CN1365789A - Nano medicine 'Baolong' and its preparing process - Google Patents
Nano medicine 'Baolong' and its preparing process Download PDFInfo
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- CN1365789A CN1365789A CN 01101988 CN01101988A CN1365789A CN 1365789 A CN1365789 A CN 1365789A CN 01101988 CN01101988 CN 01101988 CN 01101988 A CN01101988 A CN 01101988A CN 1365789 A CN1365789 A CN 1365789A
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Abstract
A nanometre medicine "Baolong" is prepared from the nanometre powders of 27 Chinese medicinal materials including tuckahoe, halloysitum rubrum, agastache, pinellia tuber, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of dispeling the wind and be good for the stomach, cure mainly children's's wind-phlegm milk regurgitation diarrheal nano medicine ' Baolong ', the invention still further relates to the method for this medication preparation.
Embracing imperial ball is a kind of classical Chinese patent medicine, and effect such as be good for the stomach that mainly containing dispels the wind is used for diseases such as children's's wind-phlegm milk regurgitation diarrhoea.But traditional armful imperial ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Baolong ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Baolong '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano Poria 30-80 part nanometer Halloysitum Rubrum 15-40 part nanometer Herba Pogostemonis 20-55 part
Nanometer Rhizoma Pinelliae Preparatum 20-50 part nanometer Pericarpium Citri Reticulatae 15-40 part nanometer Cortex Magnoliae Officinalis 15-40 part
Nanometer Herba Menthae 20-50 part nanometer Folium Perillae 15-50 part nanometer Bombyx Batryticatus 20-50 part
Nanometer Rhizoma Dioscoreae 15-40 part nanometer Concretio Silicea Bambusae 25-55 part nanometer Lignum Santali Albi 15-40 part
Nano angelica root 15-40 part nanometer Fructus Amomi 15-40 part nanometer Radix Saposhnikoviae 15-50 part
Nanometer Herba Schizonepetae 25-55 part nanometer Rhizoma Typhonii 15-50 part nanometer Radix Angelicae Pubescentis 15-50 part
Nanometer Radix Paeoniae Alba 15-40 part nanometer Fructus Chebulae 15-40 part nanometer Fructus Piperis Longi 15-40 part
Nanometer Rhizoma Atractylodis Macrocephalae 25-55 part nanometer Rhizoma Chuanxiong 15-50 part nanometer Radix Aucklandiae 15-40 part
Nanometer Cinnabaris 25-80 part nano gastrodia 15-40 part nano cyperus tuber 15-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano Poria 40-60 part nanometer Halloysitum Rubrum 20-30 part nanometer Herba Pogostemonis 25-45 part
Nanometer Rhizoma Pinelliae Preparatum 25-40 part nanometer Pericarpium Citri Reticulatae 20-30 part nanometer Cortex Magnoliae Officinalis 20-30 part
Nanometer Herba Menthae 25-40 part nanometer Folium Perillae 20-40 part nanometer Bombyx Batryticatus 25-40 part
Nanometer Rhizoma Dioscoreae 20-30 part nanometer Concretio Silicea Bambusae 30-45 part nanometer Lignum Santali Albi 20-30 part
Nano angelica root 20-30 part nanometer Fructus Amomi 20-30 part nanometer Radix Saposhnikoviae 20-40 part
Nanometer Herba Schizonepetae 30-45 part nanometer Rhizoma Typhonii 20-40 part nanometer Radix Angelicae Pubescentis 20-40 part
Nanometer Radix Paeoniae Alba 20-30 part nanometer Fructus Chebulae 20-30 part nanometer Fructus Piperis Longi 20-30 part
Nanometer Rhizoma Atractylodis Macrocephalae 30-45 part nanometer Rhizoma Chuanxiong 20-40 part nanometer Radix Aucklandiae 20-30 part
Nanometer Cinnabaris 30-60 part nano gastrodia 20-30 part nano cyperus tuber 20-30 part
The optimum weight proportioning of medicine of the present invention is:
38 parts of 25 parts of nanometer Herba Pogostemonis of 50 parts of nanometer Halloysitum Rubrums of nano Poria
25 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 31 parts of nanometer Pericarpium Citri Reticulataes of nanometer Rhizoma Pinelliae Preparatum
31 parts of 31 parts of nanometer Bombyx Batryticatus of 31 parts of nanometer Folium Perillaes of nanometer Herba Menthae
25 parts in 38 parts of nanometer Lignum Santali Albis of 25 parts of nanometer Concretio Silicea Bambusaes of nanometer Rhizoma Dioscoreae
31 parts of 25 parts of nanometer Radix Saposhnikoviaes of 25 parts of nanometer Fructus Amomis of nano angelica root
31 parts of 31 parts of nanometer Radix Angelicae Pubescentiss of 38 parts of nanometer Rhizoma Typhoniis of nanometer Herba Schizonepetae
25 parts of 25 parts of nanometer Fructus Piperis Longi of 25 parts of nanometer Fructus Chebulaes of the nanometer Radix Paeoniae Alba
