[go: up one dir, main page]

CR20130192A - Derivados de bencimidazol como inhibidores de cinasa p13 - Google Patents

Derivados de bencimidazol como inhibidores de cinasa p13

Info

Publication number
CR20130192A
CR20130192A CR20130192A CR20130192A CR20130192A CR 20130192 A CR20130192 A CR 20130192A CR 20130192 A CR20130192 A CR 20130192A CR 20130192 A CR20130192 A CR 20130192A CR 20130192 A CR20130192 A CR 20130192A
Authority
CR
Costa Rica
Prior art keywords
cinasa
bencimidazol
inhibitors
derivatives
Prior art date
Application number
CR20130192A
Other languages
English (en)
Inventor
Junya Qu
Ralph Rivero
Robert Sanchez
Rosanna Tedesco
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CR20130192A publication Critical patent/CR20130192A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CR20130192A 2010-10-06 2013-05-02 Derivados de bencimidazol como inhibidores de cinasa p13 CR20130192A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39031410P 2010-10-06 2010-10-06
US201161528397P 2011-08-29 2011-08-29

Publications (1)

Publication Number Publication Date
CR20130192A true CR20130192A (es) 2013-10-03

Family

ID=45925614

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130192A CR20130192A (es) 2010-10-06 2013-05-02 Derivados de bencimidazol como inhibidores de cinasa p13

Country Status (39)

