CN1365777A - Nano medicine 'Qipi' and its preparing process - Google Patents
Nano medicine 'Qipi' and its preparing process Download PDFInfo
- Publication number
- CN1365777A CN1365777A CN 01100878 CN01100878A CN1365777A CN 1365777 A CN1365777 A CN 1365777A CN 01100878 CN01100878 CN 01100878 CN 01100878 A CN01100878 A CN 01100878A CN 1365777 A CN1365777 A CN 1365777A
- Authority
- CN
- China
- Prior art keywords
- nanometer
- nano
- parts
- medicine
- part nanometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 230000008569 process Effects 0.000 title description 2
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000208340 Araliaceae Species 0.000 claims abstract description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 235000005903 Dioscorea Nutrition 0.000 claims description 5
- 241000234273 Dioscorea Species 0.000 claims description 5
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 5
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 235000004879 dioscorea Nutrition 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000010271 massa medicata fermentata Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A nanometre medicine "Qipi" is prepared from the nanometre powders of 11 Chinese medicinal materials including ginseng, bighead atractylodes rhizome, liquorice root, tangerine peel, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of invigorating the spleen and regulating the stomach, the antidiarrheal that helps digestion, cure mainly the nano medicine ' Qipi ' of weakness of the spleen and stomach, dyspepsia, abdominal distention loose stool, the invention still further relates to the method for this medication preparation.
Opening the spleen ball is a kind of classical Chinese patent medicine, mainly contains facilitating digestion, regulates gastrointestinal function, antiulcer, effect such as antibacterial, is used for diseases such as weakness of the spleen and stomach, dyspepsia, abdominal distention loose stool.But traditional to open the disintegrate of spleen ball slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Qipi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Qipi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ginseng 70-150 part nano Poria 70-150 part nanometer Radix Glycyrrhizae 30-80 part
Nanometer Pericarpium Citri Reticulatae 30-80 part nanometer Rhizoma Dioscoreae 70-150 part nanometer Semen Nelumbinis 70-150 part
Nanometer Fructus Crataegi 70-150 part nanometer Massa Medicata Fermentata 50-120 part nanometer Fructus Hordei Germinatus 30-80 part
Nanometer Rhizoma Alismatis 30-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ginseng 80-120 part nano Poria 80-120 part nanometer Radix Glycyrrhizae 40-60 part
Nanometer Pericarpium Citri Reticulatae 40-60 part nanometer Rhizoma Dioscoreae 80-120 part nanometer Semen Nelumbinis 80-120 part
Nanometer Fructus Crataegi 80-120 part nanometer Massa Medicata Fermentata 60-100 part nanometer Fructus Hordei Germinatus 40-60 part
Nanometer Rhizoma Alismatis 40-60 part
The optimum weight proportioning of medicine of the present invention is:
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nano Porias of nano ginseng
100 parts in 100 parts of nanometer Semen Nelumbinis of 50 parts of nanometer Rhizoma Dioscoreaes of nanometer Pericarpium Citri Reticulatae
50 parts in 80 parts of nanometer Fructus Hordei Germinatus of 100 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
50 parts of nanometer Rhizoma Alismatis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Qipi ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Qipi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the common spleen pill material that opens is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Qipi ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as chronic gastroenteritis, dyspepsia, tuberculosis, anemia, and clinical efficacy significantly is better than traditional spleen ball that opens.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nano Porias of nano ginseng
100 parts in 100 parts of nanometer Semen Nelumbinis of 50 parts of nanometer Rhizoma Dioscoreaes of nanometer Pericarpium Citri Reticulatae
50 parts in 80 parts of nanometer Fructus Hordei Germinatus of 100 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
50 parts of nanometer Rhizoma Alismatis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nano Porias of nano ginseng
100 parts in 100 parts of nanometer Semen Nelumbinis of 50 parts of nanometer Rhizoma Dioscoreaes of nanometer Pericarpium Citri Reticulatae
50 parts in 80 parts of nanometer Fructus Hordei Germinatus of 100 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
50 parts of nanometer Rhizoma Alismatis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make that nanometer opens the spleen powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nano Porias of nano ginseng
100 parts in 100 parts of nanometer Semen Nelumbinis of 50 parts of nanometer Rhizoma Dioscoreaes of nanometer Pericarpium Citri Reticulatae
50 parts in 80 parts of nanometer Fructus Hordei Germinatus of 100 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
50 parts of nanometer Rhizoma Alismatis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer and open the spleen membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Qipi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ginseng 70-150 part nano Poria 70-150 part nanometer Radix Glycyrrhizae 30-80 part
Nanometer Pericarpium Citri Reticulatae 30-80 part nanometer Rhizoma Dioscoreae 70-150 part nanometer Semen Nelumbinis 70-150 part
Nanometer Fructus Crataegi 70-150 part nanometer Massa Medicata Fermentata 50-120 part nanometer Fructus Hordei Germinatus 30-80 part
Nanometer Rhizoma Alismatis 30-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Qipi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ginseng 80-120 part nano Poria 80-120 part nanometer Radix Glycyrrhizae 40-60 part
Nanometer Pericarpium Citri Reticulatae 40-60 part nanometer Rhizoma Dioscoreae 80-120 part nanometer Semen Nelumbinis 80-120 part
Nanometer Fructus Crataegi 80-120 part nanometer Massa Medicata Fermentata 60-100 part nanometer Fructus Hordei Germinatus 40-60 part
Nanometer Rhizoma Alismatis 40-60 part
3, nano medicine ' Qipi ' according to claim 1, wherein the weight proportion of each nano raw material is:
50 parts in 100 parts of nanometer Radix Glycyrrhizaes of 100 parts of nano Porias of nano ginseng
100 parts in 100 parts of nanometer Semen Nelumbinis of 50 parts of nanometer Rhizoma Dioscoreaes of nanometer Pericarpium Citri Reticulatae
50 parts in 80 parts of nanometer Fructus Hordei Germinatus of 100 parts of nanometer Massa Medicata Fermentatas of nanometer Fructus Crataegi
50 parts of nanometer Rhizoma Alismatis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Qipi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Qipi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100878 CN1365777A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Qipi' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100878 CN1365777A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Qipi' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365777A true CN1365777A (en) | 2002-08-28 |
Family
ID=4651969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100878 Pending CN1365777A (en) | 2001-01-19 | 2001-01-19 | Nano medicine 'Qipi' and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1365777A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102435692A (en) * | 2011-12-30 | 2012-05-02 | 吉林益民堂制药有限公司 | HPLC fingerprint spectrum-based quality detection method for spleen-enlightening oral liquid medicinal material water extract |
-
2001
- 2001-01-19 CN CN 01100878 patent/CN1365777A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102435692A (en) * | 2011-12-30 | 2012-05-02 | 吉林益民堂制药有限公司 | HPLC fingerprint spectrum-based quality detection method for spleen-enlightening oral liquid medicinal material water extract |
| CN102435692B (en) * | 2011-12-30 | 2014-01-22 | 吉林益民堂制药有限公司 | Method for constructing HPLC (High Performance Liquid Chromatography) fingerprint spectrum of medicinal water extracts of Qipi oral liquid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1368064A (en) | Nano medicine 'yishenbugu' for tonifying kidney and strengthening bone and its preparing process | |
| CN1368334A (en) | Nano emdicine 'Weiling' and its preparing process | |
| CN1365777A (en) | Nano medicine 'Qipi' and its preparing process | |
| CN1366895A (en) | Nano supplement both qi and blood preparation medicine and preparation method thereof | |
| CN1365810A (en) | Nano medicine 'Guishao Dihuang' and its preparing process | |
| CN1368203A (en) | Nano medicine 'Zanglian' and its preparing process | |
| CN1368201A (en) | Nano medicine 'Fukangbao' and its preparing process | |
| CN1368302A (en) | Nano medicine for treating infantile dysentery and its preparing process | |
| CN1368343A (en) | Nano medicine 'Kanglebiyan' and its preparing process | |
| CN1368274A (en) | Nano medicine 'Zhibao Lingzhi' and its preparing process | |
| CN1365805A (en) | Nano medicine 'Chenxiang Huaqi' and its preparing process | |
| CN1365717A (en) | Nano medicine 'Jianer Xiaoshi' and its preparing process | |
| CN1368155A (en) | Nano medicine 'Huanshao' and its preparing process | |
| CN1368224A (en) | Nano medicine 'Chaishaoliujun' and its preparing process | |
| CN1368339A (en) | Nano emdicine 'Wubishan' and its preparing process | |
| CN1368115A (en) | Nano medicine 'Yangshen Baofei' and its preparing process | |
| CN1365801A (en) | Nano medicine 'Shenrong Guben' and its preparing process | |
| CN1368160A (en) | Nano medicine 'Jianpibuxue' and its preparing process | |
| CN1368356A (en) | Nano medicine 'Tianjingbushen' and its preparing process | |
| CN1368189A (en) | Nano medicine 'Xiangsuzhengwei' and its preparing process | |
| CN1368170A (en) | Nano medicine 'Shenshu' and its preparing process | |
| CN1365709A (en) | Nano medicine for child to relieve cough and its preparing process | |
| CN1368195A (en) | Nano medicine 'Buxuedanggui' and its preparing process | |
| CN1368351A (en) | Nano medicine 'Hexue' and its preparing process | |
| CN1368320A (en) | Nano medicine 'Shengerfa' and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |