CN1362158A - Nano Xinkaokang Medicine and its preparation - Google Patents
Nano Xinkaokang Medicine and its preparation Download PDFInfo
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- CN1362158A CN1362158A CN 01100313 CN01100313A CN1362158A CN 1362158 A CN1362158 A CN 1362158A CN 01100313 CN01100313 CN 01100313 CN 01100313 A CN01100313 A CN 01100313A CN 1362158 A CN1362158 A CN 1362158A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
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- 238000000034 method Methods 0.000 claims abstract description 12
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 10
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 19
- 241000242759 Actiniaria Species 0.000 claims description 9
- 244000020518 Carthamus tinctorius Species 0.000 claims description 9
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 235000005412 red sage Nutrition 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 235000014375 Curcuma Nutrition 0.000 claims description 5
- 241000208966 Polygala Species 0.000 claims description 5
- 241000219780 Pueraria Species 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000164439 Curcuma angustifolia Species 0.000 claims 1
- 241001106041 Lycium Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 244000292697 Polygonum aviculare Species 0.000 abstract 1
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
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- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000407170 Curcuma Species 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
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- 206010002383 Angina Pectoris Diseases 0.000 description 3
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 230000000916 dilatatory effect Effects 0.000 description 2
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- 230000023597 hemostasis Effects 0.000 description 2
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Abstract
The present invention discloses a nano Xinnaokang preparation medicine. It is made up by using 16 Chinese medicinal materials of nmano salvia, nano red peony, nano flowery knotweed, nano lycium, nano earthworm and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size isl ess than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of blood circulation promoting and blood stasis dispelling, sensible hemostasis, blood vessel dilating, the strong blood flow volume of increase hat, cure mainly the nanometer XINNAOKANG preparation medicine of coronary heart disease, angina pectoris and cerebral arteriosclerosis, the invention still further relates to the method for this medication preparation.
XINNAOKANG JIAONANG is a kind of classical Chinese patent medicine, mainly contains effects such as blood circulation promoting and blood stasis dispelling, sensible hemostasis, blood vessel dilating, the strong blood flow volume of increase hat, is used for coronary heart disease, angina pectoris and cerebral arteriosclerosis.But traditional XINNAOKANG JIAONANG disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer XINNAOKANG preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer XINNAOKANG preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano red sage 40-120 part nanometer Radix Paeoniae Rubra 20-100 part nanometer Radix Polygoni Multiflori Preparata 20-100 part
Nanometer Fructus Lycii 20-100 part nanometer Radix Puerariae 20-100 part nanometer Rhizoma Chuanxiong 20-100 part
Nano safflower 10-80 part nanometer Rhizoma Alismatis 20-100 part nanometer Radix Achyranthis Bidentatae 20-100 part
Nanometer earthworm 20-100 part nanometer Radix Curcumae 2-10 part nanometer Radix Polygalae 20-100 part
Nanometer Rhizoma Anemones Altaicae 20-100 part nm acid Semen Ziziphi Spinosae 10-80 part nanometer Cor Cervi powder 20-100 part
Nanometer Radix Glycyrrhizae 10-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano red sage 60-100 part nanometer Radix Paeoniae Rubra 40-80 part nanometer Radix Polygoni Multiflori Preparata 40-80 part
Nanometer Fructus Lycii 40-80 part nanometer Radix Puerariae 40-80 part nanometer Rhizoma Chuanxiong 40-80 part
Nano safflower 20-60 part nanometer Rhizoma Alismatis 40-80 part nanometer Radix Achyranthis Bidentatae 40-80 part
Nanometer earthworm 40-80 part nanometer Radix Curcumae 4-8 part nanometer Radix Polygalae 40-80 part
Nanometer Rhizoma Anemones Altaicae 40-80 part nm acid Semen Ziziphi Spinosae 20-60 part nanometer Cor Cervi powder 40-80 part
Nanometer Radix Glycyrrhizae 20-60 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 80 parts of nanometer Radix Paeoniae Rubra of nano red sage, 60 nanometer Radix Polygoni Multiflori Preparatas
60 parts of 60 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Radix Puerariaes of nanometer Fructus Lycii
60 parts of 60 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Rhizoma Alismatis of nano safflower
60 parts of 6 parts of nanometer Radix Polygalaes of 60 parts of nanometer Radix Curcumaes of nanometer earthworm
60 parts in 40 parts of nanometer Cor Cervi of 60 parts of nm acid Semen Ziziphi Spinosaes of nanometer Rhizoma Anemones Altaicae powder
40 parts in nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature,-0.05 to-0.1MPa reciprocal of duty cycle, with the instantaneous drying of hypersonic velocity, promptly makes the nanometer prepared slices of Chinese crude drugs.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature,-0.05 to-0.1Mpa vacuum, with the instantaneous drying of hypersonic velocity jet, XINNAOKANG preparation nano powder;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common XINNAOKANG JIAONANG preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer XINNAOKANG preparation medicine is identical.
