CN1985921B - Chinese medicine composition for treating common cold and its preparing method - Google Patents

Abstract

The invention provides a traditional Chinese medicine for dispelling wind, clearing heat, detoxifying and relieving sore throat and a preparation method thereof. The traditional Chinese medicine is made from honeysuckle, scutellaria baicalensis, nepeta, gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, bellflower, mint, cicada slough, windproof, and licorice. The medicament of the present invention extracts the active components in the medicinal material and makes them into different dosage forms such as oral liquid, tablet, capsule, granule, dripping pill, soft capsule, etc., so as to meet the needs of different patients.

Description

A kind of traditional Chinese medicine composition for treating common cold and preparation method thereof

technical field

The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating colds and a preparation method thereof.

Background technique

Cold is a common disease and frequently-occurring disease, especially in spring and winter, when the incidence rate is high. Its symptoms are nasal congestion, runny nose, headache, cough, fever, etc., which make people feel very uncomfortable and will affect normal life in severe cases. Colds are mostly upper respiratory tract infections caused by viruses, and the pathogens are rhinoviruses, coronaviruses, parainfluenza viruses, adenoviruses, etc. Most colds in adults are caused by rhinoviruses and coronaviruses. Rhinovirus has a strong transmission ability and a high infection rate. It is mostly popular in autumn and spring and is the main virus that causes colds. Coronaviruses are more common in winter. So far there is no specific treatment drug. Drugs such as morpholine, adenosine vidarabine, and polyinosin may have a certain inhibitory effect on the reproduction of some viruses, but they are not effective on all viruses that cause the common cold.

Currently commercially available anti-cold medicines are various in variety, most of which are compound preparations. The compound preparation mainly utilizes the synergistic effect between various medicines to give full play to the advantages of each medicine to achieve the purpose of symptomatic treatment. Although chemical drugs have good curative effects in relieving symptoms such as headache, fever, cough, nasal congestion, runny nose, and sneezing caused by colds, they mainly relieve symptoms, and most of the cold medicines made of compounds have a good effect. Side effects such as drowsiness cannot be ignored. At present, there are many traditional Chinese medicines for treating colds, and the dosage forms are also various. There are not only slow-acting pills, but also quick-acting drop pills, injections, and powder injections; there are not only granules that can replace tea, but also tablets that are easy to take. There are both effervescent agents that can satisfy the curiosity of patients and suppositories that are suitable for children. However, in terms of the current clinical efficacy, whether it is a single preparation or a compound preparation, the low efficacy of drugs is still one of the main factors affecting the use of patients. . In the selection of traditional Chinese medicine with high natural degree and low side effects; compound drugs with high curative effect and side effects, patients often give up traditional Chinese medicine with low toxic and side effects and choose compound drugs with relatively large side effects to treat colds in order to relieve symptoms quickly.

Contents of the invention

The purpose of the present invention is to provide a Chinese medicinal composition for treating common cold.

Another object of the present invention is to provide a preparation method of a traditional Chinese medicine composition for treating colds.

The pharmaceutical composition of the present invention is made from honeysuckle, scutellaria baicalensis, nepeta, gardenia, forsythia, crocus crocus, silkworm, rehmannia glutinosa, shegan, bellflower, mint, cicada slough, windproof and licorice.

In the pharmaceutical composition of the present invention, fried Gardenia is Gardenia (stir-fried); Bombyx mori is Bombyx mori (made from ginger).

The dosage and proportioning of each component of the medicine of the present invention are obtained through a large number of explorations and experiments by the inventor. The raw materials of each component have good curative effects in the following proportioning ranges by weight: 36 to 145 parts of honeysuckle, 36 to 145 parts of Scutellaria baicalensis, 36-145 parts, Nepeta 36-145 parts, Gardenia 36-145 parts, Forsythia 36-145 parts, Scrophulariaceae 36-145 parts, Bombyx mori 22-85 parts, Rehmannia glutinosa 55-215 parts, Shegan 11-45 parts 22-85 parts of bellflower, 22-85 parts of mint, 22-85 parts of cicadas, 22-85 parts of windproof, 11-45 parts of licorice.

The raw materials of each component of the preferred pharmaceutical composition of the present invention have good curative effects in the following proportioning ranges by weight: 53.54-86.70 parts of honeysuckle, 53.54-86.70 parts of Scutellaria baicalensis, 53.54-86.70 parts of Schizonepeta, 53.54-86.70 parts of Gardenia 53.54-86.70 parts of Forsythia, 53.54-86.70 parts of Scrophulariaceae, 33.57-51.55 parts of Silkworm, 86.27-129.81 parts of Rehmannia, 17.54-26.70 parts of Shegan, 33.57-51.55 parts of Campanulaceae, 33.57-51.55 parts of Mint, 33.57-55 parts of Fangfeng 51.55 parts, cicada slough 33.57-51.55 parts, licorice 17.54-26.70 parts.

More preferably, the raw materials of each component of the pharmaceutical composition of the present invention have good curative effects in the following proportioning ranges by weight: 69-75 parts of honeysuckle, 69-75 parts of Scutellaria baicalensis, 69-75 parts of Schizonepeta, 69-75 parts of Gardenia 75 parts, 69-75 parts of Forsythia, 69-75 parts of Scrophulariaceae, 40-47 parts of silkworm, 100-115 parts of Rehmannia glutinosa, 20-25 parts of Shegan, 40-47 parts of Campanulaceae, 40-47 parts of mint, 40 parts of cicada slough ～47 parts, 40～47 parts of Fangfeng, 20～24 parts of licorice.

The best pharmaceutical compositions of the present invention have good curative effects in the following proportioning ranges of each component raw material: 72 parts of honeysuckle, 72 parts of Scutellaria baicalensis, 72 parts of Schizonepeta, 72 parts of gardenia, 72 parts of forsythia, 72 parts of Scrophulariae, 43 parts of Silkworm, 108 parts of Dihuang, 22 parts of Shegan, 43 parts of Campanulaceae, 43 parts of Mint, 43 parts of cicada slough, 43 parts of Fangfeng, 22 parts of Licorice.

The preparation and preparation of the active components of the composition of the present invention can adopt the following methods: extraction method, water extraction method, water extraction alcohol precipitation method, extraction method, dipping method, percolation method, reflux extraction method, continuous reflux extraction method, large It can be prepared by one or several combined application of porous resin adsorption method. For example, these crude drugs can be ground into powder; these medicines can also be decocted together, and then the decoction is concentrated to make a decoction; The raw material is extracted by the following process, but this cannot limit the protection scope of the present invention.

The proportion by weight of the crude drug used for the extraction of the following pharmaceutical active components can be any proportion, preferably the proportion by weight of the crude drug is within the dosage range provided by the present invention.

The preparation method of the pharmaceutically active active component of the present invention is as follows:

a. Take 36-145 parts of honeysuckle, 36-145 parts of skullcap, 36-145 parts of nepeta, 36-145 parts of gardenia, 36-145 parts of forsythia, 36-145 parts of Scrophulariaceae, 22-85 parts of silkworm, 55-215 parts of Rehmannia, 11-45 parts of Shegan, 22-85 parts of Campanulaceae, 22-85 parts of Mint, 22-85 parts of Cicada, 22-85 parts of Fangfeng, 11-45 parts of Licorice for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 1 to 12 times the amount of ethanol to reflux for 1 to 3 times, each time for 1 to 3 hours, the concentration of ethanol is 30% to 95%, reclaim ethanol, and concentrate until it is at 45 to 85°C The relative density is 1.00～1.35, and dried to obtain the medicinal powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, Nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 1 to 8 times the amount of water, soak for 0.5 to 5 hours, use steam distillation for 1 to 8 hours, and collect The volatile oil is stored in another device, and the dregs continue to be extracted; ②Extraction: the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc., after extracting the volatile oil, add water and decoct 1 to 3 times, each decocting for 0.5 to 3 hours, combine the decoction, filter After filtration, the filtrate is concentrated to a relative density of 1.00-1.35 at 50-85°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 10-85%, let it stand for 4-48 hours, and filter; ④recover ethanol, Concentrate to a relative density of 1.00-1.45 at 50-90°C, dry to obtain medicinal powder II; combine medicinal powder I and medicinal powder II, and pulverize into fine powder.

Preferably, the preparation method of the pharmaceutical active ingredient of the present invention is as follows:

a. Take 53.54-86.70 parts of honeysuckle, 53.54-86.70 parts of Scutellaria baicalensis, 53.54-86.70 parts of nepeta, 53.54-86.70 parts of gardenia, 53.54-86.70 parts of forsythia, 53.54-86.70 parts of Scrophulariaceae, 33.57-51.55 parts of silkworm, 86.27-129.81 parts of Rehmannia, 17.54-26.70 parts of Shegan, 33.57-51.55 parts of Campanulaceae, 33.57-51.55 parts of Mint, 33.57-51.55 parts of Fangfeng, 33.57-51.55 parts of Cicada, 17.54-26.70 parts of Licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 to 10 times the amount of ethanol to reflux twice, each time for 1 to 2 hours, the concentration of ethanol is 40 to 90%, reclaim ethanol, and concentrate to a relative density of 1.02 at 45 to 80°C ~1.30, dry to obtain powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, windproof and other four medicinal materials, combine them together, add 1 to 7 times the amount of water, soak for 1 to 4 hours, and use steam distillation for 1 to 7 hours. Collect the volatile oil and store it in another device, and continue to extract the dregs of the medicine; ②Extraction: Add water to the dregs after extracting the volatile oil from the rest of the medicinal materials, the dregs of Scutellaria baicalensis and honeysuckle, etc., add water and decoct twice, each decoction for 1 to 2 hours, combine the decoction, and filter , the filtrate was concentrated to a relative density of 1.04-1.30 at 60-75°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 20-80%, let stand for 8-36 hours, and filter; ④Recover ethanol, concentrate When the relative density is 1.00-1.30 at 60-80°C, dry it to obtain medicinal powder II: combine medicinal powder I and medicinal powder II, and grind them into fine powder.

Further preferably, the preparation method of the pharmaceutically active component of the present invention is as follows:

a. Take 69-75 parts of honeysuckle, 69-75 parts of skullcap, 69-75 parts of Nepeta, 69-75 parts of gardenia, 69-75 parts of forsythia, 69-75 parts of Scrophulariaceae, 40-47 parts of silkworm, 100-115 parts of Rehmannia glutinosa, 20-25 parts of Shegan, 40-47 parts of bellflower, 40-47 parts of mint, 40-47 parts of cicada slough, 40-47 parts of Fangfeng, 20-24 parts of licorice for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 3 to 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60 to 70%, reclaim ethanol, and concentrate to a relative density of 1.05 to 1.25 at 50 to 70°C , dry to obtain powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, windproof and other four medicinal materials, combine them together, add 3 to 5 times the amount of water, soak for 1 to 2 hours, use steam distillation for 2 to 4 hours, Collect the volatile oil and store it in another device, and continue to extract the dregs of the medicine; ②Extraction: Add water to the dregs after extracting the volatile oil from the rest of the medicinal materials, the dregs of Scutellaria baicalensis and honeysuckle, etc., add water and decoct twice, each decoction for 1 to 2 hours, combine the decoction, and filter , the filtrate was concentrated to a relative density of 1.04-1.20 at 65-70°C, and allowed to cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 20-80%, let stand for 8-36 hours, and filter; ④ recover ethanol, concentrate When the relative density is 1.05-1.25 at 65-75°C, dry it to obtain medicinal powder II; combine medicinal powder I and medicinal powder II, and grind them into fine powder.

Optimally, the preparation method of the pharmaceutical active ingredient of the present invention is as follows:

a. Take 72 parts of honeysuckle, 72 parts of skullcap, 72 parts of nepeta, 72 parts of gardenia, 72 parts of forsythia, 72 parts of scrophulariaceae, 43 parts of silkworm, 108 parts of rehmannia, 22 parts of shegan, 43 parts of platycodon, 43 parts of mint 43 parts of cicada slough, 43 parts of Fangfeng, 22 parts of licorice for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicinal powder II is obtained; the medicinal powder I and the medicinal powder II are combined and crushed into fine powder.

The active component of the present invention can be made into any pharmaceutical preparation; the active component of the medicine of the present invention can be added with various conventional adjuvants required for preparing different dosage forms, such as disintegrants, lubricants, binders, etc. Conventional traditional Chinese medicine preparation methods are prepared into any commonly used dosage forms, such as tablets, sugar-coated tablets, film-coated tablets, enteric-coated tablets, powders, capsules, soft capsules, pills, granules, oral liquids, granules, Pills, micropills, intramuscular injections, drips, ointments, ointments, plasters, etc.; best made into tablets, pills, oral liquids, granules, capsules, and soft capsules.

The preparation method of the pharmaceutical tablet of the present invention, wherein the medicinal powder I and the medicinal powder II prepared in the step b are mixed with fine powder and volatile oil, mixed with common auxiliary materials for tablets, and compressed into tablets.

Preferably, the preparation method of the tablet of the present invention, wherein the mixed fine powder of the medicinal powder I and the medicinal powder II prepared in step b, adds one or more of auxiliary materials such as starch, dextrin, lactose, PVP, sodium carboxymethyl starch Combine, mix evenly, add alcohol with a concentration of 8-75% to granulate, and the dosage is 4-60% of the dosage of the medicinal powder and auxiliary materials; dry the granules and spray into volatile oil; add magnesium stearate, silica gel, polyethylene glycol One or several combinations, mixed evenly, compressed into tablets, coated or uncoated, to obtain tablets.

Further preferably, the preparation method of the tablet of the present invention, wherein the powder I and powder II prepared in step b are mixed fine powder, and one or more of auxiliary materials such as starch, dextrin, lactose, PVP, sodium starch glycolate are added Mix evenly, add 10-70% ethanol to granulate, the dosage is 5-50% of the dosage of medicine powder and excipients; dry the granules, spray into volatile oil; add magnesium stearate, silica gel, polyethylene glycol One or several combinations of them, mixed evenly, compressed into tablets, coated or uncoated, to obtain tablets.

Most preferably, the preparation method of the tablet of the present invention, wherein the medicinal powder I and medicinal powder II prepared in step b are mixed with fine powder, and starch is added, the amount of starch is 0.4 to 2 times the weight of medicinal powder I and medicinal powder II, mixed evenly, and the concentration is increased. Granulate with 10-70% ethanol, and the dosage is 5-50% of the dosage of medicine powder and starch; dry the granules, spray into volatile oil; add magnesium stearate, mix evenly, compress into tablets, and coat to obtain tablets.

The preparation method of the dropping pill of the present invention, wherein the medicinal powder I and the medicinal powder II prepared in the step b are mixed with fine powder, volatile oil and common auxiliary materials of the dropping pill, and the dripping pill is formed.

Preferably, the preparation method of the dropping pills of the present invention, wherein the powder I and powder II prepared in step b are mixed with fine powder and volatile oil, mixed evenly, and added to polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol 1500 One or any combination of these ingredients is heated and melted, and the dripping speed is 15-90 drops/min, which is dropped into the condensate to obtain the dropping pill.

Further preferably, the preparation method of the dropping pills of the present invention, wherein the medicinal powder I and the medicinal powder II prepared in step b are mixed with fine powder and volatile oil, mixed uniformly, and one of polyethylene glycol 6000 and polyethylene glycol 4000 or any combination is added, Heating and melting, using a dropping speed of 20-80 drops/min, dropping into the condensed liquid to obtain dropping pills.

More preferably, the preparation method of the dropping pills of the present invention, wherein the medicinal powder I and the medicinal powder II prepared in step b are mixed with fine powder and volatile oil, mixed evenly, and polyethylene glycol 6000: polyethylene glycol 1 to 30 times the amount of the medicinal powder is added. Alcohol 4000=1～5: 1～4 mixture, heating and melting, using a dropping speed of 25～75 drops/min, drop into liquid paraffin, or methyl silicone oil or methyl silicone oil: liquid paraffin=1～4:1～ 3 in the condensate, that is, drop pills.

Most preferably, the preparation method of dropping pill of the present invention, wherein the medicated powder I and medicated powder II that step b makes mix fine powder, volatile oil, mix uniformly, add the polyethylene glycol 6000 of medicated powder 20 times amount: Polyethylene glycol 4000= The mixture of 3:2 is heated and melted at a rate of 40 drops/min, and dropped into liquid paraffin, or the condensate of methyl silicone oil: liquid paraffin in a ratio of 3:1, to obtain dropping pills.

The preparation method of the capsule of the present invention, wherein the active component medicinal powder I and medicinal powder II prepared in step b are mixed with fine powder, sprayed into volatile oil, mixed uniformly, packed into medicinal capsules, and capsules are obtained.

Preferably, in the preparation method of the capsule of the present invention, the mixed fine powder of medicated powder I and medicated powder II prepared in step b adds auxiliary materials, wherein the auxiliary materials are selected from one of auxiliary materials such as starch, dextrin, lactose, PVP, and sodium carboxymethyl starch. Combination of one or several kinds, mixed evenly, adding ethanol with a concentration of 8-75% to granulate, the dosage is 4%-60% of the dosage of powder and auxiliary materials; drying the granules, spraying volatile oil; adding auxiliary materials, the auxiliary materials are selected from stearin One or several combinations of magnesium oxide, silica gel, polyethylene glycol, mixed evenly, and packed into medicinal capsules to obtain capsules.

Further preferably, the preparation method of the capsule of the present invention, wherein the mixed fine powder of the medicinal powder I and the medicinal powder II prepared in step b adds auxiliary materials, the auxiliary materials are selected from one or more combinations of starch, dextrin, and lactose, and the amount of the auxiliary materials used is The weight is 0.5-6 times of the sum of the weight of the medicine powder I and the medicine powder II, mix evenly, add 10-70% ethanol to make granules, and the dosage is 5%-50% of the medicine powder and auxiliary materials; dry the granules, spray into volatile oil Add lubricant, lubricant is selected from one or more combination in magnesium stearate, silica gel, polyethylene glycol, the weight of used lubricant is 0.1～8% of the sum of the weight of medicated powder I and medicated powder II, mix evenly, and put into medicinal capsules to obtain capsules.

Add starch to the mixed fine powder of medicated powder I and medicated powder II prepared in step b, the weight of starch is 0.5-2 times of the sum of the weight of medicated powder I and medicated powder II, mix evenly, add 20-30% ethanol to granulate, dosage It is 10%-30% of the amount of powder and auxiliary materials; dry the granules, spray into volatile oil; add magnesium stearate, the weight of magnesium stearate is 0.1-2% of the sum of the weight of powder I and powder II, mix evenly, Pack into medicinal capsules to obtain capsules.

The preparation method of the granules of the present invention, wherein the powder I and the powder II prepared in step b are mixed with fine powder and commonly used auxiliary materials for granules to be granulated, the granules are dried, and volatile oil is sprayed to obtain the granules.

Preferably, in the method for preparing granules of the present invention, one or more combinations of auxiliary materials such as sucrose powder, soluble starch, dextrin, and ring auxiliary materials are added to the mixed fine powder of medicinal powder I and medicinal powder II prepared in step b, Granulating with water, the dosage is 8-50% of the dosage of the medicinal powder and auxiliary materials, drying the granules, and spraying volatile oil to obtain granules.

Further preferably, in the preparation method of granules of the present invention, one or more combinations of auxiliary materials such as sucrose powder, soluble starch, dextrin, and ring auxiliary materials are added to the mixed fine powder of medicinal powder I and medicinal powder II prepared in step b, The amount of auxiliary materials used is 0.3-6 times of the weight of medicinal powder I and medicinal powder II, mixed uniformly, granulated with water, the dosage is 10-30% of the dosage of medicinal powder and auxiliary materials, dried the granules, and sprayed into volatile oil to obtain granules.

Most preferably, the method for preparing granules of the present invention, wherein the mixed fine powder of medicated powder I and medicated powder II prepared in step b adds one or a combination of soluble starch and cyclodextrin auxiliary materials, and the amount of the auxiliary materials used is medicated powder I and 0.4 to 3 times the weight of powder II, mix evenly, add water to granulate, the dosage is 10 to 30% of the dosage of powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules. .

The preparation method of the soft capsule of the present invention, wherein the volatile oil prepared in step b is mixed evenly with Tween 80, an appropriate amount of water is added, emulsified with an emulsifying machine for 5 to 30 minutes, and a volatile oil emulsion is obtained; glycerin, substrate, medicated powder I and medicated powder II are mixed fine powder , mix well, homogenize with a homogenizer for 10 to 60 minutes, then add volatile oil emulsion and mix evenly, and use a homogenizer to homogenize for 10 to 60 minutes to obtain the contents of the soft capsule; the base is vegetable oil, polyethylene glycol or One or any combination of Tween 80; take the above content and compress the soft capsule with a rotary capsule rolling machine.

Preferably, in the preparation method of the soft capsule of the present invention, the volatile oil prepared in step b is mixed evenly with Tween 80, an appropriate amount of water is added, and emulsified with an emulsifying machine for 8 to 20 minutes to obtain a volatile oil emulsion; take glycerin, matrix, medicinal powder I and medicinal powder II , mix well, homogenize for 20-40min with a homogenizer, then add volatile oil emulsion and mix evenly, and homogenize for 20-40min with a homogenizer to obtain the contents of the soft capsule; the base is vegetable oil, polyethylene glycol or One or any combination of Tween 80; take the above content and compress the soft capsule with a rotary capsule rolling machine.

Further preferably, the preparation method of the soft capsule of the present invention, wherein the volatile oil prepared in step b is mixed evenly with Tween 80, an appropriate amount of water is added, and emulsified with an emulsifying machine for 10 minutes to obtain a volatile oil emulsion; take glycerin, matrix, medicated powder I and medicated powder II, Mix well, homogenize for 30 minutes with a homogenizer, then add volatile oil emulsion and mix evenly, and homogenize for 30 minutes with a homogenizer to make a medicinal powder with 5-40%, volatile oil with 0.01-5%, matrix with 10-50%, glycerin with 0.25-8 %, 1% to 10% water, and the balance is the content of the Tween soft capsule, and the base is one or any combination of vegetable oil, polyethylene glycol or Tween 80; Machine compressed soft capsules.

Best, the preparation method of dropping pill of the present invention, wherein the volatile oil that step b makes adds Tween 80 and mixes evenly, adds water appropriate amount, emulsifies with emulsifier 10min, obtains volatile oil emulsion; Get glycerin, substrate, medicated powder I and medicated powder II, Mix well, homogenize for 30 minutes with a homogenizer, then add volatile oil emulsion and mix evenly, and homogenize for 30 minutes with a homogenizer to make medicinal powder 12.61%, volatile oil 0.14%, matrix 25%, glycerin 1.25%, water 5%, Tween 56% of the soft capsule content, the base is one or any combination of vegetable oil, polyethylene glycol or Tween 80; get the above content and compress the soft capsule with a rotary capsule rolling machine.

