CN1660275A - 'Ganmaoning' gel preparation for enfant and preparation method - Google Patents
'Ganmaoning' gel preparation for enfant and preparation method Download PDFInfo
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- CN1660275A CN1660275A CN 200410081639 CN200410081639A CN1660275A CN 1660275 A CN1660275 A CN 1660275A CN 200410081639 CN200410081639 CN 200410081639 CN 200410081639 A CN200410081639 A CN 200410081639A CN 1660275 A CN1660275 A CN 1660275A
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- fructus
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- volatile oil
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of semi-fluid or gel for treating infantile cold is prepared from mint, schizonepeta ear, bitter apricot kernel and arctium fruit. Its preparing process is also disclosed.
Description
Technical field: the present invention is a kind of ' Ganmaoning ' gel preparation for enfant and preparation method thereof, belongs to medicine
Technical field.
Technical background: flu is mainly caused by virus, is infectious, but the secondary bacterial infection, when health was suffered from cold, the blood vessel of nasal mucosa began to shrink, local anoxia, temperature reduces, dysbolismus, its defense function is destroyed, and virus is just taken advantage of the crack and enter.When having some inkling of a cold, there are drying or burn feeling in nasal cavity and nasal cavity rear, sneeze, and nasal obstruction after 1～2 day, flowing water sample nasal mucus increases the weight of later on gradually.Often with General Symptomies such as fever, headache, extremity asthenia, joint aches, appetite differences.If the patient is after 2 weeks, symptom does not see yet to alleviate on the contrary and increases the weight of that this is that complication has taken place.Common complication has acute catarrhal otitis media, acute suppurative otitis media, acute sinusitis, acute pharyngolaryngitis, acute tracheitis and pneumonia etc.After taking place and closing disease, treatment time then will prolong, and has increased patient's misery.As delay treatment or treatment are not thorough again, and repeatedly outbreak of flu, then can develop into chronic rhinitis, pharyngitis, sinusitis, otitis media even myocarditis etc., influence study, work even life are not sneezed at paralysis.And the medicine that is used for the treatment of infantile common cold now is diversified, the XIAOER GANMAO TANGJIANG of wherein having gone on the market is exactly a kind of active drug for the treatment of infantile anemopyretic cold, but owing to contain a large amount of nutrient substance such as sugar, very easily cause moldy metamorphism, also be easy to generate precipitation, make store, use, transportation is very inconvenient.The applicant had once submitted a application number and had been " 20041004774.3 ", and name is called the application of " Chinese medicine preparation of treatment infantile common cold and preparation method thereof ", is mainly used in the infantile common cold fever, and sweating is not well, nasal obstruction watery nasal discharge, cough pharyngalgia etc.But continuing the discovery of research back: the loss in the heating process of preparation gel of the volatile oil of Herba Pogostemonis, Herba Menthae, Flos Chrysanthemi is very serious, has influenced the curative effect of medicine greatly.Because the child is to the dislike emotion of common drug preparation, so existing dosage form still is not the dosage form kind at the children characteristics, infant uses conventional tablet, capsule that certain difficulty, displeased acceptance are arranged.In the real life, child patient quantity is huge, and is poor to the ability to accept of general formulation, and the outward appearance of medicine, mouthfeel directly influence the application and the curative effect of medicine; In view of the develop rapidly of medical science and to these situations that deepen continuously of dosage form research, need exploitation effective medicine preparation that a kind of market prospect is wide, the child takes like a shot, the treatment of pediatric patient is reached a new high, thereby infantile common cold patient's quality of life is further improved.
Summary of the invention: the objective of the invention is to: a kind of ' Ganmaoning ' gel preparation for enfant and preparation method thereof is provided; The present invention is directed to prior art, we are made be subjected to the similar fruit jelly that the child likes or the product of soft sweet type gel deeply, not only inherited its original effect, and improved mouthfeel and appearance character, more can be accepted by the child.Children's extremely is ready to take, and has reduced the adult and has advised the trouble of feeding, and is not only tasty, and therapeutical effect is good, has enriched the dosage form kind, and market prospect is very wide; And, select feasible substrate and technology rationally, product appearance, good mouthfeel at pharmaceutical properties.
