CN1366907A - Nano Jianmin throat-benefiting preparation medicine and preparation method thereof - Google Patents
Nano Jianmin throat-benefiting preparation medicine and preparation method thereof Download PDFInfo
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- CN1366907A CN1366907A CN 01102046 CN01102046A CN1366907A CN 1366907 A CN1366907 A CN 1366907A CN 01102046 CN01102046 CN 01102046 CN 01102046 A CN01102046 A CN 01102046A CN 1366907 A CN1366907 A CN 1366907A
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- 239000003814 drug Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 241000931705 Cicada Species 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 19
- 239000000843 powder Substances 0.000 claims description 9
- 239000010231 banlangen Substances 0.000 claims description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 235000014435 Mentha Nutrition 0.000 claims description 4
- 241001072983 Mentha Species 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000008569 process Effects 0.000 abstract description 2
- 229930195210 Ophiopogon Natural products 0.000 abstract 1
- 244000248557 Ophiopogon japonicus Species 0.000 abstract 1
- 235000006751 Platycodon Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 241001530126 Scrophularia Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 229930189914 platycodon Natural products 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010002953 Aphonia Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
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- 239000013078 crystal Substances 0.000 description 2
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- 238000009472 formulation Methods 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
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- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000016150 acute pharyngitis Diseases 0.000 description 1
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- 230000004089 microcirculation Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The present invention discloses a nano Jianmin throat-benefiting preparation medicine. It is made up by using 12 Chinese medicinal materials of nano scrophularia, nano ophiopogon, nano cicada molting, nano chebule, nano platycodon and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of pharynx-clearing throat-benefiting, YIN nourishing and the production of body fluid promoting, detoxifcation pathogenic fire purging, cure mainly the nano Jianmin throat-benefiting preparation medicine of laryngopharynx swelling and pain, aphonia and upper respiratory tract infection, the invention still further relates to the method for this medication preparation.
JIANMIN YINHOU PIAN is a kind of classical Chinese patent medicine, mainly contains effects such as antiinflammatory, antibacterial, the secretion that increases total protein in saliva and the saliva and expansion blood capillary, microcirculation improvement, is used for laryngopharynx swelling and pain, aphonia and upper respiratory tract infection.But traditional JIANMIN YINHOU PIAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Jianmin throat-benefiting preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Jianmin throat-benefiting preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Scrophulariae 10-50 part nanometer 10-50 Radix Ophiopogonis part nanometer Periostracum Cicadae 10-50 part
Nanometer Fructus Chebulae 8-50 part nanometer Radix Platycodonis 8-50 part nano Radix Isatidis 10-50 part
Nanometer Semen Sterculiae Lychnophorae 10-50 part nanometer Radix Rehmanniae 8-50 part nanometer FRUCTUS TERMINALIAE IMMATURUS 8-50 part
Nanometer Radix Glycyrrhizae 5-30 part nanometer Oleum menthae 0.1-1 part nanometer Mentholum 0.1-1 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Scrophulariae 20-40 part nanometer 20-40 Radix Ophiopogonis part nanometer Periostracum Cicadae 20-40 part
Nanometer Fructus Chebulae 15-40 part nanometer Radix Platycodonis 15-40 part nano Radix Isatidis 20-40 part
Nanometer Semen Sterculiae Lychnophorae 20-40 part nanometer Radix Rehmanniae 15-35 part nanometer FRUCTUS TERMINALIAE IMMATURUS 15-35 part
Nanometer Radix Glycyrrhizae 8-20 part nanometer Oleum menthae 0.3-0.8 part nanometer Mentholum 0.3-0.8 part
The optimum weight proportioning of medicine of the present invention is:
30 parts of 30 parts of nanometers of nanometer Radix Scrophulariae, 30 parts of nanometer Periostracum Cicadaes Radix Ophiopogonis
28 parts of 25 parts of nano Radix Isatidis of 25 parts of nanometer Radix Platycodoniss of nanometer Fructus Chebulae
25 parts of 25 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of 28 parts of nanometer Radix Rehmanniae of nanometer Semen Sterculiae Lychnophorae
