CN1366924A - Nano throat-benefiting preparation medicine and preparation method - Google Patents
Nano throat-benefiting preparation medicine and preparation method Download PDFInfo
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- CN1366924A CN1366924A CN 01102065 CN01102065A CN1366924A CN 1366924 A CN1366924 A CN 1366924A CN 01102065 CN01102065 CN 01102065 CN 01102065 A CN01102065 A CN 01102065A CN 1366924 A CN1366924 A CN 1366924A
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Abstract
The present ivnention discloses a nano Qinghou Liyan preparation medicine. It is made up by using 13 Chinese medicinal materials of nano scutellaria, nano Chinese olive, nano platycodon, nano bamboo shavings, nano sterculia and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. It grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of relieving sore-throat by clearing away heat, the chest stuffiness relieving wets one's whistle, treating acute and chronic pharyngitis, tonsillitis, pharyngeal dryness, hoarseness; Use the nano throat-benefiting preparation medicine that the effect of protection vocal cords is arranged always, the invention still further relates to the method for this medication preparation.
The throat-benefiting granule is a kind of classical Chinese patent medicine, mainly contains the effect such as wet one's whistle of relieving sore-throat by clearing away heat, the chest stuffiness relieving, is used for acute/chronic pharyngitis, tonsillitis, pharyngeal dryness, hoarseness; Use always the effect of protection vocal cords is arranged.But traditional throat-benefiting granule absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano throat-benefiting preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano throat-benefiting preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Scutellariae 50-150 part nanometer FRUCTUS TERMINALIAE IMMATURUS 50-200 part nanometer Radix Platycodonis 100-300 part
Nanometer Caulis Bambusae In Taenia 50-300 part nanometer Semen Sterculiae Lychnophorae 50-300 part nano Juhong 30-200 part
Nanometer Fructus Aurantii 50-300 part nanometer Folium Mori 50-300 part nano cyperus tuber 50-200 part
Nanometer Fructus Perillae 50-300 part nanometer Caulis Perillae 50-300 part nanometer Lignum Aquilariae Resinatum 50-300 part
Nanometer Mentholum 1-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Scutellariae 80-120 part nanometer FRUCTUS TERMINALIAE IMMATURUS 100-140 part nanometer Radix Platycodonis 150-250 part
Nanometer Caulis Bambusae In Taenia 100-200 part nanometer Semen Sterculiae Lychnophorae 100-200 part nano Juhong 60-150 part
Nanometer Fructus Aurantii 100-200 part nanometer Folium Mori 100-150 part nano cyperus tuber 80-120 part
Nanometer Fructus Perillae 100-150 part nanometer Caulis Perillae 100-150 part nanometer Lignum Aquilariae Resinatum 100-200 part
Nanometer Mentholum 3-8 part
The optimum weight proportioning of medicine of the present invention is:
200 parts of 120 parts of nanometer Radix Platycodoniss of 100 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of nanometer Radix Scutellariae
100 parts of 150 parts of nano Juhongs of 150 parts of nanometer Semen Sterculiae Lychnophoraes of nanometer Caulis Bambusae In Taenia
100 parts of 120 parts of nano cyperus tubers of 150 parts of nanometer Folium Mori of nanometer Fructus Aurantii
150 parts of 120 parts of nanometer Lignum Aquilariae Resinatum of 120 parts of nanometer Caulis Perillaes of nanometer Fructus Perillae
5 parts of nanometer Mentholums
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition:
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get throat-benefiting preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano throat-benefiting preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common throat-benefiting granular preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano throat-benefiting preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for acute/chronic pharyngitis, tonsillitis, pharyngeal dryness, hoarseness; Use treatment of conditions such as the effect of protection vocal cords is arranged always, clinical efficacy significantly is better than traditional throat-benefiting granule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
200 parts of 120 parts of nanometer Radix Platycodoniss of 100 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of nanometer Radix Scutellariae
100 parts of 150 parts of nano Juhongs of 150 parts of nanometer Semen Sterculiae Lychnophoraes of nanometer Caulis Bambusae In Taenia
