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MX2009009782A - Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas. - Google Patents

Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas.

Info

Publication number
MX2009009782A
MX2009009782A MX2009009782A MX2009009782A MX2009009782A MX 2009009782 A MX2009009782 A MX 2009009782A MX 2009009782 A MX2009009782 A MX 2009009782A MX 2009009782 A MX2009009782 A MX 2009009782A MX 2009009782 A MX2009009782 A MX 2009009782A
Authority
MX
Mexico
Prior art keywords
egfr
src
treatment
cancer
treatment method
Prior art date
Application number
MX2009009782A
Other languages
English (en)
Inventor
Webster Cavenee
Frank Furnari
Terrance Grant Johns
Andrew Scott
Original Assignee
Ludwig Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res filed Critical Ludwig Inst Cancer Res
Publication of MX2009009782A publication Critical patent/MX2009009782A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere al tratamiento de enfermedades mediadas por EGFR, en particular cáncer, inhibiendo o bloqueando EGFR y src en combinación o simultáneamente. La invención se refiere al tratamiento, prevención o modulación de cáncer, particularmente enfermedades mediadas por EGFR, con uno o más moduladores de EGFR e inhibidores de src en combinación. La invención además se refiere al tratamiento de cáncer con anticuerpos anti-EGFR e inhibidores de src. También se describen métodos y composiciones para el tratamiento de cáncer con el anticuerpo anti-EGFR mAb806 en combinación o en serie con un inhibidor de src o inhibidores de src.
MX2009009782A 2007-03-15 2008-03-14 Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas. MX2009009782A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91808407P 2007-03-15 2007-03-15
PCT/US2008/003369 WO2008115404A1 (en) 2007-03-15 2008-03-14 Treatment method using egfr antibodies and src inhibitors and related formulations

Publications (1)

Publication Number Publication Date
MX2009009782A true MX2009009782A (es) 2010-09-10

Family

ID=39766230

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009782A MX2009009782A (es) 2007-03-15 2008-03-14 Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas.

Country Status (9)

Country Link
US (1) US9023356B2 (es)
EP (1) EP2134854B1 (es)
JP (2) JP5618549B2 (es)
CN (1) CN101688229B (es)
AU (3) AU2008227123B2 (es)
CA (1) CA2680854C (es)
ES (1) ES2542152T3 (es)
MX (1) MX2009009782A (es)
WO (1) WO2008115404A1 (es)

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CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
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PL2769737T3 (pl) * 2009-07-20 2017-08-31 Bristol-Myers Squibb Company Kombinacja przeciwciała anty-ctla-4 z etopozydem w leczeniu synergicznym chorób proliferacyjnych
US8506963B2 (en) * 2009-09-22 2013-08-13 Shanghai Cancer Institute Anti-EFGRv3 monoclonal antibody
KR101108642B1 (ko) * 2009-09-29 2012-02-09 주식회사 녹십자 표피 성장 인자 수용체에 특이적으로 결합하는 항체
WO2012099968A1 (en) * 2011-01-19 2012-07-26 The Trustees Of The University Of Pennsylvania Compositions and methods for treating skin cancer associated diseases
JP2013116051A (ja) * 2011-12-01 2013-06-13 Sysmex Corp 腫瘍細胞のダサチニブへの感受性の判定方法およびその利用
WO2013152313A1 (en) 2012-04-05 2013-10-10 The Regents Of The University Of California Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition
CN106459200B (zh) 2014-03-21 2019-12-06 艾伯维公司 抗-egfr抗体及抗体药物偶联物
WO2015195721A1 (en) * 2014-06-16 2015-12-23 Purdue Research Foundation Compositions and methods for treating cancer
US20170022576A1 (en) 2015-03-18 2017-01-26 The Regents Of The University Of California Compositions and methods for identifying anti-cancer, anti-metastatic and anti-stress agents
WO2017075424A1 (en) * 2015-10-29 2017-05-04 Tapinos Nikolaos Methods for regulation and treatment of glioma cell migration and glioblastoma
CN113321700B (zh) * 2020-06-02 2022-07-01 泰比瑞医药科技(石家庄)有限公司 一种降解靶蛋白的双功能化合物及其用途
CN114099422A (zh) * 2020-08-25 2022-03-01 泰州迈博太科药业有限公司 一种重组抗egfr单抗前体的制剂
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
CN116271048A (zh) * 2023-04-10 2023-06-23 昆明理工大学 一种src蛋白或其编码基因的下调剂在制备治疗三阴性乳腺癌药物中的应用

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