CN1368249A - Nano medicine 'Dali' and its preparing process - Google Patents
Nano medicine 'Dali' and its preparing process Download PDFInfo
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- CN1368249A CN1368249A CN 01102583 CN01102583A CN1368249A CN 1368249 A CN1368249 A CN 1368249A CN 01102583 CN01102583 CN 01102583 CN 01102583 A CN01102583 A CN 01102583A CN 1368249 A CN1368249 A CN 1368249A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims description 12
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 8
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 17
- 241000125175 Angelica Species 0.000 claims description 8
- 241000717739 Boswellia sacra Species 0.000 claims description 8
- 244000020518 Carthamus tinctorius Species 0.000 claims description 8
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 8
- 241001489978 Eupolyphaga Species 0.000 claims description 8
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 8
- 241001057584 Myrrha Species 0.000 claims description 8
- 241001464849 Ophisaurus Species 0.000 claims description 8
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 8
- 241000180649 Panax notoginseng Species 0.000 claims description 8
- 241000219061 Rheum Species 0.000 claims description 8
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000004863 Frankincense Substances 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 235000019509 white turmeric Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre (0.1-200 nm) medicine "Dali" is prepared from the nanometre powders of 22 Chinese medicinal materials including red sage root, Chinese angelica root, zedoary, rehmannia root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of relaxing muscles and tendons to promote blood circulation, expelling wind and removing dampness, analgesic nano medicine ' Dali ', the invention still further relates to the method for this medication preparation.
Medicated wine is a kind of classical Chinese patent medicine energetically, mainly contains effects such as relaxing muscles and tendons to promote blood circulation, expelling wind and removing dampness, pain relieving, is used for diseases such as traumatic injury, anemofrigid-damp arthralgia.But traditional medicated wine energetically absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Dali ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Dali '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Salviae Miltiorrhizae 4-9 part nano Chinese angelica tail 1-5 part nanometer Rhizoma Curcumae 3-10 part
Nanometer Radix Dipsaci 4-9 part nanometer Radix Rehmanniae 6-18 part nanometer Radix Notoginseng 6-17 part
Nanometer rhizoma sparganic 4-9 part nanometer Cortex Acanthopancis 6-18 part nanometer Rhizoma Drynariae 3-8 part
Nanometer Radix Paeoniae Rubra 3-8 part nano rhubarb 3-8 part nanometer Olibanum 3-8 part
Nanometer Myrrha 3-8 part nanometer Pericarpium Citri Reticulatae Viride 3-8 part nanometer Radix Aconiti Preparata 1-9 part
Nano angelica root 1-8 part nano safflower 1-8 part nanometer Eupolyphaga Seu Steleophaga 12-40 part
Nanometer Radix Rubiae 15-40 part nanometer Pyritum 4-9 part nanometer Ophisaurus 1-5 part
Nanometer Radix Achyranthis Bidentatae 6-18 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Salviae Miltiorrhizae 5-8 part nano Chinese angelica tail 1-3 part nanometer Rhizoma Curcumae 5-9 part
Nanometer Radix Dipsaci 5-8 part nanometer Radix Rehmanniae 8-15 part nanometer Radix Notoginseng 8-15 part
Nanometer rhizoma sparganic 5-8 part nanometer Cortex Acanthopancis 8-15 part nanometer Rhizoma Drynariae 4-6 part
Nanometer Radix Paeoniae Rubra 4-7 part nano rhubarb 4-7 part nanometer Olibanum 4-7 part
Nanometer Myrrha 4-7 part nanometer Pericarpium Citri Reticulatae Viride 4-7 part nanometer Radix Aconiti Preparata 2-7 part
