CN1284074A - 新化合物 - Google Patents
新化合物 Download PDFInfo
- Publication number
- CN1284074A CN1284074A CN98813490A CN98813490A CN1284074A CN 1284074 A CN1284074 A CN 1284074A CN 98813490 A CN98813490 A CN 98813490A CN 98813490 A CN98813490 A CN 98813490A CN 1284074 A CN1284074 A CN 1284074A
- Authority
- CN
- China
- Prior art keywords
- pyridyl
- yloxy
- butyl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE97045462 | 1997-12-05 | ||
| SE9704546A SE9704546D0 (sv) | 1997-12-05 | 1997-12-05 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1284074A true CN1284074A (zh) | 2001-02-14 |
Family
ID=20409283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98813490A Pending CN1284074A (zh) | 1997-12-05 | 1998-12-01 | 新化合物 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1037889A1 (no) |
| JP (1) | JP2001525406A (no) |
| KR (1) | KR20010032800A (no) |
| CN (1) | CN1284074A (no) |
| AU (1) | AU1791599A (no) |
| BR (1) | BR9813378A (no) |
| CA (1) | CA2312357A1 (no) |
| EE (1) | EE200000321A (no) |
| HU (1) | HUP0100731A3 (no) |
| IL (1) | IL136368A0 (no) |
| NO (1) | NO20002787L (no) |
| PL (1) | PL340837A1 (no) |
| SE (1) | SE9704546D0 (no) |
| SK (1) | SK8442000A3 (no) |
| TR (1) | TR200001544T2 (no) |
| WO (1) | WO1999029686A1 (no) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101511787B (zh) * | 2006-07-06 | 2011-11-30 | 葛兰素集团有限公司 | 作为p2x7-受体拮抗剂的被取代的n-苯基甲基-5-氧代-脯氨酸-2-酰胺及它们的使用方法 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9901875D0 (sv) * | 1999-05-25 | 1999-05-25 | Astra Pharma Prod | Novel compounds |
| SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
| TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
| SE9904652D0 (sv) * | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
| JP2002330787A (ja) * | 2000-10-21 | 2002-11-19 | Astrazeneca Ab | 化学物質 |
| PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
| US7071223B1 (en) | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| WO2004099146A1 (en) | 2003-05-12 | 2004-11-18 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
| GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
| RU2006146675A (ru) | 2004-06-29 | 2008-07-10 | Пфайзер Продактс Инк. (Us) | Способ получения производных 5-[4-(2-гидроксипропил)-3,5-диоксо-4,5-дигидро-3н-[1,2,4] триазин-2-ил] бензамида снятием защиты с промежуточных продуктов, содержащих защищенный гидроксил |
| TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| MX2008011919A (es) | 2006-03-16 | 2008-11-28 | Renovis Inc | Compuestos de bicicloheteroarilo como moduladores de p2x7 y usos de los mismos. |
| ES2569677T3 (es) | 2006-03-16 | 2016-05-12 | Second Genome, Inc. | Compuestos bicicloheteroarilo como moduladores de P2X7 y usos de los mismos |
| TW200813018A (en) | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
| PL2049478T3 (pl) * | 2006-07-06 | 2012-09-28 | Glaxo Group Ltd | Podstawione N-fenylometylo 5-okso-prolino-2-amidy jako antagoniści receptora P2X7 oraz sposoby ich zastosowania |
| CA2680275C (en) | 2007-03-09 | 2016-08-23 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| US20100168171A1 (en) * | 2007-03-28 | 2010-07-01 | Paul John Beswick | Piperidinone Carboxamide Derivatives as P2X7 Modulators |
| US20100144727A1 (en) * | 2007-03-29 | 2010-06-10 | Paul John Beswick | Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators |
| WO2008119825A2 (en) | 2007-04-03 | 2008-10-09 | Glaxo Group Limited | Imidazolidine carboxamide derivatives as p2x7 modulators |
| US8119661B2 (en) | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| GB0803729D0 (en) * | 2008-02-29 | 2008-04-09 | Ge Healthcare Ltd | Imaging the central nervous system |
| JP5506776B2 (ja) | 2008-03-25 | 2014-05-28 | アフェクティス ファーマシューティカルズ アーゲー | 新規ｐ２ｘ７ｒ拮抗薬及びその使用法 |
| WO2010118921A1 (en) | 2009-04-14 | 2010-10-21 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
