A0 (en)	1983-09-30
FI831779L (fi)	1983-11-22
ES542185A0 (es)	1985-12-16
GB2120251B (en)	1985-11-27
GR78849B (ko)	1984-10-02
IS2808A7 (is)	1983-11-22
ES522573A0 (es)	1985-10-01
FI831779A0 (fi)	1983-05-19
ES542187A0 (es)	1985-12-16
NO162515C (no)	1990-01-10
KR900006116B1 (ko)	1990-08-22
NO162515B (no)	1989-10-02
ES8603415A1 (es)	1985-12-16
ZA833264B (en)	1984-06-27
DK223783A (da)	1983-11-22
CA1242201A (en)	1988-09-20
FI79300C (fi)	1989-12-11
AU1464483A (en)	1983-11-24
DD216454A5 (de)	1984-12-12
EP0095450A3 (en)	1984-09-05
ES8600242A1 (es)	1985-10-01
DK223783D0 (da)	1983-05-19
IS1380B6 (is)	1989-08-28
MW2083A1 (en)	1985-06-12
HU193785B (en)	1987-11-30
GB2120251A (en)	1983-11-30
PT76734A (en)	1983-06-01
FI79300B (fi)	1989-08-31
JPS58210064A (ja)	1983-12-07
ES8603417A1 (es)	1985-12-16
NO831807L (no)	1983-11-22
ES8603416A1 (es)	1985-12-16
PT76734B (en)	1986-03-27
ES542186A0 (es)	1985-12-16
NZ204284A (en)	1985-11-08

Publication	Publication Date	Title
EP0026317B1 (de)	1985-10-16	Optisch aktive 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0002208B1 (de)	1981-03-11	Nitrosubstituierte 1,4-Dihydropyridine, diese enthaltende Arzneimittel sowie deren Herstellung
DE2117571A1 (de)	1972-10-19	Unsymmetrische 1,4-Dihydropyridincarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel I. Arfm: Farbenfabriken Bayer AG, 5090 Leverkusen
EP0088274A1 (de)	1983-09-14	Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln
DE2928485A1 (de)	1981-01-29	Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
DE2117572A1 (de)	1972-10-19	Unsymmetrische 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel II
EP0114270B1 (de)	1987-04-01	Acylderivate von 1,4:3,6-Dianhydro-hexiten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE2407115A1 (de)	1974-10-10	Neue 1,4-dihydropyridinderivate
DE2841667A1 (de)	1980-04-10	Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
CH631164A5 (de)	1982-07-30	Verfahren zur herstellung von neuem 1-cyclopropylmethyl-4-(3-jod-5h-dibenzo(a,d)cyclohepten-5-yliden)piperidin.
EP0052300A1 (de)	1982-05-26	C-3 verknüpfte 1,4-Dihydropyridine, ihre Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung
DE69718968T2 (de)	2003-10-09	3-(bis-substituierte-phenylmethylen)oxindol-derivate
DD211554A5 (de)	1984-07-18	Verfahren zur herstellung neuer dihydropyridine
DE2252822C3 (de)	1976-05-06	6-pyrimidinyl-acethydroxamsaeuren
DE3412947A1 (de)	1985-10-17	Tetrahydothienopyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2711225A1 (de)	1977-09-29	N-(mercaptoacyl)-histidine
DE2717001A1 (de)	1978-10-19	Arzneimittel mit antithrombotischer wirkung
EP0068259A1 (de)	1983-01-05	Substituierte 2-Amino-pyridinderivate, Verfahren zu ihrer Herstellung, ihre Verwendung in Arzneimitteln, sowie deren Herstellung
DE2650013A1 (de)	1978-05-11	1.4-dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsaeure-isopropyl-(2-propoxy-aethyl)-ester, mehrere verfahren zu seiner herstellung sowie seine verwendung als peripherer vasodilatator
DE2611089A1 (de)	1976-10-14	Thiazolinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
EP0042093A2 (de)	1981-12-23	4-Aralkyl-1,4-dihydropyridine, Verfahren zu deren Herstellung, ihre Verwendung in Arzneimitteln sowie deren Herstellung
DE2034587A1 (de)	1971-02-11	Neue, insbesondere sympathikolytische pharmazeutische Zusammensetzungen auf der Basis von Isochinolinen und neue substituierte Isochinoline
DE3121175A1 (de)	1982-12-16	Erythro-1,2,3-triphenyl-1-pentanon-derivate sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2521347B2 (de)	1980-05-22	Hydroxylsubstituierte 2-Chlor- a -(tertbutylaminomethyD-benzylalkohole, Herstellungsverfahren und Arzneimittel
DE3012190A1 (de)	1980-10-02	Pharmazeutisches mittel auf der basis 1,3,5-substituierter biuret-verbindungen

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