In the present invention, the vegetable oil is one or any combination of rapeseed oil, soybean oil, peanut oil, sunflower oil, cottonseed oil, corn oil, sesame oil, olive oil, and safflower oil.

The preferred vegetable oil is one or any combination of soybean oil, peanut oil and olive oil.

Dropping pill of the present invention can adopt following method to prepare, comprises the steps:

a. Take 36-145 parts of honeysuckle, 36-145 parts of skullcap, 36-145 parts of nepeta, 36-145 parts of gardenia, 36-145 parts of forsythia, 36-145 parts of Scrophulariaceae, 22-85 parts of silkworm, 55-215 parts of Rehmannia, 11-45 parts of Shegan, 22-85 parts of Campanulaceae, 22-85 parts of Mint, 22-85 parts of Cicada, 22-85 parts of Fangfeng, 11-45 parts of Licorice for later use;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted with 45-85% ethanol for 1-4 times, each time for 0.5-4 hours, recover ethanol, add water Boil an appropriate amount, filter while hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, Nepeta, Fangfeng, and mint to extract volatile oils, gardenia, forsythia, Scrophulariaceae, silkworm, rehmannia glutinosa, and Shegan , platycodon root, cicada slough, and licorice are decocted with water for 1 to 4 times, each time for 0.5 to 4 hours, the decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.03 to 1.25 at 50 to 90°C, and ethanol is added to make the alcohol content reach Stand still at 40-80%, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.04-1.40 at 50-90°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix evenly, add one or any combination of polyethylene glycol 6000, polyethylene glycol 4000, polyethylene glycol 1500, heat to melt, and adopt a dropping speed of 15-90 drops/min, Drop into the condensate to get the drop pill.

The preparation method of preferred dropping pill of the present invention, comprises the steps:

a. Take 53.54-86.70 parts of honeysuckle, 53.54-86.70 parts of Scutellaria baicalensis, 53.54-86.70 parts of nepeta, 53.54-86.70 parts of gardenia, 53.54-86.70 parts of forsythia, 53.54-86.70 parts of Scrophulariaceae, 33.57-51.55 parts of silkworm, 86.27-129.81 parts of Rehmannia, 17.54-26.70 parts of Shegan, 33.57-51.55 parts of Campanulaceae, 33.57-51.55 parts of Mint, 33.57-51.55 parts of Fangfeng, 33.57-51.55 parts of Cicada, 17.54-26.70 parts of Licorice;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted with 50-80% ethanol for 2-4 times, each time for 0.5-3.5 hours, recover ethanol, add water Boil an appropriate amount, filter while hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, Nepeta, Fangfeng, and mint to extract volatile oils, gardenia, forsythia, Scrophulariaceae, silkworm, rehmannia glutinosa, and Shegan , platycodon root, cicada slough, and licorice are decocted with water for 2 to 4 times, each time for 0.5 to 3.5 hours, the decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.05 to 1.15 at 55 to 85°C, and ethanol is added to make the alcohol content reach Stand still at 50-70%, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.06-1.35 at 55-85°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix evenly, add one of polyethylene glycol 6000, polyethylene glycol 4000 or any combination, heat and melt, and use a dropping speed of 20-80 drops/min, drop into the condensate, That is, drop pills.

The preparation method of further preferred dropping pills of the present invention may further comprise the steps:

a. Take 69-75 parts of honeysuckle, 69-75 parts of skullcap, 69-75 parts of Nepeta, 69-75 parts of gardenia, 69-75 parts of forsythia, 69-75 parts of Scrophulariaceae, 40-47 parts of silkworm, 100-115 parts of Rehmannia glutinosa, 20-25 parts of Shegan, 40-47 parts of bellflower, 40-47 parts of mint, 40-47 parts of cicada slough, 40-47 parts of Fangfeng, 20-24 parts of licorice for later use;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted with 55-75% ethanol for 2-3 times, each time for 1-3 hours, recover ethanol, add water Boil an appropriate amount, filter while hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, Nepeta, Fangfeng, and mint to extract volatile oils, gardenia, forsythia, Scrophulariaceae, silkworm, rehmannia glutinosa, and Shegan , platycodon root, cicada slough, and licorice are decocted with water for 2 to 3 times, each time for 1 to 3 hours, the decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.06 to 1.11 at 60 to 80°C, and ethanol is added to make the alcohol content reach Stand still at 55-65%, filter, recover ethanol from the filtrate and concentrate until the relative density is 1.10-1.30 at 60-80°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix well, add the mixture of polyethylene glycol 6000: polyethylene glycol 4000 = 1 ~ 5: 1 ~ 4 in 1 to 20 times the amount of the medicinal powder, heat and melt, and use a dripping speed of 25 to 75 drop/min, drop into liquid paraffin, or methyl silicone oil or methyl silicone oil: liquid paraffin = 1 ~ 4: 1 ~ 3 condensate, that is, drop pills.

The preparation method of the best dropping pill of the present invention comprises the steps:

a. Take 72 parts of honeysuckle, 72 parts of skullcap, 72 parts of nepeta, 72 parts of gardenia, 72 parts of forsythia, 72 parts of scrophulariaceae, 43 parts of silkworm, 108 parts of rehmannia, 22 parts of shegan, 43 parts of platycodon, 43 parts of mint 43 parts of cicada slough, 43 parts of Fangfeng, 22 parts of licorice for later use;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 65% ethanol, each time for 2 hours, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, add ethanol to make the alcohol content reach 60% and let stand. Filtrate, recover ethanol from the filtrate and concentrate to a relative density of 1.16-1.20 at 70°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix evenly, add the mixture of polyethylene glycol 6000: polyethylene glycol 4000 = 2-4: 2-3 of 4-6 times the amount of medicinal powder, heat and melt, and use a dripping speed of 35-65 Drops/min, drop into the condensate (liquid paraffin, or methyl silicone oil: liquid paraffin=3:1), to get the drop pill.

Capsules of the present invention can adopt following preparation method, comprise the steps:

(a). Take 36-145 parts of honeysuckle, 36-145 parts of skullcap, 36-145 parts of nepeta, 36-145 parts of gardenia, 36-145 parts of forsythia, 36-145 parts of Scrophulariaceae, 22-85 parts of silkworm 55-215 parts of Rehmannia glutinosa, 11-45 parts of Shegan, 22-85 parts of bellflower, 22-85 parts of mint, 22-85 parts of cicada slough, 22-85 parts of Fangfeng, 11-45 parts of licorice for later use;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted with 45-85% ethanol for 1-4 times, each time for 0.5-4 hours, and the ethanol is recovered , add an appropriate amount of water to boil, filter while it is hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the volatile oils of honeysuckle, nepeta, windproof, and mint, and gardenia, forsythia, crocodile, silkworm, and rehmannia glutinosa . When the content reaches 40-80%, stand still, filter, recover ethanol from the filtrate and concentrate until the relative density is 1.04-1.40 at 50-90°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

(c). Take the medicinal powder, spray it into volatile oil; mix evenly, put it into medicinal capsules, and obtain capsules. The preparation method of preferred capsule of the present invention, comprises the steps:

(a). Take 53.54-86.70 parts of honeysuckle, 53.54-86.70 parts of Scutellaria baicalensis, 53.54-86.70 parts of nepeta, 53.54-86.70 parts of gardenia, 53.54-86.70 parts of forsythia, 53.54-86.70 parts of Scrophulariaceae, 33.57-51.55 parts of silkworm 86.27-129.81 parts of Rehmannia glutinosa, 17.54-26.70 parts of Shegan, 33.57-51.55 parts of Bellflower, 33.57-51.55 parts of Mint, 33.57-51.55 parts of Fangfeng, 33.57-51.55 parts of cicada slough, 17.54-26.70 parts of licorice for later use;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted with 55-75% ethanol for 2-3 times, each time for 1-3 hours, and the ethanol is recovered , add an appropriate amount of water to boil, filter while it is hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the volatile oils of honeysuckle, nepeta, windproof, and mint, and gardenia, forsythia, crocodile, silkworm, and rehmannia glutinosa , Shegan, Platycodon grandiflora, cicada slough, and licorice are decocted with water for 2 to 3 times, each time for 1 to 3 hours, and the decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.06 to 1.11 at 60 to 80°C. When the content reaches 55-65%, let it stand still, filter, recover the ethanol from the filtrate and concentrate it to a relative density of 1.10-1.30 at 60-80°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain a medicinal powder;

(c). Take the medicinal powder and add the conventional auxiliary materials of the capsule, granulate according to the conventional preparation method of the capsule, spray into the volatile oil; mix evenly, put it into a medicinal capsule, and obtain the capsule.

The preparation method of the best capsule of the present invention comprises the steps:

(a). Take 72 parts of honeysuckle, 72 parts of Scutellaria, 72 parts of Nepeta, 72 parts of Gardenia, 72 parts of Forsythia, 72 parts of Scrophulariaceae, 43 parts of silkworm, 108 parts of Rehmannia glutinosa, 22 parts of Shegan, 43 parts of Campanulaceae, 43 parts of mint, 43 parts of cicada slough, 43 parts of Fangfeng, 22 parts of licorice for later use;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 65% ethanol, each time for 2 hours, and the ethanol is recovered, and an appropriate amount of water is added to boil. Filtrate hot and reserve the filtrate; extract the dregs of Scutellaria baicalensis ethanol and the dregs of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oil with gardenia, forsythia, crocodile, silkworm, rehmannia glutinosa, shegan, platycodon grandiflora, and cicada slough 1. Add water to licorice and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.06 to 1.11 at 70°C, and ethanol is added to make the alcohol content reach 60%. place, filter, and recover ethanol from the filtrate and concentrate to a relative density of 1.16 to 1.20 at 70°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

(c). Take the medicine powder, add one or more combinations of auxiliary materials such as sucrose powder, lactose, starch, dextrin, lactose, PVP, sodium carboxymethyl starch, mix evenly, and add concentration of 10 to 70% ethanol to prepare Granules, the amount of capsules is 5% to 50% of the dosage of the medicinal powder and auxiliary materials; the granules are dried, sprayed into volatile oil; mixed evenly, packed into medicinal capsules, and the gel is obtained.

The above components can be increased or decreased according to the corresponding proportion during production. For example, the unit of kilogram or ton can be used for large-scale production, and the unit of gram can also be used for small-scale production, and the weight can be increased or decreased. The weight ratio of crude drug materials between them remains unchanged.

Detailed ways

In order to understand the present invention better, below by observing above-mentioned pharmaceutical composition to exorcising evil effect (antiviral, antibacterial effect), heat-clearing effect, anti-inflammatory effect, the impact on immune function, analgesic effect and animal acute toxicity test , Animal long-term toxicity test, to illustrate the effect of the medicine of the present invention. The medicine used in the following test is prepared according to the method of Example 10. For ease of description, the medicine obtained according to Example 10 will be referred to as the medicine of the present invention for short.

1. Exorcism effect (anti-virus, anti-bacterial effect)

1. In vitro anti-influenza virus test research of medicine of the present invention

The test results show that the medicine of the present invention not only has direct killing effect on influenza virus type A3 and type B, but also has the effect of blocking virus reproduction. The minimum effective concentration of its direct killing effect is 0.1g of crude drug/ml, and the minimum effective concentration of its blocking effect of reproduction is 0.5g of crude drug/ml.

2. The inhibitory effect of the medicine of the present invention on influenza virus in mice

The test results show that the medicine of the present invention can significantly reduce the degree of pneumonia in mice caused by influenza virus, and can specifically inhibit the proliferation of influenza virus in mouse lungs. It shows that the medicine of the present invention has a certain preventive effect on influenza.

3. the antibacterial action of medicine of the present invention

Test result shows: medicine of the present invention has obvious inhibitory effect to common pathogenic bacteria of respiratory tract such as: staphylococcus aureus, epiphysis, lung bar, lung double ball, enterosphere, alpha chain, beta chain etc., and antimicrobial spectrum is wider, especially It has a higher inhibitory rate against more toxic pathogenic bacteria such as Staphylococcus aureus, chain A, chain B, etc. Compared with the reference drug Yinqiao Jiedu Tablet, the antibacterial spectrum and antibacterial strength are similar.

4. The protective effect of the medicament of the present invention on the death of lethal Staphylococcus aureus infection in mice

The test results show that the medicine of the present invention has a better therapeutic effect on patients infected with Staphylococcus aureus.

2. Heat-clearing effect

By observing the influence of the medicine of the present invention on the body temperature of typhoid, paratyphoid, and B triple vaccine-induced fever rabbits; the influence on the body temperature of yeast-induced fever rats: the influence on the body temperature of 2,4-dinitrophenol-induced fever rats, It is found that the medicine of the present invention has a definite antipyretic effect.

3. Anti-inflammatory effect

By observing the influence of the medicine of the present invention on the increase of vascular permeability caused by histamine, the influence of the mouse ear inflammation caused by croton oil, and the influence research on rat egg white joint swelling, the results show that the medicine of the present invention has obvious Anti-inflammatory effect.

4. Effects on immune function

1. The influence of medicine of the present invention on non-specific immune function

Through experimental observation, it is found that the drug of the present invention can improve the specific immune function of normal mice and mice whose immune function is suppressed due to virus infection, and the enhancement of reticuloendothelial system phagocytosis has been positively correlated with the dose used.

2. The drug of the present invention has an influence on the percentage of ANAE-positive lymphocytes in the peripheral blood of normal and model mice

The test results show that the medicine of the present invention has a regulating effect on cellular immunity.

5. Analgesic effect

Experimental observation and obtained experimental data results show that the medicine of the present invention has good analgesic effect on abdominal pain caused by acetic acid.

6. Animal acute toxicity test

The test results show that: according to the requirements of the maximum tolerated dose determination test, the medicine of the present invention is given three times in a day with 2 g of crude drug and each administration volume of 0.4 ml/10 g, except for transient loose stools. Toxic reaction. The total daily dose is 240g crude drug/kg, which is equivalent to 300 times of the adult clinical dosage, and still does not cause death, indicating that the acute toxicity of this product is very small, safe for oral administration, and can be used clinically.

7. Animal long-term toxicity test

The test results show that: the medicine of the present invention is administered through intragastric administration when two dose levels are low (22g crude drug/kg, equivalent to 28 times the clinical dosage of adults) and high (50g crude drug/kg, equivalent to 63 times the clinical dosage of adults). After 16 days, no obvious drug toxicity was found in the general state, body weight, diet, blood picture, liver and kidney function, and pathological microscope examination of important organs of the animals. It shows that the toxicity of this product is very low, and the clinical dosage is safe and reliable.

The preparation method of the medicament of the present invention is further illustrated by the following examples.

Example 1

a. Take prescription 1: 36g of honeysuckle, 36g of skullcap, 36g of nepeta, 36g of gardenia, 36g of forsythia, 36g of scrophulariae, 22g of silkworm, 55g of rehmannia glutinosa, 11g of shegan, 22g of platycodon grandiflorum, 22g of mint, 22g of cicada slough, 22g of windproof, licorice 11g spare;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 12 times the amount of ethanol to reflux 3 times, each time for 3 hours, the concentration of ethanol is 90%, recover ethanol, concentrate to a relative density of 1.03-1.35 at 70°C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 8 times the amount of water, soak for 0.5 hours, use steam distillation for 1 hour, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, and decoct for 3 hours each time. Density 1.02-1.30, let cool; ③ Alcohol precipitation: Add ethanol to make the alcohol content reach 85%, let stand for 48 hours, filter; ④ Recover ethanol, concentrate to relative density 1.05-1.45 at 90°C, dry to obtain medicinal powder I;

c. Take medicated powder I and medicated powder II, add dextrin, mix evenly, add 80% ethanol to granulate, the dosage is 80% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add magnesium stearate, mix Evenly, compress into tablets to obtain tablets.

Example 2

a. Take prescription 2: 145g honeysuckle, 145g skullcap, 145g nepeta, 145g gardenia, 145g forsythia, 145g scrophulariae, 85g silkworm, 215g rehmannia, 45g shegan, 85g bellflower, 85g mint, 85g cicada slough, 85g windproof, 45g licorice for later use;

b. Extraction of medicinal powder I: Take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux once, extract for 1 hour, the concentration of ethanol is 30%, recover ethanol, concentrate to a relative density of 1.03-1.35 at 45°C, dry, and obtain medicinal powder I;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 1 times the amount of water, soak for 0.5 hours, use steam distillation for 8 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting volatile oil, decoct for 0.5 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.02 at 50°C. ～1.30, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 10%, let it stand for 4 hours, filter; ④Recover ethanol, concentrate to a relative density of 1.05～1.45 at 50°C, dry, and obtain medicinal powder I;

c. Take medicated powder I and medicated powder II, add starch and lactose, mix evenly, add 5% ethanol to granulate, the dosage is 2% of the amount of medicated powder and auxiliary materials; dry the granules, spray volatile oil; add silica gel, mix evenly, Tablet pressing and coating to obtain tablets.

Example 3

a. Take prescription three: 145g honeysuckle, 45g skullcap, 36g nepeta, 36g gardenia, 145g forsythia, 36g crocus, 22g silkworm, 55g rehmannia, 11g shegan, 85g bellflower, 85g mint, 22g cicada slough, 85g windproof, 45g licorice for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux 3 times, for the first time for 3 hours, for the second time for 2 hours, for the third time for 1 hour, the concentration of ethanol is 40%, reclaim ethanol, concentrate to 45 The relative density at ℃ is 1.03～1.35, and it is dried to obtain powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, Nepeta, peppermint, and Fangfeng four herbs, combine them together, add 4.5 times the amount of water, soak for 3 hours, use steam distillation for 5 hours, collect the volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle and other volatile oils, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to Relative density at 60°C is 1.02-1.30, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 25%, let it stand for 32 hours, filter; ④Recover ethanol, concentrate to relative density at 60°C of 1.05-1.45 , dry to obtain powder I;

c. Take medicated powder I and medicated powder II, add PVP and sodium carboxymethyl starch, mix well, add concentration and be 75% ethanol to granulate, and the dosage is 60% of the amount of medicated powder and auxiliary materials; the granules are dried and sprayed into volatile oil; Magnesium fatty acid and polyethylene glycol, mixed evenly, compressed into tablets, coated or not, to obtain tablets.

Example 4

a. Take prescription four: 86.70g of honeysuckle, 86.70g of skullcap, 86.70g of Nepeta, 86.70g of gardenia (fried), 86.70g of forsythia, 86.70g of scrophulariaceae, 51.55g of silkworm (made from ginger), 129.81g of rehmannia glutinosa, Shegan 26.70g, Campanulaceae 51.55g, Mint 51.55g, Fangfeng 51.55g, Cicada slough 51.55g, Licorice 26.70g for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times the amount of ethanol to reflux twice, each time for 3 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to a relative density of 1.05-1.25 at 65 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 7 times the amount of water, soak for 4 hours, use steam distillation for 7 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle and other volatile oils, add water for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 75°C Relative density 1.04～1.20, let cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 80%, let it stand for 40 hours, filter; ④ recover ethanol, concentrate to relative density 1.14～1.25 at 80 ℃, dry, get Powder II;

c. Take medicated powder I and medicated powder II, add PVP, mix evenly, add 75% ethanol to granulate, the dosage is 60% of the amount of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add polyethylene glycol, mix well , Tablets, that is, tablets.

Example 5

a. Take prescription five: honeysuckle 53.54g, scutellaria baicalensis 53.54g, nepeta 53.54g, gardenia (fried) 53.54g, forsythia 53.54g, scrophulariaceae 53.54g, silkworm (made from ginger) 33.57g, rehmannia glutinosa 86.27g, Shegan 17.54g, Campanulaceae 33.57g, Mint 33.57g, Fangfeng 33.57g, Cicada slough 33.57g, Licorice 17.54g for later use;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.05-1.25 at 50°C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, windproof and other four herbs, combine them together, add 1 times the amount of water, soak for 1 hour, use steam distillation for 1 hour, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60°C Relative density 1.04～1.20, let cool; ③ Alcohol precipitation: add ethanol to make the alcohol content reach 15%, let stand for 6-40 hours, filter; ④ recover ethanol, concentrate to relative density 1.14～1.25 at 60℃, dry , to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, mix evenly, add 10% ethanol to granulate, the dosage is 60% of the amount of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add magnesium stearate, mix well , compressed into tablets, coated or uncoated, that is, tablets.

Example 6

a. Take prescription six: honeysuckle 86.70g, scutellaria baicalensis 53.54g, Nepeta 86.70g, gardenia (fried) 53.54g, forsythia 86.70g, Scrophulariaceae 53.54g, silkworm (made from ginger) 51.55g, rehmannia glutinosa 86.27g, Shegan 26.70g, Campanulaceae 33.57g, Mint 51.55g, Fangfeng 33.57g, Cicada slough 51.55g, Licorice 17.54g for later use;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, the first time is 2 hours, the second time is 1 hour, the concentration of ethanol is 40% to 80%, reclaim ethanol, concentrate to 50～65 ℃ When the relative density is 1.05 ~ 1.25, dry to get the powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 3 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate until it is at 65°C Relative density 1.04～1.20, let cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 35%, stand still for 24 hours, filter; ④ recover ethanol, concentrate to relative density 1.14～1.25 at 75 ℃, dry, get Powder II;

c. Take medicated powder I and medicated powder II, add dextrin, PVP, sodium carboxymethyl starch, mix evenly, add 20% ethanol to granulate, and the dosage is 40% of the dosage of medicated powder and auxiliary materials; dry the granules and spray into volatile oil ; Add silica gel, mix evenly, compress into tablets, coated or uncoated to obtain tablets.

Example 7

a. Take prescription 7: 75g of honeysuckle, 75g of skullcap, 75g of Nepeta, 75g of gardenia, 75g of forsythia, 75g of scrophulariae, 47g of silkworm, 115g of rehmannia glutinosa, 25g of shegan, 47g of bellflower, 47g of mint, 47g of cicada, 47g of windproof, 24g licorice for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 8 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to a relative density of 1.10-1.25 at 60 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 4 times the amount of water, soak for 3 hours, use steam distillation for 6 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 36 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Get medicated powder I and medicated powder II, add starch and PVP, mix well, add concentration and be 70% ethanol to granulate, consumption is 50% of medicated powder and auxiliary material consumption; Dry granule, spray into volatile oil; Add polyethylene glycol, Mix evenly, compress into tablets, and coat to obtain tablets.

Example 8

a. Take prescription eight: 69g honeysuckle, 69g skullcap, 69g Nepeta, 69g gardenia, 69g forsythia, 69g scrophulariae, 40g silkworm, 100g rehmannia, 20g shegan, 40g bellflower, 40g mint, 40g cicada slough, 40g windproof, 20g licorice for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, recover ethanol, concentrate to a relative density of 1.10 to 1.25 at 55 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 1 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04-1.20 at 60°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let it stand for 8 hours, and filter; ④Recover ethanol, concentrate to relative density at 80°C Density 1.14～1.25, dry to get medicine powder II;

c. Take medicinal powder I and medicinal powder II, add dextrin, mix evenly, add 10% ethanol to granulate, the dosage is 15% of the dosage of medicinal powder and auxiliary materials; dry the granules, spray into volatile oil; add polyethylene glycol, mix Uniform, compressed, coated or uncoated, that is, tablets.

Example 9

a. Take prescription nine: 75g of honeysuckle, 69g of skullcap, 75g of nepeta, 69g of gardenia, 75g of forsythia, 75g of scrophulariaceae, 40g of silkworm, 115g of rehmannia glutinosa, 25g of shegan, 40g of bellflower, 40g of mint, 40g of cicada slough, 47g of windproof, 20g licorice for later use;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times of amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 55%, reclaim ethanol, concentrate to relative density 1.10～1.25 when 55～60 ℃, dry, obtain Powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 3.5 times the amount of water, soak for 2.5 hours, use steam distillation for 4.5 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, decoct for 2.5 hours for the first time, and 1.5 hours for the second time, combine the decoction, and filter , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 40%, let stand for 18 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Take medicinal powder I and medicinal powder II, add an appropriate amount of dextrin and lactose, mix well, add 40% ethanol to granulate, and the dosage is 25% of the dosage of medicinal powder and auxiliary materials; the granules are dried and sprayed into volatile oil; Magnesium fatty acid, mixed evenly, compressed into tablets, coated, to obtain tablets.

Example 10

a. Take prescription ten: Honeysuckle 72g, Scutellaria baicalensis 72g, Nepeta 72g, Gardenia 72g, Forsythia 72g, Scrophulariaceae 72g, Silkworm 43g, Rehmannia glutinosa 108g, Shegan 22g, Campanulaceae 43g, Mint 43g, Cicada slough 43g, Fangfeng 43g, 22g licorice for later use;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add starch, the amount of starch is 2 times of the weight of medicated powder I and medicated powder II, mix well, add concentration and be 50% ethanol to granulate, the dosage is 20% of the dosage of medicated powder and starch; dry the granules , spray into volatile oil; add magnesium stearate, mix evenly, compress into tablets, and coat to obtain tablets.

Example 11

A. get prescription, and prescription is standby with embodiment 7;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 9 times of amount of ethanol to reflux 3 times, 1 hour for the first time, 2 hours for the second time, 3 hours for the third time, the concentration of ethanol is 50～60%, reclaim ethanol, concentrate to Dry at 45°C to 70°C with a relative density of 1.02 to 1.25 to obtain medicinal powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 7.5 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc., after extracting the volatile oil, add water to decoct twice, each decocting for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to 50-80 At ℃, the relative density is 1.02-1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 40 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.05 at 50-80℃ ～1.45, get medicine powder II;

c. Take medicated powder I and medicated powder II, add an equal amount of starch, dextrin, lactose, mix well, add concentration and be 80% ethanol to granulate, and the dosage is 6% of the dosage of medicated powder and auxiliary materials; the granules are dried and sprayed into volatile oil; Add silica gel, mix evenly, and press into tablets to obtain tablets.

Example 12

A. get prescription, and prescription is standby with embodiment 9;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times of amount of ethanol to reflux once, extract for 3 hours, the concentration of ethanol is 90%, reclaim ethanol, concentrate to relative density 1.12～1.25 when 65 ℃～70 ℃, dry, get Powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, Nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 3.5 times the amount of water, soak for 5 hours, use steam distillation for 1.5 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct 3 times, each decocting for 1.5 hours, combine the decoctions, filter, and concentrate the filtrate to 60-80 The relative density at ℃ is 1.12～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 55%, let stand for 48 hours, filter; ④recover ethanol, concentrate to relative density 1.15～1.35 at 50～80℃ , to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add dextrin, lactose, PVP, mix evenly, add 80% ethanol to granulate, the dosage is 80% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin One or several combinations of magnesium sulfate, silica gel, polyethylene glycol, mixed evenly, compressed into tablets, coated, to obtain tablets.

Example 13

A. get prescription, and prescription is standby with embodiment 3;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2.5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 85%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 4 times the amount of water, soak for 0.5 hours, use steam distillation for 6 hours, collect volatile oils and store them in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct twice, the first decoction for 1 hour, the second decoction for 2 hours, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.14-1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 8 hours, and filter; ④Recover ethanol, concentrate to 70°C The relative density is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add starch, lactose, and sodium carboxymethyl starch, mix well, add concentration and be 70% ethanol to granulate, and the dosage is 50% of the dosage of medicated powder and auxiliary materials; the granules are dried and sprayed into Volatile oil; add magnesium stearate and silica gel, mix evenly, compress into tablets, and coat to obtain tablets.

Example 14

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 6.5 times the amount of ethanol to reflux twice, each time for 0.5 hours, the concentration of ethanol is 70%, reclaim ethanol, concentrate to relative density 1.05～1.08 at 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction is 2.5 hours, the second decoction is 1.5 hours, and the decoction is combined and filtered. After filtration, the filtrate was concentrated to a relative density of 1.06-1.15 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 65%, let it stand for 24 hours, and filter; ④Recover ethanol, concentrate to 70°C The relative density is 1.16～1.20, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix evenly, add 70% ethanol to granulate, and the dosage is 5% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add stearic acid Magnesium, mixed evenly, compressed into tablets, without coating, to obtain tablets.

Example 15

a. Take honeysuckle 145g, scutellaria baicalensis 45g, nepeta 36g, gardenia 36g, forsythia 145g, scrophulariaceae 36g, silkworm 22g, rehmannia glutinosa 55g, shegan 11g, bellflower 85g, mint 85g, cicada slough 22g, windproof 85g, licorice 45g for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 1.5 times the amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 45%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: The remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. extract the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 2 hours, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: Add ethanol to make the alcohol content reach 20%, let it stand for 22 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add the combination of PVP and sodium carboxymethyl starch, mix well, add concentration and be 20% ethanol to granulate, and the consumption is 20% of the medicated powder and auxiliary material consumption; the granules are dried and sprayed into volatile oil; Add polyethylene glycol, mix evenly, compress into tablets, and coat or not coat to obtain tablets.

Example 16

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux 3 times, each time for 1.5 hours, the concentration of ethanol is 95%, reclaim ethanol, concentrate to a relative density of 1.01～1.35 at 85° C., dry to obtain medicinal powder I ;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, Nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 5 times the amount of water, soak for 4 hours, use steam distillation for 3 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate until it is relatively hot at 85°C. Density 1.01-1.35, let cool; ③ Alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 32 hours, filter; ④ Recover ethanol, concentrate to a relative density of 1.01-1.45 at 90°C, dry to obtain a medicinal powder II;

c. Take medicinal powder I and medicinal powder II, add common auxiliary materials for tablets to granulate; dry the granules, spray into volatile oil; add common auxiliary materials for tablets, mix evenly, and press into tablets to obtain tablets.

Example 17

A. get prescription, and prescription is standby with embodiment 3;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 30%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 45 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 4 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 50-55°C When the relative density is 1.04-1.25, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 18 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.04-1.45 at 50-90°C, Dried to obtain medicinal powder II;

c. Take medicinal powder I and medicinal powder II, add common excipients for tablets to granulate; dry the granules, spray into volatile oil; add common excipients for tablets, mix evenly, compress into tablets, coat or not coat, and obtain tablets.

Example 18

A. get prescription, and prescription is standby with embodiment 4;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to a relative density of 1.02～1.30 at 45°C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, windproof and other four herbs, combine them together, add 1 times the amount of water, soak for 1 hour, use steam distillation for 1 hour, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 8 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.20 at 60～80℃ , dried to obtain medicinal powder II;

c. Take medicinal powder I and medicinal powder II, add common excipients for tablets to granulate; dry the granules, spray into volatile oil; add common excipients for tablets, mix evenly, compress into tablets, coat or not coat, and obtain tablets.

Example 19

A. get prescription, and prescription is standby with embodiment 5;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 6 times of amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 90%, reclaim ethanol, be concentrated to relative density 1.02～1.20 in the time of 45～50 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 3 times the amount of water, soak for 3 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and the volatile oil extracted from honeysuckle, for 2 hours for the first time, and 1 hour for the second time, combine the decoction, filter, and concentrate the filtrate When the relative density is 1.05-1.20 at 60-75°C, let it cool; ③Alcohol precipitation: Add ethanol to make the alcohol content reach 60%, let stand for 16 hours, and filter; ④Recover ethanol, concentrate to 60-70°C The relative density is 1.05-1.20, and dried to obtain the medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, the amount of starch is 0.4 times of the weight of medicated powder I and medicated powder II, mix evenly, add concentration and be 70% ethanol to granulate, the dosage is 50% of the dosage of medicated powder and starch; dry the granules , spray into volatile oil; add magnesium stearate, mix evenly, compress into tablets, and coat to obtain tablets.

Example 20

A. get prescription, and prescription is standby with embodiment 6;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, the first time is 2 hours, the second time is 1 hour, the concentration of ethanol is 70%, reclaim ethanol, concentrate to the relative density when 55～60 ℃ 1.06～1.25, dry to obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil. When the relative density is 1.04-1.30 at 60-75°C, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 12 hours, and filter; ④Recover ethanol, concentrate to 70-80°C The relative density is 1.05-1.30, and dried to obtain the medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, the amount of starch is 1 time of the weight of medicated powder I and medicated powder II, mix well, add concentration and be 50% ethanol to granulate, the dosage is 20% of the dosage of medicated powder and starch; dry the granules , spray into volatile oil; add magnesium stearate, mix evenly, compress into tablets, and coat to obtain tablets.

Example 21

A. get prescription, and prescription is standby with embodiment 6;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to relative density 1.05～1.25 at 50～70 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 3 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 8 hours, filter; ④Recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add dextrin, mix evenly, add concentration of 10% ethanol to granulate, the dosage is 40% of the amount of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add silica gel, mix evenly, press Tablets, coated or uncoated, that is, tablets.

Example 22

A. get prescription, and prescription is standby with embodiment 8;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, be concentrated to relative density 1.05～1.25 at 50～60 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 70%, let stand for 18 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, the amount of starch is 1.5 times of the weight of medicated powder I and medicated powder II, mix well, add concentration and be 30% ethanol to granulate, the dosage is 30% of the dosage of medicated powder and starch; dry the granules , spray into volatile oil; add magnesium stearate, mix evenly, compress into tablets, and coat to obtain tablets.

Example 23

A. get prescription, and prescription is standby with embodiment 9;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 5.5 times of amount of ethanol to reflux twice, each 2 hours, the concentration of ethanol is 55%, reclaim ethanol, be concentrated to relative density 1.05～1.15 when 55～65 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2.5 times the amount of water, soak for 1.5 hours, use steam distillation for 3.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.11, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 40%, let stand for 40 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.15 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, the amount of starch is 1.2 times of the weight of medicated powder I and medicated powder II, mix evenly, add concentration and be 60% ethanol to granulate, the dosage is 15% of the dosage of medicated powder and starch; dry the granules .Spray into volatile oil; add magnesium stearate, mix evenly, compress into tablets, and coat to obtain tablets.

Example 24

a. Take 36g of honeysuckle, 36g of skullcap, 36g of nepeta, 36g of gardenia, 36g of forsythia, 36g of scrophulariaceae, 22g of silkworm, 55g of rehmannia glutinosa, 11g of shegan, 22g of bellflower, 22g of mint, 22g of cicada slough, 22g of windproof, 11g of licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 12 times the amount of ethanol to reflux 3 times, each time for 4 hours, the concentration of ethanol is 90%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.25 at 70 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 12 times the amount of water, soak for 5 hours, use steam distillation for 8 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct 3 times for 3 hours each time, combine the decoctions, filter, and concentrate the filtrate to 80°C When the relative density is 1.02-1.30, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 48 hours, filter; ④Recover ethanol, concentrate to a relative density of 1.05-1.15 at 85°C, and obtain a medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 6000, heat and melt, adopt a dripping speed of 90 drops/min, and drop them into the condensate to obtain the dropping pills.

Example 25

a. Take 145g of honeysuckle, 145g of skullcap, 145g of nepeta, 145g of gardenia, 145g of forsythia, 145g of scrophulariae, 85g of silkworm, 215g of rehmannia, 45g of shegan, 85g of bellflower, 85g of mint, 85g of cicada slough, 85g of windproof, and 45g of licorice. ;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux 3 times, each time for 0.5 hours, the concentration of ethanol is 30%, recover ethanol, concentrate to a relative density of 1.12 to 1.25 at 45 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 1 times the amount of water, soak for 0.2 hours, use steam distillation for 1 hour, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, add water to decoct once for 0.2 hours, combine the decoctions, filter, and concentrate the filtrate until it is relatively hot at 30°C. Density 1.02-1.30, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 10%, let it stand for 4 hours, filter; ④Recover ethanol, concentrate to a relative density of 1.05-1.45 at 40°C, and obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 4000, heat to melt, adopt a dripping speed of 80 drops/min, and drop them into the condensate to obtain dropping pills.

Example 26

a. Take honeysuckle 145g, scutellaria baicalensis 45g, nepeta 36g, gardenia 36g, forsythia 145g, scrophulariaceae 36g, silkworm 22g, rehmannia glutinosa 55g, shegan 11g, bellflower 85g, mint 85g, cicada slough 22g, windproof 85g, licorice 45g for later use ;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 10 times the amount of ethanol to reflux 3 times, for the first time for 3 hours, for the second time for 2 hours, for the third time for 1 hour, the concentration of ethanol is 80%, reclaim ethanol, concentrate to 65 The relative density at ℃ is 1.05～1.20, and it is dried to obtain powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 10 times the amount of water, soak for 4 hours, use steam distillation for 7 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct 3 times for 2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 60~ Relative density at 70°C is 1.05～1.25, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 75%, let it stand for 36 hours, filter; ④Recover ethanol, concentrate to a relative density of 1.05～ at 70～80℃ 1.45, get medicine powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 1500, heat to melt, adopt a dripping speed of 85 drops/min, and drop them into the condensate to obtain dropping pills.

Example 27

a. Take 86.70g of honeysuckle, 86.70g of Scutellaria baicalensis, 86.70g of Schizonepeta, 86.70g of gardenia (fried), 86.70g of forsythia, 86.70g of Scrophulariaceae, 51.55g of silkworm (made from ginger), 129.81g of rehmannia glutinosa, and 26.70g of shegan , bellflower 51.55g, peppermint 51.55g, windproof 51.55g, cicada slough 51.55g, licorice 26.70g for spare;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 2 times the amount of ethanol to reflux once, extract for 3 hours, the concentration of ethanol is 40%, recover ethanol, concentrate to a relative density of 1.05-1.20 at 50°C, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 2 times the amount of water, soak for 0.5 hours, use steam distillation for 1.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water to decoct once, decoct for 2.5 hours, combine the decoction, filter, and concentrate the filtrate to 40-50°C When the relative density is 1.05-1.25, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let it stand for 8 hours, and filter; Get Powder II;

c. Take medicine powder I, medicine powder II, volatile oil, mix well, add the mixture of polyethylene glycol 6000 and polyethylene glycol 1500, the amount added is polyethylene glycol 6000: polyethylene glycol 1500 is 3: 1, heat Melting, using a dropping speed of 20-80 drops/min, dropping into the condensed liquid, that is, dropping pills.

Example 28

a. Take 53.54g of honeysuckle, 53.54g of Scutellaria baicalensis, 53.54g of Nepeta, 53.54g of Gardenia (fried), 53.54g of Forsythia, 53.54g of Scrophulariaceae, 33.57g of silkworm (made from ginger), 86.27g of Rehmannia glutinosa, 17.54g of Shegan , bellflower 33.57g, peppermint 33.57g, windproof 33.57g, cicada slough 33.57g, licorice 17.54g for spare;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 8 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, be concentrated to relative density 1.02～1.15 in the time of 55～60 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 4 times the amount of water, soak for 3 hours, use steam distillation for 6 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 80%, let it stand for 12 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000=5:1 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 of 10 times the amount of medicinal powder, heat Melt, adopt the dropping speed of 65-75 drops/min, drop into the condensate (liquid paraffin, or methyl silicone oil: liquid paraffin = 4:1), and drop pills are obtained.

Example 29

a. Take honeysuckle 86.70g, scutellaria baicalensis 53.54g, nepeta 86.70g, gardenia (fried) 53.54g, forsythia 86.70g, scrophulariaceae 53.54g, silkworm (made from ginger) 51.55g, rehmannia glutinosa 86.27g, shegan 26.70g , Bellflower 33.57g, mint 51.55g, Fangfeng 33.57g, cicada slough 51.55g, licorice 17.54g for spare;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 55～60 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 1 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 1 hour, the second decoction for 1 hour, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let it stand for 12 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 1: 1 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 of 4 times the amount of medicinal powder, and heat Melt it, adopt a dropping speed of 45-55 drops/min, drop it into the condensate of methyl silicone oil: liquid paraffin = 4:1, and obtain the dropping pill.

Example 30

a. Take 75g honeysuckle, 75g skullcap, 75g nepeta, 75g gardenia, 75g forsythia, 75g scrophulariaceae, 47g silkworm, 115g rehmannia glutinosa, 25g shegan, 47g bellflower, 47g mint, 47g cicada slough, 47g windproof, 24g licorice for later use ;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to relative density 1.02～1.15 at 55～57 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extraction of volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 40%, let it stand for 20 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicine powder I, medicine powder II, volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000=2:3 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 of 6 times the amount of medicine powder, heat Melt it, and drop it into liquid paraffin at a dropping speed of 65-75 drops/min to obtain a dropping pill.

Example 31

a. Take 69g of honeysuckle, 69g of skullcap, 69g of nepeta, 69g of gardenia, 69g of forsythia, 69g of scrophulariaceae, 40g of silkworm, 100g of rehmannia glutinosa, 20g of shegan, 40g of bellflower, 40g of mint, 40g of cicada slough, 40g of windproof, 20g of licorice for later use ;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 600%, reclaim ethanol, be concentrated to relative density 1.02～1.15 at 55～60 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicine powder I, medicine powder II, volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000=5:1 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 of 4 times the amount of medicine powder, heat Melt it, and drop it into the methyl silicone oil at a dropping speed of 55-65 drops/min to obtain a dropping pill.

Example 32

a. Take 75g honeysuckle, 69g skullcap, 75g nepeta, 69g gardenia, 75g forsythia, 75g scrophulariaceae, 40g silkworm, 115g rehmannia glutinosa, 25g shegan, 40g bellflower, 40g mint, 40g cicada slough, 47g windproof, 20g licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 to 8 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 55 to 60 ° C, and dry , get medicinal powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, combine them together, add 3 times the amount of water, soak for 2.5 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction is 3 hours, the second decoction is 2 hours, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 15 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 1500=2: 3 mixture of polyethylene glycol 6000 and polyethylene glycol 1500 of 5.5 times the amount of medicinal powder, heat Melt it, adopt a dropping speed of 65-70 drops/min, drop it into the condensate of liquid methyl silicone oil: liquid paraffin = 1:1, and obtain the dropping pill.

Example 33

a. Take 72g honeysuckle, 72g skullcap, 72g nepeta, 72g gardenia, 72g forsythia, 72g scrophulariaceae, 43g silkworm, 10gg rehmannia glutinosa, 22g shegan, 43g bellflower, 43g mint, 43g cicada slough, 43g windproof, 22g licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 to 8 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40 to 80%, reclaim ethanol, and concentrate to a relative density of 1.02 to 1.02 at 55°C to 60°C 1.15, dry to obtain medicinal powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, windproof and other four medicinal materials, combine them together, add 1 to 4 times the amount of water, soak for 1 to 3 hours, use steam distillation for 2 to 6 hours, Collect the volatile oil and store it in another device, and continue to extract the dregs; ②Extraction: add water to decoct the dregs after extracting the volatile oil from the rest of the medicinal materials, Scutellaria baicalensis and honeysuckle, for 2 hours for the first time, and 1 hour for the second time. hours, combined the decoction, filtered, the filtrate was concentrated to a relative density of 1.04-1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 20-80%, let stand for 8-36 hours, filter ; ④ reclaim ethanol, concentrate to relative density 1.14～1.25 at 70 ℃, get medicine powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 in the amount of 1 to 10 times the medicinal powder , heating and melting, adopting a dropping speed of 70 to 75 drops/min, dripping in the condensing agent of methyl silicone oil: liquid paraffin = 3: 1, to obtain dropping pills.

Example 34

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux 3 times, for the first time for 3 hours, for the second time for 2 hours, for the third time for 1 hour, the concentration of ethanol is 75%, reclaim ethanol, concentrate to 90 At ℃, the relative density is 1.02～1.25 and dried to obtain the powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 4 hours, use steam distillation for 2 hours, collect volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: The remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. extract the volatile oil, add water and decoct for 3 times, the first time is 3 hours, the second time is 2 hours, the third time is 1 hour, combined and decocted liquid, filtered, and the filtrate was concentrated to a relative density of 1.02-1.30 at 50-60°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 10%, stand still for 16 hours, and filter; ④recover ethanol, concentrate When the relative density is 1.05-1.45 at 50-80°C, the medicinal powder II is obtained;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 6000 with 3 times the amount of medicinal powder I and medicinal powder II, heat and melt, and use a dripping speed of 80-90 drops/min to drip into the condensate, That is, drop pills.

Example 35

A. get prescription, and prescription is standby with embodiment 2;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, the first time is 3 hours, the second time is 2 hours, the concentration of ethanol is 75%, reclaim ethanol, concentrate until it is relatively stable at 50 ° C ~ 60 ° C Density 1.05～1.20, dry to get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: The remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. extract the volatile oil, add water and decoct twice, the first decoction is 2 hours, the second decoction is 1 hour, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.07-1.20 at 60-80°C, and let it cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 65%, let stand for 36 hours, and filter; ④ recover ethanol, concentrate to The relative density is 1.10-1.35 at 50-80℃, and the medicine powder II is obtained;

c. Get medicine powder I, medicine powder II, volatile oil, mix evenly, add the mixture of polyethylene glycol 6000, polyethylene glycol 4000 of 5 times medicine powder I and medicine powder II weight, polyethylene glycol 6000: polyethylene glycol 4000 is 4:1, heating and melting, using a dropping speed of 35-40 drops/min, dropping into methyl silicone oil to obtain dropping pills.

Example 36

A. get prescription, and prescription is standby with embodiment 3;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times of amount of ethanol to reflux once, extract for 3 hours, the concentration of ethanol is 30%, reclaim ethanol, concentrate to relative density 1.04～1.15 when 45 ℃～50 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 4 times the amount of water, soak for 3.5 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: The remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. extract the volatile oil, add water and decoct twice, the first decoction is 2 hours, the second decoction is 1 hour, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.02-1.30 at 50-80°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 8 hours, and filter; ④Recover ethanol and concentrate to The relative density at 50-80°C is 1.07-1.25, and the medicine powder II is obtained;

c. Get medicine powder I, medicine powder II, volatile oil, mix evenly, add the mixture of polyethylene glycol 4000, polyethylene glycol 1500 of 6 times medicine powder weight, polyethylene glycol 4000: polyethylene glycol 1500 is 3: 2, Heating and melting, adopting a dropping speed of 65-70 drops/min, dropping into liquid paraffin to obtain dropping pills.

Example 37

A. get prescription, and prescription is standby with embodiment 4;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extraction of volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 40%, let stand for 30 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 4000 of 4 times the amount of medicinal powder I and medicinal powder II, heat and melt, adopt a dripping speed of 50-60 drops/min, and drop in liquid paraffin at 8°C In the middle, drop pills are obtained.

Example 38

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to relative density 1.04～1.12 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 3 times the amount of water, soak for 2.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 40°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 12 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Get medicine powder I, medicine powder II, volatile oil, mix evenly, add the mixture of polyethylene glycol 6000, polyethylene glycol 4000 of 4 times medicine powder weight, polyethylene glycol 6000: polyethylene glycol 4000 is 3: 2, Heating and melting, using a dropping speed of 40-50 drops/min, dropping into liquid paraffin at 0-10°C to obtain dropping pills.

Example 39

A. get prescription, and prescription is standby with embodiment 6;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to relative density 1.09～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 2.5 times the amount of water, soak for 1 hour, use steam distillation for 3.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 50°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60-80%, let it stand for 8 hours, and filter; ④recover ethanol, concentrate to The relative density at 70°C is 1.14～1.25, and the medicine powder II is obtained;

c. Get medicine powder I, medicine powder II, volatile oil, mix evenly, add the mixture of polyethylene glycol 6000, polyethylene glycol 4000 of 7 times medicine powder weight, polyethylene glycol 6000: polyethylene glycol 4000 is 3: 1, Heating and melting, using a dropping speed of 50-80 drops/min, dropping into methyl silicone oil at -10-10°C, to obtain dropping pills.

Example 40

A. get prescription, and prescription is standby with embodiment 7;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 55°C to 60°C, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs: ②Extraction: The remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. extract the volatile oil, add water to decoct twice, decoct for 2 hours for the first time, decoct for 1 hour for the second time, and combine the decoction, Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 70%, let it stand for 18 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add 4 times the amount of medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 1: 4 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat Melt it, adopt a dropping speed of 75-80 drops/min, drop it into the condensate of methyl silicone oil: liquid paraffin = 1:3, and obtain the dropping pill.

Example 41

A. get prescription, and prescription is standby with embodiment 8;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 80°C, and let it cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 50%, let stand for 16 hours, and filter; ④ recover ethanol, concentrate to a relative density of 1.14 ～1.25 (70 ℃ meter), get medicine powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add 3 times of medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 5: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat Melt it, and drop it into methyl silicone oil at a dropping speed of 50-60 drops/min to obtain a dropping pill.

Example 42

A. get prescription, and prescription is standby with embodiment 9;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 8 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 60°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 40%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to a relative density of 1.14 ～1.25 (70 ℃ meter), get medicine powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add 6 times the amount of medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat Melt it, adopt the dropping speed of 45-55 drops/min, and drop it into liquid paraffin at 0°C to obtain the dropping pill.

Example 43

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to relative density 1.06～1.12 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filter, concentrate the filtrate to a relative density of 1.04-1.20 (70°C), and let it cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 30%, let it stand for 15 hours, and filter; ④ recover ethanol, concentrate to a relative density of 1.14 ～1.25 (70 ℃ meter), get medicine powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add 5 times the amount of medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat Melt it, adopt the dropping speed of 65-75 drops/min, and drop it into liquid paraffin at 5°C to obtain the dropping pill.

Example 44

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, concentrate to relative density 1.12～1.15 (55 ℃～60 ℃ meter), dry , get medicinal powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.15-1.20 (70°C), and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 70%, let it stand for 20 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.14 ～1.25 (70 ℃ meter), get medicine powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add 6 times the amount of medicinal powder, polyethylene glycol 6000: polyethylene glycol 1500 = 5: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 1500, heat Melt it, adopt a dropping speed of 40 drops/min, and drop it into methyl silicone oil at 5°C to obtain a dropping pill.

Example 45

a. Take 72g honeysuckle, 72g skullcap, 72g nepeta, 72g gardenia, 72g forsythia, 72g scrophulariaceae, 43g silkworm, 108g rehmannia glutinosa, 22g shegan, 43g bellflower, 43g mint, 43g cicada slough, 43g windproof, 22g licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 57 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extraction of volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 50%, let it stand for 24 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add 5 times the amount of medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat Melt it, adopt a dropping speed of 70-75 drops/min, drop it into the condensing agent of methyl silicone oil: liquid paraffin = 3:1, and obtain the dropping pill.

Example 46

A. get prescription, and prescription is standby with embodiment 8;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 59 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 30%, let it stand for 20 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add 4 times the amount of medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat Melt it, and drop it into liquid paraffin at a dropping speed of 70-75 drops/min to obtain a dropping pill.

Example 47

A. get prescription, and prescription is standby with embodiment 10;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in a separate device; Scutellaria baicalensis is extracted 4 times with 85% ethanol, each time for 4 hours, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water and decoct 4 times, each time for 4 hours, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.03-1.25 at 90°C, add ethanol to make the alcohol content reach 80%, let stand, filter, recover the ethanol from the filtrate and Concentrate to a relative density of 1.04-1.40 at 90°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix them evenly, add polyethylene glycol 6000, heat to melt, adopt a dropping speed of 75-90 drops/min, drop them into methyl silicone oil at -10-10°C, and obtain the dropping pills.

Example 48

A. get prescription, and prescription is standby with embodiment 2;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted once with 45% ethanol, extracted for 0.5 hours, recovered ethanol, and boiled with appropriate amount of water. Filter while hot , the filtrate is ready for use; the medicinal residues extracted from Scutellaria baicalensis ethanol and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, and licorice. Decoct once, extract for 0.5 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.03-1.25 at 50°C, add ethanol to make the alcohol content reach 40%, let stand, filter, recover the ethanol from the filtrate and concentrate to At 50°C, the relative density is 1.04-1.40, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix them evenly, add polyethylene glycol 4000, heat to melt, and drop them into liquid paraffin at a dropping speed of 65-70 drops/min to obtain dropping pills.

Example 49

A. get prescription, and prescription is standby with embodiment 3;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 65% ethanol, each time for 3 hours, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water to decoct twice, each time for 3 hours, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.03-1.25 at 60°C, add ethanol to make the alcohol content reach 50%, let stand, filter, recover the ethanol from the filtrate and Concentrate to a relative density of 1.04-1.40 at 70°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix them evenly, add polyethylene glycol 1500, heat to melt, adopt a dropping speed of 65-80 drops/min, and drop them into 0-10°C to obtain the dropping pills.

Example 50

A. get prescription, and prescription is standby with embodiment 4;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted 4 times with 80% ethanol, each time for 3.5 hours, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water and decoct 4 times, each time for 3.5 hours, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.05 to 1.15 at 85°C, add ethanol to make the alcohol content reach 70%, let stand, filter, recover the ethanol from the filtrate and Concentrate to a relative density of 1.06-1.35 at 85°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix them evenly, add polyethylene glycol 6000, heat to melt, and drop them into the vegetable oil at a dropping speed of 50-60 drops/min to obtain the dropping pills.

Example 51

A gets prescription, and prescription is standby with embodiment 5;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 50% ethanol, each time for 0.5 hours, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water to decoct twice, each time for 0.5 hours, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.05-1.15 at 55°C, add ethanol to make the alcohol content reach 50%, let stand, filter, recover the ethanol from the filtrate and Concentrate to a relative density of 1.06-1.35 at 55°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix them evenly, add polyethylene glycol 4000, heat to melt, and drop them into liquid paraffin at a dropping rate of 70-80 drops/min to obtain dropping pills.

Example 52

A. get prescription, and prescription is standby with embodiment 6;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 70% ethanol, the first time is 3.5 hours, the second time is 2 hours, and the ethanol is recovered. Add an appropriate amount of water to boil, filter while hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the volatile oils of honeysuckle, nepeta, windproof, and peppermint, and gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, Shegan, platycodon, cicada, and licorice are decocted twice with water, the first time is 3.5 hours, the second time is 2 hours, the decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.05-1.15 at 75°C, and ethanol is added to make the alcohol When the content reaches 65%, stand still, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.06-1.35 at 65°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 1:4 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 in 10 times the amount of medicinal powder, heat to melt, and use dropwise The speed is 65-75 drops/min, drop into liquid paraffin, and drop pills are obtained.

Example 53

A. get prescription, and prescription is standby with embodiment 7;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted 3 times with 75% ethanol, each time for 3 hours, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water and decoct 3 times, each time for 3 hours, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.06-1.11 at 80°C, add ethanol to make the alcohol content reach 65%, let stand, filter, recover the ethanol from the filtrate and Concentrate until the relative density is 1.10-1.30 at 60-80°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 5: 1 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 in 8 times the amount of medicinal powder, heat to melt, and use dropwise The speed is 60-75 drops/min, drop into methyl silicone oil, and drop pills are obtained.

Example 54

A. get prescription, and prescription is standby with embodiment 8;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted 3 times with 60% ethanol, the first time is 3 hours, the second time is 2 hours, and the third time For 1 hour, recover ethanol, add appropriate amount of water to boil, filter while it is hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, nepeta, windproof, and mint after extracting volatile oils, gardenia, forsythia, and crocodile , silkworm, rehmannia glutinosa, shegan, bellflower, cicada slough, licorice and decoct 3 times, the first time for 3 hours, the second time for 2 hours, the third time for 1 hour, combine the decoction, filter, and concentrate the filtrate to 70°C When the relative density is 1.06-1.11, add ethanol to make the alcohol content reach 58%, let stand, filter, reclaim ethanol from the filtrate and concentrate to a relative density of 1.10-1.30 at 75°C, add Scutellaria baicalensis ethanol extract, concentrate, and dry to obtain get medicine powder;

c. Take the medicinal powder and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 1500 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 1500 of 6 times the amount of medicinal powder, heat to melt, and use dropwise The speed is 25-75 drops/min, drop into the condensate of liquid methyl silicone oil: liquid paraffin=1:3, and drop pills are obtained.

Example 55

A. get prescription, and prescription is standby with embodiment 9;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 65% ethanol, the first time is 2 hours, the second time is 1 hour, and the ethanol is recovered. Add an appropriate amount of water to boil, filter while hot, and use the filtrate for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the volatile oils of honeysuckle, nepeta, windproof, and peppermint, and gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, Add water to decoct Shegan, Campanulaceae, Cicada, and Licorice twice, the first time for 2 hours, and the second time for 1 hour, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.06-1.11 at 65°C. Add ethanol to make the alcohol When the content reaches 65%, stand still, filter, recover the ethanol from the filtrate and concentrate it to a relative density of 1.10-1.30 at 65°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain the medicinal powder:

c. Take the medicinal powder and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 2: 1 mixture of polyethylene glycol 6000 and polyethylene glycol 4000 in 6 times the amount of the medicinal powder, heat to melt, and use dropwise The speed is 50-75 drops/min, drop into the condensate of methyl silicone oil: liquid paraffin = 3:1, and drop pills are obtained.

Example 56

A. get prescription, and prescription is standby with embodiment 10;

b. The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 65% ethanol, each time for 2 hours, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, add ethanol to make the alcohol content reach 60% and let stand. Filtrate, recover ethanol from the filtrate and concentrate to a relative density of 1.16-1.20 at 70°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix evenly, add 4 to 6 times the amount of medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat to melt, The dripping speed is 45-75 drops/min, drop into liquid paraffin, and drop pills are obtained.

Example 57

A. get prescription, and prescription is standby with embodiment 10;

b. The above fourteen flavors, extract volatile oil from honeysuckle, Nepeta, windproof, and peppermint, and collect the distilled aqueous solution in another device; add 75% ethanol to extract scutellaria baicalensis twice, 1 hour each time, recover ethanol, add appropriate amount of water to boil, and filter while hot and the filtrate is ready for use; the medicinal residues extracted with ethanol from Scutellaria baicalensis and the volatile oils extracted from honeysuckle, nepeta, windproof, and peppermint are mixed with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, licorice Add water and decoct twice, the first time for 3 hours, the second time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.06-1.11 at 75°C, add ethanol to make the alcohol content reach 60% and let stand. Filtrate, recover ethanol from the filtrate and concentrate to a relative density of 1.16-1.20 at 75°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

c. Take the medicinal powder and volatile oil, mix well, add 5 times the amount of the medicinal powder, polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2 mixture of polyethylene glycol 6000 and polyethylene glycol 4000, heat to melt, and use dropwise The speed is 45-75 drops/min, drop into the condensate of methyl silicone oil: liquid paraffin = 3:1, and drop pills are obtained.

Example 58

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux once, extract for 4 hours, the concentration of ethanol is 30%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.25 at 45 to 70°C, and dry to obtain medicinal powder I;

Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux once, extract for 1 hour, the concentration of ethanol is 95%, recover ethanol, concentrate to a relative density of 1.01-1.35 at 45-85°C, dry, and obtain medicinal powder I;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 1 times the amount of water, soak for 0.5 hours, use steam distillation for 1 hour, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials and the dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, extract for 3 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density at 50-85°C 1.02 ~ 1.35, let cool; ③ Alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 48 hours, filter; ④ recover ethanol, concentrate to a relative density of 1.02 ~ 1.45 at 50 ~ 90 ° C, dry to obtain Powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 6000 of 25 times the amount of medicinal powder, heat and melt, adopt a dripping speed of 80 drops/min, and drop them into the condensate to obtain dripping pills.

Example 59

A. get prescription, and prescription is standby with embodiment 2;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 12 times of amount of ethanol to reflux 3 times, each time for 4 hours, the concentration of ethanol is 90%, reclaim ethanol, concentrate to relative density 1.02～1.25 when 45～70 ℃, dry, get Powder I;

Extraction of medicinal powder I: take Scutellaria baicalensis and add 12 times the amount of ethanol to reflux 3 times, each time for 3 hours, the concentration of ethanol is 95%, recover ethanol, concentrate to a relative density of 1.00-1.35 at 45-85°C, and dry to obtain medicinal powder I ;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 8 times the amount of water, soak for 5 hours, use steam distillation for 8 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, for 3 hours each time, combine the decoctions, filter, and concentrate the filtrate to 50-85°C When the relative density is 1.00-1.35, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 10%, let it stand for 4 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.00-1.45 at 50-90°C, Dried to obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 4000 of 30 times the amount of medicinal powder, heat and melt, adopt a dripping speed of 45-50 drops/min, and drop them into the condensate to obtain the dripping pill .

Example 60

A. get prescription, and prescription is standby with embodiment 4;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 90%, reclaim ethanol, be concentrated to relative density 1.02～1.30 in the time of 45～80 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 7 times the amount of water, soak for 4 hours, use steam distillation for 7 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 36 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.20 at 60～80℃ , dried to obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix them evenly, add polyethylene glycol 6000, heat to melt, adopt a dripping speed of 50-60 drops/min, and drop them into the condensate to obtain dropping pills.

Example 61

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.02-1.30 at 45 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, windproof and other four herbs, combine them together, add 1 times the amount of water, soak for 1 hour, use steam distillation for 1 hour, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 8 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.20 at 60～80℃ , dried to obtain medicinal powder II;

c. Take medicine powder I, medicine powder II, and volatile oil, mix them evenly, add a mixture of polyethylene glycol 6000 and polyethylene glycol 4000 of 10 times the amount of medicine powder, polyethylene glycol 6000: polyethylene glycol 4000 is 2: 1, heat Melting, using a dropping speed of 50 drops/min, dropping into the condensate, that is, dropping pills.

Example 62

A. get prescription, and prescription is standby with embodiment 6;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, for the first time for 2 hours, and for the second time for 1 hour, the concentration of ethanol is 70%, reclaim ethanol, and concentrate to a relative density of 1.02～ at 70°C 1.30, dry to obtain powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 3 hours, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 50%, let stand for 16 hours, filter; ④recover ethanol, concentrate to relative density 1.06～1.20 at 60～80℃ , dried to obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add polyethylene glycol 4000 of 15 times the amount of medicinal powder, heat and melt, and adopt a dripping speed of 30 drops/min, drip into the condensate to obtain a dropping pill.

Example 63

A. get prescription, and prescription is standby with embodiment 7;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, concentrate to relative density 1.05～1.25 when 50～70 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 24 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 5: 1 mixture of 30 times the amount of medicinal powder, heat and melt, and adopt a dripping speed of 35 to 45 drops/ min, drop into the condensate of methyl silicone oil: liquid paraffin = 4:1 to obtain the dropping pill.

Example 64

A. get prescription, and prescription is standby with embodiment 8;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to relative density 1.05～1.25 at 50～70 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 3 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 12 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 1: 1 mixture of 10 times the amount of medicinal powder, heat and melt, and adopt a dripping speed of 25 to 75 drops/ min, drop into the condensate of methyl silicone oil: liquid paraffin = 1:3 to obtain the dropping pill.

Example 65

A. get prescription, and prescription is standby with embodiment 9;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to a relative density of 1.05-1.25 at 55°C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3.5 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, decocting for 1 to 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65 Relative density at ~70°C is 1.04~1.20, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let stand for 16 hours, filter; ④Recover ethanol, concentrate to relative density 1.05 at 65~75°C ~1.25, dry to obtain powder II;

c. Get medicine powder I, medicine powder II, volatile oil, mix evenly, add the mixture of polyethylene glycol 6000: polyethylene glycol 4000=2: 3 of medicine powder 15 times amount, heat and melt, adopt dripping speed to be 55～65 drops/ min, drop into liquid paraffin to get dropping pills.

Example 66

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 6 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60-70%, recover ethanol, concentrate to a relative density of 1.05-1.25 at 50-70°C, and dry , get medicinal powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, windproof and other four medicinal materials, combine them together, add 3 to 5 times the amount of water, soak for 1 to 2 hours, use steam distillation for 2 to 4 hours, Collect the volatile oil and store it in another device, and continue to extract the dregs of the medicine; ②Extraction: Add water to the dregs after extracting the volatile oil from the rest of the medicinal materials, the dregs of Scutellaria baicalensis and honeysuckle, etc., add water and decoct twice, each decoction for 1 to 2 hours, combine the decoction, and filter , the filtrate was concentrated to a relative density of 1.04-1.20 at 65-70°C, and allowed to cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 20-80%, let stand for 8-36 hours, and filter; ④ recover ethanol, concentrate When the relative density is 1.05 to 1.25 at 65 to 75°C, dry it to obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 2: 3 mixture of 5 times the amount of medicinal powder, heat and melt, and adopt a dropping speed of 45 to 50 drops/ min, drop into the methyl silicone oil, that is, drop pills.

Example 67

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 45%, reclaim ethanol, concentrate to a relative density of 1.05 to 1.25 at 40 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 30%, let stand for 24 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add polyethylene glycol 6000: polyethylene glycol 4000 = 4: 3 mixture of 6 times the amount of medicinal powder, heat and melt, and adopt a dripping speed of 50 to 60 drops/ min, drop into liquid paraffin to get dropping pills.

Example 68

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Take medicinal powder I, medicinal powder II, and volatile oil, mix well, add 20 times the amount of medicinal powder, a mixture of polyethylene glycol 6000: polyethylene glycol 4000 = 3: 2, heat and melt, and adopt a dripping speed of 40 drops/min, Drop into liquid paraffin, or the condensate of methyl silicone oil: liquid paraffin at a ratio of 3:1 to obtain a drop pill.

Example 69

a. Take 36g of honeysuckle, 36g of Scutellaria baicalensis, 36g of nepeta, 36g of gardenia, 36g of forsythia, 36g of scrophulariaceae, 22g of silkworm, 55g of rehmannia glutinosa, 11g of shegan, 22g of bellflower, 22g of mint, 22g of cicada slough, 22g of windproof, 11g of licorice;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to 60 ℃ when the relative density is 1.05～1.10, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 2 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the relative density of the filtrate is 1.05-1.15 when concentrated to 80°C, and let it cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 70%, let stand for 16 hours, and filter; ④ recover ethanol, and concentrate to 80°C when the relative density 1.14～1.25, get medicine powder II;

c. Take medicinal powder I and medicinal powder II, add the combination of starch and dextrin, mix well, add 50% ethanol to granulate, and the dosage is 30% of the dosage of medicinal powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin Magnesium acid is mixed evenly, and the mixture is uniformly packed into medicinal capsules to obtain capsules.

Example 70

a. Take 145g honeysuckle, 145g skullcap, 145g nepeta, 145g gardenia, 145g forsythia, 145g crocus, 85g silkworm, 215g rehmannia, 45g shegan, 85g bellflower, 85g mint, 85g cicada slough, 85g windproof, 45g licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 2.5 hours, the concentration of ethanol is 35%, reclaim ethanol, concentrate to relative density 1.07～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 3.5 times the amount of water, soak for 2.5 hours, use steam distillation for 3.5 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 45%, let stand for 12 hours, and filter; ④Recover ethanol, concentrate to 70°C The relative density is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix well, add 30% ethanol to granulate, the dosage is 40% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add silica gel, mix homogeneously, mix evenly, pack into medicinal capsules, and obtain capsules.

Example 71

a. Take 145g of honeysuckle, 45g of Scutellaria baicalensis, 36g of nepeta, 36g of gardenia, 145g of forsythia, 36g of scrophulariaceae, 22g of silkworm, 55g of rehmannia glutinosa, 11g of shegan, 85g of bellflower, 85g of mint, 22g of cicada slough, 85g of windproof, 45g of licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 6.5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.08～1.10 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 4.5 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 3 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the relative density of the filtrate is 1.04-1.20 when concentrated to 80°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 75%, let it stand for 24 hours, and filter; ④Recover ethanol, and concentrate to 80°C when the relative density 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add the combination of dextrin and PVP, mix evenly, add 75% ethanol to granulate, and the dosage is 35% of the amount of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin The combination of magnesium sulfate and silica gel is uniformly mixed and packed into medicinal capsules to obtain capsules.

