CN1391473A - Vla-4抑制剂化合物 - Google Patents
Vla-4抑制剂化合物 Download PDFInfo
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- CN1391473A CN1391473A CN00809510A CN00809510A CN1391473A CN 1391473 A CN1391473 A CN 1391473A CN 00809510 A CN00809510 A CN 00809510A CN 00809510 A CN00809510 A CN 00809510A CN 1391473 A CN1391473 A CN 1391473A
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- pyrrolidinyl
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- Organic Chemistry (AREA)
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- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14169299P | 1999-06-30 | 1999-06-30 | |
| US14160199P | 1999-06-30 | 1999-06-30 | |
| US14160299P | 1999-06-30 | 1999-06-30 | |
| US60/141,602 | 1999-06-30 | ||
| US60/141,692 | 1999-06-30 | ||
| US60/141,601 | 1999-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1391473A true CN1391473A (zh) | 2003-01-15 |
Family
ID=27385682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00809510A Pending CN1391473A (zh) | 1999-06-30 | 2000-06-30 | Vla-4抑制剂化合物 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1189612A4 (es) |
| JP (1) | JP2003503350A (es) |
| CN (1) | CN1391473A (es) |
| AR (1) | AR035011A1 (es) |
| AU (1) | AU781438B2 (es) |
| BR (1) | BR0012068A (es) |
| CA (1) | CA2369308A1 (es) |
| HK (1) | HK1043318A1 (es) |
| IL (1) | IL146288A0 (es) |
| MX (1) | MXPA01013406A (es) |
| NO (1) | NO324892B1 (es) |
| TW (1) | TWI283240B (es) |
| WO (1) | WO2001000206A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101006097B (zh) * | 2004-08-16 | 2012-07-11 | 默沙东公司 | Vla-4拮抗剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004504266A (ja) | 2000-01-17 | 2004-02-12 | バイエル アクチェンゲゼルシャフト | 置換アリールケトン類 |
| DE10006453A1 (de) * | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
| AU2001268607A1 (en) | 2000-06-21 | 2002-01-02 | Bristol-Myers Squibb Company | Piperidine amides as modulators of chemokine receptor activity |
| MXPA03005838A (es) | 2000-12-28 | 2003-09-10 | Daichi Pharmaceutical Co Ltd | Inhibidores de antigenos de aparicion muy tardia-4. |
| CN1990469A (zh) | 2001-06-27 | 2007-07-04 | 史密丝克莱恩比彻姆公司 | 作为二肽酶抑制剂的氟代吡咯烷 |
| GB0123765D0 (en) * | 2001-10-03 | 2001-11-21 | Bayer Ag | Para-amino benzoic acids |
| DE60325959D1 (de) * | 2002-05-09 | 2009-03-12 | Baker Medical Res Inst Prahran | Aminosäureanaloga |
| WO2004002481A1 (en) | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
| RU2340605C2 (ru) * | 2002-06-27 | 2008-12-10 | Ново Нордиск А/С | Арилкарбонильные производные в качестве терапевтических средств |
| JP4691988B2 (ja) | 2002-10-03 | 2011-06-01 | 小野薬品工業株式会社 | Lpa受容体拮抗剤 |
| GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| EP1623975A4 (en) | 2003-05-09 | 2008-07-02 | Daiichi Seiyaku Co | PROCESS FOR PREPARING A PYRROLIDINE DERIVATIVE |
| WO2005009992A1 (ja) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | シクロヘキサンカルボン酸類 |
| MXPA06003951A (es) * | 2003-10-07 | 2006-06-27 | Renovis Inc | Derivados de amida como ligandos del canal de ion y composiciones farmaceuticas y sus metodos de uso. |
| RU2386622C9 (ru) | 2004-01-06 | 2021-04-21 | Ново Нордиск А/С | Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы |
| JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
| US8129366B2 (en) | 2005-12-13 | 2012-03-06 | Daiichi Sankyo Company, Limited | VLA-4 inhibitory drug |
| CN101827826A (zh) | 2007-10-16 | 2010-09-08 | 诺瓦提斯公司 | 4-苯基-5-氧代-咪唑衍生物、其药物组合物及其应用 |
| PT2260020E (pt) * | 2008-03-26 | 2014-10-28 | Novartis Ag | Inibidores das desacetilases b baseados no hidroxamato |
| JP5536227B2 (ja) * | 2009-11-18 | 2014-07-02 | スヴェン・ライフ・サイエンシズ・リミテッド | α4β2ニコチン性アセチルコリン受容体リガンドとしての二環式化合物 |
| JP5976011B2 (ja) * | 2011-04-05 | 2016-08-23 | 武田薬品工業株式会社 | スルホンアミド誘導体およびその用途 |
| CN112040945A (zh) | 2018-06-12 | 2020-12-04 | Vtv治疗有限责任公司 | 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途 |
| HRP20250191T1 (hr) | 2018-10-30 | 2025-04-11 | Gilead Sciences, Inc. | Derivati 3-(kinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidin-2,4-diona kao inhibitori alfa4beta7 integrina za liječenje upalnih bolesti |
| US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
| AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
| WO2020173861A1 (de) | 2019-02-26 | 2020-09-03 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| EP4013499A1 (en) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| US12391658B2 (en) | 2020-02-18 | 2025-08-19 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
| AU2021289309A1 (en) | 2020-06-08 | 2023-01-19 | Vtv Therapeutics Llc | Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| US6248713B1 (en) * | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| EP1001764A4 (en) * | 1997-05-29 | 2005-08-24 | Merck & Co Inc | HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION |
| WO1999020272A1 (en) * | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Azapeptide acids as cell adhesion inhibitors |
| BR9813331A (pt) * | 1997-10-31 | 2000-08-22 | Aventis Pharma Ltd | Composto, uso do mesmo, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano que sofra ou esteja sujeito a condições que possam ser melhoradas pela administração de um inibidor da adesão celular mediada pela a4b1, e, resina |
| AU3716499A (en) * | 1998-04-21 | 1999-11-08 | Aventis Pharma Limited | Substituted diamines and their use as cell adhesion inhibitors |
| EA004792B1 (ru) * | 1998-06-30 | 2004-08-26 | Пфайзер Продактс Инк. | Непептидные ингибиторы vla-4-зависимого клеточного связывания, полезные в лечении воспалительных, аутоиммунных и респираторных заболеваний |
-
2000
- 2000-06-30 CA CA002369308A patent/CA2369308A1/en not_active Abandoned
- 2000-06-30 WO PCT/US2000/018079 patent/WO2001000206A1/en not_active Ceased
- 2000-06-30 EP EP00945035A patent/EP1189612A4/en not_active Withdrawn
- 2000-06-30 HK HK02105102.2A patent/HK1043318A1/zh unknown
- 2000-06-30 MX MXPA01013406A patent/MXPA01013406A/es active IP Right Grant
- 2000-06-30 JP JP2001505915A patent/JP2003503350A/ja active Pending
- 2000-06-30 AR ARP000103363A patent/AR035011A1/es unknown
- 2000-06-30 AU AU59031/00A patent/AU781438B2/en not_active Ceased
- 2000-06-30 IL IL14628800A patent/IL146288A0/xx not_active IP Right Cessation
- 2000-06-30 TW TW089112968A patent/TWI283240B/zh not_active IP Right Cessation
- 2000-06-30 CN CN00809510A patent/CN1391473A/zh active Pending
- 2000-06-30 BR BR0012068-5A patent/BR0012068A/pt not_active Application Discontinuation
-
2001
- 2001-12-21 NO NO20016319A patent/NO324892B1/no unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101006097B (zh) * | 2004-08-16 | 2012-07-11 | 默沙东公司 | Vla-4拮抗剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO324892B1 (no) | 2007-12-27 |
| AU5903100A (en) | 2001-01-31 |
| HK1043318A1 (zh) | 2002-09-13 |
| IL146288A0 (en) | 2002-07-25 |
| WO2001000206A1 (en) | 2001-01-04 |
| TWI283240B (en) | 2007-07-01 |
| JP2003503350A (ja) | 2003-01-28 |
| EP1189612A4 (en) | 2005-02-16 |
| CA2369308A1 (en) | 2001-01-04 |
| NO20016319L (no) | 2002-02-28 |
| BR0012068A (pt) | 2002-05-14 |
| MXPA01013406A (es) | 2003-09-04 |
| EP1189612A1 (en) | 2002-03-27 |
| AR035011A1 (es) | 2004-04-14 |
| NO20016319D0 (no) | 2001-12-21 |
| AU781438B2 (en) | 2005-05-26 |
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