CN106199026A - Full-automatic chemiluminescence immunoassay analysis meter - Google Patents
Full-automatic chemiluminescence immunoassay analysis meter Download PDFInfo
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- CN106199026A CN106199026A CN201610131478.7A CN201610131478A CN106199026A CN 106199026 A CN106199026 A CN 106199026A CN 201610131478 A CN201610131478 A CN 201610131478A CN 106199026 A CN106199026 A CN 106199026A
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- 238000004458 analytical method Methods 0.000 title claims abstract description 42
- 238000003018 immunoassay Methods 0.000 title claims abstract description 27
- 230000007246 mechanism Effects 0.000 claims abstract description 138
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 51
- 238000004140 cleaning Methods 0.000 claims abstract description 33
- 230000003287 optical effect Effects 0.000 claims abstract description 26
- 230000012447 hatching Effects 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 18
- 238000005070 sampling Methods 0.000 claims abstract description 15
- 238000010926 purge Methods 0.000 claims abstract description 13
- 238000011534 incubation Methods 0.000 claims abstract description 12
- 238000007689 inspection Methods 0.000 claims abstract description 12
- 238000001514 detection method Methods 0.000 claims description 18
- 239000011521 glass Substances 0.000 claims description 18
- 239000000758 substrate Substances 0.000 claims description 10
- 230000005540 biological transmission Effects 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 7
- 238000000151 deposition Methods 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000011068 loading method Methods 0.000 claims description 2
- 238000003556 assay Methods 0.000 abstract description 6
- 238000012742 biochemical analysis Methods 0.000 abstract description 2
- 230000033001 locomotion Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000036039 immunity Effects 0.000 description 3
- 238000004851 dishwashing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000745 gonadal hormone Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to automatization's biochemical analysis apparatus technical field, disclose a kind of Full-automatic chemiluminescence immunoassay analysis meter, including frame, analysis portion and control portion, analysis portion includes transmitting transfer system, sampling system, incubation system, purging system and Systems for optical inspection, transmits transfer system and includes automatically entering cup mechanism and grasping mechanism；Sampling system includes sample scheduling institution, reagent disc mechanism and sample charging mechanism；Incubation system includes hatching disc mechanism and mixing mechanism；Purging system includes cleaning disc mechanism；Systems for optical inspection includes light-metering disc mechanism and light collecting mechanism.The Full-automatic chemiluminescence immunoassay analysis meter that the present invention proposes, control to transmit transfer system, sampling system, incubation system, purging system and Systems for optical inspection by control portion automatically to work, whole analysis is so made to operate whole-course automation, avoid the uncertain problems such as individual variation that manual operation exists, human error, operation be lack of standardization, improve the accuracy of chemiluminescence immune assay.
Description
Technical field
The present invention relates to the technical field of automatization's biochemical analysis apparatus, particularly relate to a kind of full-automatic chemical and send out
Light immunity analysis instrument.
Background technology
Chemiluminescence immune assay has highly sensitive, high specificity, range of linearity width, automaticity height
Etc. advantageous feature, it has also become the Main Means of clinical diagnosis.But, domestic Full-automatic chemiluminescence immunity divides
Analysis is started late, and clinical practice develops quickly, and the most only detection such as gonadal hormone, thyroxin project is used
Chemoluminescence method detects, along with the further development of technology, tumor markers, metabolism class material, biography
Catch an illness mark, the disease marker etc. for the treatment of cardiac and cerebral vascular diseases can detect project and get more and more, meanwhile, and chemistry
Electrochemiluminescent immunoassay detection also has it uncertain, and this uncertainty is mainly derived from test operation and detection system.
At present, the detecting instrument great majority in the industry are to use manually to carry out test operation, semi-automatic detection
Mode, detecting instrument the most only realizes detecting readings function, and manual operation exists individual variation, artificial
Error, operating the uncertainties such as lack of standardization, in sample size, drawback exposes in the case of test event is various
Nothing left.Therefore, how a kind of automaticity is proposed high and detect Full-automatic chemiluminescence fast and accurately and exempt from
Epidemic disease analyser is technical problem the most urgently to be resolved hurrily.