25 parts of 31 parts of nanometer Radix Aucklandiae of 38 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
25 parts of 25 parts of nano cyperus tubers of 47 parts of nano gastrodias of nanometer Cinnabaris
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Baolong ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Baolong ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common armful of imperial pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Baolong ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as children's's wind-phlegm milk regurgitation diarrhoea, and clinical efficacy significantly is better than traditional imperial ball of embracing.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
38 parts of 25 parts of nanometer Herba Pogostemonis of 50 parts of nanometer Halloysitum Rubrums of nano Poria
25 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 31 parts of nanometer Pericarpium Citri Reticulataes of nanometer Rhizoma Pinelliae Preparatum
31 parts of 31 parts of nanometer Bombyx Batryticatus of 31 parts of nanometer Folium Perillaes of nanometer Herba Menthae
25 parts in 38 parts of nanometer Lignum Santali Albis of 25 parts of nanometer Concretio Silicea Bambusaes of nanometer Rhizoma Dioscoreae
31 parts of 25 parts of nanometer Radix Saposhnikoviaes of 25 parts of nanometer Fructus Amomis of nano angelica root
31 parts of 31 parts of nanometer Radix Angelicae Pubescentiss of 38 parts of nanometer Rhizoma Typhoniis of nanometer Herba Schizonepetae
25 parts of 25 parts of nanometer Fructus Piperis Longi of 25 parts of nanometer Fructus Chebulaes of the nanometer Radix Paeoniae Alba
25 parts of 31 parts of nanometer Radix Aucklandiae of 38 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
25 parts of 25 parts of nano cyperus tubers of 47 parts of nano gastrodias of nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
38 parts of 25 parts of nanometer Herba Pogostemonis of 50 parts of nanometer Halloysitum Rubrums of nano Poria
25 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 31 parts of nanometer Pericarpium Citri Reticulataes of nanometer Rhizoma Pinelliae Preparatum
31 parts of 31 parts of nanometer Bombyx Batryticatus of 31 parts of nanometer Folium Perillaes of nanometer Herba Menthae
25 parts in 38 parts of nanometer Lignum Santali Albis of 25 parts of nanometer Concretio Silicea Bambusaes of nanometer Rhizoma Dioscoreae
31 parts of 25 parts of nanometer Radix Saposhnikoviaes of 25 parts of nanometer Fructus Amomis of nano angelica root
31 parts of 31 parts of nanometer Radix Angelicae Pubescentiss of 38 parts of nanometer Rhizoma Typhoniis of nanometer Herba Schizonepetae
25 parts of 25 parts of nanometer Fructus Piperis Longi of 25 parts of nanometer Fructus Chebulaes of the nanometer Radix Paeoniae Alba
25 parts of 31 parts of nanometer Radix Aucklandiae of 38 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
25 parts of 25 parts of nano cyperus tubers of 47 parts of nano gastrodias of nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make that nanometer is embraced imperial powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
38 parts of 25 parts of nanometer Herba Pogostemonis of 50 parts of nanometer Halloysitum Rubrums of nano Poria
25 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 31 parts of nanometer Pericarpium Citri Reticulataes of nanometer Rhizoma Pinelliae Preparatum
31 parts of 31 parts of nanometer Bombyx Batryticatus of 31 parts of nanometer Folium Perillaes of nanometer Herba Menthae
25 parts in 38 parts of nanometer Lignum Santali Albis of 25 parts of nanometer Concretio Silicea Bambusaes of nanometer Rhizoma Dioscoreae
31 parts of 25 parts of nanometer Radix Saposhnikoviaes of 25 parts of nanometer Fructus Amomis of nano angelica root
31 parts of 31 parts of nanometer Radix Angelicae Pubescentiss of 38 parts of nanometer Rhizoma Typhoniis of nanometer Herba Schizonepetae
25 parts of 25 parts of nanometer Fructus Piperis Longi of 25 parts of nanometer Fructus Chebulaes of the nanometer Radix Paeoniae Alba
25 parts of 31 parts of nanometer Radix Aucklandiae of 38 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
25 parts of 25 parts of nano cyperus tubers of 47 parts of nano gastrodias of nanometer Cinnabaris
