CN1365770A - Nano medicine 'Miaoji' and its preparing process - Google Patents
Nano medicine 'Miaoji' and its preparing process Download PDFInfo
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- CN1365770A CN1365770A CN 01100871 CN01100871A CN1365770A CN 1365770 A CN1365770 A CN 1365770A CN 01100871 CN01100871 CN 01100871 CN 01100871 A CN01100871 A CN 01100871A CN 1365770 A CN1365770 A CN 1365770A
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- 239000003814 drug Substances 0.000 title description 28
- 238000000034 method Methods 0.000 title description 10
- 239000000463 material Substances 0.000 description 13
- 229940079593 drug Drugs 0.000 description 11
- 239000000843 powder Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 241000213006 Angelica dahurica Species 0.000 description 6
- 241000221377 Auricularia Species 0.000 description 6
- 241000717739 Boswellia sacra Species 0.000 description 6
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 6
- 244000223014 Syzygium aromaticum Species 0.000 description 6
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 6
- 241000270708 Testudinidae Species 0.000 description 6
- 239000002775 capsule Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 241000241550 Cyathula Species 0.000 description 4
- 239000006187 pill Substances 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 206010062575 Muscle contracture Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 208000006111 contracture Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004863 Frankincense Substances 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000006196 drop Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 229940100688 oral solution Drugs 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
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- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
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- 208000026435 phlegm Diseases 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
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- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre medicine "Miaoji" is prepared from the nanometre powders of 17 Chinese medicinal materials including black fungus, Chinese angelica root, white peony root, Chuan-xiong rhizome, chaenomeles fruit, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of bone and muscle strengthening, treatment of arthritis and promoting collateral and channels, promoting blood circulation and stopping pain, cure mainly numb limbs and tense tendons contracture, arthralgia, lassitude loin and legs's nano medicine ' Miaoji ', the invention still further relates to the method for this medication preparation.
Wonderful Ji ball is a kind of classical Chinese patent medicine, mainly contains effects such as antibiotic, antiinflammatory, analgesia, is used for diseases such as numb limbs and tense tendons contracture, arthralgia, lassitude loin and legs.But traditional wonderful Ji ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Miaoji ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Miaoji '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Auricularia 200-400 part nano Chinese angelica 20-45 part nanometer Radix Paeoniae Alba 7-15 part
Nanometer Rhizoma Chuanxiong 8-20 part nanometer Fructus Chaenomelis 10-25 part nanometer Cortex Eucommiae 10-30 part
Nanometer Radix Dipsaci 20-50 part nanometer Radix Cyathulae 20-50 part nanometer Rhizoma Atractylodis 20-50 part
Nanometer Fructus Foeniculi 5-15 part nanometer Radix Aucklandiae 4-15 part nano clove 4-15 part
Nanometer Fructus Caryophylli 4-8 part nanometer Olibanum 5-15 part nano Poria 30-80 part
Nanometer Rhizoma Smilacis Glabrae 20-50 part nano tortoise plastron 30-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Auricularia 250-350 part nano Chinese angelica 25-38 part nanometer Radix Paeoniae Alba 8-12 part
Nanometer Rhizoma Chuanxiong 9-15 part nanometer Fructus Chaenomelis 12-20 part nanometer Cortex Eucommiae 15-25 part
Nanometer Radix Dipsaci 25-40 part nanometer Radix Cyathulae 25-40 part nanometer Rhizoma Atractylodis 25-40 part
Nanometer Fructus Foeniculi 6-10 part nanometer Radix Aucklandiae 5-10 part nano clove 5-10 part
Nanometer Fructus Caryophylli 5-7 part nanometer Olibanum 6-10 part nano Poria 40-60 part
Nanometer Rhizoma Smilacis Glabrae 25-40 part nano tortoise plastron 40-60 part
The optimum weight proportioning of medicine of the present invention is:
10 parts of 32 parts of nanometer Radix Paeoniae Albas of 300 parts of nano Chinese angelicas of nanometer Auricularia
20 parts of 16 parts of nanometer Cortexs Eucommiae of 12 parts of nanometer Fructus Chaenomeliss of nanometer Rhizoma Chuanxiong
32 parts of 32 parts of nanometer Rhizoma Atractylodis of 32 parts of nanometer Radix Cyathulaes of nanometer Radix Dipsaci
6 parts of 6 parts of nano cloves of 8 parts of nanometer Radix Aucklandiae of nanometer Fructus Foeniculi
50 parts of 8 parts of nano Porias of 6 parts of nanometer Olibanums of nanometer Fructus Caryophylli
50 parts of 32 parts of nano tortoise plastrons of nanometer Rhizoma Smilacis Glabrae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Miaoji ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Miaoji ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common wonderful Ji pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Miaoji ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for rheumatic psoitis, rheumatic myofibrositis, muscular fasciae syndrome, chronic lumbar muscle strain etc., be applied in because of deficiency of the liver and kindey, the phlegm-damp lumbago due to the meridians of being detained, the numb limbs and tense tendons contracture, treatment of conditions such as arthralgia, clinical efficacy significantly are better than traditional wonderful Ji ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