Summary of the invention
It is an object of the invention to overcome above-mentioned the deficiencies in the prior art, it is provided that a kind of Full-automatic chemiluminescence is exempted from
Epidemic disease analyser, it is achieved that chemiluminescence immune assay is full-automatic, it is to avoid manually-operated individual variation,
Human error, operate the uncertain problems such as lack of standardization, improve the accuracy of chemiluminescence immune assay.
Embodiments provide a kind of Full-automatic chemiluminescence immunoassay analysis meter, this Full-automatic chemiluminescence
Immunity analysis instrument includes: frame, is arranged at the analysis portion in described frame, and is used for controlling described analysis
The control portion that portion runs；Described analysis portion includes:
Transmit transfer system, including for deposit, screen and feeding reaction cup automatically enter cup mechanism, and
For transferring the grasping mechanism of described reaction cup, described automatically enter cup mechanism and be arranged in described frame, described
Grasping mechanism is movably set in described frame and is positioned at described automatically enter cup mechanism side and coordinate with it；
Sampling system, including the sample dispatcher for depositing and dispatch sample tube being arranged in described frame
Structure, be rotatably arranged in described frame and be positioned at described sample scheduling institution side for depositing and dispatching
The reagent disc mechanism of Reagent Tube, is movably arranged in described frame and is positioned at described reagent disc mechanism side
Model machine is added for what the reagent in the sample in described sample tube and described Reagent Tube was transferred load to described reaction cup
Structure, described sample scheduling institution enters between cup mechanism and described reagent disc mechanism automatically described, and described
Sample charging mechanism enters between cup mechanism, described sample scheduling institution and described reagent disc mechanism automatically described；
Incubation system, including the use being rotatably arranged in described frame and being positioned at described reagent disc mechanism side
Sample in being opposite to described reaction cup thereon carries out hatching the disc mechanism of hatching of operation, and is arranged at
Hatch in described frame and described in being positioned on the upside of disc mechanism for through described in hatch the institute after disc mechanism is hatched
State the sample in reaction cup and carry out the mixing mechanism of mixing operation；
Purging system, including the use being rotatably arranged in described frame and hatching described in being positioned at disc mechanism side
In to through described in hatch the sample in the described reaction cup after disc mechanism is hatched carry out three rank clean separate and to clearly
Wash the sample in the described reaction cup after separation and carry out the cleaning disc mechanism of substrate filling and mixing；
Systems for optical inspection, including be arranged at described cleaning disc mechanism and described hatch between disc mechanism for
Sample in described reaction cup after described cleaning disc mechanism cleans separation and substrate filling and mixing is carried out
The light-metering disc mechanism of optical detection, and it is arranged at the light collecting mechanism that described light-metering disc mechanism side coordinates with it；
Described control portion is arranged in described frame, and with described transmission transfer system, described sampling system,
Described incubation system, described purging system and the electrical connection of described Systems for optical inspection.
Further, described reagent disc mechanism includes the rotary case carrying described Reagent Tube, encloses and is located at institute
State rotary case periphery and the described Reagent Tube being carried in described rotary case can be carried out the outer pot of cold preservation, transmission
It is connected to the bottom side of described rotary case with the first driving assembly driving it to rotate, and is arranged at described outer pot
And being used between described rotary case drives described Reagent Tube to rotate to carry out the tumbler of mixing operation.
Further, described sampling system also includes the bar code scanner being arranged in described frame, and
Just can be certainly after being arranged on described sample scheduling institution and described rotary case and being scanned by described bar code scanner
The scanning window of dynamic heating.
Further, described sample charging mechanism include being arranged in described frame and one end optionally rotate to
Described sample scheduling institution, described reagent disc mechanism and described hatch one of them sample arm of disc mechanism, if
It is placed in described frame to drive described sample arm to rotate and the second driving assembly of lifting, and is arranged at institute
State the sample needle of sample arm outer end.
Further, described sample scheduling institution includes the sample sample introduction track being arranged in described frame, with
And it being arranged at the emergency treatment sample bit of described sample sample introduction track side, described sample-adding is taken in one end of described sample arm
Pin can turn to described sample sample introduction track and described emergency treatment sample bit.
Further, described automatically enter that cup mechanism includes being arranged in described frame for described in load store
The reaction cup load store portion of reaction cup, is arranged at described side, reaction cup load store portion interfaced
For transmitting the reaction cup transport unit of described reaction cup, and butt up against described reaction cup transport unit outer end and can turn
Dynamic enters a glass rotating disk automatically.
