CN109406810A - Sample analysis apparatus, sample incubation device and its control method - Google Patents
Sample analysis apparatus, sample incubation device and its control method Download PDFInfo
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- CN109406810A CN109406810A CN201710703969.9A CN201710703969A CN109406810A CN 109406810 A CN109406810 A CN 109406810A CN 201710703969 A CN201710703969 A CN 201710703969A CN 109406810 A CN109406810 A CN 109406810A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
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- General Physics & Mathematics (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention provides a kind of sample incubation devices, comprising: driving mechanism, for exporting rotary motion；And it is incubated for mechanism, it is set in the driving mechanism, the driving mechanism drives the incubation mechanism rotation；The incubation mechanism includes being incubated for disk and multiple reaction cups with ball, opens up multiple putting holes on the incubation disk, multiple reaction cups are installed in multiple putting holes；The driving mechanism drives the incubation mechanism rotation, so that the ball moves in the reaction cup, and stirs the liquid in the reaction cup.The effect of ball centrifugal force is lower can to move the sample and reagent that can be stirred to react in cup in reaction cup, so that sample is sufficiently mixed with reagent, guarantee to be uniformly mixed, and then guarantee that testing result is accurate, so that sample analysis apparatus plays more preferably function.The present invention also provides the control methods of a kind of sample analysis apparatus and sample incubation device.
Description
Technical field
The present invention relates to technical field of medical equipment, more particularly to a kind of sample analysis apparatus, sample incubation device and
Its control method.
Background technique
In the automatic detection field of medical instrument, need to simulate the environment of human body when testing and analyzing the extract of human body
Temperature will generally use incubating device.Incubating device is in order to meet increasing inspection demand, generally simultaneously using tray type structure
And more incubation position is arranged on disk.Currently, reaction cup, there are many shape, also there are many forms for the placement of reaction cup.Often
The reaction cup seen has the band ball container etc. that cylindric, square column, cross sectional shape are rectangle, corresponding mode are as follows:
Cylindric or square column is put in circumference array, or array is put in rectangular area；Band ball rectangle reaction cup is in square
Shape is put in region.But incubating device is using above-mentioned reaction cup when cooperating corresponding disposing way to place, the liquid in reaction cup
Body can not mix, and cause mixed effect bad, and then influence testing result.
Summary of the invention
Based on this, it is necessary to which aiming at the problem that influencing mixed effect when current reaction cup is placed, providing one kind can make
The sample incubation device that sample is uniformly mixed with reagent is obtained, while a kind of control applied to above-mentioned sample incubation device being also provided
Method, and a kind of sample analysis apparatus containing above-mentioned sample incubation device is provided.
Above-mentioned purpose is achieved through the following technical solutions:
A kind of sample incubation device, comprising:
Driving mechanism, for exporting rotary motion；And
It is incubated for mechanism, is set in the driving mechanism, the driving mechanism drives the incubation mechanism rotation；
The incubation mechanism includes being incubated for disk and multiple reaction cups with ball, opens up multiple placements on the incubation disk
Hole, multiple reaction cups are installed in multiple putting holes；
The driving mechanism drives the incubation mechanism rotation, so that the ball moves in the reaction cup, and stirs
Mix the liquid in the reaction cup.
Each reaction cup is greater than described along the size of the radial direction for being incubated for disk in one of the embodiments,
Size of the reaction cup along the circumferential direction for being incubated for disk.
Each reaction cup is less than described along the size of the radial direction for being incubated for disk in one of the embodiments,
Size of the reaction cup along the circumferential direction for being incubated for disk.
The cross sectional shape of the reaction cup bottom is arc in one of the embodiments,.
The mechanism that is incubated for further includes the heating element for heating to the incubation disk in one of the embodiments,
The heating element is in contact with the incubation disk.
The mechanism that is incubated for further includes the heat preservation for keeping the temperature for being incubated for disk in one of the embodiments,
Pot, the incubation disk are set in the fireless cooker, and the heating element is located between the fireless cooker and the incubation disk.
The sample incubation device is in sample analysis apparatus, the sample analysis to be set in one of the embodiments,
Standby corresponding the incubations Pan Chu, which has, to be put glass station and takes a glass station, one of them described putting hole move to described in put a glass work
, one of them in remaining described putting hole takes a glass station in described.
A kind of sample incubation device, comprising:
Driving mechanism, for exporting rotary motion；And
It is incubated for mechanism, is set in the driving mechanism, the driving mechanism drives the incubation mechanism rotation；
The mechanism that is incubated for includes the reaction cup of incubation disk and multiple cross sections in rectangle, is opened up on the incubation disk multiple
Putting hole, multiple reaction cups are respectively arranged in the putting hole, are provided with ball, Duo Gesuo in each reaction cup
It states reaction cup successively to arrange along the incubation disk circumferencial direction, the rectangle extending direction of each putting hole is the incubation disk
Radial direction；
The driving mechanism drives the incubation mechanism rotation, so that the ball moves in the reaction cup, and stirs
Mix the liquid in the reaction cup.
A kind of control method of sample incubation device, applied to the sample incubation dress as described in any of the above-described technical characteristic
It sets, the controlling party of the sample incubation device includes the following steps:
Obtain the current location information for being incubated for one of them putting hole of disk；
Obtain the target position information of the putting hole；
The incubation disk rotation is driven in the current location information and the target position information according to the putting hole
To target position.