Country Link
US (10) US20130196990A1 (es)
EP (2) EP2624696B1 (es)
JP (1) JP5719028B2 (es)
KR (1) KR101594002B1 (es)
CN (1) CN103124496B (es)
AR (1) AR083296A1 (es)
AU (1) AU2011312594B2 (es)
BR (1) BR112013008259A2 (es)
CA (1) CA2812608C (es)
CL (1) CL2013000935A1 (es)
CO (1) CO6700852A2 (es)
CR (1) CR20130192A (es)
CY (1) CY1118792T1 (es)
DK (1) DK2624696T3 (es)
DO (1) DOP2013000059A (es)
EA (1) EA022623B1 (es)
ES (2) ES2616238T3 (es)
HR (1) HRP20170279T1 (es)
HU (1) HUE033209T2 (es)
IL (1) IL225140A (es)
JO (1) JO3194B1 (es)
LT (1) LT2624696T (es)
MA (1) MA34591B1 (es)
ME (1) ME02663B (es)
MX (1) MX337662B (es)
MY (1) MY170236A (es)
NZ (1) NZ608069A (es)
PE (1) PE20140192A1 (es)
PH (1) PH12013500646A1 (es)
PL (1) PL2624696T3 (es)
PT (1) PT2624696T (es)
RS (1) RS55662B1 (es)
SG (1) SG188974A1 (es)
SI (1) SI2624696T1 (es)
SM (1) SMT201700158T1 (es)
TW (1) TWI513690B (es)
UY (1) UY33648A (es)
WO (1) WO2012047538A1 (es)
ZA (1) ZA201301951B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103124496B (zh) 2010-10-06 2016-03-30 葛兰素史密丝克莱恩有限责任公司 作为pi3激酶抑制剂的苯并咪唑衍生物
US8778937B2 (en) * 2011-12-20 2014-07-15 Glaxosmithkline Llc Benzimidazole boronic acid derivatives as PI3 kinase inhibitors
KR20150103735A (ko) * 2013-01-09 2015-09-11 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 조합물
WO2015042027A1 (en) * 2013-09-19 2015-03-26 Glaxosmithkline Llc Combination drug therapy
CA2921156A1 (en) * 2013-09-19 2015-03-26 Glaxosmithkline Llc Combination drug therapy
CN106831722B (zh) * 2013-10-16 2019-08-30 上海璎黎药业有限公司 稠合杂环化合物、其制备方法、药物组合物和用途
CN103910682B (zh) * 2013-11-28 2016-03-02 大连理工大学 一种基于邻苯二胺环化的苯并咪唑类化合物制备方法
JP2017502016A (ja) * 2013-12-20 2017-01-19 バイオメッド バレー ディスカバリーズ，インコーポレイティド １型ｍｅｋ阻害剤およびｅｒｋ阻害剤の組み合わせを使用するがんの処置
KR20170012558A (ko) 2014-06-13 2017-02-02 길리애드 사이언시즈, 인코포레이티드 포스파티딜이노시톨 3-키나제 억제제
JP2017522274A (ja) 2014-06-13 2017-08-10 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
SG11201609527PA (en) 2014-06-13 2016-12-29 Gilead Sciences Inc Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
AU2015274696B2 (en) 2014-06-13 2018-09-27 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
WO2015191752A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CA2967546A1 (en) 2014-12-19 2016-06-23 Janssen Pharmaceutica Nv Heterocyclyl linked imidazopyridazine derivatives as pi3k.beta. inhibitors
HRP20191550T1 (hr) * 2014-12-19 2019-11-29 Janssen Pharmaceutica Nv Derivati imidazopiridazina kao inhibitori pi3kbeta
GB201504689D0 (en) 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Chemical compounds
WO2017060406A1 (en) 2015-10-09 2017-04-13 Janssen Pharmaceutica Nv Quinoxaline and pyridopyrazine derivatives as pi3kbeta inhibitors
US10729680B2 (en) * 2016-01-14 2020-08-04 Bayer Pharma Aktiengesellschaft 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
WO2017216293A1 (en) * 2016-06-16 2017-12-21 Janssen Pharmaceutica Nv Azabenzimidazole derivatives as pi3k beta inhibitors
LT3472160T (lt) 2016-06-16 2021-04-26 Janssen Pharmaceutica Nv Biciklinio piridino, pirazino ir pirimidino dariniai kaip pi3k beta inhibitoriai
CN109689062B (zh) * 2016-07-11 2023-02-17 丹娜法伯癌症研究院 使用抗PI3Kβ和抗免疫检查点药剂的组合治疗PTEN缺陷型上皮癌的方法
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
WO2018057808A1 (en) 2016-09-23 2018-03-29 Gilead Sciences, Inc. Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors
EP3548034A4 (en) * 2016-12-05 2020-07-08 Microbiotix, Inc. BROAD SPECTRUM INHIBITORS OF FILOVIRUS
AU2018246321B2 (en) 2017-03-29 2021-07-29 Janssen Pharmaceutica Nv Quinoxaline and pyridopyrazine derivatives as PI3K-beta inhibitors
SI3658552T1 (sl) 2017-07-28 2023-11-30 Yuhan Corporation Postopek za pripravo N-(5-((4-(4-((dimetilamino)metil)-3-fenil-1H-pirazol-1-il)pirimidin-2-il )amino)-4-metoksi-2-morfolinofenil)akrilamida z reagiranjem ustreznega amina s 3-halo-propionil kloridom
WO2019106605A1 (en) 2017-12-01 2019-06-06 Board Of Regents, The University Of Texas System Combination treatment for cancer
US11253189B2 (en) 2018-01-24 2022-02-22 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for evaluating neuromodulation therapy via detection of magnetic fields
CN111000847B (zh) * 2020-01-02 2021-03-19 黑龙江中医药大学 一种治疗肺纤维化的药物制剂及其用途
CN111346095B (zh) * 2020-03-14 2021-06-08 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 用于治疗神经外科术后头痛的药物制剂

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400835A1 (en) 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
IL95975A (en) 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5559235A (en) 1991-10-29 1996-09-24 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
TW284688B (es) 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
WO1993020078A1 (en) 1992-04-03 1993-10-14 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US5502187A (en) 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
GB9210400D0 (en) 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
US5342947A (en) 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
CZ154994A3 (en) 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
JPH0867674A (ja) 1993-07-02 1996-03-12 Senju Pharmaceut Co Ltd 眼圧降下剤
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
EP0694535A1 (en) 1994-04-29 1996-01-31 Eli Lilly And Company Non-peptidyl tachykinin receptor antagonists
US5491237A (en) 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
DE19514579A1 (de) 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
WO1997025041A1 (en) 1996-01-09 1997-07-17 Eli Lilly And Company Benzimidzolyl neuropeptide y receptor antagonists
WO1997031635A1 (en) 1996-03-01 1997-09-04 Eli Lilly And Company Methods of treating or preventing sleep apnea
AU2207897A (en) 1996-03-11 1997-10-01 Eli Lilly And Company Methods of treating or preventing interstitial cystitis
WO1998039343A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel benzimidazole inhibitors of fructose-1,6-bisphosphatase
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
EP1165557B1 (en) 1999-04-02 2004-09-29 Neurogen Corporation ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
JP2000323278A (ja) 1999-05-14 2000-11-24 Toray Ind Inc 発光素子
CA2378047A1 (en) 1999-07-15 2001-01-25 Methvin Isaac Heterocyclic compounds for the treatment of migraine
US6534535B1 (en) 1999-08-12 2003-03-18 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
WO2001021634A1 (en) 1999-09-21 2001-03-29 Lion Bioscience Ag Benzimidazole derivatives and combinatorial libraries thereof
TWI224597B (en) 1999-12-03 2004-12-01 Ono Pharmaceutical Co Triazaspiro[5.5]undecane derivatives and a medicine containing the derivatives as an active ingredient
WO2001057020A1 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
US6472095B2 (en) 2000-12-29 2002-10-29 Utc Fuel Cells, Llc Hybrid fuel cell reactant flow fields
TW593278B (en) 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
WO2002072549A1 (en) 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
KR20030093248A (ko) 2001-03-19 2003-12-06 오노 야꾸힝 고교 가부시키가이샤 트리아자스피로[5.5]운데칸 유도체를 유효성분으로서함유하는 약제
FR2822463B1 (fr) 2001-03-21 2004-07-30 Lipha Derives bicycliques de guanidines et leurs applications en therapeutique
WO2002076960A1 (en) 2001-03-22 2002-10-03 Abbott Gmbh & Co. Kg Transition metal mediated process
SK12002003A3 (en) * 2001-03-28 2004-10-05 Bristol Myers Squibb Co Novel tyrosine kinase inhibitors
US7081454B2 (en) * 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
TWI236474B (en) 2001-04-03 2005-07-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
JP4323810B2 (ja) 2001-04-20 2009-09-02 ワイス ５−ヒドロキシトリプトアミン−６リガンドとしてのヘテロシクリルオキシ−、−チオキシ−および−アミノベンザゾール誘導体
KR20030088507A (ko) 2001-04-20 2003-11-19 와이어쓰 5-하이드록시트립타민-6 리간드로서의헤테로사이클릴알콕시-, -알킬티오- 및-알킬아미노벤즈아졸 유도체
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
CA2449977A1 (en) 2001-06-15 2002-12-27 Genentech, Inc. Human growth hormone antagonists
JP4558314B2 (ja) 2001-07-20 2010-10-06 ベーリンガー インゲルハイム （カナダ） リミテッド ウイルスポリメラーゼインヒビター
FR2827862A1 (fr) 2001-07-27 2003-01-31 Lipha Derives imidazolylalkylarylalcanoiques et leurs applications en therapeutique