Further, described grasping mechanism include being arranged in described frame and one end optionally rotate to
Described cleaning disc mechanism, described light-metering disc mechanism, described in hatch disc mechanism and described automatically enter glass rotating disk its
One of crawl arm, be arranged in described frame with drive described crawl arm rotate and lifting the 3rd driving
Assembly, and it is arranged at the handgrip for capturing described reaction cup of described crawl arm outer end.
Further, described in hatch disc mechanism and include hatching dish, and be in transmission connection in the described end hatching dish
Side is to drive its 4th driving assembly rotated.
Further, described light-metering disc mechanism includes rotatably being arranged in described frame and be positioned at described cleaning
Disc mechanism and the described optical detection dish hatched between dish, and be arranged at described optical detection try to get to the heart of a matter side with drive
Its 5th driving assembly rotated.
Further, described Full-automatic chemiluminescence immunoassay analysis meter also includes being arranged in described frame to receive
Collection processes the collection system of used described reaction cup, and described collection system includes abandoning for described reaction cup
Throwing cup position.
Based on technique scheme, the Full-automatic chemiluminescence immunoassay analysis meter that the embodiment of the present invention proposes, lead to
Cross control portion to control to transmit transfer system, sampling system, incubation system, purging system and Systems for optical inspection
Automatically work so that whole analyze operation whole-course automation, it is to avoid individual variation that manual operation exists,
Human error, operate the uncertain problems such as lack of standardization, improve the accuracy of chemiluminescence immune assay.
Accompanying drawing explanation
Fig. 1 is the structural representation of the Full-automatic chemiluminescence immunoassay analysis meter that the embodiment of the present invention proposes；
Fig. 2 is the schematic flow sheet of the Full-automatic chemiluminescence immunoassay analysis meter work in the embodiment of the present invention.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with accompanying drawing and reality
Execute example, the present invention is further elaborated.Only should be appreciated that specific embodiment described herein
Only in order to explain the present invention, it is not intended to limit the present invention.
It should be noted that when element is referred to as " being fixed on " or " being arranged at " another element, and it can be straight
It is connected on another element or may be simultaneously present centering elements.When an element is known as " being connected to " separately
One element, it can be directly to another element or may be simultaneously present centering elements.
It addition, also, it should be noted the orientation term such as left and right, upper and lower in the embodiment of the present invention,
It is only relative concept or with the normal operating condition of product as reference each other, and should not be regarded as having
Restrictive.Below in conjunction with specific embodiment, the realization of the present invention is described in detail.
As shown in Figure 1 to Figure 2, the embodiment of the present invention proposes a kind of Full-automatic chemiluminescence immunoassay analysis meter,
It includes frame 1, analysis portion 2 and control portion (being not drawn in accompanying drawing), and wherein, frame 1 is whole point
The body supports part of analyzer, analysis portion 2 and control portion are arranged in frame 1, and control portion is used for controlling
Analysis portion 2 carries out automatic chemiluminescence immunoassay.Specifically, analysis portion 2 can include transmitting transfer system
System 21, sampling system 22, incubation system 23, purging system 24 and Systems for optical inspection 25, wherein:
Transmit transfer system 21, including for deposit, screen and feeding reaction cup automatically enter cup mechanism 211,
And for transferring the reaction cup automatically entered in cup mechanism 211 to purging system 24 or incubation system 23 or light
Learn the grasping mechanism 212 of detecting system 25, here, automatically enter cup mechanism 211 and be arranged in frame 1, grab
Take mechanism 212 to be movably arranged in frame 1 and be positioned at this automatically enter cup mechanism 211 side and coordinate with it；
Sampling system 22, including the sample dispatcher for depositing and dispatch sample tube being arranged in frame 1
Structure 221, be rotatably provided in frame 1 be positioned at sample scheduling institution 221 side for depositing and adjusting
The reagent disc mechanism 222 of degree Reagent Tube, be movably arranged in frame 1 is positioned at reagent disc mechanism 222 side
