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AR035011A1 - Compuestos inhibidores de vla-4 - Google Patents

Compuestos inhibidores de vla-4

Info

Publication number
AR035011A1
AR035011A1 ARP000103363A ARP000103363A AR035011A1 AR 035011 A1 AR035011 A1 AR 035011A1 AR P000103363 A ARP000103363 A AR P000103363A AR P000103363 A ARP000103363 A AR P000103363A AR 035011 A1 AR035011 A1 AR 035011A1
Authority
AR
Argentina
Prior art keywords
substituted
formula
alkyl
aryl
lower alkyl
Prior art date
Application number
ARP000103363A
Other languages
English (en)
Inventor
John Baldwin
Edward Mcdonald
Kevin Joseph Moriarty
Christopher Ronald Sarko
Nobuo Machinaga
Atsushi Nakayama
Jun Chiba
Shin Iimura
Yoshiyuki Yoneda
Original Assignee
Daiichi Seiyaku Co
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co, Pharmacopeia Inc filed Critical Daiichi Seiyaku Co
Publication of AR035011A1 publication Critical patent/AR035011A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Reivindicación 1: Un compuesto representado por la fórmula (1), o una sal del mismo donde: W es seleccionado entre arilo, arilo sustituido, heteroarilo y heteroarilo sustituido; W1 es seleccionado entre arileno, arileno sustituido, heteroarileno y heteroarileno sustituido; A es seleccionado entre =O, =S y =NH; R es seleccionado entre un enlace directo, un grupo alquenileno y -(CH2)n, donde n es seleccionado entre 1 y 2; X es seleccionado entre -C(O)-, -CH2- y -S(O)2-; M es seleccionado entre radicales del grupo de fórmulas (2a), (2b), (2c) ó (2d) donde: el resto de fórmula (3) es un resto heterocíclico divalente de 4, 5, 6 o 7 miembros, donde el átomo de nitrógeno es el punto de unión a X; R1, R2 y R3 son seleccionados independientemente entre -H, -OH, -NH2, átomo de halógeno, alquilo, alquilo sustituido, arilo, arilo sustituido, alcoxi, alcoxi sustituido, monoalquilamino, monoalquilamino sustituido, dialquilamino, dialquilamino sustituido, cicloalquilamino, cicloalquilamino sustituido, alquilsulfonilamino, alquilsulfonilamino sustituido, arilsulfonilamino, arilsulfonilamino sustituido, ariloxi, ariloxi sustituido, heteroariloxi, heteroariloxi sustituido, benciloxi y benciloxi sustituido, o aquellos dos radicales entre ellos forman juntos un residuo carbocíclico o heterocíclico de 3, 4, 5, 6 o 7 miembros eventualmente sustituido con 1 a 3 sustituyentes seleccionados independientemente entre -OH, átomo de halógeno, -NH2, alquilo, alcoxi, arilo, ariloxi, alquilamino, benciloxi y heteroarilo; R4 es seleccionado entre -H y alquilo inferior; Y es un enlace directo o un radical divalente seleccionado entre -C(O)-, -C(O)NH-, alquenileno, alquinileno y -(CH2)kY2-, donde k es seleccionado entre 1, 2 y 3 e Y2 es un enlace directo un radical divalente seleccionado entre -O-, -S-, -S(O)-, -S(O)2- y -NY3-, donde Y3 es seleccionado entre -H y alquilo inferior; Z es seleccionado entre arileno, arileno sustituido, heterociclileno, heterociclileno sustituido, cicloalquileno y cicloalquileno sustituido; A1 es un enlace directo o un radical divalente seleccionado entre alquenileno, alquinileno, -(CH2)t-, donde t es seleccionado entre 1, 2 y 3, y -O(CH2)v, donde v es seleccionado entre 0, 1, 2 y 3; y R5 es seleccionado entre -OH, alcoxi inferior, -NHOH, un resto de fórmula (4a) ó fórmula (4b); donde el resto fórmula (5) es un resto heterocíclico divalente de 4, 5 6 o 7 