Example 72

a. Take 86.70g of honeysuckle, 86.70g of Scutellaria baicalensis, 86.70g of Schizonepeta, 86.70g of gardenia (fried), 86.70g of forsythia, 86.70g of Scrophulariaceae, 51.55g of silkworm (made from ginger), 129.81g of rehmannia glutinosa, and 26.70g of shegan , bellflower 51.55g, mint 51.55g, windproof 51.55g, cicada slough 51.55g, licorice 26.70g;

Extraction of medicinal powder I: take Scutellaria baicalensis and add 5.5 times the amount of ethanol to reflux twice, each time for 2.5 hours, the concentration of ethanol is 70%, recover ethanol, concentrate to a relative density of 1.10 to 1.15 at 55° C., and dry to obtain medicinal powder I;

b. Extraction of Medicinal Powder II: ①Extraction of volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 2 times the amount of water, soak for 1 hour, use steam distillation for 6 hours, collect the volatile oil and store it in another container , the dregs continue to extract; ②Extraction: the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water to decoct twice, decoct for 2 hours for the first time, decoct for 1 hour for the second time, and combine the decoction , filtered, and the filtrate was concentrated to a relative density of 1.14 to 1.20 at 50°C, and allowed to cool: ③ alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 20 hours, and filter; ④ recover ethanol and concentrate to 60°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix well, add concentration of 10% ethanol to granulate, the dosage is 20% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add polyethylene glycol Alcohol, mix evenly, mix evenly, pack in medicinal capsules, obtain capsules.

Example 73

a. Take 53.54g of honeysuckle, 53.54g of Scutellaria baicalensis, 53.54g of Nepeta, 53.54g of Gardenia (fried), 53.54g of Forsythia, 53.54g of Scrophulariaceae, 33.57g of silkworm (made from ginger), 86.27g of Rehmannia glutinosa, 17.54g of Shegan , bellflower 33.57g, mint 33.57g, windproof 33.57g, cicada slough 33.57g, licorice 17.54g;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 55° C. to 60° C., and dry , get medicinal powder I;

Extraction of medicinal powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 4 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 3 hours, the second decoction for 2 hours, combine the decoction, filter After filtration, the filtrate is concentrated to a relative density of 1.04-1.20 (70°C), and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 20 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.14- 1.25 (measured at 70°C), the powder II was obtained;

c. Take medicated powder I and medicated powder II, add starch, mix uniformly, add concentration and be 80% ethanol to granulate, the dosage is 50% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add magnesium stearate and mix evenly, Mix evenly, pack into medicinal capsules, and obtain capsules.

Example 74

a. Take honeysuckle 86.70g, scutellaria baicalensis 53.54g, nepeta 86.70g, gardenia (fried) 53.54g, forsythia 86.70g, scrophulariaceae 53.54g, silkworm (made from ginger) 51.55g, rehmannia glutinosa 86.27g, shegan 26.70g , bellflower 33.57g, mint 51.55g, windproof 33.57g, cicada slough 51.55g, licorice 17.54g;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 8 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to relative density 1.02～1.15 (55 ℃～60 ℃ meter), dry , get medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 4 times the amount of water, soak for 3 hours, use steam distillation for 6 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.04-1.20 (70°C), and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 36 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.14- 1.25 (measured at 70°C), the powder II was obtained;

c. Take medicinal powder I and medicinal powder II, add the combination of dextrin and lactose, mix evenly, add 60% ethanol to granulate, and the dosage is 45% of the dosage of medicinal powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin Magnesium Oxide, mixed uniformly, and packed into medicinal capsules to obtain capsules.

Example 75

a. Take 75g honeysuckle, 75g skullcap, 75g nepeta, 75g gardenia, 75g forsythia, 75g scrophulariaceae, 47g silkworm, 115g rehmannia glutinosa, 25g shegan, 47g bellflower, 47g mint, 47g cicada slough, 47g windproof, 24g licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 8 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to relative density 1.02～1.15 (55 ℃～60 ℃ meter), dry , get medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 5 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct twice, the first decoction for 4 hours, the second decoction for 2 hours, combine the decoction, filter After filtration, the relative density of the filtrate was 1.04-1.20 when concentrated to 85°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 80%, let it stand for 10 hours, and filter; ④Recover ethanol, and the relative density when concentrated to 85°C 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add the combination of lactose and PVP, mix well, add concentration of 40% ethanol to granulate, the dosage is 5% of the amount of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add polyethylene glycol Alcohol, mix evenly, pack into medicinal capsules, and obtain capsules.

Example 76

a. Take 69g honeysuckle, 69g skullcap, 69g nepeta, 69g gardenia, 69g forsythia, 69g scrophulariae, 40g silkworm, 100g rehmannia, 20g shegan, 40g platycodon, 40g mint, 40g cicada, 40g windproof, 20g licorice;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to 85 ℃ when relative density is 1.02～1.15, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 5 times the amount of water, soak for 1 hour, use steam distillation for 6 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the relative density of the filtrate is 1.04-1.20 when concentrated to 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let it stand for 12 hours, and filter; ④recover ethanol, and concentrate to 75°C when the relative density 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add the combination of starch and carboxymethyl starch sodium, mix evenly, add concentration and be 70% ethanol to granulate, and the consumption is 35% of the medicated powder and auxiliary material consumption; the granules are dried and sprayed into volatile oil; A combination of magnesium stearate, silica gel and polyethylene glycol is added, mixed evenly, and packed into medicinal capsules to obtain capsules.

Example 77

a. Take 75g honeysuckle, 69g skullcap, 75g nepeta, 69g gardenia, 75g forsythia, 75g scrophulariae, 40g silkworm, 115g rehmannia glutinosa, 25g shegan, 40g bellflower, 40g mint, 40g cicada slough, 47g windproof, 20g licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 4.5 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 65 ℃～70 ℃, dry, Get medicine powder I;

Extraction of medicinal powder II: ①Extract volatile oil: Combine four herbs such as honeysuckle, nepeta, peppermint, and windproof, add 6 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct 3 times, each decocting for 1 hour, combine the decoctions, filter, and concentrate the filtrate to 70-80 The relative density at ℃ is 1.15～1.20, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 65%, let it stand for 48 hours, filter; ④Recover ethanol, concentrate to relative density 1.35～1.45 at 50～60℃ , to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add dextrin, mix evenly, add concentration and be 80% ethanol to granulate, the dosage is 80% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add magnesium stearate, silica gel The combination is mixed uniformly and loaded into medicinal capsules to obtain capsules.

Example 78

a. Take 72g of honeysuckle, 72g of Scutellaria baicalensis, 72g of nepeta, 72g of gardenia, 72g of forsythia, 72g of scrophulariaceae, 43g of silkworm, 108g of rehmannia glutinosa, 22g of shegan, 43g of bellflower, 43g of mint, 43g of cicada slough, 43g of windproof, 22g of licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 30%, reclaim ethanol, concentrate to relative density 1.02～1.25 when 45 ℃～50 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 5 times the amount of water, soak for 5 hours, use steam distillation for 1 hour, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct twice for 0.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 50-60 The relative density at ℃ is 1.12～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 45%, let stand for 4 hours, filter; ④recover ethanol, concentrate to relative density 1.15～1.25 at 50～80℃ , to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix well, add concentration of 55% ethanol to granulate, the dosage is 40% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add silica gel, mix evenly, and put into medicinal capsules to obtain capsules.

Example 79

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 10 times the amount of ethanol to reflux 3 times, each time for 1 hour, the concentration of ethanol is 30%, reclaim ethanol, concentrate to a relative density of 1.02～1.25 at 70 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 8 times the amount of water, soak for 0.5 hours, use steam distillation for 1 hour, collect the volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc., after extracting the volatile oil, add water and decoct 3 times, each decocting for 0.5 hours, combine the decoctions, filter, and concentrate the filtrate until it is at 80°C Relative density 1.02-1.30, let cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 48 hours, filter; ④recover ethanol, concentrate to relative density 1.05-1.45 at 80°C, and obtain medicine powder II ;

c. Take medicinal powder I and medicinal powder II, add the combination of dextrin and lactose, mix evenly, add 80% ethanol to granulate, and the dosage is 2% of the dosage of medicinal powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin Magnesium Oxide, mixed evenly, packed into medicinal capsules, to obtain capsules.

Example 80

A. get prescription, and prescription is standby with embodiment 2;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 9 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 30%, reclaim ethanol, concentrate to 75 ℃ when the relative density is 1.02～1.25, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 5 times the amount of water, soak for 5 hours, use steam distillation for 1 hour, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct twice for 0.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 75 ° C Density 1.12-1.20, let cool; ③Alcohol precipitation: Add ethanol to make the alcohol content reach 45%, let it stand for 4 hours, filter; ④Recover ethanol, concentrate to 75 ℃ when the relative density is 1.15-1.25, and obtain medicine powder II;

c. Take medicated powder I and medicated powder II, add the combination of PVP, sodium carboxymethyl starch, mix evenly, add concentration of 5% ethanol to granulate, the dosage is 80% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil ; Add silica gel, mix evenly, and pack into medicinal capsules to obtain capsules.

Example 81

A. get prescription, and prescription is standby with embodiment 9;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to relative density 1.02～1.15 when 65 ℃～70 ℃, dry, Get medicine powder I;

Extraction of medicinal powder II: ①Extract volatile oil: Combine four herbs such as honeysuckle, nepeta, peppermint, and windproof, add 6 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct 3 times, each decocting for 1 hour, combine the decoctions, filter, and concentrate the filtrate to 70-80 The relative density at ℃ is 1.15-1.20, let it cool: ③ Alcohol precipitation: Add ethanol to make the alcohol content reach 65%, let stand for 48 hours, filter; ④ Recover ethanol, concentrate to relative density 1.35-1.45 at 50-60, Get Powder II;

c. Get medicated powder I, medicated powder II, add the combination of starch, dextrin, lactose, PVP, carboxymethyl starch sodium, mix uniformly, add concentration and be 80% ethanol granulation, consumption is 80% of medicated powder and adjuvant consumption; The granules are dried and sprayed with volatile oil; the combination of magnesium stearate and silica gel is added, mixed evenly, and packed into medicinal capsules to obtain capsules.

Example 82

A. get prescription, and prescription is standby with embodiment 7;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 55°C to 60°C, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 3 times the amount of water, soak for 3 hours, use steam distillation for 3 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the relative density of the filtrate is 1.04-1.20 when it is concentrated to 80°C, and it is allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 30%, let it stand for 36 hours, and filter; ④Recover ethanol, and the relative density when concentrated to 80°C 1.14～1.25, get medicine powder II;

c. Get medicated powder I, medicated powder II, add the combination of starch, dextrin, lactose, PVP, carboxymethyl starch sodium, mix well, add concentration and be 10% ethanol granulation, consumption is 5% of medicated powder and auxiliary material consumption; The granules are dried and sprayed with volatile oil; the combination of magnesium stearate, silica gel and polyethylene glycol is added, mixed evenly, and packed into medicinal capsules to obtain capsules.

Example 83

A. get prescription, and prescription is standby with embodiment 10;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 8 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to 55 ℃～60 ℃ when relative density 1.02～1.15, dry, get Powder I;

Extraction of medicinal powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 4 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 80%, let it stand for 8 hours, and filter; ④Recover ethanol, concentrate to 70°C The relative density is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add the combination of lactose and PVP, mix well, add concentration of 30% ethanol to granulate, the dosage is 45% of the amount of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add poly72 Alcohol, mix evenly, pack into medicinal capsules, and obtain capsules.

Example 84

A. get prescription, and prescription is standby with embodiment 3;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40-80%, reclaim ethanol, concentrate to a relative density of 1.02-1.15 at 85°C-90°C, Dried to obtain medicated powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 4 times the amount of water, soak for 3 hours, use steam distillation for 6 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.04 to 1.20 at 85°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 50%, let it stand for 24 hours, and filter; ④Recover ethanol, concentrate to 85°C The relative density is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicinal powder I and medicinal powder II, add the combination of dextrin and lactose, mix evenly, add 70% ethanol to granulate, and the dosage is 50% of the dosage of medicinal powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin Magnesium Oxide, mixed uniformly, and packed into medicinal capsules to obtain capsules.

Example 85

A. get prescription, and prescription is standby with embodiment 4;

Extraction of medicinal powder I: Take Scutellaria baicalensis and add 6 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 50%, recover ethanol, concentrate to a relative density of 1.02 to 1.15 at 45°C to 50°C, and dry to obtain the medicinal powder I;

b. Extraction of Medicinal Powder II: ①Extraction of volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 2 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another container , the dregs continue to extract; ②Extraction: the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water to decoct twice, decoct for 2 hours for the first time, decoct for 1 hour for the second time, and combine the decoction , filtered, and the filtrate was concentrated to a relative density of 1.04 to 1.20 at 80°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 55%, stand for 16 hours, and filter; ④recover ethanol, concentrate to 80 The relative density at ℃ is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add starch, mix uniformly, add concentration and be 75% ethanol to granulate, the dosage is 8% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add magnesium stearate and mix evenly, Mix evenly, pack into medicinal capsules, and obtain capsules.

Example 86

A. get prescription, and prescription is standby with embodiment 7;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to a relative density of 1.10-1.15 at 65°C, and dry to obtain medicinal powder I ;

Extraction of Medicinal Powder II; ① Extraction of volatile oil: Combine the four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 2 times the amount of water, soak for 1 hour, use steam distillation for 6 hours, collect the volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.14 to 1.20 at 55°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let stand for 20 hours, and filter; ④Recover ethanol, concentrate to 55°C Density 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix evenly, add concentration of 50% ethanol to granulate, the dosage is 20% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add polyethylene glycol Alcohol, mix evenly, mix evenly, pack in medicinal capsules, obtain capsules.

Example 87

A. get prescription, and prescription is standby with embodiment 8;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 6 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to 70 ℃ when the relative density is 1.08～1.10, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 4 times the amount of water, soak for 3 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the relative density of the filtrate is 1.04-1.20 when concentrated to 50°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 75%, let it stand for 24 hours, and filter; ④recover ethanol, and concentrate to 50°C when the relative density 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add the combination of dextrin and PVP, mix evenly, add 45% ethanol to granulate, and the dosage is 15% of the amount of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin The combination of magnesium sulfate and silica gel is uniformly mixed and packed into medicinal capsules to obtain capsules.

Example 88

A. take prescription, and prescription is standby with embodiment 5;;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 35%, recycle ethanol, concentrate to 58 ℃ when relative density is 1.07～1.15, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 2 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the relative density of the filtrate was 1.04-1.20 when concentrated to 62°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 45%, let it stand for 12 hours, and filter; ④Recover ethanol, and concentrate to 62°C when the relative density 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix evenly, add 60% ethanol to granulate, the dosage is 50% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add silica gel, mix homogeneously, mix evenly, pack into medicinal capsules, and obtain capsules.

Example 89

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.05～1.10 (55 ℃～60 ℃ meter), dry , get medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 2 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.05-1.15 (70°C), and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 65%, let it stand for 24 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.14- 1.25 (measured at 70°C), the powder II was obtained;

c. Take medicated powder I and medicated powder II, add the combination of starch and dextrin, mix evenly, add concentration to be 55% ethanol to granulate, and the dosage is 20% of the amount of medicated powder and auxiliary materials; the granules are dried and sprayed into volatile oil; The magnesium stearate is mixed evenly, and packed into medicinal capsules to obtain capsules.

Example 90

A. get prescription, and prescription is standby with embodiment 4;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux 3 times, for the first time for 2 hours, for the second time for 1 hour, the concentration of ethanol is 85%, reclaim ethanol, and concentrate to a relative density of 1.02～ at 65°C 1.25, dry to obtain powder I;

c. Extraction of medicinal powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 6 times the amount of water, soak for 4 hours, use steam distillation for 7 hours, collect volatile oil and store in another container , the dregs continue to extract; ②Extraction: the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct twice, each decocting for 2 hours, combine the decoction, filter, and concentrate the filtrate to 75 The relative density at ℃ is 1.02～1.25, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 40 hours, filter; ④recover ethanol, concentrate to the relative density at 75 ℃ of 1.05～1.45, get Powder II;

d. Take medicinal powder I and medicinal powder II, add the combination of dextrin and lactose, mix evenly, add 75% ethanol to granulate, and the dosage is 60% of the dosage of medicinal powder and auxiliary materials; dry the granules, spray into volatile oil; add stearin Magnesium Oxide, mixed uniformly, packed into medicinal capsules, to obtain capsules.

Example 91

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux once, each time for 1 hour, the concentration of ethanol is 35%, recover ethanol, concentrate to a relative density of 1.02 to 1.25 at 50 ° C, dry, and obtain medicinal powder I ;

c. Extraction of medicinal powder II: ①Extraction of volatile oil: Combine the four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 1 times the amount of water, soak for 1 hour, use steam distillation for 1 hour, collect the volatile oil and store it in another container , and the dregs continue to extract: ②Extraction: the dregs of the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct twice, each decocting for 1 hour, combine the decoction, filter, and concentrate the filtrate to 60 The relative density at ℃ is 1.02～1.25, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 15%, let it stand for 6～40 hours, filter; ④Recover ethanol, concentrate to the relative density at 60℃ of 1.05～1.45 , to obtain medicinal powder II;

d. Take medicated powder I and medicated powder II, add the combination of starch and carboxymethyl starch sodium, mix evenly, add concentration and be 75% ethanol to granulate, and the consumption is 4% of the medicated powder and auxiliary material consumption; the granules are dried and sprayed into volatile oil; Add silica gel, mix evenly, and pack into medicinal capsules to obtain capsules.

Example 92

A. get prescription, and prescription is standby with embodiment 7;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 55°C, and dry to obtain medicinal powder I ;

c. Extraction of Medicinal Powder II: ①Extraction of volatile oil: Combine four medicinal materials such as honeysuckle, Nepeta, peppermint, and Fangfeng, add 4 times the amount of water, soak for 1 hour, use steam distillation for 5 hours, collect the volatile oil and store it in another container , the dregs continue to extract; ②Extraction: the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water to decoct twice, decoct for 2 hours for the first time, decoct for 1 hour for the second time, and combine the decoction , filtered, the filtrate was concentrated to a relative density of 1.04-1.20 at 70°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 80%, stand for 36 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

d. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix well, add concentration and be 70% ethanol to granulate, the dosage is 5% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add polyethylene glycol Alcohol, mix evenly, pack in medicinal capsules, obtain capsules.

Example 93

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.06 to 1.11 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④Recover ethanol, concentrate to 70°C The relative density is 1.16～1.20, and the medicine powder II is obtained;

c. Take medicinal powder I and medicinal powder II, add starch, the weight of starch is 0.5-2 times of the sum of the weight of medicinal powder I and medicinal powder II, mix evenly, add concentration of 65% ethanol to granulate, the dosage is 14% of the dosage of medicinal powder and auxiliary materials %; the granules are dried, sprayed into volatile oil; magnesium stearate is added, the weight of magnesium stearate is 2% of the sum of the weight of medicated powder I and medicated powder II, mixed evenly, and packed into medicinal capsules to obtain capsules.

Example 94

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux 3 times, each time for 1.5 hours, the concentration of ethanol is 95%, reclaim ethanol, concentrate to a relative density of 1.01～1.35 at 85° C., dry to obtain medicinal powder I ;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, Nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 5 times the amount of water, soak for 4 hours, use steam distillation for 3 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate until it is relatively hot at 85°C. Density 1.01-1.35, let cool; ③ Alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 32 hours, filter; ④ Recover ethanol, concentrate to a relative density of 1.01-1.45 at 90°C, dry to obtain a medicinal powder II;

c. Take medicinal powder I and medicinal powder II, spray into volatile oil, mix evenly, put them into medicinal capsules, and obtain capsules.

Example 95

A. get prescription, and prescription is standby with embodiment 3;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 30%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 45 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 4 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 50-55°C When the relative density is 1.04-1.25, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 18 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.04-1.45 at 50-90°C, Dried to obtain medicinal powder II;

c. Take medicinal powder I and medicinal powder II, spray into volatile oil, mix evenly, put them into medicinal capsules, and obtain capsules.

Example 96

A. get prescription, and prescription is standby with embodiment 4;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to a relative density of 1.02～1.30 at 45°C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, windproof and other four herbs, combine them together, add 1 times the amount of water, soak for 1 hour, use steam distillation for 1 hour, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 8 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.20 at 60～80℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add auxiliary materials, wherein the auxiliary materials are selected from dextrin and lactose, mix well, add concentration and be 75% ethanol to granulate, and the consumption is 4% of the amount of the medicinal powder and auxiliary materials; the particles are dried and sprayed into volatile oil; Add silica gel, mix evenly, and pack into medicinal capsules to obtain capsules.

Example 97

A. get prescription, and prescription is standby with embodiment 5;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 6 times of amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 90%, reclaim ethanol, be concentrated to relative density 1.02～1.20 in the time of 45～50 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 3 times the amount of water, soak for 3 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and the volatile oil extracted from honeysuckle, for 2 hours for the first time, and 1 hour for the second time, combine the decoction, filter, and concentrate the filtrate When the relative density is 1.05-1.20 at 60-75°C, let it cool; ③Alcohol precipitation: Add ethanol to make the alcohol content reach 60%, let stand for 16 hours, and filter; ④Recover ethanol, concentrate to 60-70°C The relative density is 1.05-1.20, and dried to obtain the medicinal powder II;

c. Take medicated powder I and medicated powder II, add auxiliary materials, wherein starch, mix evenly, add concentration and be 55% ethanol to granulate, the dosage is 25% of the amount of medicinal powder and auxiliary materials; dry the granules, spray into volatile oil; add polyethylene glycol , mix evenly, and pack into medicinal capsules to obtain capsules.

Example 98

A. get prescription, and prescription is standby with embodiment 6;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, the first time is 2 hours, the second time is 1 hour, the concentration of ethanol is 70%, reclaim ethanol, concentrate to the relative density when 55～60 ℃ 1.06～1.25, dry to obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil. When the relative density is 1.04-1.30 at 60-75°C, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 12 hours, and filter; ④Recover ethanol, concentrate to 70-80°C The relative density is 1.05-1.30, and dried to obtain the medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, the weight of starch used is 6 times of the sum of the weight of medicated powder I and medicated powder II, mix evenly, add concentration and be 70% ethanol to granulate, and the dosage is 50% of the amount of medicated powder and auxiliary materials The granules are dried and sprayed into volatile oil; magnesium stearate is added, and the weight of the magnesium stearate used is 0.1% of the sum of the weight of medicated powder I and medicated powder II, mixed evenly, and packed into medicinal capsules to obtain capsules.

Example 99

A. get prescription, and prescription is standby with embodiment 7;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to relative density 1.05～1.25 at 50～70 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 3 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 8 hours, filter; ④Recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add auxiliary materials, the auxiliary materials are selected from the combination of dextrin and lactose, the weight of the used auxiliary materials is 0.5 times of the sum of the weight of medicated powder I and medicated powder II, mix evenly, and add concentration of 30% ethanol to granulate , consumption is 5% of medicated powder and adjuvant consumption; Granule is dried, sprays into volatile oil; Add lubricant, lubricant is selected from one or more combinations of magnesium stearate, silica gel, and the weight of used lubricant is medicated powder 1 and 8% of the sum of the weight of the medicinal powder II, mixed uniformly, and packed into medicinal capsules to obtain capsules.