For the sample in sample tube and the reagent in Reagent Tube being transferred load to the sample charging mechanism 223 in reaction cup,
Here, sample scheduling institution 221 is being entered between cup mechanism 211 and reagent disc mechanism 222 automatically, and adds
Model machine structure 223 is entering between cup mechanism 211, sample scheduling institution 221 and reagent disc mechanism 222 automatically；
Incubation system 23, including the use being positioned at reagent disc mechanism 222 side being rotatably provided in frame 1
What the sample in being opposite to reaction cup thereon carried out hatching operation hatches disc mechanism 231, and is arranged on
Being positioned in frame 1 hatch on the upside of disc mechanism 231 for the reaction after hatching disc mechanism 231 and hatching
Sample in Bei carries out the mixing mechanism 232 of mixing operation；
Purging system 24, hatches the clear of disc mechanism 231 side including being rotatably provided in being positioned in frame 1
Dishwashing mechanism 241, this cleaning disc mechanism 241 is for the reaction cup after hatching disc mechanism 231 and hatching
In sample carry out three rank clean separate and to clean separate after reaction cup in sample carry out substrate filling and
Mixing, this cleaning disc mechanism 241 includes the cleaning dish 2411 being rotatably provided in frame 1, and arranges
Below cleaning dish 2411 and for driving its motor rotated (being not drawn in accompanying drawing), herein, this cleaning
Dish 2411 has heating function, by cleaning dish 2411 temperature is controlled, and drive and control of electric machine cleaning dish 2411
Rotary motion etc., it is achieved to three times of reaction cup cleanings, clean after terminating, substrate function of injecting can be realized；
Systems for optical inspection 25, including being arranged on the survey cleaned disc mechanism 241 and hatch between disc mechanism 231
CD mechanism 251, and it is arranged on this light-metering disc mechanism 251 side the light collecting mechanism 252 coordinated with it,
Herein, light-metering disc mechanism 251 is for cleaning separation and substrate filling and mixing to through over cleaning disc mechanism 241
After reaction cup in sample carry out optical detection；
Above-mentioned control portion is arranged in frame 1, and with transmit transfer system 21, sampling system 22, hatch and be
System 23, purging system 24 and Systems for optical inspection 25 electrically connect.
The Full-automatic chemiluminescence immunoassay analysis meter that the embodiment of the present invention proposes, it controls to transmit by control portion
Transfer system 21, sampling system 22, incubation system 23, purging system 24 and Systems for optical inspection 25 are certainly
Start building to make so that whole analyze operation whole-course automation, it is to avoid individual variation that manual operation exists, people
Work error, operate the uncertain problems such as lack of standardization, improve the accuracy of chemiluminescence immune assay.
Further, in an embodiment of the present invention, mentioned reagent disc mechanism 222 can include carrying examination
The rotary case 2221 of agent pipe, encloses and is located at this rotary case 2221 periphery and can be to being carried in this rotary case 2221
Reagent Tube carry out the outer pot 2222 of cold preservation, be in transmission connection in the bottom side of rotary case 2221 to drive it to rotate
The first driving assembly (being not drawn in accompanying drawing), and be arranged between outer pot 2222 and rotary case 2221
For driving Reagent Tube to rotate to carry out the tumbler (being not drawn in accompanying drawing) of mixing operation.So, first
Driving assembly starts, and drives rotary case 2221 axial rotation, and meanwhile, outer pot 2222 maintains static, so,
Tumbler between outer pot 2222 and rotary case 2221 is under the effect of rotary case 2221 axial rotation
Rotate, so drive Reagent Tube to rotate and carry out automatic mixing operation.
Further, in an embodiment of the present invention, above-mentioned sampling system 22 may also include and is arranged on frame 1
On bar code scanner (being not drawn in accompanying drawing), and be arranged on above-mentioned sample scheduling institution 221 and above-mentioned
Just the scanning window that can automatically heat after on rotary case 2221 and being scanned by bar code scanner (is not drawn in accompanying drawing
Go out).So, can be by bar code scanner momentarily in sample scheduling institution 221 and rotary case 2221
Scanning window heat, to prevent sample scheduling institution 221 and rotary case 2221 from atomization occurring.Certainly,
According to practical situation and real needs, in other embodiments of the invention, above-mentioned sampling system 22 can be also
Other version, the most uniquely limits.