The current location information refers to the putting hole in current location and the incubation in one of the embodiments,
The first central angle that disk initial position and the center of circle for being incubated for disk are formed, the target position information refer to the target position
The second central angle formed with the incubation disk initial position and the center of circle for being incubated for disk, according to first central angle and institute
The difference for stating the second central angle drives the incubation disk to turn to the target position.
The control method of the sample incubation device further includes following steps in one of the embodiments:
Obtain the signal when incubation disk is in idle condition；
Described one of them described putting hole for being incubated for disk is driven to turn to the first swing position along the first rotation direction；
The static preset time of the incubation disk；
The putting hole for being incubated for disk is driven to turn to the second swing position along the second rotation direction.
The putting hole for being incubated for disk moves to first swing position and described in one of the embodiments,
When the second swing position, the incubation disk executes forced oscillation operation.
The incubation disk timing in one of the embodiments, first swing position and described second swing position
One in setting is the incubation disk initial position.
A kind of sample analysis apparatus, including for conveying filling into cup device, for the transfer of transfer reaction cup for reaction cup
It sets, the sample testing apparatus for detecting sample and the sample incubation device as described in any of the above-described technical characteristic；
It is described into cup device, the transfer device and the sample testing apparatus station in the one of the sample incubation device
The reaction cup conveyed into cup device can be transferred in the sample incubation device by side, the transfer device, and described turn
Reaction cup in the sample incubation device can also be transferred in the sample testing apparatus by moving device.
The sample analysis apparatus further includes recyclable device in one of the embodiments, and the recyclable device is set to
The side of the sample testing apparatus；
The sample testing apparatus can be detected the reaction cup completed and be transferred to the recycling by the transfer device
In device.
The recyclable device, which has, in one of the embodiments, loses rim of a cup, described to have into cup device into rim of a cup, described
Sample analysis apparatus has glass station of putting for corresponding to the sample incubation device setting, and the sample testing apparatus has detection work
Position, it is described into rim of a cup, it is described lose rim of a cup, it is described put a glass station, the detection station is collinearly arranged, and the corresponding transfer device
Motion profile.
After adopting the above technical scheme, the invention has the benefit that
Sample analysis apparatus, sample incubation device and its control method of the invention, the reaction cup with ball are placed on
It sets in hole, such driving mechanism, which drives the incubation disk for being incubated for mechanism to make rotating motion, can generate centrifugal force, so that reaction cup
In ball under the influence of centrifugal force in reaction cup；Effective solution current reaction cup influences mixed effect when placing
Problem, ball moves the sample and reagent that can be stirred to react in cup in reaction cup, so that sample is sufficiently mixed with reagent, protects
Card is uniformly mixed, and then guarantees that testing result is accurate, so that sample analysis apparatus plays more preferably function.
Detailed description of the invention
Fig. 1 is that the sample incubation device of one embodiment of the invention removes the perspective view of lid；
Fig. 2 is the top view of sample incubation device shown in FIG. 1；
Fig. 3 is the schematic cross-sectional view of sample incubation device shown in FIG. 1；
Fig. 4 is the partial enlarged view at A shown in Fig. 3；
Fig. 5 is that sample incubation device shown in Fig. 2 adds lid top view；
Fig. 6 is the top view that sample incubation device shown in Fig. 2 removes reaction cup；
Fig. 7 is the flow chart for being incubated for disk and executing forced oscillation；
Wherein:
100- sample incubation device；
110- driving mechanism；
111- driving motor；
112- transmission parts；
120- is incubated for mechanism；
121- is incubated for disk；
1211- putting hole；
122- heating element；
123- fireless cooker；
124- reaction cup；
1241- ball；
130- lid.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, by the following examples, it and combines attached
Figure, is further elaborated sample analysis apparatus of the invention, sample incubation device and its control method.It should manage
Solution, described herein specific examples are only used to explain the present invention, is not intended to limit the present invention.
" connection ", " connection " described in the application include unless otherwise instructed directly or indirectly connecting (connection).At this
In the description of invention, it is to be understood that term " on ", "lower", "front", "rear", "left", "right", "vertical", "horizontal",
The orientation or positional relationship of the instructions such as "top", "bottom", "inner", "outside", " clockwise ", " counterclockwise " is side based on the figure
Position or positional relationship, are merely for convenience of description of the present invention and simplification of the description, rather than the device or member of indication or suggestion meaning
Part must have a particular orientation, be constructed and operated in a specific orientation, therefore be not considered as limiting the invention.
In the present invention unless specifically defined or limited otherwise, fisrt feature in the second feature " on " or " down " can be with
It is that the first and second features directly contact or the first and second features pass through intermediary mediate contact.Moreover, fisrt feature exists
Second feature " on ", " top " and " above " but fisrt feature be directly above or diagonally above the second feature, or be merely representative of
First feature horizontal height is higher than second feature.Fisrt feature can be under the second feature " below ", " below " and " below "
One feature is directly under or diagonally below the second feature, or is merely representative of first feature horizontal height less than second feature.
Referring to Fig. 1, Fig. 2 and Fig. 6, Fig. 1 is that the sample incubation device 100 of one embodiment of the invention removes the vertical of lid 130
Body figure, Fig. 2 are the top view of sample incubation device 100 shown in FIG. 1, and Fig. 6 is that sample incubation device 100 shown in Fig. 2 removes
The top view of reaction cup 124.The present invention provides a kind of sample incubation device 100, which is applied to sample
In analytical equipment, which installs the reaction cup 124 with ball 1421, is used for sample to be measured and reagent
Be heated to about 37 DEG C before formal measurement, to be incubated for the sample in reaction cup 124, and then guarantee reaction normally into
Row.It should be noted that the specific type of sample to be measured is unrestricted, in some embodiments, sample to be measured includes solid
Body sample or liquid sample.It is appreciated that being needed for liquid sample to be placed on sample rack just when being detected to liquid sample
It can be carried out.Further liquid sample includes but is not limited to blood sample.Using sample incubation device 100 of the invention to sample
When being incubated for, sample is enabled to be sufficiently mixed with reagent, guarantee to be uniformly mixed, and then guarantees that testing result is accurate, so that
Sample analysis apparatus plays more preferably function.
In the present invention, sample incubation device 100 includes driving mechanism 110 and incubation mechanism 120.Mechanism 120 is incubated for set
It being placed in driving mechanism 110, is incubated for mechanism 120 and is used to be incubated for sample, driving mechanism 110, which is used to drive, is incubated for the rotation of mechanism 120,
So that being incubated for mechanism 120 moves to corresponding position, so that sample analysis apparatus executes corresponding operation to mechanism 120 is incubated for.
Driving mechanism 110 can export rotary motion, and then incubation mechanism 120 is driven to make rotating motion.Incubation machine is enabled in this way
Structure 120 generates centrifugal force, so that the sample being incubated in mechanism 120 is uniformly mixed under the action of the centrifugal force with reagent.
Specifically, being incubated for mechanism 120 includes being incubated for disk 121 and multiple reaction cups 124 with ball 1421, it is incubated for disk 121
On open up multiple putting holes 1211, multiple reaction cups 124 are respectively installed in multiple putting holes 1211.Driving mechanism 110 with incubate
The transmission connection of disk 121 is educated, driving mechanism 110 can drive incubation disk 121 to make rotating motion.Sample incubation device 100 is to sample
When this carries out being incubated for operation, sample and reagent are by the puncture needle mechanism of sample analysis apparatus, comprehensive needle mechanism and reagent needle machine
Structure is transferred in each reaction cup 124 of sample incubation device 100.When driving mechanism 110 drives incubation disk 121 to rotate, it is incubated for
The reaction cup 124 that disk 121 is able to drive in putting hole 1211 thereon rotates together, and then the ball 1421 in reaction cup 124 exists
The reciprocally swinging in reaction cup 124 is incubated under the centrifugal force effect that the rotation of disk 121 generates, with the sample being stirred to react in cup 124
With reagent, the operation of mixing sample and reagent is realized.Preferably, ball 1421 can be steel ball.Optionally, it is incubated for disk 121
Shape setting in disk form avoids other components of sample analysis apparatus when such driving structure drives incubation disk 121 to rotate
It is interfered with disk 121 is incubated for, the whole installation of convenience sample analytical equipment.Certainly, in other embodiments of the invention,
Incubation disk 121 can also be square, oval or other are able to drive the shape that reaction cup 124 rotates thereon.
The centrifugal force that incubation disk 121 rotation that the driving of driving mechanism 110 is incubated for mechanism 120 generates enables to ball 1421
Reciprocally swinging is stirred to react sample and reagent in cup 124 in reaction cup 124.In addition, driving mechanism 110 is incubated for disk in driving
121 startings can generate inertia force with when shutting down, when speed change rotates, and ball 1421 also can be in reaction cup under the action of inertia force
Reciprocally swinging in 124, with the sample and reagent being stirred to react in cup 124.Optionally, driving mechanism 110 exports reciprocating rotary
Transhipment is dynamic, and then incubation mechanism 120 is driven to do crankmotion, by being incubated for the reciprocally swinging of disk 121, can increase sample
With the mixed effect of reagent.Certainly, in other embodiments of the invention, driving mechanism 110 also transport by exportable single direction rotation
It is dynamic, and then incubation mechanism 120 is driven to do unidirectional rotary motion.
Preferably, multiple putting holes 1211 are set gradually on the circumferencial direction for being incubated for disk 121.Sample is enabled in this way
Incubating device 100 is simultaneously incubated for multiple samples, improves operating efficiency.Multiple reaction cups 124 are respectively installed to multiple put
It sets in hole 1211.Moreover, can also retransfer new reaction cup 124 after the reaction cup 124 being incubated on disk 121 is diverted and place
Into putting hole 1211.
It can be each reaction cup 124 and be greater than reaction cup 124 along incubation disk along the size for the radial direction for being incubated for disk 121
The size of 121 circumferential direction.Here reaction cup 124 refers to that reaction cup 124 is pacified along the size for the radial direction for being incubated for disk 121
Be attached to be incubated for disk 121 putting hole 1211 in reaction cup 124 along be incubated for 121 radial direction of disk length dimension；124 edge of reaction cup
The size for being incubated for the circumferential direction of disk 121 refers to that reaction cup 124 is installed to reaction cup 124 in the putting hole 1211 for being incubated for disk 121
Along the length dimension for being incubated for 121 circumferential direction of disk.The length dimension of the radial direction of each reaction cup 124 is greater than circumferential direction
Length dimension, that is to say, that each reaction cup 124 is in the length dimension side that the modes of emplacement being incubated on disk 121 is reaction cup 124
To being extended along the radial direction for being incubated for disk 121, multiple reaction cups 124 extend in a radial direction on being incubated for disk 121 and edge
Circumferencial direction is successively arranged.Since the size of reaction cup 124 radially is greater than the size of circumferential direction, so that ball 1421
Radially there is certain space in reaction cup 124.It is rotated in this way, the driving of driving mechanism 110 is incubated for disk 121 and does
When movement, the centrifugal force of radial direction can be generated by being incubated for disk 121, and ball 1421 can be in reaction cup under radial centrifugal force effect
Space reciprocally swinging in 124 radially, with the sample and reagent being stirred to react in cup 124, so that sample and reality
Border is uniformly mixed.Meanwhile the length direction of multiple reaction cups 124 can also to be incubated for disk 121 along radially extending for disk 121 is incubated for
It is compact-sized, it is easy to accomplish scheduling.
