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BR9813378A - Composto, processo para preparar o mesmo, e uso do mesmo, composição farmacêutica, e processo para a preparação da mesma, e, processo de efetuar a imunossupressão - Google Patents

Composto, processo para preparar o mesmo, e uso do mesmo, composição farmacêutica, e processo para a preparação da mesma, e, processo de efetuar a imunossupressão

Info

Publication number
BR9813378A
BR9813378A BR9813378-0A BR9813378A BR9813378A BR 9813378 A BR9813378 A BR 9813378A BR 9813378 A BR9813378 A BR 9813378A BR 9813378 A BR9813378 A BR 9813378A
Authority
BR
Brazil
Prior art keywords
same
preparing
pharmaceutical composition
compound
effecting immunosuppression
Prior art date
Application number
BR9813378-0A
Other languages
English (en)
Inventor
Andrew Baxter
David Cheshire
Thomas Mcinally
Michael Mortimore
David Cladingboel
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of BR9813378A publication Critical patent/BR9813378A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARAR O MESMO, E USO DO MESMO, COMPOSIçãO FARMACêUTICA, E PROCESSO PARA A PREPARAçãO DA MESMA, E, PROCESSO DE EFETUAR A IMUNOSSUPRESSãO". A invenção fornece novos compostos, um processo para a sua preparação, composições farmacêuticas que os contenham, um processo para preparar as composições farmacêuticas e seu uso em terapia.
BR9813378-0A 1997-12-05 1998-12-01 Composto, processo para preparar o mesmo, e uso do mesmo, composição farmacêutica, e processo para a preparação da mesma, e, processo de efetuar a imunossupressão BR9813378A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704546A SE9704546D0 (sv) 1997-12-05 1997-12-05 Novel compounds
PCT/SE1998/002190 WO1999029686A1 (en) 1997-12-05 1998-12-01 Novel compounds

Publications (1)

Publication Number Publication Date
BR9813378A true BR9813378A (pt) 2000-10-10

Family

ID=20409283

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813378-0A BR9813378A (pt) 1997-12-05 1998-12-01 Composto, processo para preparar o mesmo, e uso do mesmo, composição farmacêutica, e processo para a preparação da mesma, e, processo de efetuar a imunossupressão

Country Status (16)

Country Link
EP (1) EP1037889A1 (pt)
JP (1) JP2001525406A (pt)
KR (1) KR20010032800A (pt)
CN (1) CN1284074A (pt)
AU (1) AU1791599A (pt)
BR (1) BR9813378A (pt)
CA (1) CA2312357A1 (pt)
EE (1) EE200000321A (pt)
HU (1) HUP0100731A3 (pt)
IL (1) IL136368A0 (pt)
NO (1) NO20002787L (pt)
PL (1) PL340837A1 (pt)
SE (1) SE9704546D0 (pt)
SK (1) SK8442000A3 (pt)
TR (1) TR200001544T2 (pt)
WO (1) WO1999029686A1 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9901875D0 (sv) * 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
SE9904505D0 (sv) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
JP2002330787A (ja) * 2000-10-21 2002-11-19 Astrazeneca Ab 化学物質
WO2003042190A1 (en) 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
MXPA05012086A (es) 2003-05-12 2006-02-22 Pfizer Prod Inc Inhibidores de benzamida del receptor p2x7.
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
EP1776352A1 (en) 2004-06-29 2007-04-25 Pfizer Products Inc. Method for preparing 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h[1,2,4]triazin-2-yl]-benzamide derivatives by deprotecting the hydroxyl-protected precursers
DK2001474T3 (en) 2006-03-16 2016-05-09 Second Genome Inc BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND APPLICATIONS THEREOF
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
WO2007109160A2 (en) 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
TW200813018A (en) 2006-06-09 2008-03-16 Astrazeneca Ab Novel compounds
GB0613473D0 (en) * 2006-07-06 2006-08-16 Glaxo Group Ltd Novel compounds
KR101398264B1 (ko) 2006-07-06 2014-05-26 글락소 그룹 리미티드 Ｐ２ｘ７­수용체 길항제로서의 치환된 ｎ­페닐메틸­５­옥소­프롤린­２­아미드 및 그의 사용 방법
JP2010520875A (ja) 2007-03-09 2010-06-17 レノビス， インコーポレイテッド Ｐ２ｘ７調節因子としてのビシクロヘテロアリール化合物およびその使用
US20100168171A1 (en) * 2007-03-28 2010-07-01 Paul John Beswick Piperidinone Carboxamide Derivatives as P2X7 Modulators
EP2139875A2 (en) * 2007-03-29 2010-01-06 Glaxo Group Limited Oxazolidine and morpholine carboxamide derivatives as p2x7 modulators
CA2682649A1 (en) 2007-04-03 2008-10-09 Glaxo Group Limited Imidazolidine carboxamide derivatives as p2x7 modulators
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system
NZ587799A (en) 2008-03-25 2012-06-29 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
EP2243772B1 (en) 2009-04-14 2012-01-18 Affectis Pharmaceuticals AG Novel P2X7R antagonists and their use
EP2322149A1 (en) 2009-11-03 2011-05-18 Universidad del Pais Vasco Methods and compositions for the treatment of ischemia
CN102858741A (zh) 2010-05-14 2013-01-02 阿费克蒂斯制药股份公司 制备p2x7r拮抗剂的新方法
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
BR112020010125B1 (pt) 2017-11-21 2023-11-21 3M Innovative Properties Company Composição de emulsão óleo em água à base de plantas comestível e uso da mesma em um tecido bucal
CN111511348A (zh) 2017-12-20 2020-08-07 3M创新有限公司 口腔组合物及使用方法
CN111511362A (zh) 2017-12-20 2020-08-07 3M创新有限公司 口腔组合物及使用方法
US12390488B2 (en) 2018-12-29 2025-08-19 Solventum Intellectual Properties Company Oral articles and methods of use

Also Published As

Publication number Publication date
CN1284074A (zh) 2001-02-14
IL136368A0 (en) 2001-06-14
AU1791599A (en) 1999-06-28
JP2001525406A (ja) 2001-12-11
PL340837A1 (en) 2001-02-26
HUP0100731A3 (en) 2002-08-28
EE200000321A (et) 2001-08-15
CA2312357A1 (en) 1999-06-17
SE9704546D0 (sv) 1997-12-05
NO20002787L (no) 2000-08-01
SK8442000A3 (en) 2001-01-18
HUP0100731A2 (hu) 2002-05-29
WO1999029686A1 (en) 1999-06-17
NO20002787D0 (no) 2000-05-31
EP1037889A1 (en) 2000-09-27
TR200001544T2 (tr) 2000-11-21
KR20010032800A (ko) 2001-04-25

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]