miembros, donde el átomo de nitrógeno es el punto de unión a X; R6 y R7 son independientemente seleccionados entre -H, -OH, átomo de halógeno, alquilo y alcoxi; Y1 es un radical divalente seleccionado entre -O-, -S-, -S(O)-, -S(O)2- y -NY4-, donde Y4 es seleccionado entre -H y alquilo inferior; Z1 es un radical divalente seleccionado entre arileno, arileno sustituido, heterociclileno, heterociclileno sustituido, cicloalquileno y cicloalquileno sustituido; A2 es un enlace directo o un radical divalente seleccionado entre alquenileno, alquinileno y -(CH2)e, donde e es seleccionado entre 1, 2 y 3, y R8 es seleccionado entre -OH, alcoxi inferior, -NHOH, un resto de fórmula (4a) ó (4b); donde L es de fórmula (6), donde su parte cíclica es un resto heterocíclico divalente de 4, 5, 6 o 7 miembros, eventualmente sustituido con 1 a 3 sustituyentes seleccionados independientemente entre alquilo, alcoxi, hidroxialquilo, -OH, benciloxi, -NH2, átomo de halógeno, arilo y heteroarilo, y dicho resto heterocíclico puede estar fusionado a 1 o 2 residuos carbocíclicos o heterocíclicos adicionales eventualmente sustituidos con 1 a 3 sustituyentes independientemente seleccionados entre alquilo, ariloxi, alcoxi, hidroxialquilo, -OH, benciloxi, -NH2, átomo de halógeno, arilo y heteroarilo; m y g son independientemente seleccionados entre 0, 1, 2 y 3; X1 es seleccionado entre -CH= y -N=; R9 es seleccionado entre -H y alquilo inferior; R10 es seleccionado entre -CO2H, alcoxi-carbonilo inferior, un resto de fórmula (4a), (7) ó (8) y Z2 es seleccionado entre -H, -CO2H y grupo alcoxicarbonilo inferior; donde R11 es seleccionado entre -O-, o el grupo de fórmulas (9) y -NR12-, donde R12 es seleccionado entre -H, alquilo, alquilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, arilo sustituido, bencilo, bencilo sustituido, alquenilo inferior, alquenilo inferior sustituido y alquinilo inferior, donde el enlace de la izquierda es el punto de unión a X y el enlace de la derecha es el punto de unión a Z3; Z3 es seleccionado entre un enlace directo y un resto hidrocarbonado alifático divalente C1-12 y su uno o mas átomos de carbono pueden estar sustituidos con -O- o -NR13-, donde R13 es seleccionado entre -H y alquilo inferior; uno o más átomos de hidrógeno unidos a un átomo de carbono alifático pueden estar sustituidos con alquilo inferior, y fórmula (10), donde x es seleccionado entre 0 y 1; y es seleccionado entre 1, 2 y 3 y R14 es seleccionado entre -H, -OH y átomo de halógeno, o un resto del grupo (11), siempre que Z4 sea seleccionado entre los tres grupos divalentes formulados siguientes en el caso limitado de que R11 sea -NR12, fórmula (12) donde R14a es seleccionado entre -H, -OH, alquilo inferior y átomo de halógeno; un grupo de fórmulas (13), donde el enlace de la izquierda es el punto de unión a R11 y el enlace de la derecha es el punto de unión a Q2; Q2 es un radical divalente seleccionado entre arileno, arileno sustituido, heterociclileno, heterociclileno sustituido, cicloalquileno, cicloalquileno sustituido, formula (14), donde R15 y R16 son independientemente seleccionados entre -H, átomo de halógeno y alquilo inferior, y fórmula (15), donde R17 y R18 son independientemente seleccionados entre -H, alquilo inferior, alquilo inferior sustituido y alquenilo inferior, y L1 es seleccionado entre -CO2H y -CO2R19, donde R19 es un alquilo inferior.
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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0107624A (pt) 2000-01-17 2002-11-12 Bayer Ag Arilcetonas substituìdas
DE10006453A1 (de) * 2000-02-14 2001-08-16 Bayer Ag Piperidylcarbonsäuren als Integrinantagonisten
AU2001268607A1 (en) 2000-06-21 2002-01-02 Bristol-Myers Squibb Company Piperidine amides as modulators of chemokine receptor activity
RU2290403C2 (ru) 2000-12-28 2006-12-27 Дайити Фармасьютикал Ко., Лтд. Ингибиторы vla-4
AU2002322344C1 (en) 2001-06-27 2006-02-16 Smithkline Beecham Corporation Fluoropyrrolidines as dipeptidyl peptidase inhibitors
GB0123765D0 (en) * 2001-10-03 2001-11-21 Bayer Ag Para-amino benzoic acids
JP2005530772A (ja) * 2002-05-09 2005-10-13 ミモトープス・プロプライエタリー・リミテッド アミノ酸類縁体
JP4881559B2 (ja) 2002-06-27 2012-02-22 ノボ・ノルデイスク・エー／エス 治療薬としてのアリールカルボニル誘導体
CN1678311A (zh) * 2002-06-27 2005-10-05 诺沃挪第克公司 用作治疗剂的芳基羰基衍生物
US7820682B2 (en) 2002-10-03 2010-10-26 Ono Pharmaceutical Co., Ltd. LPA receptor antagonist
GB0225944D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
US7345179B2 (en) 2003-05-09 2008-03-18 Daiichi Pharmaceutical Co., Ltd. Process for producing pyrrolidine derivative
CA2770493A1 (en) 2003-07-24 2005-02-03 Daiichi Pharmaceutical Co., Ltd. Cyclohexanecarboxylic acid compound
US7432281B2 (en) * 2003-10-07 2008-10-07 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
RU2386622C9 (ru) 2004-01-06 2021-04-21 Ново Нордиск А/С Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы
JP2005350417A (ja) * 2004-06-11 2005-12-22 Dai Ichi Seiyaku Co Ltd 還元的エーテル化法を用いたピロリジン誘導体の製造法
AU2005277634B2 (en) * 2004-08-16 2011-02-17 Merck Sharp & Dohme Corp. VLA-4 antagonists
EP1961750B1 (en) 2005-12-13 2013-09-18 Daiichi Sankyo Company, Limited Vla-4 inhibitory drug
US7786155B2 (en) 2007-10-16 2010-08-31 Novartis Ag Organic compounds
ES2519474T3 (es) * 2008-03-26 2014-11-07 Novartis Ag Inhibidores de las desacetilasas B basados en hidroxamato
DK2513085T3 (en) * 2009-11-18 2016-12-05 Suven Life Sciences Ltd Alfa4beta2 bicyclic compounds as nicotinic acetylcholine receptor ligands
JP5976011B2 (ja) 2011-04-05 2016-08-23 武田薬品工業株式会社 スルホンアミド誘導体およびその用途
JP2021526130A (ja) 2018-06-12 2021-09-30 ブイティーブイ・セラピューティクス・エルエルシー インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用
ES2987796T3 (es) 2018-10-30 2024-11-18 Gilead Sciences Inc Derivados de N-benzoil-fenilalanina como inhibidores de la integrina alfa4beta7 para el tratamiento de enfermedades inflamatorias
KR102641718B1 (ko) 2018-10-30 2024-02-29 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
MX2021005050A (es) 2018-10-30 2021-06-15 Gilead Sciences Inc Derivados de quinolina como inhibidores de integrina alfa4beta7.
KR20210133984A (ko) 2019-02-26 2021-11-08 바이엘 악티엔게젤샤프트 해충 방제제로서의 축합된 비시클릭 헤테로시클릭 유도체
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
KR20230048502A (ko) 2020-06-08 2023-04-11 브이티브이 테라퓨틱스 엘엘씨 ｛2-[3-사이클로헥실-3-(트랜스-4-프로폭시-사이클로헥실)-우레이도]-티아졸-5-일설파닐｝-아세트산의 염 또는 공결정 및 그의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US6248713B1 (en) * 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
EP1001764A4 (en) * 1997-05-29 2005-08-24 Merck & Co Inc HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION
WO1999020272A1 (en) * 1997-10-21 1999-04-29 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
CN1327443A (zh) * 1997-10-31 2001-12-19 艾文蒂斯药品有限公司 取代的酰苯胺化合物
AU3716499A (en) * 1998-04-21 1999-11-08 Aventis Pharma Limited Substituted diamines and their use as cell adhesion inhibitors
CA2336625A1 (en) * 1998-06-30 2000-01-06 Louis Stanley Chupak Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases

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