| EA201201548A1 (ru) | 2010-05-14 | 2013-05-30 | Эффектис Фармасьютиклз Аг | Новые способы получения p2x7r антагонистов |
| WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| EP3713540B1 (en) | 2017-11-21 | 2025-08-20 | Solventum Intellectual Properties Company | Plant based oil-in-water oral emulsions and methods of use |
| JP7341143B2 (ja) | 2017-12-20 | 2023-09-08 | スリーエム イノベイティブ プロパティズ カンパニー | 口腔用組成物及び使用方法 |
| US11324681B2 (en) | 2017-12-20 | 2022-05-10 | 3M Innovative Properties Company | Oral compositions and methods of use |
| CN113226287B (zh) | 2018-12-29 | 2025-10-17 | 舒万诺知识产权公司 | 口腔制品及使用方法 |
-
1997
- 1997-12-05 SE SE9704546A patent/SE9704546D0/xx unknown
-
1998
- 1998-12-01 IL IL13636898A patent/IL136368A0/xx unknown
- 1998-12-01 CN CN98813490A patent/CN1284074A/zh active Pending
- 1998-12-01 HU HU0100731A patent/HUP0100731A3/hu unknown
- 1998-12-01 CA CA002312357A patent/CA2312357A1/en not_active Abandoned
- 1998-12-01 SK SK844-2000A patent/SK8442000A3/sk unknown
- 1998-12-01 BR BR9813378-0A patent/BR9813378A/pt not_active Application Discontinuation
- 1998-12-01 JP JP2000524280A patent/JP2001525406A/ja not_active Withdrawn
- 1998-12-01 AU AU17915/99A patent/AU1791599A/en not_active Abandoned
- 1998-12-01 EP EP98962753A patent/EP1037889A1/en not_active Withdrawn
- 1998-12-01 EE EEP200000321A patent/EE200000321A/xx unknown
- 1998-12-01 PL PL98340837A patent/PL340837A1/xx unknown
- 1998-12-01 KR KR1020007006117A patent/KR20010032800A/ko not_active Withdrawn
- 1998-12-01 WO PCT/SE1998/002190 patent/WO1999029686A1/en not_active Ceased
- 1998-12-01 TR TR2000/01544T patent/TR200001544T2/xx unknown
-
2000
- 2000-05-31 NO NO20002787A patent/NO20002787L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101511787B (zh) * | 2006-07-06 | 2011-11-30 | 葛兰素集团有限公司 | 作为p2x7-受体拮抗剂的被取代的n-苯基甲基-5-氧代-脯氨酸-2-酰胺及它们的使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1791599A (en) | 1999-06-28 |
| HUP0100731A3 (en) | 2002-08-28 |
| SE9704546D0 (sv) | 1997-12-05 |
| KR20010032800A (ko) | 2001-04-25 |
| IL136368A0 (en) | 2001-06-14 |
| EP1037889A1 (en) | 2000-09-27 |
| JP2001525406A (ja) | 2001-12-11 |
| NO20002787D0 (no) | 2000-05-31 |
| SK8442000A3 (en) | 2001-01-18 |
| NO20002787L (no) | 2000-08-01 |
| WO1999029686A1 (en) | 1999-06-17 |
| PL340837A1 (en) | 2001-02-26 |
| EE200000321A (et) | 2001-08-15 |
| HUP0100731A2 (hu) | 2002-05-29 |
| CA2312357A1 (en) | 1999-06-17 |
| TR200001544T2 (tr) | 2000-11-21 |
| BR9813378A (pt) | 2000-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1284074A (zh) | 新化合物 | |
| EP3661921B1 (en) | Selective inhibitors of nlrp3 inflammasome | |
| CN1585640B (zh) | 作为药物组合物的n-金刚烷基甲基衍生物和中间体以及其制备方法 | |
| CN1407968A (zh) | 金刚烷衍生物 | |
| CN1434794A (zh) | 金刚烷衍生物 | |
| RU2565596C2 (ru) | Производные циклических аминов в качестве антагонистов рецептора ер4 | |
| CN1434806A (zh) | 取代的咪唑神经肽yy5受体拮抗剂 | |
| CN116348447A (zh) | Apol1的抑制剂及其使用其的方法 | |
| CN1832925A (zh) | 新的p2x7受体拮抗剂和它们的用途 | |
| CN1483024A (zh) | Vla-4抑制剂 | |
| KR20090110950A (ko) | (피라진 유도체) 퀴녹살린 화합물 및 이의 용도 | |
| CN1662497A (zh) | N－[苯基(哌啶－2－基)甲基]苯甲酰胺衍生物,其制备方法及其在治疗中的应用 | |
| CN1859904A (zh) | 用于治疗阿尔茨海默氏病的苄醚和苄氨基β－分泌酶抑制剂 | |
| CN104619702B (zh) | Ccr2的稠合环戊基拮抗剂 | |
| CN109867676A (zh) | 一种吡咯并嘧啶衍生的化合物、药物组合物以及其用途 | |
| CN105916852B (zh) | 作为RORc调节剂的芳基磺内酰胺衍生物 | |
| JP2024516633A (ja) | オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 | |
| CN1029968C (zh) | N-杂芳基-嘌呤-6-胺的制备方法 | |
| CN1082044A (zh) | 吲哚衍生物 | |
| EP1716135B1 (en) | Piperidinylcarbonyl-pyrrolidines and their use as melanocortin agonists | |
| TW202317546A (zh) | 調節ikzf2之芳基化合物及醫藥組合物 | |
| CN1561327A (zh) | 新的氨基苯酰苯类化合物 | |
| KR20250026779A (ko) | 3-(술포닐 또는 술폰이미도일)프로프-2-엔-1-일]-2-옥소-1,2-디히드로피리딘-3-카르복스아미드 유도체(3-(sulphonyl or sulfonimidoyl)prop-2-en-1-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives) | |
| CN1118476C (zh) | 抗病毒蛋白酶抑制剂 | |
| JP2005179281A (ja) | ビフェニル化合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |