CN1679763A - Gel preparation of mulberry leaf and chrysanthemum and its preparing method - Google Patents
Gel preparation of mulberry leaf and chrysanthemum and its preparing method Download PDFInfo
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- CN1679763A CN1679763A CN 200510020289 CN200510020289A CN1679763A CN 1679763 A CN1679763 A CN 1679763A CN 200510020289 CN200510020289 CN 200510020289 CN 200510020289 A CN200510020289 A CN 200510020289A CN 1679763 A CN1679763 A CN 1679763A
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- Prior art keywords
- gel
- preparation
- flos chrysanthemi
- folium mori
- spica prunellae
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- 240000000249 Morus alba Species 0.000 title abstract 2
- 235000008708 Morus alba Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 title description 2
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Landscapes
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of gel for treating cold, headache, hypertension, dizziness, sore throat, nail-like deep-rooted boil, etc is prepared from prunella spike, wild chrysanthemum flower, mulberry leaf and matrix.
Description
Technical field: the present invention is a kind of summer Sang Ju Yin gel preparation and preparation method thereof, belongs to the technical field of medicine.
Technical background: the XIASANGJU KELI agent is formed by Spica Prunellae, Folium Mori and Flos Chrysanthemi compatibility, have: relieve inflammation or internal heat, make eye bright, eliminating stagnation, detumescence, dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, effects such as liver heat removing and eyesight improving, the wind heat clearing away of loosing, be used for anemopyretic cold, the conjunctival congestion headache, hypertension, dizziness and tinnitus, laryngopharynx swelling and pain, diseases such as furuncle swelling toxin.As the classical Chinese prescription of heat-clearing and toxic substances removing, its curative effect is more significant.But we find when research: this Chinese medicine granules has added a large amount of adjuvants, taking dose is big, be unfavorable for medicine storage, carry, and the effective ingredient oleanolic acid of Spica Prunellae have strong-hydrophobicity (25 ℃ the time in the water dissolubility be 4.61 μ g/ml, in the time of 37 ℃ 17.59 μ g/ml), influence it greatly in gastrointestinal stripping and absorption, caused bioavailability low, influenced its curative effect greatly; The active ingredient chlorogenic acid of Folium Mori, Flos Chrysanthemi is the caffeic acid quinate, and poor stability can also can be by alkali catalyzed hydrolysis by acid, so pH value is very crucial in the production of preparation chlorogenic acid related preparations.That is to say that not only the dosage form kind is single for existing preparation, and the reliability of the stability of product quality and curative effect is all relatively poor, can not satisfies the needs in market and the development speed of adaptation pharmaceutical technology fully; In real life, the patient is poor to the ability to accept of general formulation, and the outward appearance of medicine, mouthfeel directly influence the application and the curative effect of medicine; In view of the develop rapidly of medical science and to these situations that deepen continuously of dosage form research, need exploitation effective medicine preparation that a kind of market prospect is wide, the patient takes like a shot, patient's treatment is reached a new high, thereby patient's quality of life is further improved.
Summary of the invention: the objective of the invention is to: a kind of summer Sang Ju Yin gel preparation and preparation method thereof is provided; The present invention is directed to prior art, we are made fruit jelly or the soft sweet type gel that liked by women and children, the patient extremely is ready to take, reduce the adult and advised the trouble of feeding child administration, not only tasty, and also therapeutical effect is good, enriched the dosage form kind, market prospect is very wide; And, select feasible substrate and technology rationally, product appearance, good mouthfeel at pharmaceutical properties.
The present invention constitutes like this: calculate according to weight, it is made into fluid or semifluid gel oral formulations by Spica Prunellae 450～600g, Flos Chrysanthemi Indici 60～90g and Folium Mori 150～200g and an amount of substrate, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.It can also be prepared into: soft capsule, dispersible tablet, drop pill, pellet or slow releasing preparation or the like.Say accurately: it by Spica Prunellae 500g, Flos Chrysanthemi Indici 80g and Folium Mori 175g and Konjac glucomannan, carrageenan, xanthan gum, locust bean gum by 5: 5: 1: 1 part by weight mixes the gel preparation that the substrate that obtains is prepared into, and is semifluid or solid gel shape.