The present invention constitutes like this: calculate according to weight, it is by Herba Menthae 50～100g, Herba Schizonepetae 50～80g, Semen Armeniacae Amarum 60～100g, Fructus Arctii 60～100g, Radix Scutellariae 60～100g, Radix Platycodonis 50～80g, Radix Peucedani 60～100g, the Radix Angelicae Dahuricae 20～40g, Fructus Gardeniae (stir-fry) 30～50g, Fructus Crataegi (Jiao) 20～40g, Massa Medicata Fermentata (Jiao) 20～40g, Fructus Hordei Germinatus (Jiao) 20～40g, Rhizoma Phragmitis 100～150g, Flos Lonicerae 100～150g and Fructus Forsythiae 60～100g and an amount of substrate are made into fluid or semifluid gel oral formulations, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.It can also be prepared into: soft capsule, dispersible tablet, drop pill, pellet, slow releasing preparation, granule, capsule.Say accurately: calculate according to weight, it is by Herba Menthae 80g, Herba Schizonepetae 67g, Semen Armeniacae Amarum 80g, Fructus Arctii 80g, Radix Scutellariae 80g, Radix Platycodonis 67g, Radix Peucedani 80g, Radix Angelicae Dahuricae 27g, Fructus Gardeniae (stir-fry) 40g, Fructus Crataegi (Jiao) 27g, Massa Medicata Fermentata (Jiao) 27g, Fructus Hordei Germinatus (Jiao) 27g, Rhizoma Phragmitis 120g, Flos Lonicerae 120g and Fructus Forsythiae 80g and the gel preparation that is prepared into as the pectin and the alginate of substrate, product is semifluid or solid gel shape, similar fruit jelly or soft sweet type gel.Preferred manufacturing procedure is: Herba Menthae, extracting volatile oil from schizonepeta spike, in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, and in the time of 60 ℃, ground 0.5 hour, get clathrate; The Semen Armeniacae Amarum system of getting aqua armeniacae; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, get supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, be condensed into clear paste, clear paste added to mix homogeneously in the substrate for preparing, after the sterilization promptly.
Gel in the preparation of the present invention prepares like this: Herba Menthae, extracting volatile oil from schizonepeta spike, in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, and in the time of 60 ℃, ground 0.5 hour, get clathrate; The Semen Armeniacae Amarum system of getting aqua armeniacae; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; Pectin with 0.3%, 0.3% alginate are put into cold water, make it to disperse, and soak 20～30min, make the abundant water absorption and swelling of substrate, add 12% sucrose, heating, add citric acid, transfer pH3.0, agitation and filtration then, filter the back and add the hybrid medicine extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to rapidly about 30 ℃, condensation, drying, promptly.
In this product, Herba Menthae dispelling wind and heat pathogens, the clear sharp head, Herba Schizonepetae is delivered diffusing wind, and the Semen Armeniacae Amarum relieving cough and asthma is monarch drug in the side; The Fructus Arctii dispelling wind and heat pathogens, the Radix Scutellariae heat clearing and damp drying, the Radix Platycodonis lung qi dispersing eliminates the phlegm, and Radix Peucedani lowering the adverse-rising QI to resolve phlegm, dispelling wind-heat, the Radix Angelicae Dahuricae loose, and wind dehumidifies, awakening consciousness, the Fructus Gardeniae clearing away heat-damp and promoting diuresis, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus regulating QI to expel dampness are ministerial drug in the side; Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae dispelling wind and heat pathogens are adjuvant drug in the side, and all medicines are harmonious, and are total to the diffusing wind heat of long memorial, the effect of clearing and antitussive.