DE10139416A1 (de) 2001-08-17 2003-03-06 Aventis Pharma Gmbh Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2829765A1 (fr) 2001-09-14 2003-03-21 Lipha Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
US7087593B2 (en) 2001-10-02 2006-08-08 Acadia Pharmaceuticals Inc. Benzimidazolidinone derivatives as muscarinic agents
WO2004089942A2 (en) 2001-10-02 2004-10-21 Acadia Pharmaceuticals Inc. Benzimidazolidinone derivatives as muscarinic agents
EP1434579B1 (en) 2001-10-09 2011-06-08 Amgen Inc. Imidazole derivatives as antiinflammatory agents
US6673815B2 (en) 2001-11-06 2004-01-06 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
AU2002349477A1 (en) 2001-11-26 2003-06-10 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
EP1513522A2 (en) 2002-01-18 2005-03-16 Sri International Methods of treating conditions associated with an edg receptor
DE60336633D1 (de) 2002-02-15 2011-05-19 Bridgestone Corp Kautschukzusammensetzung und daraus hergestellter pneumatischer reifen
KR20040098013A (ko) 2002-03-13 2004-11-18 어레이 바이오파마 인크. Ｍｅｋ 억제제로서의 ｎ3 알킬화된 벤즈이미다졸 유도체
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
PA8569301A1 (es) 2002-03-13 2004-10-08 Array Biopharma Inc "derivados de bencimidazol n3 alquilado como inhibidores de mek" "n3 alkylated benzimidazole derivatives as mek inhibitors"
BR0306016A (pt) 2002-03-13 2005-01-04 Array Biopharma Inc Derivados de benzimidazol n3 alquilado como inibidores da mek
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
DE10229777A1 (de) 2002-07-03 2004-01-29 Bayer Ag Indolin-Phenylsulfonamid-Derivate
US7205412B2 (en) 2002-07-03 2007-04-17 Samsung Electronics Co., Ltd. Antibiotic additive and ink composition comprising the same
CA2494942A1 (en) 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
US20040063938A1 (en) 2002-09-30 2004-04-01 Pfizer Inc Process for preparing haloalkyl pyrimidines
AU2003294249A1 (en) 2002-11-08 2004-06-03 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
WO2004052862A1 (ja) 2002-12-10 2004-06-24 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
US7135493B2 (en) 2003-01-13 2006-11-14 Astellas Pharma Inc. HDAC inhibitor
WO2004082621A2 (en) 2003-03-15 2004-09-30 Bethesda Pharmaceuticals, Inc. Novel ppar agonists, pharmaceutical compositions and uses thereof
JP3819415B2 (ja) * 2003-04-09 2006-09-06 日本たばこ産業株式会社 複素芳香５員環化合物及びその医薬用途
WO2004093912A1 (ja) 2003-04-23 2004-11-04 Kyowa Hakko Kogyo Co. Ltd. 好中球性炎症疾患の予防および／または治療剤
EP1620413A2 (en) 2003-04-30 2006-02-01 Cytokinetics, Inc. Compounds, compositions, and methods
SE0301699D0 (sv) * 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
JP2007516180A (ja) 2003-07-02 2007-06-21 スゲン，インコーポレイティド ｃ−Ｍｅｔ阻害薬としてのアリールメチルトリアゾロおよびイミダゾピラジン類
US7312215B2 (en) * 2003-07-29 2007-12-25 Bristol-Myers Squibb Company Benzimidazole C-2 heterocycles as kinase inhibitors
DE10342503A1 (de) * 2003-09-12 2005-04-14 Merck Patent Gmbh Benzyl-Benzimidazolylderivate
DE602004027932D1 (de) 2003-09-22 2010-08-12 S Bio Pte Ltd Benzimidazolderivate: herstellung und pharmazeutische anwendungen
WO2005051929A1 (en) 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Conversion of aromatic nitriles into tetrazoles
WO2005051928A1 (en) 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Process for production of tetrazolyl compounds
WO2005066151A2 (en) 2003-12-19 2005-07-21 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20050209284A1 (en) 2004-02-12 2005-09-22 Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors
JP4866723B2 (ja) 2004-02-26 2012-02-01 協和発酵キリン株式会社 好中球性炎症疾患の予防及び／または治療剤
JP4870660B2 (ja) 2004-03-15 2012-02-08 アノーメッド インコーポレイティド Ｃｘｃｒ４アンタゴニストの合成プロセス
