CN1366957A - Nano Bawei Shenqi preparation medicine and preparation method - Google Patents
Nano Bawei Shenqi preparation medicine and preparation method Download PDFInfo
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- CN1366957A CN1366957A CN 01102153 CN01102153A CN1366957A CN 1366957 A CN1366957 A CN 1366957A CN 01102153 CN01102153 CN 01102153 CN 01102153 A CN01102153 A CN 01102153A CN 1366957 A CN1366957 A CN 1366957A
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Abstract
The present ivnention discloses a nano Bawei Shenqi preparation medicine. It is made up by using 8 Chinese medicinal materials of nano cooked rehmannia, nano dioscorea, nano poria, nano schisandra, nano cinnamon bark and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of nano Bawei Shenqi preparation medicine of warming and recuperating the kidney-YANG, the invention still further relates to the method for this medication preparation.
BAWEI SHENQQI WAN is a kind of classical Chinese patent medicine, mainly contain blood sugar lowering, blood fat reducing, enhance immunity, the endocrine of improving, remove effects such as free radical, diuresis, blood pressure lowering, be used for insufficiency of kidney-YANG, soreness of waist and knee joint, lower limb creeping chill, cramp and pain in the lower abdomen, edema, dysuria or frequent micturition, sexual impotence, the enuresis, pulse in CHI being feeble is weak and the phlegm retention cough with asthma, quench one's thirst, syndrome such as beriberi.But traditional BAWEI SHENQQI WAN disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Bawei Shenqi preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Bawei Shenqi preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Rehmanniae Preparata 300-650 nanometer Rhizoma Dioscoreae 120-300 part nano Poria 100-200 part
Nanometer Fructus Schisandrae Chinensis 120-300 part nanometer Cortex Cinnamomi 30-80 part nanometer Rhizoma Alismatis 100-200 part
Nanometric Radix Aconiti Lateralis Preparata 30-80 part nanometer Cortex Moutan 100-200 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Rehmanniae Preparata 350-550 nanometer Rhizoma Dioscoreae 150-250 part nano Poria 120-180 part
Nanometer Fructus Schisandrae Chinensis 150-250 part nanometer Cortex Cinnamomi 40-60 part nanometer Rhizoma Alismatis 120-180 part
Nanometric Radix Aconiti Lateralis Preparata 40-60 part nanometer Cortex Moutan 120-180 part
The optimum weight proportioning of medicine of the present invention is:
150 parts of 200 parts of nano Porias of 400 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
150 parts of 50 parts of nanometer Rhizoma Alismatis of 200 parts of nanometer Cortex Cinnamomis of nanometer Fructus Schisandrae Chinensis
150 parts of 50 parts of nanometer Cortex Moutans of nanometric Radix Aconiti Lateralis Preparata
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Bawei Shenqi preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano Bawei Shenqi preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common BAWEI SHENQQI WAN preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Bawei Shenqi preparation medicine etc. is had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for diseases of genito-urinary system, diabetes, hypertension, cataract, pant, clinical efficacy significantly is better than traditional BAWEI SHENQQI WAN.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
150 parts of 200 parts of nano Porias of 400 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
150 parts of 50 parts of nanometer Rhizoma Alismatis of 200 parts of nanometer Cortex Cinnamomis of nanometer Fructus Schisandrae Chinensis
150 parts of 50 parts of nanometer Cortex Moutans of nanometric Radix Aconiti Lateralis Preparata
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
150 parts of 200 parts of nano Porias of 400 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
150 parts of 50 parts of nanometer Rhizoma Alismatis of 200 parts of nanometer Cortex Cinnamomis of nanometer Fructus Schisandrae Chinensis
150 parts of 50 parts of nanometer Cortex Moutans of nanometric Radix Aconiti Lateralis Preparata
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Bawei Shenqi powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
150 parts of 200 parts of nano Porias of 400 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
150 parts of 50 parts of nanometer Rhizoma Alismatis of 200 parts of nanometer Cortex Cinnamomis of nanometer Fructus Schisandrae Chinensis
150 parts of 50 parts of nanometer Cortex Moutans of nanometric Radix Aconiti Lateralis Preparata
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Bawei Shenqi membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano Bawei Shenqi preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Rehmanniae Preparata 300-650 nanometer Rhizoma Dioscoreae 120-300 part nano Poria 100-200 part
Nanometer Fructus Schisandrae Chinensis 120-300 part nanometer Cortex Cinnamomi 30-80 part nanometer Rhizoma Alismatis 100-200 part
Nanometric Radix Aconiti Lateralis Preparata 30-80 part nanometer Cortex Moutan 100-200 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Bawei Shenqi preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Rehmanniae Preparata 350-550 nanometer Rhizoma Dioscoreae 150-250 part nano Poria 120-180 part
Nanometer Fructus Schisandrae Chinensis 150-250 part nanometer Cortex Cinnamomi 40-60 part nanometer Rhizoma Alismatis 120-180 part
Nanometric Radix Aconiti Lateralis Preparata 40-60 part nanometer Cortex Moutan 120-180 part
3, nano Bawei Shenqi preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
150 parts of 200 parts of nano Porias of 400 parts of nanometer Rhizoma Dioscoreaes of nanometer Radix Rehmanniae Preparata
150 parts of 50 parts of nanometer Rhizoma Alismatis of 200 parts of nanometer Cortex Cinnamomis of nanometer Fructus Schisandrae Chinensis
150 parts of 50 parts of nanometer Cortex Moutans of nanometric Radix Aconiti Lateralis Preparata
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Bawei Shenqi preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Bawei Shenqi preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| CN 01102153 CN1366957A (en) | 2001-01-20 | 2001-01-20 | Nano Bawei Shenqi preparation medicine and preparation method |
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| CN 01102153 CN1366957A (en) | 2001-01-20 | 2001-01-20 | Nano Bawei Shenqi preparation medicine and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398807A (en) * | 2014-10-30 | 2015-03-11 | 黄爱娟 | Traditional Chinese medicine for treating kidney yang weakness dysuria |
| CN108403902A (en) * | 2018-05-02 | 2018-08-17 | 李鹏康 | A kind of Chinese medicine composition for treating hypertension and its complication |
| CN112603987A (en) * | 2021-01-07 | 2021-04-06 | 海南蛛王生物科技有限公司 | Patch for treating male erectile dysfunction and preparation method thereof |
-
2001
- 2001-01-20 CN CN 01102153 patent/CN1366957A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398807A (en) * | 2014-10-30 | 2015-03-11 | 黄爱娟 | Traditional Chinese medicine for treating kidney yang weakness dysuria |
| CN108403902A (en) * | 2018-05-02 | 2018-08-17 | 李鹏康 | A kind of Chinese medicine composition for treating hypertension and its complication |
| CN112603987A (en) * | 2021-01-07 | 2021-04-06 | 海南蛛王生物科技有限公司 | Patch for treating male erectile dysfunction and preparation method thereof |
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