CN1365675A - Nano medicine 'Fuzilizhong' and its preparing process - Google Patents
Nano medicine 'Fuzilizhong' and its preparing process Download PDFInfo
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- CN1365675A CN1365675A CN 01100294 CN01100294A CN1365675A CN 1365675 A CN1365675 A CN 1365675A CN 01100294 CN01100294 CN 01100294 CN 01100294 A CN01100294 A CN 01100294A CN 1365675 A CN1365675 A CN 1365675A
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- nanometer
- aconiti lateralis
- lateralis preparata
- chinese
- radix aconiti
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 239000009518 fuzi-lizhong Substances 0.000 title abstract 2
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 18
- 241000756943 Codonopsis Species 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 229940023019 aconite Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010016326 Feeling cold Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010003011 Appendicitis Diseases 0.000 description 1
- 201000006306 Cor pulmonale Diseases 0.000 description 1
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010019617 Henoch-Schonlein purpura Diseases 0.000 description 1
- 208000031814 IgA Vasculitis Diseases 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- 206010040741 Sinus bradycardia Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000002513 anti-ovulatory effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 230000000968 intestinal effect Effects 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
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- 230000036407 pain Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 208000004124 rheumatic heart disease Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre medicine "Fuzilizhong" is prepared from the nanometre powders of 5 Chinese-medicinal materials including prepared aconite root, pilose asiabell root, white atractylode rhizome, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages include high biological utilization rate and high curative effect.
Description
The present invention relates to preparation medicine in a kind of nanometric Radix Aconiti Lateralis Preparata reason of warming middle-JIAO and strengthening the spleen, the invention still further relates to the method for this medication preparation.
Fuzi Lizhong Wan is a kind of classical Chinese patent medicine, mainly contains analgesia, regulates intestinal movement, physical strength reinforcing and effects such as cold tolerance, raising immunologic function, diseases such as coldness and pain in the epigastrium, the vomiting that is used for Deficiency and coldness of spleen and stomach had loose bowels, hands and feet being not warm.But traditional Fuzi Lizhong Wan disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully preparation medicine in the nanometric Radix Aconiti Lateralis Preparata of the increase evident in efficacy reason.
Another object of the present invention provides the preparation method of preparation medicine in this nanometric Radix Aconiti Lateralis Preparata reason.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometric Radix Aconiti Lateralis Preparata 60-140 part nanometer Radix Codonopsis 120-280 part nanometer Rhizoma Atractylodis Macrocephalae 100-200 part
Nanometer Rhizoma Zingiberis 60-140 part nanometer Radix Glycyrrhizae 60-140 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometric Radix Aconiti Lateralis Preparata 80-120 part nanometer Radix Codonopsis 160-240 part nanometer Rhizoma Atractylodis Macrocephalae 120-180 part
Nanometer Rhizoma Zingiberis 80-120 part nanometer Radix Glycyrrhizae 80-120 part
The optimum weight proportioning of medicine of the present invention is:
150 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 100 parts of nanometer Radix Codonopsis of nanometric Radix Aconiti Lateralis Preparata
100 parts in 100 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Zingiberis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 time/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get preparation nano powder in the Radix Aconiti Lateralis Preparata reason with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made preparation medicine in the nanometric Radix Aconiti Lateralis Preparata reason is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Fuzi Lizhong Wan preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that the powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of preparation medicine in the nanometric Radix Aconiti Lateralis Preparata reason etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treating stomach, duodenal ulcer, syndrome of deficient cold of spleen and stomach, stomach neurosis, vomiting, diarrhoea, acute gastroenteritis, enteritis, colitis, acute appendicitis, spit blood, have blood in stool, anovulatory dysfunctional uterine hemorrhage, hematohidrosis (anaphylactoid purpura), treatment of conditions such as rheumatic heart disease, pulmonary heart disease, sinus bradycardia, clinical efficacy significantly is better than traditional Fuzi Lizhong Wan.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
150 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 100 parts of nanometer Radix Codonopsis of nanometric Radix Aconiti Lateralis Preparata
100 parts in 100 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Zingiberis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
150 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 100 parts of nanometer Radix Codonopsis of nanometric Radix Aconiti Lateralis Preparata
100 parts in 100 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Zingiberis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make that powder needle injection, every injection content are the 5-20 milligram in the nanometric Radix Aconiti Lateralis Preparata reason, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
150 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 100 parts of nanometer Radix Codonopsis of nanometric Radix Aconiti Lateralis Preparata
100 parts in 100 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Zingiberis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make membrane in the nanometric Radix Aconiti Lateralis Preparata reason, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, preparation medicine in a kind of nanometric Radix Aconiti Lateralis Preparata reason is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometric Radix Aconiti Lateralis Preparata 60-140 part nanometer Radix Codonopsis 120-280 part nanometer Rhizoma Atractylodis Macrocephalae 100-200 part
Nanometer Rhizoma Zingiberis 60-140 part nanometer Radix Glycyrrhizae 60-140 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, preparation medicine in the nanometric Radix Aconiti Lateralis Preparata reason according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometric Radix Aconiti Lateralis Preparata 80-120 part nanometer Radix Codonopsis 160-240 part nanometer Rhizoma Atractylodis Macrocephalae 120-180 part
Nanometer Rhizoma Zingiberis 80-120 part nanometer Radix Glycyrrhizae 80-120 part
3, preparation medicine in the nanometric Radix Aconiti Lateralis Preparata reason according to claim 1, wherein the weight proportion of each nano raw material is:
150 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 100 parts of nanometer Radix Codonopsis of nanometric Radix Aconiti Lateralis Preparata
100 parts in 100 parts of nanometer Radix Glycyrrhizaes of nanometer Rhizoma Zingiberis
4, according to preparation medicine in claim 1 or the 2 or 3 described nanometric Radix Aconiti Lateralis Preparata reasons, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5, according to the pharmaceutical methods of preparation medicine in claim 1 or the 2 or 3 described nanometric Radix Aconiti Lateralis Preparata reasons, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100294 CN1365675A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Fuzilizhong' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100294 CN1365675A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Fuzilizhong' and its preparing process |
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| Publication Number | Publication Date |
|---|---|
| CN1365675A true CN1365675A (en) | 2002-08-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100294 Pending CN1365675A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Fuzilizhong' and its preparing process |
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| Country | Link |
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| CN (1) | CN1365675A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358508C (en) * | 2003-05-13 | 2008-01-02 | 沈阳药科大学 | Traditional Chinese medicine compound Fuzilizhong slow-controlled release preparation and preparation method thereof |
| CN105079767A (en) * | 2015-09-21 | 2015-11-25 | 蒋俊 | Traditional Chinese medicine for treating cardiac obstruction and preparation method of traditional Chinese medicine |
-
2001
- 2001-01-18 CN CN 01100294 patent/CN1365675A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358508C (en) * | 2003-05-13 | 2008-01-02 | 沈阳药科大学 | Traditional Chinese medicine compound Fuzilizhong slow-controlled release preparation and preparation method thereof |
| CN105079767A (en) * | 2015-09-21 | 2015-11-25 | 蒋俊 | Traditional Chinese medicine for treating cardiac obstruction and preparation method of traditional Chinese medicine |
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| WD01 | Invention patent application deemed withdrawn after publication |