It can also be that each reaction cup 124 is less than reaction cup 124 along incubation disk along the size for the radial direction for being incubated for disk 121
The size of 121 circumferential direction.Here reaction cup 124 refers to that reaction cup 124 is pacified along the size for the radial direction for being incubated for disk 121
Be attached to be incubated for disk 121 putting hole 1211 in reaction cup 124 along be incubated for 121 radial direction of disk length dimension；124 edge of reaction cup
The size for being incubated for the circumferential direction of disk 121 refers to that reaction cup 124 is installed to reaction cup 124 in the putting hole 1211 for being incubated for disk 121
Along the length dimension for being incubated for 121 circumferential direction of disk.The length dimension of the radial direction of each reaction cup 124 is less than circumferential direction
Length dimension, that is to say, that each reaction cup 124 is in the length dimension side that the modes of emplacement being incubated on disk 121 is reaction cup 124
To being extended along the circumferential direction for being incubated for disk 121, multiple reaction cups 124 extend along circumferential direction on being incubated for disk 121 and edge
Circumferencial direction is successively arranged.Since the size of reaction cup 124 radially is less than the size of circumferential direction, so that ball 1421
There is certain space along circumferential direction in reaction cup 124.In this way, driving mechanism 110 drives incubation disk 121 to rotate
The inertia force generated is moved it is also possible that space reciprocally swinging of the ball 1421 in reaction cup 124 along circumferential direction,
With the sample and reagent being stirred to react in cup 124, so that sample is uniformly mixed with reagent.
Certainly, in other embodiments of the invention, reaction cup 124 can also embark on journey in column or with other arrangement forms
Setting is driven by driving mechanism 110 on being incubated for disk 121 and is incubated for disk 121 and rotates the centrifugal force and/or inertia of generation
Power realizes reciprocally swinging of the ball 1421 in reaction cup 124, realizes that sample is uniformly mixed with reagent.It should be noted that putting
The shape for setting hole 1211 can be identical as the shape of reaction cup 124, to guarantee that reaction cup 124 is reliably mounted at putting hole 1211
In.As the cross sectional shape of reaction cup 124 and putting hole 1211 can be rectangle, circle, ellipse or other can be realized
The shape etc. that ball 1421 moves.In the present embodiment, the cross sectional shape of reaction cup 124 and putting hole 1211 is rectangle.
Certainly, in other embodiments of the invention, the shape of putting hole 1211 can also be different from the shape of reaction cup 124, as long as
Reaction cup 124 can be fixed in putting hole 1211.Such as 1211 cross sectional shape of putting hole is rectangle, reaction
The cross sectional shape of cup 124 can be ellipse, the round, rectangle smaller than the area of section of putting hole 1211 etc..
Referring to Fig. 3 and Fig. 4, Fig. 3 is the schematic cross-sectional view of sample incubation device 100 shown in FIG. 1, and Fig. 4 is Fig. 3 institute
The partial enlarged view at A shown.Optionally, the arc-shaped shape in 124 bottom of reaction cup.Bottom is that the reaction cup 124 of arc can rise
To the effect of guiding, increases inertia force when ball 1421 is swung, be further ensured that the sample in reaction cup 124 is mixed with reagent
Uniformly.Moreover, reaction cup 124 is radially set in the putting hole 1211 for being incubated for disk 121, reaction cup 124 is circumferentially square
To width dimensions can be adapted with the diameter of ball 1421, enable to ball 1421 under the action of the centrifugal force can only in this way
Radially moving, the displacement of limitation ball 1421 along circumferential direction avoids ball 1421 from glancing off during the swing,
Guarantee mixed effect.Meanwhile the reaction cup 124 of arc-shaped shape can also make the movement of ball 1421 there are the displacement of up and down direction,
Enhance mixed effect.
In general, sample analysis apparatus is in the addition sample into the reaction cup 124 for being incubated for disk 121 and when reagent, usual sample
It with reagent is added in reaction cup 124 close to the marginal position for being incubated for 121 outside of disk, such driving mechanism 110 is being incubated for disk
When 121 rotation, ball 1421, sample and reagent in reaction cup 124 can be under the action of the centrifugal force to the outer sidesways for being incubated for disk 121
Dynamic, the movement of ball 1421 mixes the sample in reaction cup 124 with reagent.