Example 100

A. get prescription, and prescription is standby with embodiment 8;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, be concentrated to relative density 1.05～1.25 at 50～60 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 70%, let stand for 18 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add auxiliary materials, auxiliary materials are selected from the combination of starch, dextrin, lactose, the weight of used auxiliary materials is 3 times of the sum of the weight of medicated powder I and medicated powder II, mix evenly, and add concentration is 40% Ethanol granulation, consumption is 30% of medicated powder and auxiliary material consumption; Granule is dried, sprays into volatile oil; Add lubricant, lubricant is selected from the combination of magnesium stearate, silica gel, polyethylene glycol, and the weight of used lubricant is 2% of the weight sum of medicinal powder I and medicinal powder II, mixed evenly, and packed into medicinal capsules to obtain capsules.

Example 101

A. get prescription, and prescription is standby with embodiment 9;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 5.5 times of amount of ethanol to reflux twice, each 2 hours, the concentration of ethanol is 55%, reclaim ethanol, be concentrated to relative density 1.05～1.15 when 55～65 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2.5 times the amount of water, soak for 1.5 hours, use steam distillation for 3.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.11, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 40%, let stand for 40 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.15 at 65～75℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, the weight of starch is 2 times of the sum of the weight of medicated powder I and medicated powder II, mix well, add concentration and be 60% ethanol to granulate, consumption is 50% of medicated powder and auxiliary material consumption; The granules are dried, sprayed into volatile oil; magnesium stearate is added, the weight of the magnesium stearate is 2% of the sum of the weight of medicated powder I and medicated powder II, mixed evenly, packed into medicinal capsules to obtain capsules.

Example 102

A. get prescription, and prescription is standby with embodiment 10;

B. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7.5 times of amount of ethanol to reflux twice, each time for 3 hours, the concentration of ethanol is 55%, reclaim ethanol, be concentrated to relative density 1.05～1.15 at 55～65 ℃, dry, get Medicinal powder I; extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, windproof and other four medicinal materials, combine them together, add 2.5 times the amount of water, soak for 1.5 hours, use steam distillation for 3 hours, collect volatile oil and ②Extraction: add water to decoct the remaining medicinal materials, Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate until Relative density at 65-70°C is 1.04-1.11, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 40%, let it stand for 40 hours, filter; ④Recover ethanol, concentrate to relative density at 65-75°C 1.05 to 1.15, dry to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add starch, the weight of starch is 1 time of the sum of the weight of medicated powder I and medicated powder II, mix evenly, add concentration and be 40% ethanol to granulate, and the dosage is 15% of the amount of medicated powder and auxiliary materials; The granules are dried, sprayed into volatile oil; magnesium stearate is added, the weight of the magnesium stearate is 1% of the sum of the weight of medicated powder I and medicated powder II, mixed evenly, packed into medicinal capsules to obtain capsules.

Example 103

(a). Get prescription, and prescription is standby with embodiment 1;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and mint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted once with 85% ethanol, extracted for 4 hours, recovered ethanol, added appropriate amount of water and boiled, while hot Filtrate, and the filtrate is ready for use; extract the dregs of Scutellaria baicalensis ethanol and the dregs of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oils with gardenia, forsythia, crocodile, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, Decoct licorice with water once, extract for 4 hours, combine the decoctions, filter, concentrate the filtrate to a relative density of 1.03-1.25 at 50-60°C, add ethanol to make the alcohol content reach 80%, let stand, filter, and recover the filtrate Concentrate with ethanol until the relative density is 1.04-1.40 at 50-60°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

(c). Take the medicinal powder, spray it into volatile oil; mix evenly, put it into medicinal capsules, and obtain capsules.

Example 104

(a). Get prescription, and prescription is standby with embodiment 3;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted 4 times with 45% ethanol, each time for 0.5 hours, and the ethanol is recovered, and an appropriate amount of water is added to boil. Filtrate hot and reserve the filtrate; extract the dregs of Scutellaria baicalensis ethanol and the dregs of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oil with gardenia, forsythia, crocodile, silkworm, rehmannia glutinosa, shegan, platycodon grandiflora, and cicada slough 1. Add water to licorice and decoct 4 times, each time for 0.5 hours, combine the decoction, filter, and concentrate the filtrate until the relative density is 1.03-1.25 at 60-70°C, add ethanol to make the alcohol content reach 40-80%, let stand, filter The ethanol is recovered from the filtrate and concentrated to a relative density of 1.04 to 1.40 at 70 to 80°C, and the ethanol extract of Scutellaria baicalensis is added, concentrated and dried to obtain a medicinal powder;

(c). Take the medicinal powder and add the conventional auxiliary materials of the capsule, granulate according to the conventional preparation method of the capsule, spray into the volatile oil; mix evenly, put it into a medicinal capsule, and obtain the capsule.

Example 105

(a). Get prescription, and prescription is standby with embodiment 5;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and mint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted 3 times with 60% ethanol, each time for 2 hours, and the ethanol is recovered, and an appropriate amount of water is added to boil. Filtrate hot and reserve the filtrate; extract the dregs of Scutellaria baicalensis ethanol and the dregs of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oil with gardenia, forsythia, crocodile, silkworm, rehmannia glutinosa, shegan, platycodon grandiflora, and cicada slough 1. Add water to licorice and decoct twice, each time for 2 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.03-1.25 at 60°C, add ethanol to make the alcohol content reach 50%, let stand, filter, and recover the filtrate Concentrate with ethanol until the relative density is 1.04-1.40 at 50°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

(c). Take the medicinal powder and add the conventional auxiliary materials of the capsule, granulate according to the conventional preparation method of the capsule, spray into the volatile oil; mix evenly, put it into a medicinal capsule, and obtain the capsule.

Example 106

(a). Get prescription, and prescription is standby with embodiment 7;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted 3 times with 75% ethanol, every 3 hours, recover ethanol, add appropriate amount of water to boil, while hot Filtrate, and the filtrate is ready for use; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oils with gardenia, forsythia, scrophulariaceae, silkworm, rehmannia glutinosa, shegan, platycodon grandiflorum, cicada slough, Decoct licorice with water for 3 times, each time for 3 hours, combine the decoction, filter, concentrate the filtrate to a relative density of 1.06-1.11 at 60-80°C, add ethanol to make the alcohol content reach 65%, let stand, filter, and filtrate Recover ethanol and concentrate until the relative density is 1.10-1.30 at 60-80°C, add the ethanol extract of Scutellaria baicalensis, concentrate and dry to obtain medicinal powder;

(c). Take the medicine powder, add sucrose powder, mix evenly, add concentration and be 75% ethanol to granulate, the dosage is 50% of the dosage of the medicine powder and auxiliary materials; the granules are dried, sprayed into volatile oil; mix well, pack into medicinal capsules , to obtain capsules.

Example 107

(a). Get prescription, and prescription is standby with embodiment 8;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and mint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 55% ethanol, each time for 1 hour, and the ethanol is recovered, and an appropriate amount of water is added to boil. Filtrate hot and reserve the filtrate; extract the dregs of Scutellaria baicalensis ethanol and the dregs of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oil with gardenia, forsythia, crocodile, silkworm, rehmannia glutinosa, shegan, platycodon grandiflora, and cicada slough 1. Add water to licorice and decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.06-1.11 at 60-80°C, add ethanol to make the alcohol content reach 55-65%, let stand, filter The ethanol is recovered from the filtrate and concentrated to a relative density of 1.10 to 1.30 at 60 to 80°C, and the ethanol extract of Scutellaria baicalensis is added, concentrated and dried to obtain a medicinal powder;

(c). Take the medicinal powder, add common auxiliary materials for granules, mix evenly, add ethanol with a concentration of 20% to granulate; dry the granules, spray into volatile oil; mix evenly, pack into medicinal capsules to obtain capsules.

Example 108

(a). Get prescription, and prescription is standby with embodiment 10;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 60% ethanol, the first time is 2 hours, the second time is 1 hour, and recovered Ethanol, add appropriate amount of water to boil, filter while it is hot, and the filtrate is for later use; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oils with gardenia, forsythia, scrophulariaceae, silkworm, Rehmannia glutinosa, shegan, bellflower, cicada slough, and licorice are decocted twice with water, the first time is 2 hours, and the second time is 1 hour. Combine the decoctions, filter, and concentrate the filtrate until the relative density is 1.06-1.11 at 60-80°C. Add ethanol to make the alcohol content reach 55-65%, let it stand still, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.10-1.30 at 60-80°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

(c). Take medicinal powder, add sucrose powder, mix uniformly, spray into volatile oil; mix uniformly, pack into medicinal capsules, and obtain capsules.

Example 109

(a). Get prescription, and prescription is standby with embodiment 9;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted with 65% ethanol for 3 times, the first time is 3 hours, the second time is 1 hour, and the second time is 1 hour. Three times for 1 hour, recover ethanol, add appropriate amount of water to boil, filter while hot, and set aside the filtrate; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, nepeta, windproof, and mint after extracting volatile oils with gardenia, forsythia, Scrophulariaceae, silkworm, rehmannia glutinosa, shegan, Platycodon grandiflorum, cicada slough, and licorice are decocted with water for 3 times, the first time is 3 hours, the second time is 1 hour, the third time is 1 hour, the decoction is combined, filtered, and the filtrate is concentrated until The relative density is 1.06-1.11 at 60-80°C, add ethanol to make the alcohol content reach 55-65%, let it stand still, filter, recover ethanol from the filtrate and concentrate until the relative density is 1.10-1.30 at 60-80°C, add baicalin ethanol The extract is concentrated and dried to obtain medicinal powder;

(c). Take the medicated powder, add PVP, mix uniformly, add concentration and be 50% ethanol to granulate, and the consumption is 15% of the medicated powder and auxiliary material consumption; The granule is dried, sprayed into volatile oil; Mixed uniformly, pack in the medicinal capsule, namely Get capsules.

Example 110

(a). Get prescription, and prescription is standby with embodiment 7;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted 3 times with 60% ethanol, the first time is 3 hours, the second time is 1 hour, the second time Three times for 1 hour, recover ethanol, add appropriate amount of water to boil, filter while hot, and set aside the filtrate; extract the medicinal residues of Scutellaria baicalensis ethanol and the medicinal residues of honeysuckle, nepeta, windproof, and mint after extracting volatile oils with gardenia, forsythia, Scrophulariaceae, silkworm, rehmannia glutinosa, shegan, bellflower, cicada slough, and licorice are decocted twice, the first time is 3 hours, the second time is 1 hour, the decoctions are combined, filtered, and the filtrate is concentrated until the relative The density is 1.06-1.11, add ethanol to make the alcohol content reach 55-65%, let it stand still, filter, recover the ethanol from the filtrate and concentrate it to a relative density of 1.10-1.30 at 70-80°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry , Dede medicine powder;

(c). Take the medicated powder, add starch, mix uniformly, add concentration and be 75% ethanol to granulate, and the dosage is 30% of the medicated powder and auxiliary material consumption; the granules are dried, sprayed into volatile oil; mixed uniformly, packed in medicinal capsules, That is, capsules are obtained.

Example 111

(a). Get prescription, and prescription is standby with embodiment 10;

(b). The above fourteen flavors, honeysuckle, nepeta, windproof, and peppermint extract volatile oil, and the distilled aqueous solution is collected in another device; Scutellaria baicalensis is extracted twice with 65% ethanol, each time for 2 hours, and the ethanol is recovered, and an appropriate amount of water is added to boil. Filtrate hot and reserve the filtrate; extract the dregs of Scutellaria baicalensis ethanol and the dregs of honeysuckle, nepeta, windproof, and peppermint after extracting volatile oil with gardenia, forsythia, crocodile, silkworm, rehmannia glutinosa, shegan, platycodon grandiflora, and cicada slough 1. Add water to licorice and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.06 to 1.11 at 70°C, and ethanol is added to make the alcohol content reach 60%. place, filter, and recover ethanol from the filtrate and concentrate to a relative density of 1.16 to 1.20 at 70°C, add the ethanol extract of Scutellaria baicalensis, concentrate, and dry to obtain medicinal powder;

(c). Take the medicinal powder, add one or more combinations of auxiliary materials such as sucrose powder, lactose, starch, dextrin, lactose, PVP, sodium carboxymethyl starch, mix evenly, add concentration and be 70% ethanol to granulate, The dosage capsule is 5% to 50% of the dosage of the medicinal powder and auxiliary materials; the granules are dried and sprayed into volatile oil; mixed evenly and packed into medicinal capsules to obtain the gel.

Example 112

a. Take 36g of honeysuckle, 36g of skullcap, 36g of nepeta, 36g of gardenia, 36g of forsythia, 36g of scrophulariaceae, 22g of silkworm, 55g of rehmannia glutinosa, 11g of shegan, 22g of bellflower, 22g of mint, 22g of cicada slough, 22g of windproof, 11g of licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times the amount of ethanol to reflux 3 times, each time for 3 hours, the concentration of ethanol is 90%, reclaim ethanol, concentrate to a relative density of 1.02～1.25 at 70 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 8 times the amount of water, soak for 5 hours, use steam distillation for 1 hour, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water to decoct 3 times, each decocting for 3 hours, combine the decoctions, filter, and concentrate the filtrate to 50°C When the relative density is 1.02-1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 48 hours, and filter; ④recover ethanol, concentrate to a relative density of 1.05-1.45 at 80°C, and obtain a medicinal powder II;

c. Take medicated powder I and medicated powder II, add the combination of soluble starch and dextrin, mix evenly, use 50% water to granulate the medicated powder and auxiliary materials, dry the granules, and spray into volatile oil to obtain granules.

Example 113

a. Take 145g of honeysuckle, 145g of skullcap, 145g of nepeta, 145g of gardenia, 145g of forsythia, 145g of scrophulariae, 85g of silkworm, 215g of rehmannia, 45g of shegan, 85g of bellflower, 85g of mint, 85g of cicada slough, 85g of windproof, and 45g of licorice. ;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 40%, recover ethanol, concentrate to a relative density of 1.05 to 1.15 at 55°C to 60°C, and dry , get medicinal powder I;

Extraction of medicinal powder II: ①Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 3 times the amount of water, soak for 1 hour, use steam distillation for 2 to 6 hours, and collect the volatile oil in another device Preserve, and continue to extract the dregs; ②Extraction: the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, decocting for 2 hours for the first time, decocting for 1 hour for the second time, and decocting together liquid, filtered, and the filtrate was concentrated to a relative density of 1.04 to 1.20 at 60°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, stand for 8 hours, and filter; ④recover ethanol, concentrate to The relative density at 70°C is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add sucrose powder, mix well, use 8% water to granulate the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 114

a. Take honeysuckle 145g, scutellaria baicalensis 45g, nepeta 36g, gardenia 36g, forsythia 145g, scrophulariaceae 36g, silkworm 22g, rehmannia glutinosa 55g, shegan 11g, bellflower 85g, mint 85g, cicada slough 22g, windproof 85g, licorice 45g for later use ;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 10 times the amount of ethanol to reflux 3 times, each time for 1 hour, the concentration of ethanol is 30%, reclaim ethanol, concentrate to a relative density of 1.02～1.08 at 45°C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 8 times the amount of water, soak for 0.5 hours, use steam distillation for 8 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, add water to decoct 1 to 3 times, each time decocting for 0.5 to 3 hours, combine the decoction, filter, and concentrate the filtrate When the relative density is 1.02-1.20 at 40-50°C, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 48 hours, and filter; ④Recover ethanol, concentrate to 60-70°C The relative density is 1.05～1.15, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add dextrin, mix evenly, use 70% water of the medicated powder and auxiliary materials to granulate, dry the granules, spray into volatile oil to obtain granules.

Example 115

a. Take 86.70g of honeysuckle, 86.70g of Scutellaria baicalensis, 86.70g of Schizonepeta, 86.70g of gardenia (fried), 86.70g of forsythia, 86.70g of Scrophulariaceae, 51.55g of silkworm (made from ginger), 129.81g of rehmannia glutinosa, and 26.70g of shegan , bellflower 51.55g, peppermint 51.55g, windproof 51.55g, cicada slough 51.55g, licorice 26.70g for spare;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to a relative density of 1.02～1.25 at 45°C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 7 times the amount of water, soak for 4 hours, use steam distillation for 5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: divide the rest of the medicinal materials into the medicinal dregs after extracting the volatile oil from Scutellaria baicalensis and honeysuckle, add water to decoct 3 times, and decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 50 ℃ relative density 1.02～1.30, let cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 65%, let it stand for 24 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.45 at 50℃, and obtain medicinal powder II;

c. Take medicinal powder I and medicinal powder II, add 4 times the mixture of sucrose powder, soluble starch, and dextrin, wherein the ratio of sucrose powder: soluble starch: dextrin is 1:1:2, and the dosage is 10% of the dosage of medicinal powder and auxiliary materials Granulate with water, dry the granules, and spray into volatile oil to obtain granules.

Example 116

a. Take 53.54g of honeysuckle, 53.54g of Scutellaria baicalensis, 53.54g of Nepeta, 53.54g of Gardenia (fried), 53.54g of Forsythia, 53.54g of Scrophulariaceae, 33.57g of silkworm (made from ginger), 86.27g of Rehmannia glutinosa, 17.54g of Shegan , Bellflower 33.57g, mint 33.57g, Fangfeng 33.57g, cicada slough 33.57g, licorice 17.54g for spare;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 4 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 50%, recover ethanol, concentrate to a relative density of 1.02 to 1.15 at 55°C to 60°C, and dry , get medicinal powder I;

Extraction of Medicinal Powder II: ①Extraction of volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 60°C, and let it cool; ③Alcohol precipitation: Add ethanol to make the alcohol content reach 80%, let stand for 36 hours, and filter; ④Recover ethanol, concentrate to 70°C The relative density is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add dextrin and mix evenly, granulate with 30% water of the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 117

a. Take honeysuckle 86.70g, scutellaria baicalensis 53.54g, nepeta 86.70g, gardenia (fried) 53.54g, forsythia 86.70g, scrophulariaceae 53.54g, silkworm (made from ginger) 51.55g, rehmannia glutinosa 86.27g, shegan 26.70g , Bellflower 33.57g, mint 51.55g, Fangfeng 33.57g, cicada slough 51.55g, licorice 17.54g for spare;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 10 times the amount of ethanol to reflux 3 times, for the first time for 3 hours, for the second time for 2 hours, for the third time for 1 hour, the concentration of ethanol is 90%, reclaim ethanol, concentrate to 50 The relative density at ℃ is 1.02～1.25, and it is dried to obtain powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, double the amount of water, soak for 5 hours, use steam distillation for 8 hours, collect the volatile oil and store it in another container, and the medicinal residue Continue to extract; ②Extraction: the rest of the medicinal materials and the dregs of Scutellaria baicalensis and honeysuckle, etc. extract the volatile oil, add water and decoct 3 times, the first time is 3 hours, the second time is 2 hours, the third time is 1 hour, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.02-1.30 at 80°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 85%, let it stand for 40 hours, and filter; ④recover ethanol, concentrate to 50°C When the relative density is 1.05-1.45, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add soluble starch, mix evenly, use 70% water to granulate the medicated powder and auxiliary materials, dry the granules, and spray volatile oil to obtain granules.

Example 118

a. Take 75g honeysuckle, 75g skullcap, 75g nepeta, 75g gardenia, 75g forsythia, 75g scrophulariaceae, 47g silkworm, 115g rehmannia glutinosa, 25g shegan, 47g bellflower, 47g mint, 47g cicada slough, 47g windproof, 24g licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, for the first time for 2 hours, and for the second time for 1 hour, the concentration of ethanol is 30%, reclaim ethanol, and concentrate to a relative density of 1.02～ at 60°C 1.25, dry to obtain powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 4.5 hours, use steam distillation for 7 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs: ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water to decoct twice, each time for 2 hours, combine the decoctions, filter, and concentrate the filtrate to 70°C When the relative density is 1.02-1.30, let it cool; ③Alcohol precipitation: Add ethanol to make the alcohol content reach 55%, let it stand for 20 hours, and filter; ④Recover the ethanol, concentrate to a relative density of 1.05-1.45 at 60°C to obtain a medicinal powder II;

c. Get medicated powder I and medicated powder II, add the combination of sucrose powder and dextrin, mix evenly, use 40% water to granulate the amount of medicated powder and auxiliary materials, dry the granules, and spray into volatile oil to obtain granules.

Example 119

a. Take 69g of honeysuckle, 69g of skullcap, 69g of nepeta, 69g of gardenia, 69g of forsythia, 69g of scrophulariaceae, 40g of silkworm, 100g of rehmannia glutinosa, 20g of shegan, 40g of bellflower, 40g of mint, 40g of cicada slough, 40g of windproof, 20g of licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 6 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.25 at 55 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 3 hours, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice for 2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 55°C When the relative density is 1.02-1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 25%, let it stand for 40 hours, and filter; ④recover ethanol, concentrate to a relative density of 1.05-1.45 at 55°C to obtain a medicinal powder II;

c. Get medicated powder I and medicated powder II, add the combination of sucrose powder and soluble starch, mix evenly, use 60% water to granulate the amount of medicated powder and auxiliary materials, dry the granules, and spray into volatile oil to obtain granules.

Example 120

a. Take 75g honeysuckle, 69g skullcap, 75g nepeta, 69g gardenia, 75g forsythia, 75g scrophulariaceae, 40g silkworm, 115g rehmannia glutinosa, 25g shegan, 40g bellflower, 40g mint, 40g cicada slough, 47g windproof, 20g licorice for later use ;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 3 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 50%, recover ethanol, concentrate to a relative density of 1.02 to 1.15 at 55°C to 60°C, and dry , get medicinal powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 7 times the amount of water, soak for 3 hours, use steam distillation for 6 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction is 3 hours, the second decoction is 2 hours, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 60-75°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 40%, let it stand for 36 hours, and filter; ④recover ethanol, concentrate to The relative density at 60-75°C is 1.14-1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add sucrose powder, mix well, use 8% water to granulate the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 121

a. Take 72g of honeysuckle, 72g of Scutellaria baicalensis, 72g of nepeta, 72g of gardenia, 72g of forsythia, 72g of scrophulariaceae, 43g of silkworm, 108g of rehmannia glutinosa, 22g of shegan, 43g of bellflower, 43g of mint, 43g of cicada slough, 43g of windproof, 22g of licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5.5 times the amount of ethanol to reflux and extract twice, each time for 1.5 hours, the concentration of ethanol is 40-80%, reclaim ethanol, concentrate to a relative density of 1.02-1.15 at 55°C-60°C , dry to obtain powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 5.5 times the amount of water, soak for 2.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 1-3 hours, the second decoction for 0.5-2 hours, Combine the decoctions, filter, concentrate the filtrate to a relative density of 1.04-1.20 at 74°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④Recover the ethanol and concentrate When the relative density is 1.14-1.25 at 74°C, the medicinal powder II is obtained;

c. Take medicinal powder I and medicinal powder II, add the combination of sucrose powder, soluble starch and dextrin, mix well, use 15% of the amount of medicinal powder and auxiliary materials to granulate, dry the granules, and spray into volatile oil to obtain granules .

Example 122

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux 3 times, for the first time for 3 hours, for the second time for 2 hours, for the third time for 1 hour, the concentration of ethanol is 30～90%, reclaim ethanol, concentrate to Relative density at 45°C is 1.02-1.25, dried to obtain powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 7 times the amount of water, soak for 3 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct 3 times, the first time is 3 hours, the second time is 2 hours, the third time is 0.5 hours, combined and decocted liquid, filtered, and the filtrate was concentrated to a relative density of 1.02-1.30 (50-80°C), and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 75%, stand for 48 hours, and filter; ④Recover ethanol, concentrate When the relative density is 1.05-1.45 at 80°C, the medicinal powder II is obtained;

c. Take medicated powder I and medicated powder II, add soluble starch, mix evenly, use 70% water to granulate the medicated powder and auxiliary materials, dry the granules, and spray volatile oil to obtain granules.

Example 123

A. get prescription, and prescription is standby with embodiment 3;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 10 times the amount of ethanol to reflux 3 times, each time for 1 hour, the concentration of ethanol is 40%, recover ethanol, concentrate to 85 ℃ when the relative density is 1.04～1.20, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Combine four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, add 7 times the amount of water, soak for 4 hours, use steam distillation for 2 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct twice for 3 hours each time, combine the decoctions, filter, and when the filtrate is concentrated to 75°C Density 1.02-1.10, let cool; ③Alcohol precipitation: Add ethanol to make the alcohol content reach 45%, let it stand for 12 hours, filter; ④Recover ethanol, concentrate to 75 ℃ when the relative density is 1.15-1.25, and obtain medicine powder II;

c. Get medicated powder I and medicated powder II, add the combination of sucrose powder and soluble starch, mix evenly, use 70% water to granulate the medicated powder and auxiliary materials, dry the granules, and spray into volatile oil to obtain granules.

Example 124

A. get prescription, and prescription is standby with embodiment 5;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times of amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 30%, reclaim ethanol, concentrate to 55 ℃～60 ℃ when relative density 1.02～1.25, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 0.5 hours, use steam distillation for 3.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials and the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting the volatile oil, add water and decoct twice, the first time for 3 hours, the second time for 1 hour, combine the decoction, filter, and filtrate When concentrated to 50°C, the relative density is 1.09-1.20, and let cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 55%, let it stand for 24 hours, and filter; ④Recover ethanol, and when concentrated to 60°C, the relative density is 1.15-1.25 , to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add dextrin, mix evenly, granulate with 5% water of the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 125

A. get prescription, and prescription is standby with embodiment 9;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 8 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to 70 ℃ when relative density is 1.02～1.15, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 6 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filter, the relative density of the filtrate is 1.04-1.20 when concentrated to 70°C, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let it stand for 8 hours, and filter; ④Recover ethanol, concentrate to 70°C Density 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add dextrin, mix evenly, granulate with 50% water of the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 126

A. get prescription, and prescription is standby with embodiment 2;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 5 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to 80 ℃ when relative density is 1.02～1.15, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 4 times the amount of water, soak for 3 hours, use steam distillation for 6 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filter, concentrate the filtrate to 60°C relative density 1.04～1.20, let cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 36 hours, filter; ④recover ethanol, concentrate to 50°C relative density 1.14～1.25, get medicine powder II;

c. Get medicated powder I and medicated powder II, add the combination of sucrose powder and soluble starch, mix well, use 50% water of the medicated powder and auxiliary materials to granulate, dry the granules, and spray into volatile oil to obtain granules.

Example 127

A. get prescription, and prescription is standby with embodiment 4;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to 75 ℃ ~ 80 ℃ when the relative density is 1.02 ~ 1.15, dry, Get medicine powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filter, concentrate the filtrate to a relative density of 1.04-1.20 at 75°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 30%, let it stand for 16 hours, and filter; ④Recover ethanol, concentrate to a relative density of 75°C 1.14～1.25, get medicine powder II;

c. Take medicated powder I and medicated powder II, add soluble starch, mix well, use 35% water to granulate the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 128

A. get prescription, and prescription is standby with embodiment 8;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux and extract twice, each time for 2 hours. The concentration of ethanol is 40-80%, reclaim ethanol, and concentrate to 45°C-50°C when the relative density is 1.02-1.15, Dried to obtain medicated powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filter, the relative density of the filtrate is 1.04-1.20 when concentrated to 50°C, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 30%, let stand for 16 hours, filter: ④recover ethanol, concentrate to 70°C Density 1.14～1.25, get medicine powder II;

c. get medicated powder I, medicated powder II, add one or more combination of auxiliary materials such as sucrose powder, soluble starch, dextrin, ring auxiliary material, mix uniformly, consumption is the water granulation of 30% of medicated powder and auxiliary material consumption, will The granules are dried and sprayed with volatile oil to obtain granules.

Example 129

A. get prescription, and prescription is standby with embodiment 6;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 7 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 70%, recover ethanol, concentrate to 55 ° C relative density 1.07～1.15, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, the relative density of the filtrate is 1.04-1.12 when concentrated to 55°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 25%, let it stand for 20 hours, and filter; ④Recover ethanol, concentrate to 55°C Density 1.14～1.22, get medicine powder II;

c. Get medicinal powder I, medicinal powder II, add the combination of sucrose powder and dextrin, mix evenly, use 30% water to granulate the dosage of medicinal powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 130

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux twice, for the first time for 2 hours, and for the second time for 1 hour, the concentration of ethanol is 45%, reclaim ethanol, and concentrate to a relative density of 1.02～ at 65°C 1.25, dry to obtain powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 5 times the amount of water, soak for 3.5 hours, use steam distillation for 3.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction is 3 hours, the second decoction is 2 hours, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 75°C, let it cool: ③alcohol precipitation: add ethanol to make the alcohol content reach 15%, let it stand for 40 hours, and filter; ④recover ethanol, concentrate to 75°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicinal powder I and medicinal powder II, add a combination of sucrose powder and dextrin, and make granules with 8% water of the medicinal powder and auxiliary materials, dry the granules, and spray into volatile oil to obtain granules.

Example 131

A. get prescription, and prescription is standby with embodiment 4;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 6 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 55%, reclaim ethanol, concentrate to relative density 1.02～1.25 when 50 ℃～65 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction is 3 hours, the second decoction is 2 hours, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 60-75°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 25%, let it stand for 18 hours, and filter; ④Recover ethanol and concentrate to The relative density at 66°C is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add one or more combinations of auxiliary materials such as sucrose powder, soluble starch, dextrin, and cyclic auxiliary materials. Dry and spray into volatile oil to obtain granules.

Example 132

A. get prescription, and prescription is standby with embodiment 8;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 8 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.02 to 1.15 at 58 ° C, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 3 times the amount of water, soak for 3 hours, use steam distillation for 5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 30 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add dextrin, mix evenly, use 18% water to granulate the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 133

A. get prescription, and prescription is standby with embodiment 7;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 6.5 times the amount of ethanol to reflux and extract twice, each time for 2 hours, the concentration of ethanol is 55%, reclaim ethanol, concentrate to a relative density of 1.02～1.15 at 57 ° C, dry, and obtain medicinal powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 2.5 times the amount of water, soak for 2.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.04-1.20 at 70°C, and let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 25%, let stand for 25 hours, and filter; ④Recover ethanol, concentrate to 70°C When the relative density is 1.14～1.25, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add soluble starch, mix evenly, use 25% water to granulate the amount of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 134

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add soluble starch, cyclodextrin adjuvant or a combination of both, the amount of used adjuvant is 0.4 to 3 times the weight of medicated powder I and medicated powder II, mix evenly, add water to granulate, The dosage is 10-30% of that of the medicinal powder and auxiliary materials.

Example 135

A. get prescription, and prescription is standby with embodiment 1;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 12 times the amount of ethanol to reflux 3 times, each time for 3 hours, the concentration of ethanol is 95%, reclaim ethanol, concentrate to a relative density of 1.00～1.35 at 85° C., dry to obtain medicinal powder I ;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 8 times the amount of water, soak for 5 hours, use steam distillation for 8 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, and decoct for 3 hours each time, combine the decoctions, filter, and concentrate the filtrate until it is relatively hot at 85°C. Density 1.01-1.35, let cool; ③ Alcohol precipitation: Add ethanol to make the alcohol content reach 85%, let stand for 48 hours, filter; ④ Recover ethanol, concentrate to a relative density of 1.01-1.45 at 50-90°C, dry, Get Powder II;

c. Take medicinal powder I and medicinal powder II, add common auxiliary materials for granules to granulate, dry the granules, and spray volatile oil to obtain granules.

Example 136

A. get prescription, and prescription is standby with embodiment 2;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux once, extract for 3 hours, the concentration of ethanol is 30%, recover ethanol, concentrate to a relative density of 1.03-1.35 at 45°C, dry, and obtain medicinal powder I;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 1 times the amount of water, soak for 0.5 hours, use steam distillation for 1 hour, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting volatile oil, extract for 3 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.05~ at 50°C. 1.35, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 10%, let it stand for 4 hours, filter; ④Recover ethanol, concentrate to a relative density of 1.00-1.45 at 50°C, dry, and obtain medicinal powder II;

c. Take medicinal powder I and medicinal powder II, add common auxiliary materials for granules to granulate, dry the granules, and spray volatile oil to obtain granules.

Example 137

A. get prescription, and prescription is standby with embodiment 4;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 90%, recover ethanol, concentrate to a relative density of 1.02 to 1.30 at 80 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 7 times the amount of water, soak for 1 hour, use steam distillation for 1 hour, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 36 hours, filter; ④recover ethanol, concentrate to the relative density of 1.02～1.30 at 60～80℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add the combination of sucrose powder and soluble starch, granulate with water, the dosage is 50% of the dosage of medicated powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 138

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.02～1.30 at 45 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 1 times the amount of water, soak for 4 hours, use steam distillation for 7 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 80%, let it stand for 8-36 hours, and filter; ④ recover the ethanol, concentrate to a relative density of 1.05 at 60-80 ℃ ~1.30, dry to obtain powder II;

c. Take medicinal powder I and medicinal powder II, add dextrin, granulate with water, the dosage is 8% of the dosage of medicinal powder and auxiliary materials, dry the granules, spray into volatile oil to obtain granules.

Example 139

A. get prescription, and prescription is standby with embodiment 6;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times of amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 60%, reclaim ethanol, be concentrated to relative density 1.02～1.30 in the time of 45～80 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 4 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 30%, let stand for 24 hours, filter; ④recover ethanol, concentrate to relative density 1.03～1.30 at 60～80℃ , dried to obtain medicinal powder II;

c. Take medicated powder I and medicated powder II, add one or more combinations of auxiliary materials such as sucrose powder, soluble starch, dextrin, and ring auxiliary materials, granulate with water, and the consumption is 10% of the amount of medicinal powder and auxiliary materials, and the granules are dried. Spray into volatile oil to obtain granules.

Example 140

A. get prescription, and prescription is standby with embodiment 7;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, concentrate to relative density 1.05～1.25 when 50～70 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 36 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Get medicated powder I, medicated powder II, add soluble starch, the amount of used soluble starch is 6 times of the weight of medicated powder I and medicated powder II, mix well, granulate with water, consumption is 30% of medicated powder and auxiliary material consumption, granule is dried, Spray into volatile oil to obtain granules.

Example 141

A. get prescription, and prescription is standby with embodiment 8;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to relative density 1.05～1.25 at 50～70 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 3 times the amount of water, soak for 1 hour, use steam distillation for 2 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 20%, let stand for 8 hours, filter; ④Recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Get medicated powder I, medicated powder II, add the combination of sucrose powder and dextrin, the amount of used auxiliary material is 3 times of the weight of medicated powder I and medicated powder II, mix well, granulate with water, consumption is 10% of medicated powder and auxiliary material consumption, The granules are dried and sprayed with volatile oil to obtain granules.

Example 142

A. get prescription, and prescription is standby with embodiment 9;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times of amount of ethanol to reflux twice, each time for 1.5 hours, the concentration of ethanol is 65%, reclaim ethanol, be concentrated to relative density 1.05～1.25 at 50～70 ℃, dry, get Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 4 times the amount of water, soak for 1.5 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle after extracting volatile oil, and decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 50%, let stand for 20 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Get medicated powder I, medicated powder II, add sucrose powder, the amount of used sucrose powder is 0.3 times of the weight of medicated powder I and medicated powder II, mix well, granulate with water, consumption is 20% of medicated powder and auxiliary material consumption, granule is dried, Spray into volatile oil to obtain granules.

Example 143

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, windproof and other four medicinal materials, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Get medicated powder I, medicated powder II, add soluble starch, the amount of used soluble starch is 3 times of the weight of medicated powder I and medicated powder II, mix well, add water to granulate, consumption is 20% of medicated powder and auxiliary material consumption, make granule.

Example 144

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add cyclodextrin, the amount of cyclodextrin used is twice the weight of medicated powder I and medicated powder II, mix well, add water to granulate, the dosage is 15% of the amount of medicated powder and auxiliary materials, and make particles.

Example 145

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Get medicated powder I and medicated powder II, add soluble starch, the amount of soluble starch used is 1 time of the weight of medicated powder I and medicated powder II, mix well, add water to granulate, the consumption is 15% of the medicated powder and auxiliary material consumption, and make granules.

Example 146

a. Take 36g of honeysuckle, 36g of skullcap, 36g of nepeta, 36g of gardenia, 36g of forsythia, 36g of scrophulariaceae, 22g of silkworm, 55g of rehmannia glutinosa, 11g of shegan, 22g of bellflower, 22g of mint, 22g of cicada slough, 22g of windproof, 11g of licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 12 times the amount of ethanol to reflux 3 times, for the first time for 3 hours, for the second time for 2 hours, for the third time for 1 hour, the concentration of ethanol is 90%, reclaim ethanol, concentrate to 70 The relative density at ℃ is 1.03～1.35, and it is dried to obtain powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 8 times the amount of water, soak for 5 hours, use steam distillation for 8 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, and decoct for 3 hours each time. Density 1.02-1.30, let cool; ③ Alcohol precipitation: Add ethanol to make the alcohol content reach 85%, let stand for 48 hours, filter; ④ Recover ethanol, concentrate to relative density 1.05-1.45 at 90°C, dry to obtain medicinal powder I;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 30 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 60 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 60 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 147

a. Take 145g honeysuckle, 145g skullcap, 145g nepeta, 145g gardenia, 145g forsythia, 145g crocus, 85g silkworm, 215g rehmannia, 45g shegan, 85g bellflower, 85g mint, 85g cicada slough, 85g windproof, 45g licorice;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 times the amount of ethanol to reflux once for 3 hours, the concentration of ethanol is 30%, recover ethanol, concentrate to a relative density of 1.03-1.35 at 45° C., and dry to obtain medicinal powder I;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 1 times the amount of water, soak for 0.5 hours, use steam distillation for 1 hour, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting volatile oil, decoct for 0.5 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.02 at 50°C. ～1.30, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 10%, let it stand for 4 hours, filter; ④Recover ethanol, concentrate to a relative density of 1.05～1.45 at 50°C, dry, and obtain medicinal powder I;

c. Mix the prepared volatile oil with Tween 80 evenly, add appropriate amount of water, and emulsify with an emulsifier for 5 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, polyethylene glycol, medicinal powder I and medicinal powder II, mix well, and use a homogenizer Homogenize for 10 minutes, then add volatile oil emulsion and mix evenly, use a homogenizer to homogenize for 10 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 148

a. Take honeysuckle 145g, scutellaria baicalensis 45g, nepeta 36g, gardenia 36g, forsythia 145g, scrophulariaceae 36g, silkworm 22g, rehmannia glutinosa 55g, shegan 11g, bellflower 85g, mint 85g, cicada slough 22g, windproof 85g, licorice 45g for later use ;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 9 times the amount of ethanol to reflux twice, for the first time for 3 hours, for the second time for 1 hour, each time for 1 to 3 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to Relative density at 50°C is 1.03-1.35, dried to obtain powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, Nepeta, peppermint, and Fangfeng four herbs, combine them together, add 4.5 times the amount of water, soak for 3.5 hours, use steam distillation for 3.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, and decoct for 2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate until it is relatively hot at 60°C. Density 1.02-1.30, let cool; ③ Alcohol precipitation: Add ethanol to make the alcohol content reach 15%, let it stand for 15 hours, filter; ④ Recover ethanol, concentrate to a relative density of 1.05-1.45 at 35°C, dry to obtain a medicinal powder I;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, polyethylene glycol, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer After 20 minutes, add the volatile oil emulsion and mix evenly, and homogenize with a homogenizer for 20 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 149

a. Take 86.70g of honeysuckle, 86.70g of Scutellaria baicalensis, 86.70g of Schizonepeta, 86.70g of gardenia (fried), 86.70g of forsythia, 86.70g of Scrophulariaceae, 51.55g of silkworm (made from ginger), 129.81g of rehmannia glutinosa, and 26.70g of shegan , bellflower 51.55g, peppermint 51.55g, windproof 51.55g, cicada slough 51.55g, licorice 26.70g for spare;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times the amount of ethanol to reflux twice, each time for 3 hours, the concentration of ethanol is 80%, reclaim ethanol, concentrate to a relative density of 1.05-1.25 at 65 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 7 times the amount of water, soak for 3 hours, use steam distillation for 7 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle and other volatile oils, add water for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 75°C Relative density 1.04～1.20, let cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 40 hours, filter; ④Recover ethanol, concentrate to 80 ℃ when the relative density is 1.14～1.25, dry to get the medicine powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 20 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, Tween 80, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer Blend for 20 minutes, then add volatile oil emulsion and mix evenly, and homogenize for 10 minutes with a homogenizer to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 150

a. Take 53.54g of honeysuckle, 53.54g of Scutellaria baicalensis, 53.54g of Nepeta, 53.54g of Gardenia (fried), 53.54g of Forsythia, 53.54g of Scrophulariaceae, 33.57g of silkworm (made from ginger), 86.27g of Rehmannia glutinosa, 17.54g of Shegan , Bellflower 33.57g, mint 33.57g, Fangfeng 33.57g, cicada slough 33.57g, licorice 17.54g for spare;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, take 2 hours for the first time, and 1.5 hours for the second time, the concentration of ethanol is 75%, reclaim ethanol, and concentrate to a relative density of 1.05 at 62 ° C ~1.25, dry to obtain powder I;

Extraction of medicinal powder II: ①Extract volatile oil: Take four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof, combine them together, add 2.5 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and the volatile oil extracted from honeysuckle, for 2 hours for the first time, and 1 hour for the second time, combine the decoction, filter, and concentrate the filtrate When the relative density is 1.04-1.20 at 64°C, let it cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 55%, let it stand for 24 hours, and filter; ④Recover ethanol, concentrate to a relative density of 1.14-1.14 at 64°C 1.25, dried to obtain medicinal powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 8 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 40 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 40 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 151

a. Take honeysuckle 86.70g, scutellaria baicalensis 53.54g, nepeta 86.70g, gardenia (fried) 53.54g, forsythia 86.70g, scrophulariaceae 53.54g, silkworm (made from ginger) 51.55g, rehmannia glutinosa 86.27g, shegan 26.70g , Bellflower 33.57g, mint 51.55g, Fangfeng 33.57g, cicada slough 51.55g, licorice 17.54g for spare;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5.5 times the amount of ethanol to reflux twice, for the first time for 1 hour, and for the second time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, and concentrate to a relative density of 1.05～ in the time of 61 DEG C 1.25, dry to obtain powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 6.5 times the amount of water, soak for 3.5 hours, use steam distillation for 3.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate until it is at 60°C Relative density 1.04～1.20, let cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 12 hours, filter; ④ recover ethanol, concentrate to relative density 1.14～1.25 at 60 ℃, dry, get Powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 30 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 10 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 152

a. Take 75g honeysuckle, 75g skullcap, 75g nepeta, 75g gardenia, 75g forsythia, 75g scrophulariaceae, 47g silkworm, 115g rehmannia glutinosa, 25g shegan, 47g bellflower, 47g mint, 47g cicada slough, 47g windproof, 24g licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 8 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 50%, reclaim ethanol, concentrate to a relative density of 1.10-1.25 at 55 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 3 times the amount of water, soak for 1 hour, use steam distillation for 6 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 80%, stand still for 36 hours, and filter; ④Recover ethanol, concentrate to a relative density at 70°C 1.14 to 1.25, dry to obtain medicinal powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30 minutes, and make soft capsule contents of 12.78% of medicinal powder, 0.14% of volatile oil, 24.83% of vegetable oil, 1.25% of glycerin, 5% of water, and 56% of Tween; take the above contents Compress the soft capsules with a rotary capsulator.

Example 153

a. Take 69g honeysuckle, 69g skullcap, 69g nepeta, 69g gardenia, 69g forsythia, 69g scrophulariae, 40g silkworm, 100g rehmannia, 20g shegan, 40g platycodon, 40g mint, 40g cicada, 40g windproof, 20g licorice;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.10-1.25 at 58 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 5 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 45%, let stand for 18 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 25 minutes to obtain a volatile oil emulsion; take glycerin, polyethylene glycol, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer 25min, then add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 25min to make soft capsules with 8% medicinal powder, 0.2% volatile oil, 34% polyethylene glycol 6000, 1.6% glycerin, 16.2% water, and 40% Tween Contents: Take the above-mentioned contents and compress the soft capsules with a rotary capsule rolling machine.

Example 154

a. Take 75g honeysuckle, 69g skullcap, 75g nepeta, 69g gardenia, 75g forsythia, 75g scrophulariaceae, 40g silkworm, 115g rehmannia glutinosa, 25g shegan, 40g bellflower, 40g mint, 40g cicada slough, 47g windproof, 20g licorice for later use ;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 71%, reclaim ethanol, be concentrated to relative density 1.10～1.25 when 55～60 ℃, dry, obtain Powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four herbs, combine them together, add 1.5 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 15 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add appropriate amount of water, and emulsify with an emulsifier for 15 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, polyethylene glycol, medicinal powder I and medicinal powder II, mix well, and use a homogenizer Homogenize for 30 minutes, then add volatile oil emulsion and mix evenly, and homogenize for 15 minutes with a homogenizer to make medicinal powder 30%, volatile oil 0.5%, vegetable oil 30%, glycerin 1.0%, water 23.5%, Tween 10%, polyethylene glycol The soft capsule content of 40005%; Get above-mentioned content and press soft capsule with rotary capsule rolling machine.

Example 155

a. Take 72g honeysuckle, 72g skullcap, 72g nepeta, 72g gardenia, 72g forsythia, 72g scrophulariaceae, 43g silkworm, 108g rehmannia glutinosa, 22g shegan, 43g bellflower, 43g mint, 43g cicada slough, 43g windproof, 22g licorice for later use ;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, substrate, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30min, make medicated powder 12.61%, volatile oil 0.14%, matrix 25%, glycerin 1.25%, water 5%, Tween 56% soft capsule content, described matrix It is one or any combination of vegetable oil, polyethylene glycol or Tween 80; take the above-mentioned contents and press the soft capsule with a rotary capsule rolling machine.

Example 156

a. take prescription, prescription embodiment 3 is standby;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 90%, recover ethanol, concentrate to a relative density of 1.02 to 1.25 at 45°C, and dry to obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof, and take four medicinal materials, except honeysuckle, and wash the remaining three herbs with water, then combine them together, add 5 times the amount of water, soak for 5 hours, use water Steam distillation for 7.5 hours, collect the volatile oil and store it in another device, and continue to extract the medicinal residues; ②Extraction: Wash the rest of the medicinal materials with water, add the medicinal residues after extracting the volatile oil with the medicinal residues of Scutellaria baicalensis and honeysuckle, add water to decoct once, and decoct for 3 hours , combined the decoction, filtered, the filtrate was concentrated to a relative density of 1.02 to 1.30 at 70°C, and allowed to cool: ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 26 hours, and filter; ④Recover ethanol, Concentrate to a relative density of 1.05 to 1.45 at 50°C to obtain medicinal powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add appropriate amount of water, and emulsify with an emulsifier for 12 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 55 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 55 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 157

a. take prescription, prescription embodiment 4 is standby;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 2.5 times of amount of ethanol to reflux twice, for the first time for 3 hours, and for the second time for 1 hour, the concentration of ethanol is 85%, reclaim ethanol, and concentrate to a relative density of 1.02～ at 75°C 1.25, dry to obtain powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof. The other three herbs except honeysuckle are washed with water respectively, then combined together, add 5.5 times the amount of water, soak for 1 hour, use water Steam distillation for 0.5 hours, collect the volatile oil and store it in another device, and continue to extract the medicinal residues; ②Extraction: Wash the rest of the medicinal materials with water, add the medicinal residues after extracting the volatile oil with the medicinal residues of Scutellaria baicalensis and honeysuckle, add water to decoct once, and decoct for 1 hour , combined the decoction, filtered, the filtrate was concentrated to a relative density of 1.02-1.30 at 70°C, and allowed to cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 75%, let it stand for 20 hours, and filter; ④Recover ethanol, Concentrate to a relative density of 1.05 to 1.45 at 40°C to obtain medicinal powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 18 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 18 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 18 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 158

a. take prescription, prescription embodiment 6 is standby;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4.5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 83%, reclaim ethanol, concentrate to a relative density of 1.10-1.25 at 57 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 3.5 times the amount of water, soak for 2.5 hours, use steam distillation for 1.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 50°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 75%, let stand for 18 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 30 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 15 minutes, and make soft capsule contents of 40% medicinal powder, 2.5% volatile oil, 10% vegetable oil, 3.0% glycerin, 14.5% water, and 30% Tween; take the above contents Compress the soft capsules with a rotary capsulator.

Example 159

a. take prescription, prescription embodiment 7 is standby;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times of amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 52%, reclaim ethanol, concentrate to relative density 1.10～1.25 when 55～60 ℃, dry, get Powder I;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 6 times the amount of water, soak for 2 hours, use steam distillation for 5.5 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 45°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 53%, let stand for 42 hours, and filter; ④Recover ethanol, concentrate to relative density at 40°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add appropriate amount of water, and emulsify with an emulsifier for 45 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 40 minutes, then Add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 45 minutes, and make soft capsule contents of 50% medicinal powder, 0.2% volatile oil, 30% vegetable oil, 1.0% glycerin, 3.8% water, and 15% Tween; take the above contents Compress the soft capsules with a rotary capsulator.

Example 160

a. take prescription, prescription embodiment 8 is standby;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 3 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to a relative density of 1.10-1.25 at 56 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 7 times the amount of water, soak for 4 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water to decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 50°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let stand for 6 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 15 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30 minutes to make soft capsule contents of 6.50% medicinal powder, 2% volatile oil, 56% vegetable oil, 3% glycerin, 15% water, and 17.5% Tween; take the above contents Compress the soft capsules with a rotary capsulator.

Example 161

a. take prescription, prescription embodiment 10 is standby;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 3.5 times of amount of ethanol to reflux twice, each time for 3 hours, the concentration of ethanol is 48%, reclaim ethanol, be concentrated to relative density 1.10～1.25 in the time of 55～60 ℃, dry, get Powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 8.5 times the amount of water, soak for 0.5 hours, use steam distillation for 0.5 hours, collect volatile oils and store them in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 35 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 60 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 60 minutes, then Add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 60 minutes, and make soft capsule contents of 20% medicinal powder, 1% volatile oil, 20% vegetable oil, 2% glycerin, 30% water, and 27% Tween; take the above contents Compress the soft capsules with a rotary capsulator.

Example 162

a. Take the prescription, and the prescription embodiment 2 is standby;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 71%, reclaim ethanol, be concentrated to relative density 1.10～1.25 when 55～60 ℃, dry, obtain Powder I;

Extraction of medicinal powder II: ①Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four herbs, combine them together, add 1.5 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 35%, let it stand for 15 hours, and filter; ④Recover ethanol, concentrate to relative density at 70°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 20 minutes to obtain a volatile oil emulsion; take glycerin, polyethylene glycol, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer 25min, then add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30min to make soft capsules with 25% medicinal powder, 0.8% volatile oil, 6% glycerin, 30% water, 13.2% Tween, and 25% polyethylene glycol 4000 Contents: Take the above-mentioned contents and compress the soft capsules with a rotary capsule rolling machine.

Example 163

a. take prescription, prescription embodiment 7 is standby;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, for the first time for 2 hours, and for the second time for 1 hour, the concentration of ethanol is 45%, reclaim ethanol, and concentrate to a relative density of 1.10～ at 57°C 1.25, dry to obtain powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 6.5 times the amount of water, soak for 4 hours, use steam distillation for 6.5 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil. , the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 75%, let it stand for 16 hours, and filter; ④Recover ethanol, concentrate to relative density at 60°C Density 1.14～1.25, dry to get medicine powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 15 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 15 minutes, and make the soft capsule contents of 35% medicinal powder, 2.5% volatile oil, 20% vegetable oil, 1.0% glycerin, 32.5% water, and 10% Tween; take the above content The soft capsules are compressed with a rotary capsule rolling machine.

Example 164

a. Take the prescription, and the prescription embodiment 1 is standby;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 11 times of amount of ethanol to reflux 2 times, each 2 hours, the concentration of ethanol is 95%, reclaim ethanol, concentrate to relative density 1.01～1.35 when 75～85 ℃, dry, obtain Powder I;

Extraction of medicinal powder II: ① extract volatile oil: take honeysuckle, nepeta, peppermint, and windproof four medicinal materials, combine them together, add 7 times the amount of water, soak for 2 hours, use steam distillation for 2.5 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, add water and decoct 3 times, the first time is 2 hours, the second time is 1 hour, the third time is 0.5 hours, and the decoction is combined. Filtrate, concentrate the filtrate to a relative density of 1.01-1.35 at 70-85°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 75%, let it stand for 36 hours, and filter; ④recover ethanol, concentrate to Relative density at 70-90°C is 1.01-1.45, dried to obtain powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add appropriate amount of water, and emulsify with an emulsifier for 25 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 50 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 50 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 165

a. Take the prescription, and the prescription embodiment 2 is standby;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 1 to 12 times the amount of ethanol to reflux twice, the first time for 3 hours, the second time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, and concentrate until it is at 45-85°C The relative density is 1.05～1.25, and dried to obtain the medicinal powder I;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 4 times the amount of water, soak for 4 hours, use steam distillation for 4 hours, collect volatile oil and store it in another container. Continue to extract the dregs; ②Extraction: Add water and decoct the remaining medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, decoct twice for 3 hours for the first time, and 1 hour for the second time, combine the decoction, filter, and concentrate the filtrate to At 50-85°C, the relative density is 1.05-1.25, and let cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 10-85%, let stand for 4-48 hours, and filter; ④ recover ethanol, concentrate to 50- The relative density at 90°C is 1.05-1.45, and dried to obtain powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 8 minutes to obtain a volatile oil emulsion; take glycerin, poly7 glycol, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer After 12 minutes, add the volatile oil emulsion and mix evenly, and homogenize for 12 minutes with a homogenizer to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 166

a. take prescription, prescription embodiment 4 is standby;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2.5 hours, the concentration of ethanol is 40%, reclaim ethanol, concentrate to a relative density of 1.10-1.15 at 50 ° C, dry, and obtain medicinal powder I ;

Extraction of medicinal powder II: ① Extract volatile oil: take honeysuckle, nepeta, peppermint, and Fangfeng four medicinal materials, combine them together, add 3 times the amount of water, soak for 3 hours, use steam distillation for 3 hours, collect volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: Add water and decoct the rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle, etc. after extracting the volatile oil, and decoct for 1.5 hours each time. Density 1.08-1.15, let cool; ③ Alcohol precipitation: Add ethanol to make the alcohol content reach 25%, let it stand for 16 hours, filter; ④ Recover ethanol, concentrate to relative density 1.08-1.15 at 50°C, dry to obtain medicinal powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 5-30 minutes to obtain a volatile oil emulsion; take glycerin, Tween 80, medicinal powder I and medicinal powder II, mix well, and use a homogenizer to homogenize Blend for 10-60 minutes, then add volatile oil emulsion and mix evenly, and homogenize for 10-60 minutes with a homogenizer to obtain the contents of the soft capsule; take the above-mentioned contents and press the soft capsule with a rotary capsule rolling machine.

Example 167

a. take prescription, prescription embodiment 4 is standby;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 10 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 90%, recover ethanol, concentrate to a relative density of 1.02 to 1.30 at 80 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 7 times the amount of water, soak for 4 hours, use steam distillation for 7 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 36 hours, filter; ④recover ethanol, concentrate to relative density 1.02～1.30 at 60～80℃ , dried to obtain medicinal powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 20 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, polyethylene glycol or Tween 80, medicated powder I and medicated powder II, and mix well. Homogenize for 40 minutes with a homogenizer, then add volatile oil emulsion and mix evenly, and homogenize for 40 minutes with a homogenizer to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 168

A. get prescription, and prescription is standby with embodiment 5;

b. Extraction of medicinal powder I: take Scutellaria baicalensis and add 2 times the amount of ethanol to reflux twice, each time for 1 hour, the concentration of ethanol is 40%, recover ethanol, concentrate to a relative density of 1.02 to 1.30 at 45 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, windproof and other four herbs, combine them together, add 1 times the amount of water, soak for 1 hour, use steam distillation for 1 hour, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③Alcohol precipitation; add ethanol to make the alcohol content reach 20%, let stand for 8 hours, filter; ④Recover ethanol, concentrate to relative density 1.03～1.30 at 60～80℃ , dried to obtain medicinal powder II;

c. Mix the obtained volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 8 minutes to obtain a volatile oil emulsion; take glycerin, vegetable oil, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 20 minutes, and then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 20 minutes to obtain the contents of the soft capsule; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 169

A. get prescription, and prescription is standby with embodiment 6;

b. Extraction of medicated powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, for the first time for 2 hours, and for the second time for 1.5 hours, the concentration of ethanol is 70%, reclaim ethanol, and concentrate to a relative density of 1.02～ at 60°C 1.30, dry to obtain powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four medicinal materials, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 2 hours, collect volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to 60-75 The relative density at ℃ is 1.04～1.30, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 30%, let stand for 12 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.30 at 60～80℃ , dried to obtain medicinal powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 15 minutes to obtain a volatile oil emulsion; take glycerin, matrix, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 15 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 15 minutes to obtain the contents of the soft capsule; the base is vegetable oil; take the above contents and press the soft capsule with a rotary capsule rolling machine.

Example 170

A. get prescription, and prescription is standby with embodiment 7;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 7 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 70%, reclaim ethanol, concentrate to a relative density of 1.05-1.25 at 70 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 5 times the amount of water, soak for 2 hours, use steam distillation for 4 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let cool; ③ alcohol precipitation: add ethanol to make the alcohol content reach 80%, let stand for 30 hours, filter; ④ recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, substrate, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add volatile oil emulsion and mix homogeneously, homogenize 30min with homogenizer, make medicated powder 40%, volatile oil 0.01%, substrate 50%, glycerin 0.25%, water 1%, the soft capsule content of 8.74% Tween, described The base is vegetable oil; the above-mentioned contents are pressed into soft capsules with a rotary capsule rolling machine.

Example 171

A. get prescription, and prescription is standby with embodiment 8;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 3 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 60%, reclaim ethanol, concentrate to a relative density of 1.05-1.25 at 50 ° C, dry, and obtain medicinal powder I ;

Extraction of Medicinal Powder II: ①Extraction of volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3 times the amount of water, soak for 2 hours, use steam distillation for 3 hours, collect the volatile oil and store it in another container. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 40%, let stand for 12 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, substrate, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30min, make medicated powder 5%, volatile oil 5%, matrix 10%, glycerin 1%, water 10%, 69% Tween soft capsule content, described matrix It is vegetable oil; the above-mentioned contents are pressed into soft capsules with a rotary capsule rolling machine.

Example 172

A. get prescription, and prescription is standby with embodiment 9;

b. the extraction of medicinal powder I: get Scutellaria baicalensis and add 6 times of amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, be concentrated to relative density 1.05～1.25 in the time of 50～70 ℃, dry, obtain Powder I;

Extraction of Medicinal Powder II: ①Extract volatile oil: Take honeysuckle, nepeta, peppermint, and windproof and other four herbs, combine them together, add 3.5 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: Add water to decoct the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc. after extracting the volatile oil, for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to 65-70 The relative density at ℃ is 1.04～1.20, let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 40%, let stand for 20 hours, filter; ④recover ethanol, concentrate to relative density 1.05～1.25 at 65～75℃ , dried to obtain medicinal powder II;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, substrate, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30min, make medicated powder 20%, volatile oil 2%, matrix 30%, glycerin 2%, water 6%, the soft capsule content of 40% Tween, described matrix It is polyethylene glycol; the above-mentioned contents are pressed into soft capsules with a rotary capsule rolling machine.

Example 173

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, substrate, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30min, make medicated powder 12.61%, volatile oil 0.14%, matrix 25%, glycerin 1.25%, water 5%, Tween 56% soft capsule content, described matrix It is vegetable oil; the above-mentioned contents are pressed into soft capsules with a rotary capsule rolling machine.

Example 174

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, substrate, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30min, make medicated powder 12.61%, volatile oil 0.14%, matrix 25%, glycerin 1.25%, water 5%, Tween 56% soft capsule content, described matrix It is poly-7 glycol; take the above content and compress the soft capsule with a rotary capsule rolling machine.

Example 175

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 5 times the amount of ethanol to reflux twice, each time for 2 hours, the concentration of ethanol is 65%, reclaim ethanol, concentrate to relative density 1.15～1.20 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of Medicinal Powder II: ① Extract volatile oil: Take four medicinal materials such as honeysuckle, Nepeta, mint, and windproof, combine them together, add 4 times the amount of water, soak for 1 hour, use steam distillation for 3 hours, collect the volatile oil and store it in another device. Continue to extract the medicinal dregs; ②Extraction: the remaining medicinal materials, the medicinal dregs of Scutellaria baicalensis and honeysuckle, etc., after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, and the decoctions are combined. Filtrate, concentrate the filtrate to a relative density of 1.06-1.11 at 70°C, and let it cool; ③alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, and filter; ④recover ethanol, concentrate to 70°C When the relative density is 1.16-1.20, the medicine powder II is obtained;

c. Mix the prepared volatile oil with Tween 80 evenly, add an appropriate amount of water, and emulsify with an emulsifier for 10 minutes to obtain a volatile oil emulsion; take glycerin, substrate, medicinal powder I and medicinal powder II, mix well, and homogenize with a homogenizer for 30 minutes, then Add the volatile oil emulsion and mix evenly, homogenize with a homogenizer for 30min, make medicated powder 12.61%, volatile oil 0.14%, matrix 25%, glycerin 1.25%, water 5%, Tween 56% soft capsule content, described matrix It is the same amount of vegetable oil, polyethylene glycol or Tween 80; take the above content and compress the soft capsule with a rotary capsule rolling machine.

Example 176

A. get prescription, and prescription is standby with embodiment 10;

b. Extraction of medicinal powder I: get Scutellaria baicalensis and add 4 times the amount of ethanol to reflux twice, each time for 2.5 hours, the concentration of ethanol is 35%, reclaim ethanol, concentrate to relative density 1.07～1.15 when 55 ℃～60 ℃, dry, Get medicine powder I;

Extraction of medicinal powder II: ①Extract volatile oil: Combine the four medicinal materials such as honeysuckle, nepeta, peppermint, and windproof together, add 3.5 times the amount of water, soak for 1.5 hours, use steam distillation for 2.5 hours, collect the volatile oil and store it in another device. Continue to extract the dregs; ②Extraction: The rest of the medicinal materials, the dregs of Scutellaria baicalensis and the dregs of honeysuckle after extracting the volatile oil, add water and decoct twice, the first decoction for 2 hours, the second decoction for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.04 to 1.20 at 70°C, and allowed to cool; ③Alcohol precipitation: add ethanol to make the alcohol content reach 45%, let stand for 12 hours, and filter; ④Recover ethanol, concentrate to 70°C The relative density is 1.14～1.25, and the medicine powder II is obtained;

c. Take medicated powder I and medicated powder II, add sodium carboxymethyl starch, mix well, add 20% ethanol to granulate, the dosage is 30% of the dosage of medicated powder and auxiliary materials; dry the granules, spray into volatile oil; add silica gel, mix homogeneously, mix evenly, pack into medicinal capsules, and obtain capsules.

Claims (7)

1. preparation method for the treatment of cold medicine is characterized in that step is as follows:

A. 72 parts of extracting honeysuckles, 72 parts of Radix Scutellariaes, 72 parts of Herba Schizonepetae, 72 parts of Fructus Gardeniaes, 72 parts of Fructus Forsythiaes, 72 parts of Radix Scrophulariaes, 43 parts of Bombyx Batryticatus, 108 parts of Radix Rehmanniae, 22 parts of Rhizoma Belamcandae, 43 parts of Radix Platycodoniss, 43 parts of Herba Menthaes, 43 parts of Periostracum Cicadaes, 43 parts of Radix Saposhnikoviaes, 22 parts in Radix Glycyrrhizae are standby;

B. the extraction of medicated powder I: get Radix Scutellariae and add 5 times of amount alcohol reflux secondaries, each 2 hours, concentration of ethanol was 65%, reclaimed ethanol, was concentrated into relative density 1.15～1.20 in the time of 55 ℃～60 ℃, and drying gets medicated powder I;

The extraction of medicated powder II: 1. extract volatile oil: four Chinese medicine materials such as extracting honeysuckle, Herba Schizonepetae, Herba Menthae, Radix Saposhnikoviae, merge together, add 4 times of water gagings, soak after 1 hour, adopted steam distillation 3 hours, collect volatile oil device preservation in addition, medicinal residues continue to extract; 2. extract: all the other medical materials and Radix Scutellariae medicinal residues and Flos Lonicerae etc. are extracted the medicinal residues behind the volatile oil, decoct with water secondary, decoct 2 hours for the first time, decoct 1 hour for the second time, and collecting decoction filters, and filtrate is concentrated into relative density 1.06～1.11 in the time of 70 ℃, puts cold; 3. precipitate with ethanol: add ethanol and make and contain the alcohol amount and reach 60%, left standstill 24 hours, filter; 4. reclaim ethanol, be concentrated into relative density 1.16～1.20 in the time of 70 ℃, get medicated powder II; Merge medicated powder I, medicated powder II, be ground into fine powder, add volatile oil, add various conventional adjuvants, make medicament.

2. treat the preparation method of cold medicine according to claim 1, the medicated powder I and the medicated powder II mixing fine powders that make of step b wherein, one or more the combination that adds starch, dextrin, lactose, PVP, carboxymethyl starch sodium adjuvant, mix homogeneously, adding concentration is 8～75% alcohol granulations, and consumption is 4～60% of medicated powder and a supplementary product consumption; With particle drying, spray into volatile oil; Add one or several combinations in magnesium stearate, silica gel, the Polyethylene Glycol, mix homogeneously, tabletting, coating or coating not promptly get tablet.

3. treat the preparation method of cold medicine according to claim 1, wherein the medicated powder I that makes of step b and medicated powder II mixing fine powders, volatile oil, mix homogeneously, the polyethylene glycol 6000 that adds 1～30 times of amount of medicated powder: Macrogol 4000=1～5: 1～4 mixture, heating dissolves, and adopting a speed is 25～75/min, splashes into liquid Paraffin, or methyl-silicone oil or methyl-silicone oil: liquid Paraffin=1～4: in 1～3 the condensed fluid, promptly get drop pill.

4. treat the preparation method of cold medicine according to claim 1, wherein add starch in the medicated powder I that makes of step b and the medicated powder II mixing fine powders, the weight of starch is medicated powder I and medicated powder II weight sum 0.5～2 times, mix homogeneously, adding concentration is 20～30% alcohol granulations, and consumption is 10%～30% of medicated powder and a supplementary product consumption; With particle drying, spray into volatile oil; Add magnesium stearate, the weight of magnesium stearate is 0.1～2% of medicated powder I and medicated powder II weight sum, and mix homogeneously in the capsule for medicine of packing into, promptly gets capsule.

5. treat the preparation method of cold medicine according to claim 1, one or both the combination that wherein adds soluble starch, cyclodextrin adjuvant in the medicated powder I that makes of step b and the medicated powder II mixing fine powders, the amount of used adjuvant is medicated powder I and medicated powder II weight 0.4～3 times, mix homogeneously, add water and granulate, consumption is 10～30% of medicated powder and a supplementary product consumption, with particle drying, spray into volatile oil, promptly get granule.

6. treat the preparation method of cold medicine according to claim 1, wherein the volatile oil that makes of step b adds the Tween 80 mix homogeneously, and it is an amount of to add water, with mulser emulsifying 10min, volatile oil Emulsion; Get glycerol, substrate, medicated powder I and medicated powder II, mixing with homogenize machine homogenize 30min, adds volatile oil Emulsion mix homogeneously again, with homogenize machine homogenize 30min, make medicated powder 12.61%, volatile oil 0.14%, substrate 25%, glycerol 1.25%, water 5%, the soft capsule content of tween 56%, described substrate is a kind of or combination in any in vegetable oil, Polyethylene Glycol or the Tween 80; Get the foregoing thing and suppress soft capsule with the rotation rolling capsule machine.

7. as the preparation method of treatment cold medicine as described in the claim 6, it is characterized in that vegetable oil in the substrate is the one or any combination in Oleum Brassicae campestris, Oleum Glycines, Oleum Arachidis hypogaeae semen, Oleum Helianthi, Oleum Gossypii semen, Semen Maydis oil, Oleum sesami, olive oil, the safflower oil.