100 parts of 120 parts of nano cyperus tubers of 150 parts of nanometer Folium Mori of nanometer Fructus Aurantii
150 parts of 120 parts of nanometer Lignum Aquilariae Resinatum of 120 parts of nanometer Caulis Perillaes of nanometer Fructus Perillae
5 parts of nanometer Mentholums
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
200 parts of 120 parts of nanometer Radix Platycodoniss of 100 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of nanometer Radix Scutellariae
100 parts of 150 parts of nano Juhongs of 150 parts of nanometer Semen Sterculiae Lychnophoraes of nanometer Caulis Bambusae In Taenia
100 parts of 120 parts of nano cyperus tubers of 150 parts of nanometer Folium Mori of nanometer Fructus Aurantii
150 parts of 120 parts of nanometer Lignum Aquilariae Resinatum of 120 parts of nanometer Caulis Perillaes of nanometer Fructus Perillae
5 parts of nanometer Mentholums
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano throat-benefiting powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Claims (6)
1, a kind of nano throat-benefiting preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Scutellariae 50-150 part nanometer FRUCTUS TERMINALIAE IMMATURUS 50-200 part nanometer Radix Platycodonis 100-300 part
Nanometer Caulis Bambusae In Taenia 50-300 part nanometer Semen Sterculiae Lychnophorae 50-300 part nano Juhong 30-200 part
Nanometer Fructus Aurantii 50-300 part nanometer Folium Mori 50-300 part nano cyperus tuber 50-200 part
Nanometer Fructus Perillae 50-300 part nanometer Caulis Perillae 50-300 part nanometer Lignum Aquilariae Resinatum 50-300 part
Nanometer Mentholum 1-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano throat-benefiting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Scutellariae 80-120 part nanometer FRUCTUS TERMINALIAE IMMATURUS 100-140 part nanometer Radix Platycodonis 150-250 part
Nanometer Caulis Bambusae In Taenia 100-200 part nanometer Semen Sterculiae Lychnophorae 100-200 part nano Juhong 60-150 part
Nanometer Fructus Aurantii 100-200 part nanometer Folium Mori 100-150 part nano cyperus tuber 80-120 part
Nanometer Fructus Perillae 100-150 part nanometer Caulis Perillae 100-150 part nanometer Lignum Aquilariae Resinatum 100-200 part
Nanometer Mentholum 3-8 part
3, nano throat-benefiting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
200 parts of 120 parts of nanometer Radix Platycodoniss of 100 parts of nanometer FRUCTUS TERMINALIAE IMMATURUS of nanometer Radix Scutellariae
100 parts of 150 parts of nano Juhongs of 150 parts of nanometer Semen Sterculiae Lychnophoraes of nanometer Caulis Bambusae In Taenia
100 parts of 120 parts of nano cyperus tubers of 150 parts of nanometer Folium Mori of nanometer Fructus Aurantii
150 parts of 120 parts of nanometer Lignum Aquilariae Resinatum of 120 parts of nanometer Caulis Perillaes of nanometer Fructus Perillae
5 parts of nanometer Mentholums
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano throat-benefiting preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano throat-benefiting preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102065 CN1366924A (en) | 2001-01-22 | 2001-01-22 | Nano throat-benefiting preparation medicine and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102065 CN1366924A (en) | 2001-01-22 | 2001-01-22 | Nano throat-benefiting preparation medicine and preparation method |
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| CN1366924A true CN1366924A (en) | 2002-09-04 |
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| CN 01102065 Pending CN1366924A (en) | 2001-01-22 | 2001-01-22 | Nano throat-benefiting preparation medicine and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095736B (en) * | 2006-06-28 | 2010-09-15 | 厦门臻琪投资管理有限公司 | Chinese traditional medicine composition for treating acute and chronic pharyngitis, tonsillitis and method of making the same |
| CN102726585A (en) * | 2012-05-29 | 2012-10-17 | 桂龙药业(安徽)有限公司 | Throat-clearing health food and preparation method thereof |
-
2001
- 2001-01-22 CN CN 01102065 patent/CN1366924A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095736B (en) * | 2006-06-28 | 2010-09-15 | 厦门臻琪投资管理有限公司 | Chinese traditional medicine composition for treating acute and chronic pharyngitis, tonsillitis and method of making the same |
| CN102726585A (en) * | 2012-05-29 | 2012-10-17 | 桂龙药业(安徽)有限公司 | Throat-clearing health food and preparation method thereof |
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Addressee: Yang Mengjun Document name: Notification before expiration of term |
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