Further, being incubated for mechanism 120 further includes for the heating element 122 for being incubated for the heating of disk 121, heating element
122 are in contact with disk 121 is incubated for.The sample and reagent that heating element 122 is used in the reaction cup 124 to incubation disk 121 carry out
Heating, so that the temperature of sample and reagent in reaction cup 124 reaches preset temperature, such as 37 DEG C or so, to reaction cup 124
In sample be incubated for, and then guarantee reaction be normally carried out.Preferably, heating element 122 can be heating film, heating film patch
In the bottom for being incubated for disk 121.Certainly, in other embodiments of the invention, heating element 122 can also for heater strip or its
He can be realized the structure of heating.Moreover, being incubated for mechanism 120 further includes the fireless cooker for keeping being incubated for the temperature of disk 121
123, it is incubated for disk 121 and is set in fireless cooker 123, heating element 122 is located at fireless cooker 123 and is incubated between disk 121.Fireless cooker
123 can play insulation effect to the incubation disk 121 after heating, so that the temperature of the sample and reagent in reaction cup 124 is kept
It is constant, the sample in reaction cup 124 is incubated for so that being incubated for disk 121, guarantees that reaction is normally carried out.
Referring to Fig. 1 and Fig. 5, Fig. 5 is that sample incubation device 100 shown in Fig. 2 adds 130 top view of lid.As one kind
Embodiment, sample incubation device 100 is in sample analysis apparatus, the corresponding Pan121Chu that is incubated for of sample analysis apparatus to have
It puts glass station and takes a glass station, one of putting hole 1211, which moves to, puts a glass station, location A as shown in Figure 5, remaining placement
In hole 1211 one of them be in take a glass station, B location as shown in Figure 5.Sample analysis apparatus will be anti-by transfer device
Answer cup 124 from be transferred into from cup device be incubated for disk 121 on, then by reaction cup 124 from be incubated for disk 121 on be transferred to pattern detection
On device, reaction cup 124 is transferred to and is incubated on disk 121 by transfer device to be carried out on putting glass station, and transfer device will be anti-
Answering cup 124 to move away from incubation disk 121 is that glass station is being taken to carry out.Moreover, transfer device include the first transfer device and
Second transfer device, the first transfer device put a glass station for reaction cup 124 to be transferred to, and the second transfer device is used for will be anti-
Cup 124 is answered to move away from incubation disk 121；Also, in order to make full use of the first transfer device and the second transfer device, improve behaviour
Make efficiency, the first transfer device can also move away the reaction cup 124 put in glass station.
One of putting hole when driving mechanism 110 drives incubation disk 121 to make rotating motion, on incubation disk 121
1211 move to and put a glass station, and one in remaining putting hole 1211, which just moves to, takes a glass station, at this point, the first transfer device
Glass station placing response cup 124 can put or taking out the reaction cup 124 in putting hole 1211, meanwhile, the second transfer device
The reaction cup 124 in the corresponding putting hole 1211 of glass station can will be taken to take out.The first transfer device and are enabled in this way
Two transfer devices are operated simultaneously, while facilitating the first transfer device and the second transfer device grabs, improve operation effect
Rate.Preferably, the angle for taking glass station and putting between glass station relative to the center of circle for being incubated for disk 121 is 90 °, to facilitate first turn
Telephone-moving structure and the second transfer device grab.Certainly, it in other embodiments of the invention, takes glass station and puts between glass station
Angle can also be other angles, as long as can adapt to the first transfer device and the second transfer device.
Further, sample analysis apparatus also has stirring station, location of C as shown in Figure 5.Sample analysis apparatus is stirring
Mix station setting agitating device, the sample in reaction cup 124 is mixed with reagent by agitating device, be further ensured that sample and
Reagent is uniformly mixed.
Sample incubation device 100 further includes support frame, and support frame is used to support fireless cooker 123.Moreover, sample incubation device
100 further include lid 130, and the lid of lid 130 is located on fireless cooker 123, reagent adding station is reserved on lid 130, is loaded this work
Position takes a glass station, puts glass station and stirs station, and corresponding operation carries out on corresponding station, avoids maloperation and pollute
Sample and reagent in reaction cup 124 guarantee that reaction is accurate.
As an embodiment, driving mechanism 110 includes driving motor 111 and is installed on driving motor 111
Transmission parts 1112.The transmission connection driving motor 111 of transmission parts 1112 and incubation disk 121, are incubated for 121 reciprocating rotary of disk with driving
Turn.One end of transmission parts 1112 and incubation disk 121 are sequentially connected, the other end and the driving motor 111 of transmission parts 1112
Output end transmission connection, such driving motor 111 can drive transmission parts 1112 to move, and then drive to be incubated for disk 121 and do and revolve
Transhipment is dynamic, so that being incubated for the generation centrifugal force of disk 121 and sample and reagent in hybrid reaction cup 124.Driving motor 111 drives
It is incubated for disk 121 to rotate, takes a glass station so that being incubated for the reaction cup 124 of the drive of disk 121 thereon and turning to, is loaded this station, additional examination
Agent station and a glass station is put, and executes corresponding operation.Transmission parts 1112 can using synchronous belt transfer assembly or other
It can be realized the component of movement transmitting, such as screw rod, sprocket wheel structure.
The present invention also provides a kind of sample incubation device 100, including for exporting rotary motion driving mechanism 110 and
It is incubated for mechanism 120.Driving mechanism 110 is set in driving mechanism 110, and driving mechanism 110, which drives, is incubated for the rotation of mechanism 120.It incubates
Educating mechanism 120 includes being incubated for disk 121 and multiple cross sections in the reaction cup 124 of rectangle, is incubated on disk 121 and opens up multiple putting holes
1211, multiple reaction cups 124 are respectively arranged in putting hole 1211, and ball 1421 is provided in each reaction cup 124, multiple anti-
Cup 124 is answered successively to arrange along 121 circumferencial direction of disk is incubated for, the rectangle extending direction of each putting hole 1211 is to be incubated for disk 121
Radial direction.Driving mechanism 110, which drives, is incubated for the rotation of mechanism 120, so that ball 1421 moves in reaction cup 124, and stirs
Liquid in reaction cup 124.