Nano angelica root 2-6 part nano safflower 2-6 part nanometer Eupolyphaga Seu Steleophaga 15-30 part
Nanometer Radix Rubiae 22-30 part nanometer Pyritum 5-8 part nanometer Ophisaurus 1-3 part
Nanometer Radix Achyranthis Bidentatae 8-15 part
The optimum weight proportioning of medicine of the present invention is:
6.8 parts of 1.7 parts of nanometer Rhizoma Curcumae of 6.8 parts of nano Chinese angelica tails of nanometer Radix Salviae Miltiorrhizae
10.23 parts of 10.23 parts of nanometer Radix Notoginseng of 6.8 parts of nanometer Radix Rehmanniae of nanometer Radix Dipsaci
5.1 parts of 10.23 parts of nanometer Rhizoma Drynariae of 6.8 parts of nanometer Cortex Acanthopanciss of nanometer rhizoma sparganic
5.1 parts of 5.1 parts of nanometer Olibanums of 5.1 parts of nano rhubarbs of nanometer Radix Paeoniae Rubra
3.4 parts of 5.1 parts of nanometer Radix Aconiti Preparatas of 5.1 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Myrrha
20.45 parts of 3.4 parts of nanometer Eupolyphaga Seu Steleophagas of 3.4 parts of nano safflowers of nano angelica root
1.4 parts of 6.8 parts of nanometer Ophisaurus of 27.3 parts of nanometer Pyritums of nanometer Radix Rubiae
Nanometer Radix Achyranthis Bidentatae 10.23
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Dali ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Dali ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the common preparation material of medicated wine energetically is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, syrup, oral solution of nano medicine ' Dali ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as traumatic injury, anemofrigid-damp arthralgia, and clinical efficacy significantly is better than traditional medicated wine energetically.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
6.8 parts of 1.7 parts of nanometer Rhizoma Curcumae of 6.8 parts of nano Chinese angelica tails of nanometer Radix Salviae Miltiorrhizae
10.23 parts of 10.23 parts of nanometer Radix Notoginseng of 6.8 parts of nanometer Radix Rehmanniae of nanometer Radix Dipsaci
5.1 parts of 10.23 parts of nanometer Rhizoma Drynariae of 6.8 parts of nanometer Cortex Acanthopanciss of nanometer rhizoma sparganic
5.1 parts of 5.1 parts of nanometer Olibanums of 5.1 parts of nano rhubarbs of nanometer Radix Paeoniae Rubra
3.4 parts of 5.1 parts of nanometer Radix Aconiti Preparatas of 5.1 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Myrrha
20.45 parts of 3.4 parts of nanometer Eupolyphaga Seu Steleophagas of 3.4 parts of nano safflowers of nano angelica root
1.4 parts of 6.8 parts of nanometer Ophisaurus of 27.3 parts of nanometer Pyritums of nanometer Radix Rubiae
Nanometer Radix Achyranthis Bidentatae 10.23
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
6.8 parts of 1.7 parts of nanometer Rhizoma Curcumae of 6.8 parts of nano Chinese angelica tails of nanometer Radix Salviae Miltiorrhizae
10.23 parts of 10.23 parts of nanometer Radix Notoginseng of 6.8 parts of nanometer Radix Rehmanniae of nanometer Radix Dipsaci
5.1 parts of 10.23 parts of nanometer Rhizoma Drynariae of 6.8 parts of nanometer Cortex Acanthopanciss of nanometer rhizoma sparganic
5.1 parts of 5.1 parts of nanometer Olibanums of 5.1 parts of nano rhubarbs of nanometer Radix Paeoniae Rubra
3.4 parts of 5.1 parts of nanometer Radix Aconiti Preparatas of 5.1 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Myrrha
20.45 parts of 3.4 parts of nanometer Eupolyphaga Seu Steleophagas of 3.4 parts of nano safflowers of nano angelica root
1.4 parts of 6.8 parts of nanometer Ophisaurus of 27.3 parts of nanometer Pyritums of nanometer Radix Rubiae
Nanometer Radix Achyranthis Bidentatae 10.23
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer membrane energetically, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest or affected part.