Compared with prior art, the application makes we fluid or the semifluid gel that liked by the child, children's extremely is ready to take, reduce the adult and advised the trouble of feeding, not only tasty, and function well analgesic, antibiotic, antiinflammatory, be a kind of active drug for the treatment of infantile anemopyretic cold, enriched the dosage form kind, market prospect is very wide.The applicant finds that in the process of development gel we form complicated, bring many difficulties to preparation; Include Herba Menthae and Herba Schizonepetae in the prescription, its volatile oil is effective ingredient, but in the gel molding process, the volatile oil and the heating that directly add Herba Menthae and Herba Schizonepetae can cause volatile oil to scatter and disappear, affect the treatment greatly, for fear of scattering and disappearing in the system gel process at volatile oil, the present invention uses beta-schardinger dextrin-that the mixed volatilization oil of Herba Menthae and Herba Schizonepetae is carried out inclusion; Include Flos Lonicerae and Radix Scutellariae in the prescription, wherein the effective ingredient of Flos Lonicerae is a chlorogenic acid, the effective ingredient of Radix Scutellariae is a baicalin, and chlorogenic acid is just the most stable under 3 the environment at pH value only, under alkaline environment, very easily be hydrolyzed to caffeic acid and related substance, and baicalin also is to be the most stable under 3 the environment at pH value, and pH value is too high or too low all can to cause open loop or hydrolysis.And substrate carrageenan, gelatin, Konjac glucomannan commonly used all need the environment of alkalescence, in order to improve the stability of effective ingredient, through series of selection, the applicant has selected for use acid proof pectin as substrate, but the rupture strength of pectin is low, large usage quantity adds alginate and can improve its rupture strength, reduces consumption, save cost, discover when both ratios be 1: 1, rupture strength is the highest, then increases along with the consumption of alginate and descends; Final pectin, the alginate of adopting pressed 1: 1 part by weight, consumption is 0.6%, the product stable effective ingredients that under tart condition, makes, gel strength ideal, good mouthfeel is selected the supplementary product kind of preparation technology, use of pharmaceutical preparation provided by the invention and consumption, ratio etc.; Guarantee its science, reasonable, feasible; The preparation that obtains has effective therapeutic effect.
Experimental example 1: Study on Forming
(1) to the research of volatile ingredient stability problem
1. include Herba Menthae and Herba Schizonepetae in the gel prescription of the present invention, its volatile oil is effective ingredient.But in the gel molding process, the volatile oil that directly adds Herba Menthae and Herba Schizonepetae can cause volatile oil directly to scatter and disappear, for fear of in the system gel process, scattering and disappearing at volatile oil, the present invention will use beta-schardinger dextrin-, and (ml: g) carrying out inclusion, below was the screening study situation of the present invention to inclusion volatile oil process conditions in 1: 7 to the mixed volatilization oil of Herba Menthae and Herba Schizonepetae.Concrete outcome sees Table 1.
Table 1 beta-schardinger dextrin-inclusion Herba Menthae, Herba Schizonepetae mixed volatilization oil recovery rate and oily utilization rate comparison sheet
Temperature is thrown oil mass beta-schardinger dextrin-amount time inclusion complex dry weight oil content inclusion rate oil recovery rate
(℃) (ml) (g) (h) (g) (ml) (％) (％)
30 1 5 1.0 4.23 0.46 68.2 87.2
30 1 7 1.5 4.39 0.51 53.4 91.6
30 1 10 2.0 4.12 0.41 41.2 68.3
40 1 5 2.0 3.54 0.34 49.5 55.7
40 1 7 1.0 3.37 0.42 37.2 74.3
40 1 10 1.5 3.15 0.26 36.9 53.9
50 1 5 1.5 3.12 0.19 42.6 30.2
50 1 7 2.0 2.84 0.26 36.4 45.9
50 1 10 1.0 2.57 0.21 29.6 34.5
The result shows that reaction temperature is the principal element that influences production technology, and oil is secondary cause with β-CD amount ratio, and mixing time is little to technogenic influence.So optimised process is 30 ℃ of inclusion temperature, oil and β-CD amount ratio be 1: 7 (ml: g), mixing time 1h.By above-mentioned optimised process inclusion sample, recording the oil mass of volatilizing in its inclusion complex is 0.58ml, and its oily utilization rate reaches 97.4%.
2. volatile oil inclusion complex stability study: get the gel that will prepare after the 1ml volatile oil inclusion respectively and directly drip each 50g of gel that 1ml volatile oil is made, measure the amount of its volatile oil, the amount of the former volatile oil is 0.52ml, and the latter is 0.And calculating its oily retention rate, the gel volatile oil retention rate that volatile oil is made through inclusion is 65.4%, is 0 and directly drip the oily gel volatile oil retention rate of making.The result shows that volatile oil is made gel after β-CD inclusion, and its stability improves greatly than the gel that directly dropping volatile oil is made in the system gel process.
(2) selection of matrix species:
As compound preparation, include Flos Lonicerae and Radix Scutellariae in the prescription, wherein the effective ingredient of Flos Lonicerae is a chlorogenic acid, the effective ingredient of Radix Scutellariae is a baicalin.And chlorogenic acid is just the most stable under 3 the environment at pH value only, very easily is hydrolyzed to caffeic acid and related substance under alkaline environment.And baicalin also is to be the most stable under 3 the environment at pH value, and pH value is too high or too low all can to cause open loop or hydrolysis.In order to improve the stability of effective ingredient, we screen the use of gel.Concrete research situation sees Table 2.
The screening situation of table 2 gel
Gel coagulant liquid pH value gel character
Carrageenan 3.0 is put does not have the molding gel after cold, is the solution shape
Konjac glucomannan 3.0 gel strengths are low, and elasticity, toughness and retentiveness are poor
Gelatin 3.0 is put does not have the molding gel after cold, is the solution shape
Pectin 3.0 gel stabilities are good, the elasticity height, and retentiveness is strong, and rupture strength is low
The result shows that pectin can form elastomeric gel under the environment of low pH value, and shows retentiveness preferably, but rupture strength is little, large usage quantity.Discover, in pectin, add the rupture strength that alginate can improve pectin.In order further to improve the performance of gel, we study the use amount of pectin and the operating position of some other additives.Concrete condition sees Table 3.
The research of the operating position of table 3 pectin use amount and additive
Rupture strength (the g/cm of pectin use amount (%) alginate use amount (%) gel
2)
0.3 - 1.01
1.0 - 6.89
0.3 0.1 1.97
0.3 0.2 5.52
0.3 0.3 7.44
0.3 0.6 6.68
0.3 0.9 5.58
The result shows, under the identical situation of pectin use amount, when the use amount of pectin and alginate is 1: 1, the rupture strength of gel is the highest, then increase and descend along with the consumption of alginate, so the gel of gel of the present invention is selected pectin, and compound interpolation alginate in proportion, and the pectin use amount is decided to be 0.3%.
Experimental example 2: pharmacodynamic experiment
(1) to the research of heating rat refrigeration function
Get Wistar rat 130～170g, the male and female dual-purpose selects the rat of body temperature basically identical to divide 2 groups at random by body weight, XIAOER GANMAO TANGJIANG group and gel group of the present invention.Survey the anus temperature 3 times behind the rat labelling, averaging is normal body temperature, and＞0.3 ℃ of person of 3 body temperature fluctuations rejects need not.Each organizes rat back subcutaneous injection 20% yeast suspension 12ml/kg, rejects Δ T＜0.8 ℃ of person after 5 hours.The XIAOER GANMAO TANGJIANG group gavages XIAOER GANMAO TANGJIANG 5g/kg, and gel group of the present invention is fed equivalent gel of the present invention.2h surveys body temperature after the administration.Concrete data see Table 4.
The refrigeration function of table 4 pair heating rat
2h body temperature behind the 5h body temperature medicine after the group normal body temperature pyrogenicity
XIAOER GANMAO TANGJIANG group 37.38 ± 0.51 38.62 ± 0.53 37.85 ± 0.46
Gel 37.41 of the present invention ± 0.45 38.67 ± 0.42 37.67 ± 0.49
By the result of table 4, we can draw, and gel of the present invention causes rat fever to yeast refrigeration function, and separate thermal effect and be not less than XIAOER GANMAO TANGJIANG.