ATE420858T1 (de) 2004-03-15 2009-01-15 Lilly Co Eli 4-(5-(aminomethyl)-indol-1- ylmethyl)benzamidderivate und verwandte verbindungen als opioidrezeptorantagonisten zur behandlung von fettleibigkeit
AU2005244736B2 (en) 2004-05-07 2012-06-28 Exelixis Patent Company Llc Raf modulators and methods of use
US7687638B2 (en) 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
AR050522A1 (es) 2004-08-16 2006-11-01 Smithkline Beecham Corp Derivados de bencimidazol como moduladores de la actividad de los receptores de quimioquina; composiciones farmaceuticas que los contienen; metodos para su preparacion y su uso en la fabricacion de medicamentos para el tratamiento contra infecciones por hiv
BRPI0515549A (pt) 2004-09-17 2008-07-29 Whitehead Biomedical Inst compostos, composições e métodos de inibição de toxicidade de alfa-sinucleìna
WO2007134169A2 (en) 2006-05-10 2007-11-22 Nuada, Llc Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
CA2585766A1 (en) 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
US20090264384A1 (en) 2004-11-01 2009-10-22 Nuada, Inc. Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
WO2006053342A2 (en) 2004-11-12 2006-05-18 Osi Pharmaceuticals, Inc. Integrin antagonists useful as anticancer agents
US20100093767A1 (en) 2004-12-03 2010-04-15 Takeda San Diego, Inc. Mitotic Kinase Inhibitors
DE602006016566D1 (de) 2005-01-10 2010-10-14 Bristol Myers Squibb Co Als antikoagulanzien verwendbare phenylglycinamid-derivate
WO2006078907A1 (en) 2005-01-20 2006-07-27 Amgen Inc. 2-substituted benzimidazole derivatives as vanilloid receptor ligands and their use in treatments
CN1834090B (zh) 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
WO2006132625A1 (en) 2005-06-03 2006-12-14 Ppg Industries Ohio, Inc. Composition for the vapor phase dehydrohalogenation of 1,1,2-trihaloethane to 1,1-dihaloethylene and methods for preparing and using such compositions
AU2006264212B2 (en) 2005-06-29 2010-10-28 Compumedics Limited Sensor assembly with conductive bridge
EP1904501A2 (en) 2005-07-11 2008-04-02 Smithkline Beecham Corporation Chemical compounds
JP2007063261A (ja) 2005-08-01 2007-03-15 Kyowa Hakko Kogyo Co Ltd Ｘ線照射による肺障害の予防及び／または治療剤
WO2007023880A1 (ja) 2005-08-24 2007-03-01 Kyowa Hakko Kogyo Co., Ltd. ケモカイン産生阻害剤
AU2006285038A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
TW200720261A (en) 2005-08-31 2007-06-01 Sankyo Co Phenylene derivatives
PT1937650E (pt) 2005-09-08 2011-09-21 S Bio Pte Ltd Compostos heterocíclicos
WO2007054965A2 (en) 2005-09-23 2007-05-18 Alembic Limited Process for preparation of tetrazoles from aromatic cyano derivatives
GB0520164D0 (en) 2005-10-04 2005-11-09 Novartis Ag Organic compounds
CN104592128A (zh) 2005-12-20 2015-05-06 阿斯利康(瑞典)有限公司 作为gabaa受体调节剂的取代的噌啉衍生物及其合成方法
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
BRPI0620196A2 (pt) 2005-12-23 2013-01-15 Astrazeneca Ab composto, processo para a preparaÇço do mesmo, composiÇço farmacÊutica, uso de um composto, e, mÉtodos para a produÇço de um efeito antibacteriano em um animal de sangue quente, para a inibiÇço de dna girase e/ou topoisomerase iv bacteriana em um animal de sangue quente e para o tratamento de uma infecÇço bacteriana em um animal de sangue quente
AU2006336504C9 (en) 2005-12-28 2015-05-14 Vertex Pharmaceuticals Incorporated 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
WO2007084390A2 (en) 2006-01-13 2007-07-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2007210159A1 (en) 2006-01-26 2007-08-09 Foldrx Pharmaceuticals, Inc. Compounds and methods for modulating protein trafficking
WO2007091950A1 (en) 2006-02-07 2007-08-16 Astrazeneca Ab Benzimidazoles and imidazopyridines useful in the treatment of diseases or disorders associated with cannabinoid receptor 2 (cb2) such as pain
WO2007101347A1 (en) 2006-03-07 2007-09-13 Aegera Therapeutics Inc. Bir domain binding compounds
BRPI0711040A2 (pt) 2006-03-31 2011-08-23 Astrazeneca Ab uso de um composto, método para o tratamento ou prevenção de distúrbios, composto, e, composição farmacêutica
DE102006025777A1 (de) 2006-05-31 2007-12-06 Merck Patent Gmbh Neue Materialien für organische Elektrolumineszenzvorrichtungen
EP1873157A1 (en) 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
EP1878724A1 (en) 2006-07-15 2008-01-16 sanofi-aventis A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
WO2008012623A1 (en) 2006-07-25 2008-01-31 Pfizer Products Inc. Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor
WO2008019309A1 (en) 2006-08-04 2008-02-14 Metabasis Therapeutics, Inc. Novel inhibitors of fructose 1,6-bisphosphatase
WO2008020920A1 (en) 2006-08-15 2008-02-21 Duke University Ros-sensitive iron chelators and methods of using the same
US20090325954A1 (en) * 2006-09-14 2009-12-31 Sam Butterworth 2-benzimidazolyl-6-morpholino-4-phenylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
ZA200902384B (en) 2006-10-19 2010-07-28 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
WO2008052072A2 (en) 2006-10-24 2008-05-02 Acadia Pharmaceuticals Inc. Compounds for the treatment of pain and screening methods therefor
PE20090054A1 (es) 2007-01-23 2009-01-26 Palau Pharma Sa Derivados de purina
JP4866901B2 (ja) 2007-02-07 2012-02-01 協和発酵キリン株式会社 ３環系化合物
EP3449923A1 (en) 2007-03-07 2019-03-06 MEI Pharma, Inc. Combination of benzimidazole anti-cancer agent and a second anti-cancer agent
WO2008107478A1 (en) 2007-03-08 2008-09-12 Janssen Pharmaceutica Nv Quinolinone derivatives as parp and tank inhibitors
WO2008147945A1 (en) 2007-05-24 2008-12-04 Wyeth Azacyclylbenzamide derivatives as histamine-3 antagonists
TW200906825A (en) 2007-05-30 2009-02-16 Scripps Research Inst Inhibitors of protein kinases
MX2009013753A (es) 2007-06-26 2010-01-26 Sanofi Aventis Una sintesis regioselectiva catalizada por cobre de bencimidazoles y azabencimidazoles.
EP2014662A1 (de) 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Indolylalkylthienopyrimidylamine als Modulatoren des EP2-Rezeptors
EP2014663A1 (de) 2007-07-12 2009-01-14 Bayer Schering Pharma AG Thienopyrimidylamine als Modulatoren des EP2-Rezeptors
NZ583350A (en) 2007-08-21 2012-03-30 Senomyx Inc Heteroaryl-hydantoin derivatives as bitter taste inhibitors
WO2009027736A2 (en) 2007-08-27 2009-03-05 Astrazeneca Ab 2,4 diaminopyrimid'lnes for the treatment of myeloproliferative disorders and cancer
WO2009039140A1 (en) 2007-09-17 2009-03-26 Smithkline Beecham Corporation Pyridopyrimidine derivatives as pi3 kinase inhibitors
US20090118301A1 (en) 2007-11-02 2009-05-07 Arbor Vita Corporation Compositions and Methods for Treating Cancer
JP2011504900A (ja) 2007-11-27 2011-02-17 セルゾーム リミティッド Ｐｉ３ｋ阻害剤としてのアミノトリアゾール
WO2009079011A1 (en) 2007-12-19 2009-06-25 The Scripps Research Institute Benzimidazoles and analogs as rho kinase inhibitors
JP5584138B2 (ja) 2008-01-11 2014-09-03 ノバルティス アーゲー キナーゼ阻害剤としてのピリミジン類
AR070127A1 (es) 2008-01-11 2010-03-17 Novartis Ag Pirrolo - pirimidinas y pirrolo -piridinas
EP2252296A1 (en) 2008-01-15 2010-11-24 Wyeth LLC 3h-[1,2,3]triazolo[4,5-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
CA2711713A1 (en) 2008-01-22 2009-07-30 Boehringer Ingelheim International Gmbh Substituted amino-benzimidazoles, medicaments comprising said compound, their use and their method of manufacture
FR2928924B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
ES2367760T3 (es) 2008-03-27 2011-11-08 Janssen Pharmaceutica, N.V. Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.
DK2271626T3 (en) 2008-03-27 2015-02-23 Janssen Pharmaceutica Nv TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN
US20090253161A1 (en) 2008-04-03 2009-10-08 Duke University Fluorescent prochelators for cellular iron detection
JP5637982B2 (ja) 2008-04-09 2014-12-10 インフィニティー ファーマシューティカルズ， インコーポレイテッド 脂肪酸アミド加水分解酵素の阻害剤
RU2010154499A (ru) 2008-06-04 2012-07-20 Астразенека Аб (Se) Производные тиазоло[5,4-b]пиридина и оксазало[5,4-b]пиридина в качестве антибактериальных средств
JP2010031250A (ja) 2008-06-23 2010-02-12 Sumitomo Chemical Co Ltd 組成物及び該組成物を用いてなる発光素子
WO2010000020A1 (en) 2008-06-30 2010-01-07 Cathrx Ltd A catheter
BRPI0914006A2 (pt) 2008-07-03 2015-10-27 Sirtris Pharmaceuticals Inc benzimidazóis e análogos relacionados como moduladores de sirtuína
EP2307414A4 (en) * 2008-07-07 2011-10-26 Xcovery Holding Co Llc SELECTIVE INHIBITORS OF PI3 KINASE ISOFORMS
US20100029655A1 (en) 2008-07-11 2010-02-04 Martin Robert Leivers Processes For The Preparation Of Anti-Viral Compounds And Compositions Containing Them
US8501957B2 (en) 2008-12-10 2013-08-06 China Medical University Benzimidazole compounds and their use as anticancer agents
SI2565193T1 (sl) 2009-01-23 2014-07-31 Rigel Pharmaceuticals, Inc. Sestavki in metode inhibicije JAK poti
JP5628841B2 (ja) 2009-02-27 2014-11-19 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎ウイルスインヒビター
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
US20120006688A1 (en) 2009-03-18 2012-01-12 Basf Se Electrolyte and surface-active additives for the electrochemical deposition of smooth, dense aluminum layers from ionic liquids
US8969342B2 (en) 2009-03-20 2015-03-03 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
WO2010114726A1 (en) 2009-03-31 2010-10-07 Merck Sharp & Dohme Corp. Aminobenzotriazole derivatives
HRP20151126T1 (hr) 2009-04-02 2015-11-20 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii DERIVATI IMIDAZO[2,1-b][1,3,4]TIADIAZOLA
WO2010118208A1 (en) 2009-04-09 2010-10-14 Exelixis, Inc. Benzoxazepin-4- (5h) -yl derivatives and their use to treat cancer
AU2010241929A1 (en) 2009-04-27 2011-10-06 High Point Pharmaceuticals, Llc Substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors
WO2010126922A1 (en) 2009-04-30 2010-11-04 Glaxosmithkline Llc Benzimidazolecarboxamides as inhibitors of fak
US8648066B2 (en) 2009-05-22 2014-02-11 Exelixis, Inc. Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture
BRPI1010896A2 (pt) 2009-05-26 2019-09-24 Exelixis Inc benzoxazepinas como inibidores de pi3k/mtor e métodos de seus usos e fabricação
WO2010141360A1 (en) 2009-06-05 2010-12-09 Merck Sharp & Dohme Corp. Biaryl benzotriazole derivatives
US9221765B2 (en) 2009-06-10 2015-12-29 North Carolina State University Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives
WO2011000020A1 (en) 2009-06-12 2011-01-06 Sbc Research Pty Ltd Enhanced method of detection
JP2011003793A (ja) 2009-06-19 2011-01-06 Idemitsu Kosan Co Ltd 有機ｅｌ素子
WO2011009010A1 (en) 2009-07-15 2011-01-20 University Of Medicine And Dentistry Of New Jersey Novel compounds for inhibiting eef2 kinase activity
BR112012010054A2 (pt) 2009-10-29 2016-05-24 Bristol Myers Squibb Co compostos quinuclidina como ligantes de receptor de acetilcolina alfa-7 nicotínicos
CN102753545A (zh) 2009-12-15 2012-10-24 盐野义制药株式会社 具有血管内皮脂酶抑制活性的噁二唑衍生物
ES2362337B1 (es) 2009-12-17 2012-05-16 Consejo Superior De Investigaciones Cient�?Ficas (Csic) Derivados de aminociclitoles, procedimiento de obtencion y usos.
CN103124496B (zh) * 2010-10-06 2016-03-30 葛兰素史密丝克莱恩有限责任公司 作为pi3激酶抑制剂的苯并咪唑衍生物
WO2015053091A1 (ja) 2013-10-11 2015-04-16 ユニ・チャーム株式会社 ペットフード