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer and embrace imperial membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Baolong ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano Poria 30-80 part nanometer Halloysitum Rubrum 15-40 part nanometer Herba Pogostemonis 20-55 part
Nanometer Rhizoma Pinelliae Preparatum 20-50 part nanometer Pericarpium Citri Reticulatae 15-40 part nanometer Cortex Magnoliae Officinalis 15-40 part
Nanometer Herba Menthae 20-50 part nanometer Folium Perillae 15-50 part nanometer Bombyx Batryticatus 20-50 part
Nanometer Rhizoma Dioscoreae 15-40 part nanometer Concretio Silicea Bambusae 25-55 part nanometer Lignum Santali Albi 15-40 part
Nano angelica root 15-40 part nanometer Fructus Amomi 15-40 part nanometer Radix Saposhnikoviae 15-50 part
Nanometer Herba Schizonepetae 25-55 part nanometer Rhizoma Typhonii 15-50 part nanometer Radix Angelicae Pubescentis 15-50 part
Nanometer Radix Paeoniae Alba 15-40 part nanometer Fructus Chebulae 15-40 part nanometer Fructus Piperis Longi 15-40 part
Nanometer Rhizoma Atractylodis Macrocephalae 25-55 part nanometer Rhizoma Chuanxiong 15-50 part nanometer Radix Aucklandiae 15-40 part
Nanometer Cinnabaris 25-80 part nano gastrodia 15-40 part nano cyperus tuber 15-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Baolong ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano Poria 40-60 part nanometer Halloysitum Rubrum 20-30 part nanometer Herba Pogostemonis 25-45 part
Nanometer Rhizoma Pinelliae Preparatum 25-40 part nanometer Pericarpium Citri Reticulatae 20-30 part nanometer Cortex Magnoliae Officinalis 20-30 part
Nanometer Herba Menthae 25-40 part nanometer Folium Perillae 20-40 part nanometer Bombyx Batryticatus 25-40 part
Nanometer Rhizoma Dioscoreae 20-30 part nanometer Concretio Silicea Bambusae 30-45 part nanometer Lignum Santali Albi 20-30 part
Nano angelica root 20-30 part nanometer Fructus Amomi 20-30 part nanometer Radix Saposhnikoviae 20-40 part
Nanometer Herba Schizonepetae 30-45 part nanometer Rhizoma Typhonii 20-40 part nanometer Radix Angelicae Pubescentis 20-40 part
Nanometer Radix Paeoniae Alba 20-30 part nanometer Fructus Chebulae 20-30 part nanometer Fructus Piperis Longi 20-30 part
Nanometer Rhizoma Atractylodis Macrocephalae 30-45 part nanometer Rhizoma Chuanxiong 20-40 part nanometer Radix Aucklandiae 20-30 part
Nanometer Cinnabaris 30-60 part nano gastrodia 20-30 part nano cyperus tuber 20-30 part
3, nano medicine ' Baolong ' according to claim 1, wherein the weight proportion of each nano raw material is:
38 parts of 25 parts of nanometer Herba Pogostemonis of 50 parts of nanometer Halloysitum Rubrums of nano Poria
25 parts of 25 parts of nanometer Cortex Magnoliae Officinalis of 31 parts of nanometer Pericarpium Citri Reticulataes of nanometer Rhizoma Pinelliae Preparatum
31 parts of 31 parts of nanometer Bombyx Batryticatus of 31 parts of nanometer Folium Perillaes of nanometer Herba Menthae
25 parts in 38 parts of nanometer Lignum Santali Albis of 25 parts of nanometer Concretio Silicea Bambusaes of nanometer Rhizoma Dioscoreae
31 parts of 25 parts of nanometer Radix Saposhnikoviaes of 25 parts of nanometer Fructus Amomis of nano angelica root
31 parts of 31 parts of nanometer Radix Angelicae Pubescentiss of 38 parts of nanometer Rhizoma Typhoniis of nanometer Herba Schizonepetae
25 parts of 25 parts of nanometer Fructus Piperis Longi of 25 parts of nanometer Fructus Chebulaes of the nanometer Radix Paeoniae Alba
25 parts of 31 parts of nanometer Radix Aucklandiae of 38 parts of nanometer Rhizoma Chuanxiongs of the nanometer Rhizoma Atractylodis Macrocephalae
25 parts of 25 parts of nano cyperus tubers of 47 parts of nano gastrodias of nanometer Cinnabaris
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Baolong 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Baolong 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101988 CN1365789A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Baolong' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101988 CN1365789A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Baolong' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365789A true CN1365789A (en) | 2002-08-28 |
Family
ID=4652363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01101988 Pending CN1365789A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Baolong' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1365789A (en) |
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2001
- 2001-01-18 CN CN 01101988 patent/CN1365789A/en active Pending
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