Another important feature of the present invention is, traditional XINNAOKANG JIAONANG disintegrate is slow, absorption is incomplete, bioavailability is not high, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer XINNAOKANG preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as coronary heart disease, angina pectoris and cerebral arteriosclerosis, and clinical efficacy is remarkable.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nanometer Radix Paeoniae Rubra of nano red sage, 60 nanometer Radix Polygoni Multiflori Preparatas
60 parts of 60 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Radix Puerariaes of nanometer Fructus Lycii
60 parts of 60 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Rhizoma Alismatis of nano safflower
60 parts of 6 parts of nanometer Radix Polygalaes of 60 parts of nanometer Radix Curcumaes of nanometer earthworm
60 parts in 40 parts of nanometer Cor Cervi of 60 parts of nm acid Semen Ziziphi Spinosaes of nanometer Rhizoma Anemones Altaicae powder
40 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly, make capsule with the fully-automatic capsule racking machine, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes 1-4 time at every turn.
Embodiment 2:
Prepare nano raw material by preceding method:
Metric system Radix Polygoni Multiflori is 60 parts in 80 parts of nanometer Radix Paeoniae Rubra of nano red sage 60
60 parts of 60 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Radix Puerariaes of nanometer Fructus Lycii
60 parts of 60 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Rhizoma Alismatis of nano safflower
60 parts of 6 parts of nanometer Radix Polygalaes of 60 parts of nanometer Radix Curcumaes of nanometer earthworm
60 parts in 40 parts of nanometer Cor Cervi of 60 parts of nm acid Semen Ziziphi Spinosaes of nanometer Rhizoma Anemones Altaicae powder
40 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make nanometer XINNAOKANG powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 80 parts of nanometer Radix Paeoniae Rubra of nano red sage, 60 nanometer Radix Polygoni Multiflori Preparatas
60 parts of 60 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Radix Puerariaes of nanometer Fructus Lycii
60 parts of 60 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Rhizoma Alismatis of nano safflower
60 parts of 6 parts of nanometer Radix Polygalaes of 60 parts of nanometer Radix Curcumaes of nanometer earthworm
60 parts in 40 parts of nanometer Cor Cervi of 60 parts of nm acid Semen Ziziphi Spinosaes of nanometer Rhizoma Anemones Altaicae powder
40 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make nanometer XINNAOKANG membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nanometer XINNAOKANG preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano red sage 40-120 part nanometer Radix Paeoniae Rubra 20-100 part nanometer Radix Polygoni Multiflori Preparata 20-100 part
Nanometer Fructus Lycii 20-100 part nanometer Radix Puerariae 20-100 part nanometer Rhizoma Chuanxiong 20-100 part
Nano safflower 10-80 part nanometer Rhizoma Alismatis 20-100 part nanometer Radix Achyranthis Bidentatae 20-100 part
Nanometer earthworm 20-100 part nanometer Radix Curcumae 2-10 part nanometer Radix Polygalae 20-100 part
Nanometer Rhizoma Anemones Altaicae 20-100 part nm acid Semen Ziziphi Spinosae 10-80 part nanometer Cor Cervi powder 20-100 part
Nanometer Radix Glycyrrhizae 10-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature,-0.05 to-0.1MPa vacuum, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer XINNAOKANG preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano red sage 60-100 part nanometer Radix Paeoniae Rubra 40-80 part nanometer Radix Polygoni Multiflori Preparata 40-80 part
Nanometer Fructus Lycii 40-80 part nanometer Radix Puerariae 40-80 part nanometer Rhizoma Chuanxiong 40-80 part
Nano safflower 20-60 part nanometer Rhizoma Alismatis 40-80 part nanometer Radix Achyranthis Bidentatae 40-80 part
Nanometer earthworm 40-80 part nanometer Radix Curcumae 4-8 part nanometer Radix Polygalae 40-80 part
Nanometer Rhizoma Anemones Altaicae 40-80 part nm acid Semen Ziziphi Spinosae 20-60 part nanometer Cor Cervi powder 40-80 part
Nanometer Radix Glycyrrhizae 20-60 part
3, nanometer XINNAOKANG preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 80 parts of nanometer Radix Paeoniae Rubra of nano red sage, 60 nanometer Radix Polygoni Multiflori Preparatas
60 parts of 60 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Radix Puerariaes of nanometer Fructus Lycii
60 parts of 60 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Rhizoma Alismatis of nano safflower
60 parts of 6 parts of nanometer Radix Polygalaes of 60 parts of nanometer Radix Curcumaes of nanometer earthworm
60 parts in 40 parts of nanometer Cor Cervi of 60 parts of nm acid Semen Ziziphi Spinosaes of nanometer Rhizoma Anemones Altaicae powder
40 parts in nanometer Radix Glycyrrhizae
4, according to claim 1 or 2 or 3 described nanometer XINNAOKANG preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer XINNAOKANG preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature,-0.05 to-0.1MPa vacuum, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100313 CN1362158A (en) | 2001-01-02 | 2001-01-02 | Nano Xinkaokang Medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100313 CN1362158A (en) | 2001-01-02 | 2001-01-02 | Nano Xinkaokang Medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
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| CN1362158A true CN1362158A (en) | 2002-08-07 |
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| CN 01100313 Pending CN1362158A (en) | 2001-01-02 | 2001-01-02 | Nano Xinkaokang Medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612353B (en) * | 2008-06-24 | 2011-09-28 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases and method for preparing same |
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2001
- 2001-01-02 CN CN 01100313 patent/CN1362158A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612353B (en) * | 2008-06-24 | 2011-09-28 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases and method for preparing same |
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