10 parts of 32 parts of nanometer Radix Paeoniae Albas of 300 parts of nano Chinese angelicas of nanometer Auricularia
20 parts of 16 parts of nanometer Cortexs Eucommiae of 12 parts of nanometer Fructus Chaenomeliss of nanometer Rhizoma Chuanxiong
32 parts of 32 parts of nanometer Rhizoma Atractylodis of 32 parts of nanometer Radix Cyathulaes of nanometer Radix Dipsaci
6 parts of 6 parts of nano cloves of 8 parts of nanometer Radix Aucklandiae of nanometer Fructus Foeniculi
50 parts of 8 parts of nano Porias of 6 parts of nanometer Olibanums of nanometer Fructus Caryophylli
50 parts of 32 parts of nano tortoise plastrons of nanometer Rhizoma Smilacis Glabrae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
10 parts of 32 parts of nanometer Radix Paeoniae Albas of 300 parts of nano Chinese angelicas of nanometer Auricularia
20 parts of 16 parts of nanometer Cortexs Eucommiae of 12 parts of nanometer Fructus Chaenomeliss of nanometer Rhizoma Chuanxiong
32 parts of 32 parts of nanometer Rhizoma Atractylodis of 32 parts of nanometer Radix Cyathulaes of nanometer Radix Dipsaci
6 parts of 6 parts of nano cloves of 8 parts of nanometer Radix Aucklandiae of nanometer Fructus Foeniculi
50 parts of 8 parts of nano Porias of 6 parts of nanometer Olibanums of nanometer Fructus Caryophylli
50 parts of 32 parts of nano tortoise plastrons of nanometer Rhizoma Smilacis Glabrae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the wonderful Ji powder needle injection of nanometer, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
10 parts of 32 parts of nanometer Radix Paeoniae Albas of 300 parts of nano Chinese angelicas of nanometer Auricularia
20 parts of 16 parts of nanometer Cortexs Eucommiae of 12 parts of nanometer Fructus Chaenomeliss of nanometer Rhizoma Chuanxiong
32 parts of 32 parts of nanometer Rhizoma Atractylodis of 32 parts of nanometer Radix Cyathulaes of nanometer Radix Dipsaci
6 parts of 6 parts of nano cloves of 8 parts of nanometer Radix Aucklandiae of nanometer Fructus Foeniculi
50 parts of 8 parts of nano Porias of 6 parts of nanometer Olibanums of nanometer Fructus Caryophylli
50 parts of 32 parts of nano tortoise plastrons of nanometer Rhizoma Smilacis Glabrae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the wonderful Ji membrane of nanometer, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: waist, back, chest or affected part.
Claims (6)
1, a kind of nano medicine ' Miaoji ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Auricularia 200-400 part nano Chinese angelica 20-45 part nanometer Radix Paeoniae Alba 7-15 part
Nanometer Rhizoma Chuanxiong 8-20 part nanometer Fructus Chaenomelis 10-25 part nanometer Cortex Eucommiae 10-30 part
Nanometer Radix Dipsaci 20-50 part nanometer Radix Cyathulae 20-50 part nanometer Rhizoma Atractylodis 20-50 part
Nanometer Fructus Foeniculi 5-15 part nanometer Radix Aucklandiae 4-15 part nano clove 4-15 part
Nanometer Fructus Caryophylli 4-8 part nanometer Olibanum 5-15 part nano Poria 30-80 part
Nanometer Rhizoma Smilacis Glabrae 20-50 part nano tortoise plastron 30-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Miaoji ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Auricularia 250-350 part nano Chinese angelica 25-38 part nanometer Radix Paeoniae Alba 8-12 part
Nanometer Rhizoma Chuanxiong 9-15 part nanometer Fructus Chaenomelis 12-20 part nanometer Cortex Eucommiae 15-25 part
Nanometer Radix Dipsaci 25-40 part nanometer Radix Cyathulae 25-40 part nanometer Rhizoma Atractylodis 25-40 part
The fragrant 5-10 part of nanometer Fructus Foeniculi 6-10 part nanometer art nano clove 5-10 part
Nanometer Fructus Caryophylli 5-7 part nanometer Olibanum 6-10 part nano Poria 40-60 part
Nanometer Rhizoma Smilacis Glabrae 25-40 part nano tortoise plastron 40-60 part
3, nano medicine ' Miaoji ' according to claim 1, wherein the weight proportion of each nano raw material is:
10 parts of 32 parts of nanometer Radix Paeoniae Albas of 300 parts of nano Chinese angelicas of nanometer Auricularia
20 parts of 16 parts of nanometer Cortexs Eucommiae of 12 parts of nanometer Fructus Chaenomeliss of nanometer Rhizoma Chuanxiong
32 parts of 32 parts of nanometer Rhizoma Atractylodis of 32 parts of nanometer Radix Cyathulaes of nanometer Radix Dipsaci
6 parts of 6 parts of nano cloves of 8 parts of nanometer Radix Aucklandiae of nanometer Fructus Foeniculi
50 parts of 8 parts of nano Porias of 6 parts of nanometer Olibanums of nanometer Fructus Caryophylli
50 parts of 32 parts of nano tortoise plastrons of nanometer Rhizoma Smilacis Glabrae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Miaoji 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Miaoji 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100871 CN1365770A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Miaoji' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100871 CN1365770A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Miaoji' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365770A true CN1365770A (en) | 2002-08-28 |
Family
ID=4651962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100871 Pending CN1365770A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Miaoji' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1365770A (en) |
-
2001
- 2001-01-19 CN CN 01100871 patent/CN1365770A/en active Pending
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