The preparation method of summer Sang Ju Yin gel preparation of the present invention: Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water 1～3 time, and each 1～2.5 hour, collecting decoction filtered, filtrate concentrates, and adds 1～3 times of amount ethanol, fully stirs standing over night, filter, filtrate recycling ethanol, concentrating under reduced pressure, standby; With Konjac glucomannan, carrageenan, xanthan gum, locust bean gum in 5: 5: 1: 1 ratio is dissolved in the hot water, and stirring and being mixed with concentration is 0.5～1.5% solution; Add above extracting solution then, adding the citric acid adjust pH is 4, stir, and cooling rapidly, promptly.
Say accurately: the gel in the described preparation prepares like this: Spica Prunellae, Flos Chrysanthemi Indici and Folium Mori are decocted with water secondary, and each 1.5 hours, collecting decoction filtered, filtrate concentrates, and adds 95% ethanol of 2 times of amounts, fully stirs standing over night, filter, filtrate recycling ethanol, concentrating under reduced pressure, standby; With Konjac glucomannan, carrageenan, xanthan gum, locust bean gum by 5: 5: 1: 1 part by weight is dissolved in the hot water, and stirring and being mixed with concentration is 0.7% solution; Add above extracting solution then, adding the citric acid adjust pH is 4, stir, and cooling rapidly, promptly.
Compared with prior art, the application makes fluid or the semifluid gel that liked by the child with we, and women and children extremely are ready to take, not only tasty, and function well analgesic, antibiotic, antiinflammatory, enriched the dosage form kind, market prospect is very wide.The applicant finds in the process of development gel, and the bioavailability height of the oleanolic acid in the gained gel of the present invention has improved the curative effect of medicine; One of effective ingredient of Folium Mori, Flos Chrysanthemi chlorogenic acid poor stability in the prescription, can also can be by alkali catalyzed hydrolysis by acid, through our discovering: at pH value is optimal stability in 4 the water liquid, so the kind of gel-type vehicle, consumption, pH value are crucial to product quality.Edible Gelatinum oxhide its gel strength, viscosity etc. under sour environment commonly used all can seriously reduce, and have a strong impact on the performance of gel; Agar is not acidproof; Acid-catalyzed hydrolysis easily takes place in carrageenan in acid solution, thereby makes gel strength and viscosity degradation, and this hydrolysis degree can be stronger under the heat temperature raising situation, and the stability of carrageenan is poorer; Konjac glucomannan needs gel under alkali condition, and easily takes off the liquid shrinkage phenomenon.For this reason we to food glue the gel characteristic after composite study.The applicant has carried out a series of experiments, final Konjac glucomannan, carrageenan, xanthan gum, the locust bean gum of adopting was by 5: 5: 1: 1 part by weight mixes the substrate that obtains, the product of gained is stable effective ingredients under about 4 the environment at pH value, have good gel concertedness can control again and take off the food glue that liquid shrinks, and selects the supplementary product kind of preparation technology, use of pharmaceutical preparation provided by the invention and consumption, ratio etc.; Guarantee its science, reasonable, feasible; The preparation that obtains has effective therapeutic effect.
Experimental example 1: Study on Forming
1, the selection of pH value
The reaction constant k of table 1 chlorogenic acid aqueous hydrolysis first _ order kinetics equation
T/℃ pH
2.0 3.0 4.0 5.0 6.0 7.0 7.5 8.0
50 0.001001 0.000664 0.000691 0.002510 0.008332 0.017940 0.045112 0.051131
60 0.001916 0.001353 0.001436 0.003625 0.011213 0.029920 0.068165 0.087250
70 0.003075 0.002357 0.002820 0.007110 0.019160 0.069630 0.105501 0.114176
80 0.004538 0.003946 0.003989 0.010702 0.027053 0.115608 0.172536 0.178704
The result of table 1 shows that the chlorogenic acid aqueous solution is the most stable when pH 3.0-4.0, considers the mouthfeel factor, and pH value is crossed low too sour and astringent, should be controlled at about 4.
2, the selection of matrix species: under the condition of pH value 4, prepare gel.