0.5 part of 0.5 part of nanometer Mentholum of 15 parts of nanometer Oleum menthaes of nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Jianmin throat-benefiting preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Jianmin throat-benefiting preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common JIANMIN YINHOU PIAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Jianmin throat-benefiting preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as acute and chronic pharyngitis and voice health, and clinical efficacy significantly is better than traditional JIANMIN YINHOU PIAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometers of nanometer Radix Scrophulariae, 30 parts of nanometer Periostracum Cicadaes Radix Ophiopogonis
28 parts of 25 parts of nano Radix Isatidis of 25 parts of nanometer Radix Platycodoniss of nanometer Fructus Chebulae
25 parts of 25 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of 28 parts of nanometer Radix Rehmanniae of nanometer Semen Sterculiae Lychnophorae
0.5 part of 0.5 part of nanometer Mentholum of 15 parts of nanometer Oleum menthaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
30 parts of 30 parts of nanometers of nanometer Radix Scrophulariae, 30 parts of nanometer Periostracum Cicadaes Radix Ophiopogonis
28 parts of 25 parts of nano Radix Isatidis of 25 parts of nanometer Radix Platycodoniss of nanometer Fructus Chebulae
25 parts of 25 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of 28 parts of nanometer Radix Rehmanniae of nanometer Semen Sterculiae Lychnophorae
0.5 part of 0.5 part of nanometer Mentholum of 15 parts of nanometer Oleum menthaes of nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Jianmin throat-benefiting powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Claims (6)
1, a kind of nano Jianmin throat-benefiting preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Scrophulariae 10-50 part nanometer 10-50 Radix Ophiopogonis part nanometer Periostracum Cicadae 10-50 part
Nanometer Fructus Chebulae 8-50 part nanometer Radix Platycodonis 8-50 part nano Radix Isatidis 10-50 part
Nanometer Semen Sterculiae Lychnophorae 10-50 part nanometer Radix Rehmanniae 8-50 part nanometer FRUCTUS TERMINALIAE IMMATURUS 8-50 part
Nanometer Radix Glycyrrhizae 5-30 part nanometer Oleum menthae 0.1-1 part nanometer Mentholum 0.1-1 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Jianmin throat-benefiting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Scrophulariae 20-40 part nanometer 20-40 Radix Ophiopogonis part nanometer Periostracum Cicadae 20-40 part
Nanometer Fructus Chebulae 15-40 part nanometer Radix Platycodonis 15-40 part nano Radix Isatidis 20-40 part
Nanometer Semen Sterculiae Lychnophorae 20-40 part nanometer Radix Rehmanniae 15-35 part nanometer FRUCTUS TERMINALIAE IMMATURUS 15-35 part
Nanometer Radix Glycyrrhizae 8-20 part nanometer Oleum menthae 0.3-0.8 part nanometer Mentholum 0.3-0.8 part
3, nano Jianmin throat-benefiting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
30 parts of 30 parts of nanometers of nanometer Radix Scrophulariae, 30 parts of nanometer Periostracum Cicadaes Radix Ophiopogonis
28 parts of 25 parts of nano Radix Isatidis of 25 parts of nanometer Radix Platycodoniss of nanometer Fructus Chebulae
25 parts of 25 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of 28 parts of nanometer Radix Rehmanniae of nanometer Semen Sterculiae Lychnophorae
0.5 part of 0.5 part of nanometer Mentholum of 15 parts of nanometer Oleum menthaes of nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Jianmin throat-benefiting preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Jianmin throat-benefiting preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102046 CN1366907A (en) | 2001-01-22 | 2001-01-22 | Nano Jianmin throat-benefiting preparation medicine and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102046 CN1366907A (en) | 2001-01-22 | 2001-01-22 | Nano Jianmin throat-benefiting preparation medicine and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1366907A true CN1366907A (en) | 2002-09-04 |
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| CN 01102046 Pending CN1366907A (en) | 2001-01-22 | 2001-01-22 | Nano Jianmin throat-benefiting preparation medicine and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734384A (en) * | 2013-12-20 | 2014-04-23 | 广东药学院 | Throat health beverage as well as preparation method and application thereof |
| CN103784753A (en) * | 2014-01-15 | 2014-05-14 | 纪晓青 | Chinese herbal medicine formula for treating nasopharyngitis and preparation method thereof |
| CN105194280A (en) * | 2014-06-26 | 2015-12-30 | 梁军 | Drug for treating hoarseness |
-
2001
- 2001-01-22 CN CN 01102046 patent/CN1366907A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734384A (en) * | 2013-12-20 | 2014-04-23 | 广东药学院 | Throat health beverage as well as preparation method and application thereof |
| CN103784753A (en) * | 2014-01-15 | 2014-05-14 | 纪晓青 | Chinese herbal medicine formula for treating nasopharyngitis and preparation method thereof |
| CN105194280A (en) * | 2014-06-26 | 2015-12-30 | 梁军 | Drug for treating hoarseness |
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