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CR9541A - Tigeciclina y metodos de preparacion - Google Patents

Tigeciclina y metodos de preparacion

Info

Publication number
CR9541A
CR9541A CR9541A CR9541A CR9541A CR 9541 A CR9541 A CR 9541A CR 9541 A CR9541 A CR 9541A CR 9541 A CR9541 A CR 9541A CR 9541 A CR9541 A CR 9541A
Authority
CR
Costa Rica
Prior art keywords
tigecicline
preparation methods
methods
disclosed
tigecycline
Prior art date
Application number
CR9541A
Other languages
English (en)
Inventor
Krishnan Lalitha
Sum Phaik-Eng
Marshall Horne Jeffrey
Joseph Tuper Adam
James Iii Mccauley Joseph
Scott Pilcher Anthony
P Michaud Adam
Daigneault Sylvain
Bernatchez Michel
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9541A publication Critical patent/CR9541A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se revelan metodos para preparar y purificar tetraciclinas, tales como tigeciclina. Tambien se revelan composiciones de tetraciclinas, tales como composiciones de tigeciclina, preparadas por estos metodos.
CR9541A 2005-05-27 2007-11-22 Tigeciclina y metodos de preparacion CR9541A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68528505P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
CR9541A true CR9541A (es) 2008-02-20

Family

ID=37023025

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9541A CR9541A (es) 2005-05-27 2007-11-22 Tigeciclina y metodos de preparacion

Country Status (21)

Country Link
US (1) US20070049562A1 (es)
EP (1) EP1888507A1 (es)
JP (1) JP2008545701A (es)
KR (1) KR20080015470A (es)
CN (1) CN101228112A (es)
AR (1) AR057032A1 (es)
AU (1) AU2006252783A1 (es)
BR (1) BRPI0610648A2 (es)
CA (1) CA2609306A1 (es)
CR (1) CR9541A (es)
EC (1) ECSP078059A (es)
GT (1) GT200600221A (es)
IL (1) IL187360A0 (es)
MX (1) MX2007014731A (es)
NI (1) NI200700301A (es)
NO (1) NO20076001L (es)
PE (1) PE20070009A1 (es)
RU (1) RU2007143157A (es)
TW (1) TW200718676A (es)
WO (1) WO2006130418A1 (es)
ZA (1) ZA200710153B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
CA2649221A1 (en) * 2006-04-17 2007-10-25 Evgeny Tsiperman Isolation of tetracycline derivatives
PT2016045E (pt) * 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
MX2008009520A (es) * 2006-11-29 2009-02-26 Teva Pharma Formas cristalinas de tigeciclina y procesos de preparacion de ellas.
EP2084126A1 (en) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
US20080214869A1 (en) * 2007-03-01 2008-09-04 Sergei Fine Processes for purification of tigecycline
US20090099376A1 (en) * 2007-10-16 2009-04-16 Wyeth Tigecycline and methods of preparing intermediates
WO2009062963A1 (en) 2007-11-14 2009-05-22 Sandoz Ag Crystalline forms of tigecycline hydrochloride
EP2252579A2 (en) * 2008-01-23 2010-11-24 Sandoz AG Antibiotic compounds
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
ES2528490T3 (es) 2008-12-18 2015-02-10 Sandoz Ag Forma cristalina C de dihidrocloruro de tigeciclina y métodos para su preparación
CA2751238A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika
CA2790240A1 (en) * 2010-03-10 2011-09-15 University Health Network Use of tigecycline for treatment of cancer
CN102276497A (zh) * 2010-06-10 2011-12-14 武汉启瑞药业有限公司 替加环素的合成方法
CN102746183B (zh) * 2011-04-20 2014-12-17 胡梨芳 替加环素结晶水合物及其制备方法和用途
MX350575B (es) 2012-09-27 2017-09-11 Bayer Cropscience Ag Procedimiento para la preparación de fenil y piridil pirrolidinas opcionalmente sustituidas.
CN102911077B (zh) * 2012-11-12 2015-01-07 成都百裕科技制药有限公司 4r-替加环素的制备方法
CN103044281A (zh) * 2013-01-02 2013-04-17 湖南赛隆药业有限公司 高纯度替加环素的制法
CN104230744B (zh) * 2014-09-01 2016-06-08 湖南尔康制药股份有限公司 一种替加环素原料药的生产方法
CN107365359B (zh) * 2017-07-17 2021-06-04 昆明理工大学 一种万古霉素手性功能单体合成方法
WO2019160037A1 (ja) * 2018-02-14 2019-08-22 国立大学法人 東京大学 酸ハロゲン化物による化合物の製造方法

Family Cites Families (49)

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USRE26271E (en) * 1967-09-26 Reductive alkylation process
US3026248A (en) * 1959-09-11 1962-03-20 Pfizer & Co C Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (es) * 1960-05-23 1966-05-25
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
US3502696A (en) * 1961-08-18 1970-03-24 Pfizer & Co C Antibacterial agents
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3145228A (en) * 1962-09-06 1964-08-18 Pfizer & Co C 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof
US3250810A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-hydroxy-6-halomethyl tetracyclines
US3250809A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives
US3219529A (en) * 1962-10-04 1965-11-23 American Cyanamid Co Stable tetracycline solutions
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US3397230A (en) * 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
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US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
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US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
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Also Published As

Publication number Publication date
AU2006252783A1 (en) 2006-12-07
NI200700301A (es) 2008-07-24
RU2007143157A (ru) 2009-07-10
NO20076001L (no) 2008-02-19
CA2609306A1 (en) 2006-12-07
IL187360A0 (en) 2008-04-13
ZA200710153B (en) 2009-08-26
BRPI0610648A2 (pt) 2010-07-13
AR057032A1 (es) 2007-11-14
ECSP078059A (es) 2008-01-23
TW200718676A (en) 2007-05-16
PE20070009A1 (es) 2007-01-29
MX2007014731A (es) 2008-02-15
US20070049562A1 (en) 2007-03-01
JP2008545701A (ja) 2008-12-18
KR20080015470A (ko) 2008-02-19
EP1888507A1 (en) 2008-02-20
WO2006130418A1 (en) 2006-12-07
CN101228112A (zh) 2008-07-23
GT200600221A (es) 2009-08-28

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)