Table 2 choice of base
Substrates quantity % gel effect
0.5 gel not
Agar 1.0 is gel not
1.5 gel not
0.5 fragility is big, easily takes off liquid and shrinks
Carrageenan 1.0 fragility are big, easily take off liquid and shrink
1.5 fragility is big, easily takes off liquid and shrinks
0.5 gel not
Konjac glucomannan 1.0 is gel not
1.5 gel not
0.5 gel not
Locust bean gum 1.0 is gel not
1.5 gel not
0.5 gel not
Xanthan gum 1.0 is gel not
1.5 gel not
The result of table 2 shows: agar is not acidproof, has a strong impact on the performance of gel; Though carrageenan energy gel, but retention ability is poor, easily takes off liquid and shrinks; Konjac glucomannan needs pH value to fall acetyl group greater than hydrolysis under 9 the strong alkaline condition could form gel, and consumption is big; Though xanthan gum, locust bean gum be gel separately, has good gel cooperative effect; So carry out the combine experiment of substrate.
2, substrate combine experiment
By orthogonal table L
9(3
1) experiment arrangement, four brood lacly mix by the proportionings in the orthogonal table, prepare gel under the condition of pH value 4, measure each gel strength of handling number, take off the liquid shrinkage factor.The results are shown in Table 3.
The mensuration of gel strength: the gel strength detector, molding cup size: diameter 4cm, high 2.5cm, formpiston jumper bar diameter is 1cm, gel strength (g/cm
2)=impulse force/active area=reading dial scale/(3.14*0.5
2)=0.785* reading.
Taking off the mensuration of liquid shrinkage factor: the glue for preparing pours in the fruit jelly cup → and sealing → sterilization (30min) → cooling → storage (room temperature, low temperature) → respectively measures and takes off the liquid shrinkage factor.During mensuration the liquid of separating out is poured out, the weight that the weighing gel alleviates was surveyed once in per 5 days, measured one month, averaged then.Take off liquid shrinkage factor (%)=(gross weight of the amount of liquid/gel of separating out) * 100%
Table 3L
9(3
4) orthogonal table factor level table
Horizontal Konjac glucomannan g carrageenan g xanthan gum g locust bean gum g
1 30 50 0 0
2 40 60 5 10
3 50 70 10 20
Arrangement of table 4 orthogonal table and result
Konjac glucomannan carrageenan xanthan gum locust bean gum gel strength (g/cm
2) take off liquid shrinkage factor (%)
1 1 1 1 1176.8 4.687
1 2 2 2 259.7 3.521
1 3 3 3 1206.4 5.118
2 1 3 3 919.5 3.305
2 2 2 1 193.7 3.259
2 3 1 2 1246.8 4.763
3 1 3 2 1186.2 1.628
3 2 1 3 157.4 3.347
3 3 2 1 1314.6 7.454
According to the result of table 4, more relatively unsubstituted mannose group is arranged on the framework of locust bean gum, with hydrophilic colloid good gel concertedness is arranged, the hardness under the condition of pH4 of composite substrate is moderate, and tough good springiness has chewiness; Best compounded combination is Konjac glucomannan, carrageenan, xanthan gum, locust bean gum=5: 5: 1: 1.
Experimental example 2: pharmacodynamic experiment
1, the research of antiinflammatory action
1. the influence of xylol induced mice otitis
Get 30 of mices, the male and female dual-purpose, body weight 18～22g is divided at random: matched group, XIASANGJU KELI group, gel group of the present invention, 10 every group.XIASANGJU KELI group and gel component of the present invention are not pressed the dosage gastric infusion in the table 4, matched group is given isopyknic normal saline, 1h after the administration, every Mus auris dextra is coated with the dimethylbenzene with 0.3ml, causes scorching back 4 hours, takes off the auricle of ears same position with the 8mm card punch, weigh, with two ear weight differences is the swelling index, the results are shown in Table 4
The influence of table 4 xylol induced mice otitis
Group dosage (g/kg) left and right sides ear weight difference (mg)
Matched group-19.8 ± 3.5
XIASANGJU KELI group 6 15.2 ± 3.8
Gel group 6 14.2 ± 3.5 of the present invention
2. to the influence of ankle swelling in rat
Get 30 of rats, male and female dual-purpose, body weight 180～220g are divided at random: matched group, XIASANGJU KELI group, gel group of the present invention, 10 every group.XIASANGJU KELI group and gel component of the present invention are not pressed the dosage gastric infusion in the table 5, every day 1 time, 3d continuously.1h after the last administration, right back sufficient plantar subcutaneous injection 1% carrageenin solution 0.1ml/ only causes inflammation rat, and before the Yu Zhiyan and cause scorching back 1,2,5,8h, measure the girth of the right back ankle joint of rat respectively with inelastic tape, and the difference of the girth of consequently scorching front and back ankle joint the results are shown in Table 5 as the swelling degree.