Claims (6)
1, a kind of nano medicine ' Dali ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Salviae Miltiorrhizae 4-9 part nano Chinese angelica tail 1-5 part nanometer Rhizoma Curcumae 3-10 part
Nanometer Radix Dipsaci 4-9 part nanometer Radix Rehmanniae 6-18 part nanometer Radix Notoginseng 6-17 part
Nanometer rhizoma sparganic 4-9 part nanometer Cortex Acanthopancis 6-18 part nanometer Rhizoma Drynariae 3-8 part
Nanometer Radix Paeoniae Rubra 3-8 part nano rhubarb 3-8 part nanometer Olibanum 3-8 part
Nanometer Myrrha 3-8 part nanometer Pericarpium Citri Reticulatae Viride 3-8 part nanometer Radix Aconiti Preparata 1-9 part
Nano angelica root 1-8 part nano safflower 1-8 part nanometer Eupolyphaga Seu Steleophaga 12-40 part
Nanometer Radix Rubiae 15-40 part nanometer Pyritum 4-9 part nanometer Ophisaurus 1-5 part
Nanometer Radix Achyranthis Bidentatae 6-18 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Dali ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Salviae Miltiorrhizae 5-8 part nano Chinese angelica tail 1-3 part nanometer Rhizoma Curcumae 5-9 part
Nanometer Radix Dipsaci 5-8 part nanometer Radix Rehmanniae 8-15 part nanometer Radix Notoginseng 8-15 part
Nanometer rhizoma sparganic 5-8 part nanometer Cortex Acanthopancis 8-15 part nanometer Rhizoma Drynariae 4-6 part
Nanometer Radix Paeoniae Rubra 4-7 part nano rhubarb 4-7 part nanometer Olibanum 4-7 part
Nanometer Myrrha 4-7 part nanometer Pericarpium Citri Reticulatae Viride 4-7 part nanometer Radix Aconiti Preparata 2-7 part
Nano angelica root 2-6 part nano safflower 2-6 part nanometer Eupolyphaga Seu Steleophaga 15-30 part
Nanometer Radix Rubiae 22-30 part nanometer Pyritum 5-8 part nanometer Ophisaurus 1-3 part
Nanometer Radix Achyranthis Bidentatae 8-15 part
3, nano medicine ' Dali ' according to claim 1, wherein the weight proportion of each nano raw material is:
6.8 parts of 1.7 parts of nanometer Rhizoma Curcumae of 6.8 parts of nano Chinese angelica tails of nanometer Radix Salviae Miltiorrhizae
10.23 parts of 10.23 parts of nanometer Radix Notoginseng of 6.8 parts of nanometer Radix Rehmanniae of nanometer Radix Dipsaci
5.1 parts of 10.23 parts of nanometer Rhizoma Drynariae of 6.8 parts of nanometer Cortex Acanthopanciss of nanometer rhizoma sparganic
5.1 parts of 5.1 parts of nanometer Olibanums of 5.1 parts of nano rhubarbs of nanometer Radix Paeoniae Rubra
3.4 parts of 5.1 parts of nanometer Radix Aconiti Preparatas of 5.1 parts of nanometer Pericarpium Citri Reticulatae Virides of nanometer Myrrha
20.45 parts of 3.4 parts of nanometer Eupolyphaga Seu Steleophagas of 3.4 parts of nano safflowers of nano angelica root
1.4 parts of 6.8 parts of nanometer Ophisaurus of 27.3 parts of nanometer Pyritums of nanometer Radix Rubiae
Nanometer Radix Achyranthis Bidentatae 10.23
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Dali 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Dali 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102583 CN1368249A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Dali' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102583 CN1368249A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Dali' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368249A true CN1368249A (en) | 2002-09-11 |
Family
ID=4652844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102583 Pending CN1368249A (en) | 2001-02-01 | 2001-02-01 | Nano medicine 'Dali' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1368249A (en) |
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2001
- 2001-02-01 CN CN 01102583 patent/CN1368249A/en active Pending
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