(2) to the influence of capillary permeability
1. the xylol induced mice capillary of skin permeability influence of increasing
Get 30 of mices, male and female half and half, body weight 18～22g is divided into 3 groups at random, and according to the content administration of table 5.Inject 0 5% azovan blue normal saline solution 0.1ml/10g body weight in the tail vein behind the 2h, melted paraxylene 0.03ml/ is only on the skin of unhairing of position, mouse web portion center immediately, mice takes off cervical vertebra execution behind the 25min, peel skin of abdomen, every skin locus coeruleus shreds to drop into operating scissors to be had in the plug teat glass, pour acetone-sodium sulfate extracting solution 10ml into, putting the dark place places, shake test tube every day gently 2～3 times, the centrifugal 15min of 2000rpm after 3 days, get supernatant in 590nm place colorimetric determination optical density, with the acetone-sodium sulfate liquid school zero of not steeping skin.Concrete data see Table 5.
The influence that table 5 xylol induced mice capillary of skin permeability increases
Group animal (only) dosage (g/kg) locus coeruleus optical density value
Model control group 10-0.53 ± 0.08
XIAOER GANMAO TANGJIANG group 10 5 0.43 ± 0.12
Gel 10 5 0.37 ± 0.10 of the present invention
The result of table 5 shows that gel xylol induced mice capillary of skin permeability of the present invention increases remarkable inhibitory action is arranged, and effect is not less than XIAOER GANMAO TANGJIANG.
2. the influence that lumbar injection acetic acid induced mice abdominal cavity capillary permeability is increased
Animal grouping and administration are with experiment 1..Lumbar injection 0.5% acetum 0.30ml/, mice takes off cervical vertebra execution behind the 25min, injects the abdominal cavity washing with 8ml saline, and inclining cleaning mixture, the centrifugal 18min of 3000rpm; Get supernatant and measure optical density in the 590nm place, concrete data see Table 6.
The table 6 pair influence that lumbar injection acetic acid induced mice abdominal cavity capillary permeability increases
Group animal (only) dosage (g/kg) peritoneal exudate optical density value
Model control group 10-0.22 ± 0.07
XIAOER GANMAO TANGJIANG group 10 5 0.18 ± 0.04
Gel group 10 5 0.14 ± 0.09 of the present invention
The result of table 6 shows that gel of the present invention increases lumbar injection acetic acid induced mice abdominal cavity capillary permeability remarkable inhibitory action is arranged, and effect is not less than XIAOER GANMAO TANGJIANG.
Concrete embodiment:
Embodiments of the invention 1: Herba Menthae 80g, Herba Schizonepetae 67g, Semen Armeniacae Amarum 80g, Fructus Arctii 80g, Radix Scutellariae 80g, Radix Platycodonis 67g, Radix Peucedani 80g, Radix Angelicae Dahuricae 27g, Fructus Gardeniae (parched) 40g, Fructus Crataegi (parched to brown) 27g, burnt Massa Medicata Fermentata 27g, Fructus Hordei Germinatus (parched to brown) 27g, Rhizoma Phragmitis 120g, Flos Lonicerae 120g and Fructus Forsythiae 80g
Herba Menthae, extracting volatile oil from schizonepeta spike in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, grind 0.5 hour in the time of 60 ℃, get clathrate; The Semen Armeniacae Amarum system of getting aqua armeniacae; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; Pectin with 0.3%, 0.3% alginate are put into cold water, make it to disperse, and soak 20～30min, make the abundant water absorption and swelling of substrate, add 12% sucrose, heating adds citric acid, transfers pH3.0, agitation and filtration is filtered the back and add hybrid medicine extract, mix homogeneously under condition of stirring then, join rapidly in the disinfecting container, seal, sterilization, be cooled to about 30 ℃ condensation, drying rapidly, promptly get gel, this product oral, three times on the one, each 2 bags, every bag of 25g.
Embodiments of the invention 2: Herba Menthae 50g, Herba Schizonepetae 50g, Semen Armeniacae Amarum 60g, Fructus Arctii 60g, Radix Scutellariae 60g, Radix Platycodonis 50g, Radix Peucedani 60g, Radix Angelicae Dahuricae 20g, Fructus Gardeniae (stir-fry) 30g, Fructus Crataegi (Jiao) 20g, Massa Medicata Fermentata (Jiao) 20g, Fructus Hordei Germinatus (Jiao) 20g, Rhizoma Phragmitis 100g, Flos Lonicerae 100g, Fructus Forsythiae 60g
Herba Menthae, extracting volatile oil from schizonepeta spike in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, grind 0.5 hour in the time of 60 ℃, get clathrate; Getting Semen Armeniacae Amarum presses and to add the water distillation behind the degrease oil and produce bitter almond water; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; 0.7% guar gum is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, add 12% sucrose, heating, add citric acid, transfer pH3.0, agitation and filtration then, filter the back and add the hybrid medicine extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Embodiments of the invention 3: Herba Menthae 100g, Herba Schizonepetae 80g, Semen Armeniacae Amarum 100g, Fructus Arctii 100g, Radix Scutellariae 100g, Radix Platycodonis 80g, Radix Peucedani 100g, Radix Angelicae Dahuricae 40g, Fructus Gardeniae (stir-fry) 50g, Fructus Crataegi (Jiao) 40g, Massa Medicata Fermentata (Jiao) 40g, Fructus Hordei Germinatus (Jiao) 40g, Rhizoma Phragmitis 150g, Flos Lonicerae 150g, Fructus Forsythiae 100g
Herba Menthae, extracting volatile oil from schizonepeta spike in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, grind 0.5 hour in the time of 60 ℃, get clathrate; Getting Semen Armeniacae Amarum presses and to add the water distillation behind the degrease oil and produce bitter almond water; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; The preparation of glue: with gelatin: glycerol: water=1: 0.3: 0.9, get gelatin and add an amount of distilled water and make its imbibition, glycerol and remaining water are put be heated to 70～80 ℃ in the glue pot in addition, mix homogeneously adds expansible gelatin and stirs, and makes it to dissolve into uniform glue, in 70 ℃ of insulations 1～2 hour, leave standstill, remove the come-up foam, filter with cloth bag, in encapsulating machine, be pressed into soft capsule, be pressed into soft capsule, put in the drum drying machine and finalize the design, whole ball, drying promptly gets soft capsule.
Embodiments of the invention 4: Herba Menthae 80g, Herba Schizonepetae 67g, Semen Armeniacae Amarum 80g, Fructus Arctii 80g, Radix Scutellariae 80g, Radix Platycodonis 67g, Radix Peucedani 80g, Radix Angelicae Dahuricae 27g, Fructus Gardeniae (stir-fry) 40g, Fructus Crataegi (Jiao) 27g, Massa Medicata Fermentata (Jiao) 27g, Fructus Hordei Germinatus (Jiao) 27g, Rhizoma Phragmitis 120g, Flos Lonicerae 120g, Fructus Forsythiae 80g
Herba Menthae, extracting volatile oil from schizonepeta spike in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, grind 0.5 hour in the time of 60 ℃, get clathrate; Method according to the pharmacopeia regulation is got Semen Armeniacae Amarum system aqua armeniacae; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing, the hybrid medicine extract, splash into the ratio that adopts PEG6000 and PEG4000 and be in 3: 2 the mixed-matrix, the water dropper model adopts No. 1 water dropper, coolant temperature is 20～22 ℃, promptly gets drop pill.