The influence of ankle swelling in rat due to table 5 on Carrageenan
Ankle swelling in rat degree (mm)
Group dosage (g/kg) 1h 2h 5h
Matched group-3.51 ± 1.67 9.41 ± 2.83 12.16 ± 1.94
XIASANGJU KELI group 6 1.34 ± 0.86 5.04 ± 2.31 8.35 ± 2.26
Gel group 6 1.35 of the present invention ± 0.82 4.44 ± 1.85 7.29 ± 2.18
More than two experimental results show that gel of the present invention can obviously alleviate mice ear due to the dimethylbenzene and the ankle swelling in rat due to the carrageenin, action intensity is not less than the XIASANGJU KELI of same dose.
2, the influence of refrigeration function
Rat is male, and body weight 140～180g selects basal body temperature 30 of 37～38 ℃ of persons, is divided at random: matched group, XIASANGJU KELI group and gel group of the present invention, 10 every group.Respectively at 2h before the administration, each organizes the fresh yeast suspension 2ml/100g body weight of rat neck subcutaneous injection 15%, in injection back 2h, XIASANGJU KELI group and gel component of the present invention are not pressed the dosage gastric infusion in the table 6, matched group is given the equal-volume normal saline, respectively at after the administration 1,2,3,4,5,6h surveys body temperature.The results are shown in Table 6
The influence of rat fever due to the table 6 pair fresh yeast
Body temperature after the administration (℃)
Group dosage (g/kg) 0h 2h 6h
Matched group-39.97 ± 0.42 39.42 ± 0.38 39.85 ± 0.24
XIASANGJU KELI group 6 40.08 ± 0.48 38.84 ± 0.43 39.51 ± 0.31
Gel group 6 40.21 of the present invention ± 0.39 37.51 ± 0.54 38.85 ± 0.42
The result of table 6 shows that the rat temperature that gel of the present invention can obviously suppress due to the fresh yeast raises, and effect obviously is better than the XIASANGJU KELI group of same dose, and more than the sustainable 6h of refrigeration function.
Concrete embodiment:
Embodiments of the invention 1: get Spica Prunellae 500g, Flos Chrysanthemi Indici 80g and Folium Mori 175g
Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate concentrates, and adds 95% ethanol of 2 times of amounts, fully stirs, and standing over night filters, filtrate recycling ethanol, and concentrating under reduced pressure, standby; With Konjac glucomannan, carrageenan, xanthan gum, locust bean gum in 5: 5: 1: 1 ratio is dissolved in the hot water, and stirring and being mixed with concentration is 0.7% solution; Add above extracting solution then, adding the citric acid adjust pH is 4, stirs, and cooling promptly gets gel rapidly, this product oral, three times on the one, each 2 bags, every bag of 25g.
Embodiments of the invention 2: get Spica Prunellae 600g, Flos Chrysanthemi Indici 90g, Folium Mori 200g
Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water 1 hour, and collecting decoction filters, and filtrate concentrates, and adds 1 times of amount ethanol, fully stirs, and standing over night filters filtrate recycling ethanol, concentrating under reduced pressure; With Konjac glucomannan, carrageenan, xanthan gum, locust bean gum in 5: 5: 1: 1 ratio is dissolved in the hot water, and stirring and being mixed with concentration is 0.7% solution; Add above extracting solution then, adding the citric acid adjust pH is 4, stirs, and cooling promptly gets gel rapidly.