The reaction cup 124 of rectangular band ball 1421 is placed in putting hole 1211, radially due to putting hole 1211
Extend, the length of putting hole 1211 radially is greater than width along circumferential direction in addition, and such drive of driving mechanism 110 is incubated
When educating the incubation disk 121 of mechanism 120 and making rotating motion, the ball 1421 in reaction cup 124 be will receive under centrifugal force effect anti-
It answers and is radially moved in cup 124, enable to ball 1421 that radially there is enough spaces, can mix
Sample and reagent in reaction cup 124 guarantee that testing result is accurate.Meanwhile sample incubation device 100 of the invention can make instead
The circumference on being incubated for disk 121 of cup 124 is answered successively to put, so that sample incubation device 100 is compact-sized, it is easy to accomplish scheduling makes
Sample analysis apparatus performance is obtained more preferably more.It should be noted that the specific structure of driving mechanism 110 and incubation mechanism 120,
Driving mechanism 110 in sample incubation device 100 in position and movement relation and above-described embodiment and to be incubated for mechanism 120 complete
It is identical, it does not just repeat one by one herein.
The present invention also provides a kind of control methods of sample incubation device 100, incubate applied to the sample in such as embodiment
Device 100 is educated, the controlling party of sample incubation device 100 includes the following steps:
Obtain the current location information for being incubated for the one of putting hole 1211 of disk 121；
Obtain the target position information of putting hole 1211；
Disk 121, which is incubated for, in current location information and target position information driving according to putting hole 1211 turns to target position
It sets.
Sample incubation device 100 of the invention first obtains when carrying out sample operations and is incubated for the one of putting hole of disk 121
1211 current location information obtains and is incubated for the one of putting hole 1211 of disk 121 relative to the initial position for being incubated for disk 121
Information；Then according to the mesh for being incubated for the determining putting hole 1211 of the putting hole 1211 next step to be executed operation on disk 121
Cursor position information, i.e. the information that the initial position of incubation disk 121 will turn to the next position is initial position relative target position
The information set；Current location information and target position information further according to putting hole 1211 determine the rotation displacement for being incubated for disk 121,
Driving mechanism 110 is incubated for disk 121 according to the rotation displacement driving for being incubated for disk 121 and rotates, so that being incubated for the putting hole on disk 121
1211 turn to target position, and execute corresponding operation.
Specifically, target position refers to putting a glass station, taking a glass station, sample-adding station, reagent adding station for sample analysis apparatus
And stirring station.Incubation disk 121 drives putting hole 1211 to turn to and puts a glass station, and sample analysis apparatus execution puts cup or cup is taken to grasp
Make.Incubation disk 121 drives putting hole 1211 to turn to and takes a glass station, and sample analysis apparatus execution takes cup to operate.It is incubated for 121 band of disk
Dynamic putting hole 1211 turns to sample-adding station, and sample analysis apparatus executes plus sample operations.It is incubated for disk 121 and drives putting hole 1211
Reactant station is turned to plus spits, sample analysis apparatus executes reagent adding operation.Incubation disk 121 drives putting hole 1211 to turn to and stirs
Station is mixed, sample analysis apparatus executes stirring operation.It putting a glass station moreover, the driving of driving mechanism 110 is incubated for disk 121, taking cup
When rotating between station, sample-adding station, reagent adding station and stirring station, centrifugal force can be generated by being incubated for disk 121, so that putting
The reciprocally swinging in reaction cup 124 of the ball 1421 in hole 1211 is set, with the sample and reagent being stirred to react in cup 124, so that
Sample is uniformly mixed with reagent.It should be noted that being incubated when the initial position for being incubated for disk 121 refers to sample analysis apparatus booting
Educate the corresponding zero-bit of one of putting hole 1211 of disk 121.
Further, current location information refers to that putting hole 1,211 121 initial position of disk and is incubated in current location with being incubated for
The first central angle that the center of circle of disk 121 is formed is educated, target position information refers to target position and is incubated for 121 initial position of disk and incubates
The second central angle that the center of circle of disk 121 is formed is educated, is incubated for 121 turns of disk according to the driving of the difference of the first central angle and the second central angle
It moves to target position.Sample incubation device 100, which first obtains, is incubated for disk 121 putting hole 1211 and initial position at current location
Relative to the first central angle that the center of circle for being incubated for disk 121 is formed, target position will be moved to by then obtaining the putting hole 1211 again
The second central angle that target position and initial position are formed relative to the center of circle for being incubated for disk 121 when setting, then pass through the second central angle
The difference of target position and current location is obtained with the difference of the first central angle, driving mechanism 110 drives according to difference and is incubated for disk
121 rotations, so that the putting hole 1211 being incubated on disk 121 turns to target position.
Optionally, as shown in fig. 7, Fig. 7 is the flow chart for being incubated for disk 121 and executing forced oscillation.Sample incubation device 100
Control method further includes following steps:
Step S1: the signal being incubated for when disk 121 is in idle condition is obtained；
Step S2: one of putting hole 1211 that driving is incubated for disk 121 turns to the first swing along the first rotation direction
Position；
Step S3: it is incubated for the static preset time of disk 121；
Step S4: the putting hole 1211 that driving is incubated for disk 121 turns to the second swing position along the second rotation direction.
When being incubated for 121 proper motion of disk, the driving of driving mechanism 110 is incubated for disk 121 and rotates, and moves to each operation position
Execute corresponding operation.Driving mechanism 110 is incubated for when disk 121 makes rotating motion in driving can also generate certain mixed effect,
When being incubated for 121 free time of disk, being incubated for disk 121 will not be rotated, and the ball 1421 in reaction cup 124 will not be in external force at this time
Lower stirring sample and reagent.In order to increase the mixed effect of sample and reagent, the driving of driving mechanism 110 is incubated for disk 121 and executes
Operation is stated, is i.e. when the putting hole 1211 of incubation disk 121 moves to the first swing position and the second swing position, is incubated for disk 121 and holds
The operation of row forced oscillation.It is incubated for disk 121 during idle time, driving mechanism 110 can drive incubation disk 121 to do pressure swinging operation, make
Disk 121 must be incubated for rotate in fireless cooker 123, the ball 1421 being incubated in the reaction cup 124 of disk 121 under the action of the centrifugal force can
Sample and reagent in enough hybrid reaction cups 124, increase mixed effect.It should be noted that preset time refer to be incubated for disk 121 to
Pause 1s less.
It should be noted that the first swing position and the second swing position can be any position for being incubated for disk 121, that is, incubate
The starting position rotated when educating 121 free time of disk can be any position for being incubated for disk 121, the knot rotated when being incubated for 121 free time of disk
Beam position can be any position for being incubated for disk 121, can increase the mixing of sample and reagent in reaction cup 124 in this way.First
Rotation direction and the second rotation direction can be same direction, can also be opposite direction, and driving mechanism 110 exports single direction rotation fortune
When dynamic, the first rotation direction and the second rotation direction can be same direction.When driving mechanism 110 exports crankmotion,
First rotation direction and the second rotation direction can be opposite direction.Preferably, the first swing position is to put a glass station, the second pendulum
Dynamic position is stirring station.In this way in the case where existing resource component actuation and parameter constant, make to be incubated for disk 121 in two phases
It is swung away from the farthest position in position, so that the swinging distance for being incubated for disk 121 is maximum, so that being incubated for disk 121 can speed up
It is run to maximum speed.The ball 1421 in reaction cup 124 has time enough to move under the action of the centrifugal force with sample at this time
To the outside of reaction cup 124, guarantee mixing effect.
Optionally, the forced oscillation operation for being incubated for disk 121 is also used as being incubated for the correct operation of disk 121.It is incubated for disk 121
One in timing, the first swing position and the second swing position is incubation 121 initial position of disk.Driving mechanism 110 drives
It is incubated for exist when disk 121 rotates and loses step phenomenon, the calibrating coordinates that forced oscillation operation setting is incubation disk 121 are moved
Make, mixing can either be played the role of, and accumulative step of losing can be eliminated and guarantee that coordinate is accurate.
The present invention also provides a kind of sample analysis apparatus, including for convey reaction cup 124 into cup device, for turning
Move the transfer device of reaction cup 124, the sample incubation dress in sample testing apparatus and above-described embodiment for detecting sample
Set 100.Reaction cup 124 into cup device for conveying improves transfer efficiency to realize the automatic conveying of empty reaction cup 124.
Transfer device is used for transfer reaction cup 124, so that reaction cup 124 can move to each position of sample analysis apparatus, it is real
Existing sample automatically analyzes detection, improves operating efficiency.Sample testing apparatus is for detecting sample, to obtain the corresponding ginseng of sample
Number.Into cup device, transfer device and sample testing apparatus station in the side of sample incubation device 100, transfer device can be incited somebody to action
In the incubation disk 121 that the reaction cup 124 conveyed into cup device is transferred to sample incubation device 100, transfer device can also be by sample
Reaction cup 124 in incubating device 100 is transferred in sample testing apparatus.
Further, sample analysis apparatus further includes recyclable device, and recyclable device is set to the side of sample testing apparatus.
Sample testing apparatus can be detected the reaction cup 124 completed and is transferred in recyclable device by transfer device.Recyclable device recycling inspection
The reaction cup 124 surveyed, avoid sample and the reagent sinuous flow in reaction cup 124 from leading to environmental pollution.
Still further, recyclable device, which has, loses rim of a cup, have into cup device into rim of a cup, sample analysis apparatus, which has, to be corresponded to
What sample incubation device 100 was arranged puts a glass station, and sample testing apparatus has detection station, into rim of a cup, loses rim of a cup, puts a glass work
Position, detection station are collinearly arranged, and the motion profile of corresponding transfer device.Shift module is in the reaction empty into rim of a cup crawl in this way
Cup 124, and it is transferred to the putting on glass station of sample incubation module；Shift module can also take out reaction cup 124 on putting glass station,
And reaction cup 124 is transferred in pattern detection module and is detected, after the completion of detection, detection module will be in pattern detection module
Reaction cup 124 be transferred to and lose in rim of a cup.Empty cup station is taken, rim of a cup is lost, puts a glass station, detection station and be collinearly arranged and enable to
Shift module saves shift module the space occupied, and then reduce sample analysis in the same direction toward straight reciprocating motion is done
The package size of equipment, while shift module moves in a straight line and is also avoided that shift module or other components interfere,
Guarantee the reliability of movement.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the record scope of this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (16)
1. a kind of sample incubation device characterized by comprising
Driving mechanism, for exporting rotary motion；And
It is incubated for mechanism, is set in the driving mechanism, the driving mechanism drives the incubation mechanism rotation；
The incubation mechanism includes being incubated for disk and multiple reaction cups with ball, opens up multiple putting holes on the incubation disk,
Multiple reaction cups are installed in multiple putting holes；
The driving mechanism drives the incubation mechanism rotation, so that the ball moves in the reaction cup, and stirs institute
State the liquid in reaction cup.
2. sample incubation device according to claim 1, which is characterized in that each reaction cup is along the incubation disk
The size of radial direction is greater than the reaction cup along the size of the circumferential direction for being incubated for disk.
3. sample incubation device according to claim 1, which is characterized in that each reaction cup is along the incubation disk
The size of radial direction is less than the reaction cup along the size of the circumferential direction for being incubated for disk.
4. sample incubation device according to claim 1, which is characterized in that the arc-shaped shape in reaction cup bottom.
5. sample incubation device according to any one of claims 1 to 4, which is characterized in that the incubation mechanism further includes
For the heating element to the incubation disk heating, the heating element is in contact with the incubation disk.
6. sample incubation device according to claim 5, which is characterized in that the incubation mechanism further includes for keeping
The fireless cooker for being incubated for the temperature of disk is stated, the incubation disk is set in the fireless cooker, and the heating element is located at the heat preservation
Between pot and the incubation disk.
7. sample incubation device according to claim 1, which is characterized in that the sample incubation device is used for sample analysis
In equipment, the sample analysis apparatus, which corresponds to the incubation Pan Chu and has, to be put glass station and takes a glass station, is put described in one of them
Set hole move to it is described put a glass station, one of them in remaining described putting hole is in described and takes a glass station.
8. a kind of sample incubation device characterized by comprising
Driving mechanism, for exporting rotary motion；And
It is incubated for mechanism, is set in the driving mechanism, the driving mechanism drives the incubation mechanism rotation；
The mechanism that is incubated for includes the reaction cup of incubation disk and multiple cross sections in rectangle, opens up multiple placements on the incubation disk
Hole, multiple reaction cups are respectively arranged in the putting hole, and ball is provided in each reaction cup, multiple described anti-
Incubation disk circumferencial direction described in cup edge is answered successively to arrange, the rectangle extending direction of each putting hole is the diameter for being incubated for disk
To direction；
The driving mechanism drives the incubation mechanism rotation, so that the ball moves in the reaction cup, and stirs institute
State the liquid in reaction cup.
9. a kind of control method of sample incubation device, which is characterized in that be applied to as described in any one of claim 1 to 7
The controlling party of sample incubation device, the sample incubation device includes the following steps:
Obtain the current location information for being incubated for one of them putting hole of disk；
Obtain the target position information of the putting hole；
The incubation disk is driven to turn to mesh in the current location information and the target position information according to the putting hole
Cursor position.
10. the control method of sample incubation device according to claim 9, which is characterized in that the current location information
Refer to first center of circle that the putting hole is formed in current location and the incubation disk initial position and the center of circle for being incubated for disk
Angle, the target position information refer to that the target position is formed with the incubation disk initial position and the center of circle for being incubated for disk
The second central angle, driven described in the incubations disk turns to according to the difference of first central angle and second central angle
Target position.
11. the control method of sample incubation device according to claim 9, which is characterized in that the sample incubation device
Control method further include following steps:
Obtain the signal when incubation disk is in idle condition；
Described one of them described putting hole for being incubated for disk is driven to turn to the first swing position along the first rotation direction；
The static preset time of the incubation disk；
The putting hole for being incubated for disk is driven to turn to the second swing position along the second rotation direction.
12. the control method of sample incubation device according to claim 11, which is characterized in that described to be incubated for the described of disk
When putting hole moves to first swing position and second swing position, the incubation disk executes forced oscillation operation.
13. the control method of sample incubation device according to claim 11, which is characterized in that the incubation disk correction
When, one in first swing position and second swing position is the incubation disk initial position.
14. a kind of sample analysis apparatus, which is characterized in that including for convey reaction cup into cup device, for transfer reaction
Transfer device, the sample testing apparatus and sample incubation as described in any one of claim 1 to 7 for detecting sample of cup
Device；
It is described into cup device, the transfer device and the sample testing apparatus station in the side of the sample incubation device,
The reaction cup conveyed into cup device can be transferred in the sample incubation device by the transfer device, the transfer dress
Setting can also be transferred to the reaction cup in the sample incubation device in the sample testing apparatus.
15. sample analysis apparatus according to claim 14, which is characterized in that the sample analysis apparatus further includes recycling
Device, the recyclable device are set to the side of the sample testing apparatus；
The sample testing apparatus can be detected the reaction cup completed and be transferred to the recyclable device by the transfer device
In.
16. sample analysis apparatus according to claim 15, which is characterized in that the recyclable device, which has, loses rim of a cup, institute
Stating has into cup device into rim of a cup, and the sample analysis apparatus puts a glass station with the corresponding sample incubation device setting,
The sample testing apparatus has a detection station, it is described into rim of a cup, described lose rim of a cup, described put a glass station, the detection station
Conllinear setting, and the motion profile of the corresponding transfer device.
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| CN112816307A (en) * | 2021-01-13 | 2021-05-18 | 北京罗特思创科技有限公司 | Blood coagulation mixing device and incubation disc comprising same |
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