Embodiments of the invention 5: Herba Menthae 80g, Herba Schizonepetae 67g, Semen Armeniacae Amarum 80g, Fructus Arctii 80g, Radix Scutellariae 80g, Radix Platycodonis 67g, Radix Peucedani 80g, Radix Angelicae Dahuricae 27g, Fructus Gardeniae (stir-fry) 40g, Fructus Crataegi (Jiao) 27g, Massa Medicata Fermentata (Jiao) 27g, Fructus Hordei Germinatus (Jiao) 27g, Rhizoma Phragmitis 120g, Flos Lonicerae 120g, Fructus Forsythiae 80g
Herba Menthae, extracting volatile oil from schizonepeta spike in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, grind 0.5 hour in the time of 60 ℃, get clathrate; Getting Semen Armeniacae Amarum presses and to add the water distillation behind the degrease oil and produce bitter almond water; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; 1.1% gelatin is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, add 12% sucrose, heating, add citric acid, transfer pH3.0, agitation and filtration then, filter the back and add the hybrid medicine extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Embodiments of the invention 6: Herba Menthae 80g, Herba Schizonepetae 67g, Semen Armeniacae Amarum 80g, Fructus Arctii 80g, Radix Scutellariae 80g, Radix Platycodonis 67g, Radix Peucedani 80g, Radix Angelicae Dahuricae 27g, Fructus Gardeniae (stir-fry) 40g, Fructus Crataegi (Jiao) 27g, Massa Medicata Fermentata (Jiao) 27g, Fructus Hordei Germinatus (Jiao) 27g, Rhizoma Phragmitis 120g, Flos Lonicerae 120g, Fructus Forsythiae 80g
Herba Menthae, extracting volatile oil from schizonepeta spike in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, grind 0.5 hour in the time of 60 ℃, get clathrate; Method according to the pharmacopeia regulation is got Semen Armeniacae Amarum system aqua armeniacae; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; 0.7% carrageenan is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, add 12% sucrose, heating, add citric acid, transfer pH3.0, agitation and filtration then, filter the back and add the hybrid medicine extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Embodiments of the invention 7: Herba Menthae 80g, Herba Schizonepetae 67g, Semen Armeniacae Amarum 80g, Fructus Arctii 80g, Radix Scutellariae 80g, Radix Platycodonis 67g, Radix Peucedani 80g, Radix Angelicae Dahuricae 27g, Fructus Gardeniae (stir-fry) 40g, Fructus Crataegi (Jiao) 27g, Massa Medicata Fermentata (Jiao) 27g, Fructus Hordei Germinatus (Jiao) 27g, Rhizoma Phragmitis 120g, Flos Lonicerae 120g, Fructus Forsythiae 80g
Herba Menthae, extracting volatile oil from schizonepeta spike in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, grind 0.5 hour in the time of 60 ℃, get clathrate; Getting Semen Armeniacae Amarum presses and to add the water distillation behind the degrease oil and produce bitter almond water or prepare bitter almond water according to the existing technology of routine; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; 0.9% hydroxypropyl cellulose is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, add 12% sucrose, heating, add citric acid, transfer pH3.0, agitation and filtration then, filter the back and add the hybrid medicine extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Claims (5)
1, a kind of ' Ganmaoning ' gel preparation for enfant, it is characterized in that: calculate according to weight, it is by Herba Menthae 50～100g, Herba Schizonepetae 50～80g, Semen Armeniacae Amarum 60～100g, Fructus Arctii 60～100g, Radix Scutellariae 60～100g, Radix Platycodonis 50～80g, Radix Peucedani 60～100g, the Radix Angelicae Dahuricae 20～40g, Fructus Gardeniae (parched) 30～50g, Fructus Crataegi (parched to brown) 20～40g, burnt Massa Medicata Fermentata 20～40g, Fructus Hordei Germinatus (parched to brown) 20～40g, Rhizoma Phragmitis 100～150g, Flos Lonicerae 100～150g and Fructus Forsythiae 60～100g and an amount of substrate are made into fluid or viscid gel oral formulations, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.
2, according to the described ' Ganmaoning ' gel preparation for enfant of claim 1, it is characterized in that: it can also be prepared into: soft capsule, dispersible tablet, drop pill, pellet, slow releasing preparation, granule or capsule.
3, according to claim 1 or 2 described ' Ganmaoning ' gel preparation for enfant, it is characterized in that: calculate according to weight, it is by Herba Menthae 80g, Herba Schizonepetae 67g, Semen Armeniacae Amarum 80g, Fructus Arctii 80g, Radix Scutellariae 80g, Radix Platycodonis 67g, Radix Peucedani 80g, Radix Angelicae Dahuricae 27g, Fructus Gardeniae (parched) 40g, Fructus Crataegi (parched to brown) 27g, burnt Massa Medicata Fermentata 27g, Fructus Hordei Germinatus (parched to brown) 27g, Rhizoma Phragmitis 120g, Flos Lonicerae 120g and Fructus Forsythiae 80g and the gel preparation that is prepared into as the pectin and the alginate of substrate, and product is semifluid or solid gel shape.
4, as the preparation method of ' Ganmaoning ' gel preparation for enfant as described in the claim 1～3 any, it is characterized in that: Herba Menthae, extracting volatile oil from schizonepeta spike, in the ratio of volatile oil: β-CD=1ml: 7g, adopt colloid milling, in the time of 60 ℃, ground 0.5 hour, get clathrate; The Semen Armeniacae Amarum system of getting aqua armeniacae; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, get supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, be condensed into clear paste, clear paste added to mix homogeneously in the substrate for preparing, after the sterilization promptly.
5, according to the preparation method of the described ' Ganmaoning ' gel preparation for enfant of claim 4, it is characterized in that:,, adopt colloid milling in the ratio of volatile oil: β-CD=1ml: 7g with Herba Menthae, extracting volatile oil from schizonepeta spike, in the time of 60 ℃, ground 0.5 hour, get clathrate; The Semen Armeniacae Amarum system of getting aqua armeniacae; Get Fructus Arctii, Radix Scutellariae, Radix Platycodonis, Radix Peucedani, the Radix Angelicae Dahuricae, Fructus Gardeniae, Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus, Rhizoma Phragmitis, Flos Lonicerae, Fructus Forsythiae and decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate left standstill 48 hours, got supernatant concentration, add the aqua armeniacae mixing, leave standstill, get supernatant, add volatile oil clathrate compound, mixing gets the hybrid medicine extract; Pectin with 0.3%, 0.3% alginate are put into cold water, make it to disperse, and soak 20～30min, make the abundant water absorption and swelling of substrate, add 12% sucrose, heating, add citric acid, transfer pH3.0, agitation and filtration then, filter the back and add the hybrid medicine extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to rapidly about 30 ℃, condensation, drying, promptly.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814194B (en) * | 2005-12-05 | 2011-02-16 | 杨雄志 | Chinese-western medicine composition for treating infant's common cold and preparation method thereof |
| CN1985921B (en) * | 2005-12-20 | 2011-04-06 | 广州王老吉药业股份有限公司 | Chinese medicine composition for treating common cold and its preparing method |
| CN102258719A (en) * | 2011-07-07 | 2011-11-30 | 江西普正制药有限公司 | Preparation method of traditional Chinese medicinal oral liquid preparation for treating children's cold |
| CN104833751A (en) * | 2015-04-28 | 2015-08-12 | 吉林益民堂制药有限公司 | Children's Ganmaoning syrup water extract HPLC standard fingerprint establishing method and applications |
| CN106237180A (en) * | 2016-08-31 | 2016-12-21 | 江西普正制药有限公司 | A kind of preparation technology of the pharmaceutical preparation for improving infantile common cold curative effect |
| CN110025568A (en) * | 2019-03-06 | 2019-07-19 | 广州中天康顺生物医药有限公司 | A kind of thixotroping pharmaceutical hydrogel matrix and its shaddock ped glycosides formulation and preparation method |
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2004
- 2004-12-25 CN CN 200410081639 patent/CN1660275A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814194B (en) * | 2005-12-05 | 2011-02-16 | 杨雄志 | Chinese-western medicine composition for treating infant's common cold and preparation method thereof |
| CN1985921B (en) * | 2005-12-20 | 2011-04-06 | 广州王老吉药业股份有限公司 | Chinese medicine composition for treating common cold and its preparing method |
| CN102258719A (en) * | 2011-07-07 | 2011-11-30 | 江西普正制药有限公司 | Preparation method of traditional Chinese medicinal oral liquid preparation for treating children's cold |
| CN102258719B (en) * | 2011-07-07 | 2013-06-12 | 江西普正制药有限公司 | Preparation method of traditional Chinese medicinal oral liquid preparation for treating children's cold |
| CN104833751A (en) * | 2015-04-28 | 2015-08-12 | 吉林益民堂制药有限公司 | Children's Ganmaoning syrup water extract HPLC standard fingerprint establishing method and applications |
| CN106237180A (en) * | 2016-08-31 | 2016-12-21 | 江西普正制药有限公司 | A kind of preparation technology of the pharmaceutical preparation for improving infantile common cold curative effect |
| CN110025568A (en) * | 2019-03-06 | 2019-07-19 | 广州中天康顺生物医药有限公司 | A kind of thixotroping pharmaceutical hydrogel matrix and its shaddock ped glycosides formulation and preparation method |
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