Embodiments of the invention 3: get Spica Prunellae 450g, Flos Chrysanthemi Indici 60g, Folium Mori 150g
Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate concentrates, and adds 95% ethanol of 2 times of amounts, fully stirs, and standing over night filters, filtrate recycling ethanol, and concentrating under reduced pressure, standby; The preparation of glue: with gelatin: glycerol: water=1: 0.2: 0.9, get gelatin and add an amount of distilled water and make its imbibition, glycerol and remaining water are put be heated to 70～80 ℃ in the glue pot in addition, mix homogeneously adds expansible gelatin and stirs, and makes it to dissolve into uniform glue, in 70 ℃ of insulations 1～2 hour, leave standstill, remove the come-up foam, filter with cloth bag, in encapsulating machine, be pressed into soft capsule, be pressed into soft capsule, put in the drum drying machine and finalize the design, whole ball, drying promptly gets soft capsule.
Embodiments of the invention 4: Spica Prunellae 500g, Flos Chrysanthemi Indici 80g, Folium Mori 175g
Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water secondary, each 1.5 hours, collecting decoction, filter, filtrate concentrates, and adds 95% ethanol of 2 times of amounts, fully stir, standing over night filters, filtrate recycling ethanol, concentrating under reduced pressure splashes into the ratio that adopts PEG6000 and PEG4000 and is in 5: 4 the mixed-matrix, and the water dropper model adopts No. 1 water dropper, coolant temperature is 20～22 ℃, promptly gets drop pill.
Embodiments of the invention 5: Spica Prunellae 500g, Flos Chrysanthemi Indici 80g, Folium Mori 175g
Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water 3 times, and each 2.5 hours, collecting decoction filtered, and filtrate concentrates, and added 3 times of amount ethanol, fully stirred, and standing over night filters filtrate recycling ethanol, concentrating under reduced pressure; With Konjac glucomannan, carrageenan, xanthan gum, locust bean gum in 5: 5: 1: 1 ratio is dissolved in the hot water, and stirring and being mixed with concentration is 0.7% solution; Add above extracting solution then, adding the citric acid adjust pH is 4, stirs, and cooling promptly gets gel rapidly.
Embodiments of the invention 6: Spica Prunellae 500g, Flos Chrysanthemi Indici 80g, Folium Mori 175g
Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate concentrates, and adds 95% ethanol of 2 times of amounts, fully stirs, and standing over night filters, filtrate recycling ethanol, and concentrating under reduced pressure, standby; 0.8% carrageenan is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, heating, agitation and filtration then, filter the back and under condition of stirring, add the medicine cream that disappears, mix homogeneously, adding the citric acid adjust pH is 4, join rapidly in the disinfecting container, seal, sterilization, be cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Embodiments of the invention 7: Spica Prunellae 500g, Flos Chrysanthemi Indici 80g, Folium Mori 175g
Spica Prunellae, Flos Chrysanthemi Indici, Folium Mori are decocted with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate concentrates, and adds 95% ethanol of 2 times of amounts, fully stirs, and standing over night filters, filtrate recycling ethanol, and concentrating under reduced pressure, standby; 0.8% hydroxypropyl cellulose is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, heating, agitation and filtration then, filter the back and add the medicine clear paste under condition of stirring, adding the citric acid adjust pH is 4, mix homogeneously, join rapidly in the disinfecting container, seal, sterilization, be cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Claims (5)
1, a kind of summer Sang Ju Yin gel preparation, it is characterized in that: calculate according to weight, it is made into fluid or semifluid gel oral formulations by Spica Prunellae 450～600g, Flos Chrysanthemi Indici 60～90g and Folium Mori 150～200g and an amount of substrate, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.
2, according to Sang Ju Yin gel preparation of described summer of claim 1, it is characterized in that: it can also be prepared into: soft capsule, dispersible tablet, drop pill, pellet or slow releasing preparation.
3, according to claim 1 or 2 described summer Sang Ju Yin gel preparations, it is characterized in that: it by Spica Prunellae 500g, Flos Chrysanthemi Indici 80g and Folium Mori 175g and Konjac glucomannan, carrageenan, xanthan gum, locust bean gum by 5: 5: 1: 1 part by weight mixes the gel preparation that the substrate that obtains is prepared into, and is semifluid or solid gel shape.
4, as the preparation method of summer Sang Ju Yin gel preparation as described in the claim 1～3 any, it is characterized in that: Spica Prunellae, Flos Chrysanthemi Indici and Folium Mori are decocted with water 1～3 time each 1～2.5 hour, collecting decoction filters, and filtrate concentrates, add 1～3 times of amount ethanol, fully stir, standing over night filters, filtrate recycling ethanol, concentrating under reduced pressure gets extracting solution, makes different preparations again.
5, according to the preparation method of Sang Ju Yin gel preparation of described summer of claim 4, it is characterized in that: the gel in the described preparation prepares like this: Spica Prunellae, Flos Chrysanthemi Indici and Folium Mori are decocted with water secondary, each 1.5 hours, collecting decoction, filter, filtrate concentrates, and adds 95% ethanol of 2 times of amounts, fully stir, standing over night filters filtrate recycling ethanol, concentrating under reduced pressure gets extracting solution, standby; With Konjac glucomannan, carrageenan, xanthan gum, locust bean gum by 5: 5: 1: 1 part by weight is dissolved in the hot water, and stirring and being mixed with concentration is 0.7% solution; Add above extracting solution then, adding the citric acid adjust pH is 4, stir, and cooling rapidly, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510020289 CN1679763A (en) | 2005-01-26 | 2005-01-26 | Gel preparation of mulberry leaf and chrysanthemum and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510020289 CN1679763A (en) | 2005-01-26 | 2005-01-26 | Gel preparation of mulberry leaf and chrysanthemum and its preparing method |
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| Publication Number | Publication Date |
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| CN1679763A true CN1679763A (en) | 2005-10-12 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455303C (en) * | 2005-12-29 | 2009-01-28 | 广州星群（药业）股份有限公司 | A new ultrasonic extraction process of chrysanthemum chrysanthemum |
| CN102688399A (en) * | 2012-06-06 | 2012-09-26 | 黄芸 | Mother chrysanthemum traditional Chinese medicine oral liquid for treating dizziness and preparation method for oral liquid |
| CN103018391A (en) * | 2011-09-23 | 2013-04-03 | 四川科伦药物研究有限公司 | Quality control method of Spica Prunellae, mulberry leaf and chrysanthemum granules |
| CN106722750A (en) * | 2017-01-22 | 2017-05-31 | 天津商业大学 | Gel for solidifying tartar sauce |
| CN107280007A (en) * | 2017-07-03 | 2017-10-24 | 李剑峰 | Improve functional food of male's sub-health state and its preparation method and application |
| CN107669758A (en) * | 2017-10-17 | 2018-02-09 | 陈国忠 | A kind of Chinese herbal medicine formula of reduction regulation sleep and preparation method thereof |
-
2005
- 2005-01-26 CN CN 200510020289 patent/CN1679763A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455303C (en) * | 2005-12-29 | 2009-01-28 | 广州星群（药业）股份有限公司 | A new ultrasonic extraction process of chrysanthemum chrysanthemum |
| CN103018391A (en) * | 2011-09-23 | 2013-04-03 | 四川科伦药物研究有限公司 | Quality control method of Spica Prunellae, mulberry leaf and chrysanthemum granules |
| CN102688399A (en) * | 2012-06-06 | 2012-09-26 | 黄芸 | Mother chrysanthemum traditional Chinese medicine oral liquid for treating dizziness and preparation method for oral liquid |
| CN102688399B (en) * | 2012-06-06 | 2013-11-06 | 黄芸 | Mother chrysanthemum traditional Chinese medicine oral liquid for treating dizziness and preparation method for oral liquid |
| CN106722750A (en) * | 2017-01-22 | 2017-05-31 | 天津商业大学 | Gel for solidifying tartar sauce |
| CN107280007A (en) * | 2017-07-03 | 2017-10-24 | 李剑峰 | Improve functional food of male's sub-health state and its preparation method and application |
| CN107669758A (en) * | 2017-10-17 | 2018-02-09 | 陈国忠 | A kind of Chinese herbal medicine formula of reduction regulation sleep and preparation method thereof |
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