Also Published As

Publication number Publication date
LT2624696T (lt) 2017-03-10
US8435988B2 (en) 2013-05-07
ES2616238T3 (es) 2017-06-12
DOP2013000059A (es) 2013-05-31
EP3170813A1 (en) 2017-05-24
IL225140A (en) 2016-09-29
US20190255064A1 (en) 2019-08-22
US10660898B2 (en) 2020-05-26
HUE033209T2 (hu) 2017-11-28
US9156797B2 (en) 2015-10-13
CN103124496B (zh) 2016-03-30
SI2624696T1 (sl) 2017-04-26
MY170236A (en) 2019-07-11
CN103124496A (zh) 2013-05-29
SG188974A1 (en) 2013-06-28
US20130197221A1 (en) 2013-08-01
EP2624696B1 (en) 2016-12-21
US8541411B2 (en) 2013-09-24
CA2812608C (en) 2020-07-14
ZA201301951B (en) 2014-08-27
PT2624696T (pt) 2017-03-21
MX2013003918A (es) 2013-06-05
EP3170813B1 (en) 2018-12-12
WO2012047538A1 (en) 2012-04-12
CL2013000935A1 (es) 2013-07-05
TWI513690B (zh) 2015-12-21
JP5719028B2 (ja) 2015-05-13
US8674090B2 (en) 2014-03-18
EP2624696A4 (en) 2014-03-26
PH12013500646A1 (en) 2015-11-13
ES2714384T3 (es) 2019-05-28
TW201307297A (zh) 2013-02-16
US20140378456A1 (en) 2014-12-25
SMT201700158T1 (it) 2017-05-08
MA34591B1 (fr) 2013-10-02
KR101594002B1 (ko) 2016-02-15
US9062003B2 (en) 2015-06-23
US20140142321A1 (en) 2014-05-22
US20140018534A1 (en) 2014-01-16
EA022623B1 (ru) 2016-02-29
US20120088767A1 (en) 2012-04-12
US20130196990A1 (en) 2013-08-01
US20150246889A1 (en) 2015-09-03
JP2013539753A (ja) 2013-10-28
UY33648A (es) 2012-04-30
JO3194B1 (ar) 2018-03-08
CA2812608A1 (en) 2012-04-12
BR112013008259A2 (pt) 2017-12-12
RS55662B1 (sr) 2017-06-30
CO6700852A2 (es) 2013-06-28
US10314845B2 (en) 2019-06-11
HRP20170279T1 (hr) 2017-04-07
PE20140192A1 (es) 2014-02-24
CY1118792T1 (el) 2017-07-12
AR083296A1 (es) 2013-02-13
EP2624696A1 (en) 2013-08-14
AU2011312594B2 (en) 2014-10-02
DK2624696T3 (en) 2017-03-13
US20180263994A1 (en) 2018-09-20
US8865912B2 (en) 2014-10-21
NZ608069A (en) 2014-06-27
US20170112844A1 (en) 2017-04-27
KR20130099142A (ko) 2013-09-05
PL2624696T3 (pl) 2017-07-31
US9872860B2 (en) 2018-01-23
MX337662B (es) 2016-03-14
EA201390302A1 (ru) 2013-09-30
AU2011312594A1 (en) 2013-04-11
ME02663B (me) 2017-06-20

Similar Documents

Publication Publication Date Title
CR20130192A (es) Derivados de bencimidazol como inhibidores de cinasa p13
CYD2019001I1 (el) Διαμορφωση της εκφρασης τρανσθυρετινης
CO6920291A2 (es) 3-pirmidin-4-il-oxazolidin-2-onas como inhibidores de la idhmutante
SMT201600108B (it) Derivato di pirazochinolina come inibitori di pde9
BR112013010099A2 (pt) boronatos como inibidores de arginase
DOP2012000282A (es) Indoles sustituidos como inhibidores ezh2
CO6801747A2 (es) Derivados de pirrolotriazinona como inhibidores de pi3k
EP2683693A4 (en) ROR-GAMMA-T INHIBITORS
EP2641343A4 (en) CONFIGURATION OF A BUILDING
EP2675909A4 (en) GLUCOSYLSTEVIA COMPOSITION
EP2720561A4 (en) Stevia-COMPOSITION
EP2713762A4 (en) Stevia-COMPOSITION
CO6831983A2 (es) Compuestos heterocíclicos como inhibidores de cinasas
CO7010824A2 (es) Inhibidores de aplicación viral
CO6870035A2 (es) Nuevos derivados bicíclicos de dihidroquinolina-2-ona
CR20120576A (es) Inhibidores de pirazolil quinazolina cinasa
CO6920296A2 (es) Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona
IL225867B (en) Coelenterazine substrates
UY33155A (es) Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa
BR112013007907A2 (pt) novos compostos de quinolina substituída como inibidores de s-nitrosoglutationa reductase
BR112013015449A2 (pt) compostos de bi-heteroarila como inibidores de vps23
CO6880068A2 (es) Aminoquinazolinas como inhibidores de quinasa
AR092198A1 (es) Derivados de pirazolopirimidinas
BR112013002122A2 (pt) derivados hetero-bicíclicos como inibidores de hcv
BR112012030193A2 (pt) compostos macrocíclicos úteis como inibidores de histona desacetilases