CN1660265A - Gel preparation of dual goldthread root and preparing method - Google Patents
Gel preparation of dual goldthread root and preparing method Download PDFInfo
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- CN1660265A CN1660265A CN 200410081548 CN200410081548A CN1660265A CN 1660265 A CN1660265 A CN 1660265A CN 200410081548 CN200410081548 CN 200410081548 CN 200410081548 A CN200410081548 A CN 200410081548A CN 1660265 A CN1660265 A CN 1660265A
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Landscapes
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of jelly or gel for treating cold, cough, mumps, infantile asthmatic pneumonia, etc is prepared from honeysuckle flower, scutellaria root, forsythia fruit, and matrix. Its preparing process is also disclosed.
Description
Technical field: the present invention is a kind of gel preparation of dual goldthread root and preparation method thereof, belongs to the technical field of medicine.
Technical background: 'Shuang Hualian ' is to be formed by Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae three flavor purification of tcm, the above two heat-clearing and toxic substances removing, the Radix Scutellariae heat clearing and damp drying, three medicines are shared, heat-clearing and toxic substances removing, also can strengthen cellular immune function, be mainly used in diseases such as heating that affection due to external wind and heat causes, cough, also can be used for mumps, children's's ASP, herpes zoster, chickenpox etc.First research and development preparation variety is a SHUANGHUANGLIAN ZHUSHEYE, by the scientific worker of Heilongjiang Province according to Chinese medical theory, and in conjunction with the modern scientific research achievement in the eighties in 20th century development, record in " Heilongjiang Province's drug standard " (version in 1986), along with China's rapid economy development, in the nineties in 20th century, formed the research climax of SHUANGHUANLIAN preparation series, in 10 years, derived granule, oral liquid, suppository, dosage forms such as injectable powder, as application number " 93100903 ", name is called " SHUANGHUANGLIAN JIAONANG and preparation method thereof ", though it is good to be used for the curative effect of child patient clinically, still not at the dosage form kind of children characteristics, infant uses existing product that certain difficulty is arranged, displeased acceptance.In the real life, child patient quantity is huge, and is poor to the ability to accept of general formulation, and the outward appearance of medicine, mouthfeel directly influence the application and the curative effect of medicine; In view of the develop rapidly of medical science and to these situations that deepen continuously of dosage form research, need exploitation effective medicine preparation that a kind of market prospect is wide, the child takes like a shot, the treatment of pediatric patient is reached a new high, thereby infantile common cold patient's quality of life is further improved.
Summary of the invention: the objective of the invention is to: a kind of gel preparation of dual goldthread root and preparation method thereof is provided; The present invention is directed to prior art, we are made be subjected to the child to like fruit jelly or the soft sweet type gel that eats deeply, children's extremely is ready to take, reduce the adult and advised the trouble of feeding, not only tasty, and also therapeutical effect is good, enriched the dosage form kind, market prospect is very wide; And, select feasible substrate and technology rationally, product appearance, good mouthfeel at pharmaceutical properties.
The present invention constitutes like this: calculate according to weight, it is made into fruit jelly or soft sweet type gel oral formulations by Flos Lonicerae 300～400g, Radix Scutellariae 300～400g, Fructus Forsythiae 700～800g and an amount of substrate, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.It can also be prepared into: soft capsule, dispersible tablet, drop pill, pellet, slow releasing preparation.Say accurately: the gel preparation that the substrate that it is mixed to obtain by 2: 3 part by weight by Flos Lonicerae 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g and Konjac glucomannan, kappa-carrageenan is prepared into is semifluid or solid gel shape.The preparation method of gel preparation of dual goldthread root of the present invention is: add the extracting solution of Flos Lonicerae, Radix Scutellariae, the preparation of Fructus Forsythiae decoction and alcohol sedimentation technique in the substrate for preparing mix homogeneously, after the sterilization promptly.Specifically:
Gel in the preparation of the present invention prepares like this: get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second, three times each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, herbal extract; Konjac glucomannan, kappa-carrageenan are pressed 2: 3 part by weight mix homogeneously, under stirring condition, 0.6% mixed-matrix is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, stir then, heat, filter, filter the back and under condition of stirring, add herbal extract, mix homogeneously joins rapidly in the disinfecting container, seals, sterilization is cooled to about 30 ℃ condensation rapidly, drying, promptly.
Compared with prior art, the application makes we fruit jelly or the soft sweet type gel that liked by the child, children's extremely is ready to take, reduce the adult and advised the trouble of feeding, not only tasty, and function well analgesic, antibiotic, antiinflammatory, be mainly used in diseases such as heating that affection due to external wind and heat causes, cough, also can be used for mumps, children's's ASP, herpes zoster, chickenpox etc.This rich choice of products the dosage form kind of this medicine, market prospect is very wide.The applicant finds in development process, the kind of gel-type vehicle and consumption have played crucial effects to outward appearance, stability, the curative effect of product, the Konjac glucomannan that the applicant selects for use is the deep processed product of plant Rhizoma amorphophalli, gelling, good stability, but it needs pH value greater than forming gel under 9 the strong alkaline condition, but the main component of medicine is chlorogenic acid, baicalin and phillyrin, wherein baicalin belongs to Flavonoid substances, facile hydrolysis becomes glycoside unit, and chlorogenic acid is unstable in alkaline solution; And as a kind of novel form, the release of medicine, to absorb whether desirable, gelling be key problem in technology problem of the present invention.The applicant has carried out a series of experiments, the blended composite substrate of part by weight that adopts Konjac glucomannan, kappa-carrageenan to press 2: 3, the product stable effective ingredients that under the condition of neutral meta-acid, makes, gel strength ideal, outward appearance is good, selects the supplementary product kind of preparation technology, use of pharmaceutical preparation provided by the invention and consumption, ratio etc.; Guarantee its science, reasonable, feasible; The preparation that obtains has effective therapeutic effect.
Experimental example 1: Study on Forming
(1) selection of matrix species
Substrates quantity % mouldability gelling performance
Kappa-carrageenan 0.8 good crisp, difference of hardness
Lambda-carrageenan 0.8 difference is gel not
Konjac glucomannan 0.8 difference is gel not
Kappa-carrageenan+Konjac glucomannan 0.8 good hardness is moderate, and tough elasticity is better
Lambda-carrageenan+Konjac glucomannan 0.8 difference is gel not
(2) screening of substrate composition and consumption
Konjac glucomannan: kappa-carrageenan consumption % gelling performance
1: 1 0.6 crisp, difference of hardness, poor toughness, no bite
1: 1 0.8 crisp, difference of hardness, poor toughness, no bite
1: 1 1.0 crisp, difference of hardness, poor toughness, no bite
Hardness was moderate in 2: 3 0.6, and tough good springiness has bite
Hardness was moderate in 2: 3 0.8, and tough elasticity is better, and bite is arranged
Hardness was big in 2: 3 1.0, and tough elasticity is strong
The result shows: coagulating property of lambda-carrageenan is poor, and Konjac glucomannan needs pH value to remove acetyl group greater than hydrolysis under 9 the strong alkaline condition could form gel, and the pH value of herbal extract is 7, and kappa-carrageenan gel fragility is big, and elasticity is little; After kappa-carrageenan and Konjac glucomannan are composite, can strengthen the gel strength and the elasticity of carrageenan; Improve the character of Konjac glucomannan, making under the medicinal liquid environment of neutral meta-acid can molding; The best composite condition of substrate is a Konjac glucomannan: the part by weight of kappa-carrageenan=2: 3, consumption is 0.6%.
Experimental example 2: release experiment with 30 livers, the normal male rat of renal function (age about 3 months, 200～250g), be divided into 3 groups at random: SHUANGHUANGLIAN KOUFUYE group, SHUANGHUANGLIAN KELI group, gel group of the present invention, 10 every group.Behind every group of rat fasting 12h, the difference single-dose, dosage is 0.6mg, and 2h advances unified feedstuff after the administration, in the back 0.5,1,2,5 of taking medicine, 10h venous blood samples 2～3ml, centrifugal 10min gets serum and places-20 ℃ of cryopreservation to measuring.
(* 10 for blood drug level-time data
-9G/ml)
Group 0.5h 1h 2h 5h 10h
SHUANGHUANGLIAN KOUFUYE group 3.9 ± 1.7 4.9 ± 1.2 4.1 ± 1.9 1.6 ± 0.5 1.3 ± 0.7
SHUANGHUANGLIAN KELI group 3.6 ± 1.2 4.3 ± 1.4 3.7 ± 1.0 1.3 ± 0.9 1.5 ± 0.6
Gel group 4.0 of the present invention ± 0.3 5.0 ± 3.6 4.1 ± 0.5 1.6 ± 0.4 1.5 ± 0.8
The result shows: preparation release ideal of the present invention is not less than the listing product.
Experimental example 3: pharmacodynamic experiment
Animal: Japan large ear rabbit, 2.2～2.7kg, male and female are all used; Kunming mouse, male and female half and half, all healthy nothing is hindered; Instrument: the full-automatic pyrogen temperature measurer of ATP-75 type; TU1221 type spectrophotometer; The AE-163 electronic balance.
(1) separates heat test the qualified rabbit of pre-thermometric is got in the influence that rabbit body temperature due to the bacterial endotoxin raises, before test day is measured administration on request behind the rectal temperature, press the body temperature random packet, injection intravenous injection, other oral administration gavages, the administration volume is 4ml/kg.Except that the blank group, each organizes after the administration intravenous injection bacterial endotoxin 50EU/kg immediately, later on every 30min, surveys rectal temperature once, with body temperature that different time is surveyed and administration precursor using warming therapy difference, for body temperature intensification value (body temperature descend 0.4 ℃ in interior person with 0).
Group dosage/gkg
-1Contain crude drug body weight/kg basal body temperature/℃ high fever/℃ the highest intensification value/℃
Model group 2.58 ± 0.32 38.39 ± 0.27 39.88 ± 0.29 1.56 ± 0.21
Blank group-2.39 ± 0.28 38.41 ± 0.22 38.73 ± 0.20 0.30 ± 0.17
SHUANGHUANGLIAN KOUFUYE 6 2.31 ± 0.18 38.35 ± 0.26 39.43 ± 0.12 1.06 ± 0.21
SHUANGHUANGLIAN ZHUSHEYE 4 2.37 ± 0.14 38.40 ± 0.14 39.69 ± 0.30 1.27 ± 0.15
Gel 6 2.32 of the present invention ± 0.32 38.76 ± 0.34 39.42 ± 0.25 1.00 ± 0.23
(2) the antiinflammatory test is got mice by body weight, sex random packet to the influence that lumbar injection acetic acid (HAC) induced mice abdominal cavity capillary permeability increases.The injection subcutaneous injection, all the other equal gastric infusions, the administration volume is 20ml/kg, be administered once every day, successive administration 7d, after 30 minutes, each caudal vein is injected the blue normal saline solution 0.1ml/10g of 0.5% ivens body weight in the last administration, and lumbar injection 0.6%HAC normal saline solution 0.2ml/ immediately, take off cervical vertebra behind the 20min and put to death, open the abdominal cavity, with 6ml normal saline washing abdominal cavity, collect cleaning mixture and centrifugal, get supernatant and survey trap in the 590nm place.
Group dosage/gkg
-1Contain the crude drug trap
Blank/water-0.118 ± 0.026
20 0.044±0.012
SHUANGHUANGLIAN KELI 30 0.078 ± 0.049
SHUANGHUANGLIAN ZHUSHEYE 20 0.074 ± 0.033
Gel 20 0.077 ± 0.042 of the present invention
(3) antibacterial tests causes that to the lumbar injection staphylococcus aureus protective effect of dead mouse gets mice by sex, body weight random packet; injection lumbar injection (last subcutaneous injection), all the other equal oral administration gavages; the administration volume is 40ml/kg; once a day; successive administration 7d, the last time behind the administration 30min, (37 ℃ ± 1 ℃ of the THIOGLYCOLLIC ACID salt culture fluid of lumbar injection staphylococcus aureus; 24h, bacterial population about 10
8/ ml), dosage is every Mus 0.5ml, observe at once, and observe 7d continuously, record dead mouse situation every day.
Group dosage/gkg
-1Contain crude drug survival number survival rate %
Blank/water-0 0
SHUANGHUANGLIAN JIAONANG 60 9 81.82
SHUANGHUANGLIAN ZHUSHEYE 40 11 100
Gel 60 10 90.91 of the present invention
The result shows: analgesic, antiinflammatory, the antibacterial action effect of product of the present invention are not less than the listing product.
Concrete embodiment:
Embodiments of the invention 1: Flos Lonicerae 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g
Get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, herbal extract; Konjac glucomannan, kappa-carrageenan are pressed 2: 3 part by weight mix homogeneously, under stirring condition, 0.6% mixed-matrix is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, stir then, heat, filter, filter the back and under condition of stirring, add herbal extract, mix homogeneously, join rapidly in the disinfecting container, seal, sterilization, be cooled to rapidly about 30 ℃, condensation, drying promptly gets gel, this product oral, three times on the one, each 2 bags, every bag of 25g.
Embodiments of the invention 2: Flos Lonicerae 400g, Radix Scutellariae 400g, Fructus Forsythiae 800g
Get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, herbal extract; 0.8% locust bean gum is put into cold water under stirring condition, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, stir then, heat, filter, filter the back and adds herbal extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to about 30 ℃ condensation rapidly, drying promptly gets gel.
Embodiments of the invention 3: Flos Lonicerae 300g, Radix Scutellariae 300g, Fructus Forsythiae 700g
Get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, and filtrate concentrates; The preparation of glue: with gelatin: glycerol: water=1: 0.3: 0.7, get gelatin and add an amount of distilled water and make its imbibition, glycerol and remaining water are put be heated to 70～80 ℃ in the glue pot in addition, mix homogeneously adds expansible gelatin and stirs, and makes it to dissolve into uniform glue, in 70 ℃ of insulations 1～2 hour, leave standstill, remove the come-up foam, filter with cloth bag, in encapsulating machine, be pressed into soft capsule, be pressed into soft capsule, put in the drum drying machine and finalize the design, whole ball, drying promptly gets soft capsule.
Embodiments of the invention 4: Flos Lonicerae 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g
Get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; Flos Lonicerae, after Fructus Forsythiae adds water temperature and soaks half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, and filtrate concentrates, splash into the ratio that adopts PEG6000 and PEG4000 and be in 3: 1 the mixed-matrix, the water dropper model adopts No. 1 water dropper, and coolant temperature is 20～22 ℃, promptly gets drop pill.
Embodiments of the invention 5: Flos Lonicerae 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g
Get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, herbal extract; 0.9% xanthan gum is put into cold water under stirring condition, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, stir then, heat, filter, filter the back and adds herbal extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to about 30 ℃ condensation rapidly, drying promptly gets gel.
Embodiments of the invention 6: Flos Lonicerae 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g
Get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, herbal extract; 1% agar is put into cold water under stirring condition, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, stir then, heat, filter, filter the back and adds herbal extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to about 30 ℃ condensation rapidly, drying promptly gets gel.
Embodiments of the invention 7: Flos Lonicerae 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g
Get Radix Scutellariae, section decocts with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction, filter, filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, is incubated 1 hour, leaves standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, herbal extract; 1.2% methylcellulose is put into cold water under stirring condition, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, stir then, heat, filter, filter the back and adds herbal extract under condition of stirring, mix homogeneously joins rapidly in the disinfecting container, seal, sterilization is cooled to about 30 ℃ condensation rapidly, drying promptly gets gel.
Claims (5)
1, a kind of gel preparation of dual goldthread root, it is characterized in that: calculate according to weight, it is made into fruit jelly or soft sweet type gel oral formulations by Flos Lonicerae 300～400g, Radix Scutellariae 300～400g, Fructus Forsythiae 700～800g and an amount of substrate, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.
2, according to the described gel preparation of dual goldthread root of claim 1, it is characterized in that: it can also be prepared into: soft capsule, dispersible tablet, drop pill, pellet or slow releasing preparation.
3, according to the described gel preparation of dual goldthread root of claim 1, it is characterized in that: the gel preparation that the substrate that it is mixed to obtain by 2: 3 part by weight by Flos Lonicerae 375g, Radix Scutellariae 375g, Fructus Forsythiae 750g and Konjac glucomannan, kappa-carrageenan is prepared into, product is semifluid or solid gel shape.
4, as the preparation method of gel preparation of dual goldthread root as described in the claim 1～3 any, it is characterized in that: add the extracting solution of Flos Lonicerae, Radix Scutellariae, the preparation of Fructus Forsythiae decoction and alcohol sedimentation technique in the substrate for preparing mix homogeneously, after the sterilization promptly.
5, preparation method according to the described gel preparation of dual goldthread root of claim 4 is characterized in that: get Radix Scutellariae, section, decoct with water three times, 2 hours for the first time, second, three times each 1 hour, collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, and filtered, precipitation adds 6～8 times of water gagings, regulate pH value to 7.0 with 40% sodium hydroxide solution, add equivalent ethanol again, stir and make dissolving, filter, filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed pH value 7.0 with ethanol, and it is standby to wave most ethanol; After Flos Lonicerae, Fructus Forsythiae add water temperature and soak half an hour, decoct secondary, each 1.5 hours, collecting decoction filters, and it is 1.20～1.25 that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 75%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 75% ethanol, stir evenly, left standstill 12 hours, and filtered, merge ethanol liquid, reclaim ethanol to there not being the alcohol flavor, add Radix Scutellariae extract, and it is an amount of to add water, regulates pH value to 7.0 with 40% sodium hydroxide solution, stir evenly, 4～8 ℃ of cold preservation 72 hours filters, herbal extract; Konjac glucomannan, κ one carrageenan are pressed 2: 3 part by weight mix homogeneously, under stirring condition, 0.6% mixed-matrix is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, stir then, heat, filter, filter the back and under condition of stirring, add herbal extract, mix homogeneously joins rapidly in the disinfecting container, seals, sterilization is cooled to about 30 ℃ condensation rapidly, drying, promptly.
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|---|---|---|---|
| CN 200410081548 CN1660265A (en) | 2004-12-16 | 2004-12-16 | Gel preparation of dual goldthread root and preparing method |
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| CN 200410081548 CN1660265A (en) | 2004-12-16 | 2004-12-16 | Gel preparation of dual goldthread root and preparing method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178137A (en) * | 2010-12-01 | 2011-09-14 | 李良 | Poria cocos, almonds, white peony root and skullcap health jelly |
| CN103330114A (en) * | 2013-06-27 | 2013-10-02 | 叶建斌 | A kind of jelly for preventing cough and its preparation method |
| CN104013679A (en) * | 2014-06-26 | 2014-09-03 | 西南大学 | Shuanghuanglian (Chinese character) effervescent suppository and preparation method thereof |
| CN104127371A (en) * | 2014-08-11 | 2014-11-05 | 大连大学 | Gel applicable to children |
| CN104523895A (en) * | 2014-11-22 | 2015-04-22 | 李任 | Traditional Chinese medicine for treating parotitis |
| CN108541796A (en) * | 2018-04-03 | 2018-09-18 | 山西中医药大学 | Folium Forsythia soft sweets and preparation method |
-
2004
- 2004-12-16 CN CN 200410081548 patent/CN1660265A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178137A (en) * | 2010-12-01 | 2011-09-14 | 李良 | Poria cocos, almonds, white peony root and skullcap health jelly |
| CN102178137B (en) * | 2010-12-01 | 2013-01-16 | 李良 | Poria cocos, almond, white paeony root and baical skullcap root health-care jelly |
| CN103330114A (en) * | 2013-06-27 | 2013-10-02 | 叶建斌 | A kind of jelly for preventing cough and its preparation method |
| CN104013679A (en) * | 2014-06-26 | 2014-09-03 | 西南大学 | Shuanghuanglian (Chinese character) effervescent suppository and preparation method thereof |
| CN104127371A (en) * | 2014-08-11 | 2014-11-05 | 大连大学 | Gel applicable to children |
| CN104523895A (en) * | 2014-11-22 | 2015-04-22 | 李任 | Traditional Chinese medicine for treating parotitis |
| CN108541796A (en) * | 2018-04-03 | 2018-09-18 | 山西中医药大学 | Folium Forsythia soft sweets and preparation method |
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