Further, in an embodiment of the present invention, above-mentioned sample charging mechanism 223 can include being rotatably provided in
Sample arm 2231 in frame 1, the being arranged in frame 1 to drive sample arm 2231 to rotate and lifting
Two driving assemblies 2232, and it is arranged on the sample needle (being not drawn in accompanying drawing) of sample arm 2231 outer end, this
Place, second drives assembly 2232 to start, and drives one end axial rotation of sample arm 2231, so, sample-adding
The other end synchronous axial system of arm 2231 also optionally rotates to sample scheduling institution 221, reagent disc mechanism
222 and hatch disc mechanism 231 at one of them.When needing to draw sample or the reagent of Reagent Tube of sample tube
Time, by manipulation control portion, control the second driving assembly 2232 and start work, second drives assembly 2232
Sample arm 2231 is driven to rotate so that sample needle rotates with sample arm 2231 and moves to specify position, afterwards,
Assembly 2232 is driven to lift sample arm 2231 by second so that sample needle liter is down to suitable position, with right
The sample of sample tube or the reagent of Reagent Tube are drawn.
Further, in an embodiment of the present invention, above-mentioned sample scheduling institution 221 can include being arranged on machine
Sample sample introduction track 2211 on frame 1, and it is arranged on the emergency treatment sample of sample sample introduction track 2211 side
Position 2212, herein, the outer end of above-mentioned sample arm 2231 is taken sample needle and is can turn to this sample sample introduction track 2211
With emergency treatment sample bit 2212 to be sampled.Certainly, according to practical situation and demand, at other of the present invention
In embodiment, above-mentioned sample scheduling institution 221 can be also other version, the most uniquely limits.
Further, in an embodiment of the present invention, above-mentioned cup mechanism 211 is automatically entered for realizing reaction cup
Automatically enter cup, what this entered that cup mechanism 211 can include being arranged in frame 1 automatically reacts for load store
The reaction cup load store portion 2111 of cup, is arranged on reaction cup load store side, portion 2111 interfaced
For transmitting the reaction cup transport unit 2112 of reaction cup, and butt up against outside this reaction cup transport unit 2112
End and rotating automatically enter glass rotating disk 2113, here, this automatically enters cup mechanism 211 and also includes for driving
Move reaction cup transport unit 2112 and automatically enter the drive part (being not drawn in accompanying drawing) of glass rotating disk 2113, this
Locating, this enters to have in glass rotating disk 2113 sample-adding position 21132 automatically, and herein, this sample-adding position 21132 is positioned at
Automatically enter the position overlapped in glass rotating disk 2113 with sample needle rotational trajectory, this position is carried out sample and
The loading of reagent；Meanwhile, automatically entering and have into cup position 21131 in glass rotating disk 2113, herein, this enters cup
Position 21131 is positioned at enters the position overlapped with the handgrip rotational trajectory of grasping mechanism 212 in glass rotating disk 2113 automatically
Putting, the reaction cup on this position can be grabbed and hatch in disc mechanism 231 by handgrip.Certainly, according to actual feelings
Condition and real needs, in other embodiments of the invention, above-mentioned automatically to enter cup mechanism 211 can be also other
Version, the most uniquely limit.
Further, in an embodiment of the present invention, above-mentioned disc mechanism 231 of hatching can include hatching dish 2311,
And be in transmission connection in this hatch the bottom side of dish 2311 with drive it to rotate the 4th driving assembly (in accompanying drawing not
Draw).By manipulation control portion, controlling the 4th driving assembly startup work, the 4th drives assembly to drive hatches
Dish 2311 rotates, and herein, this is hatched dish 2311 and has heating function, by carrying out temperature to hatching dish 2311
Degree controls, and the 4th drives Component driver to control to hatch the rotary motion etc. of dish 2311 so that reaction cup is being hatched
Dish 2311 completes sample-adding, mixes and hatch work.Certainly, according to practical situation and demand, at this
In other embodiments bright, hatch the version that disc mechanism 231 can be also other, the most uniquely limit.
In the embodiment of the present invention, above-mentioned light-metering disc mechanism 251 includes being rotatably provided in frame 1 and being positioned at
The cleaning dish 2411 of above-mentioned cleaning disc mechanism 241 and the above-mentioned optical detection dish 2511 hatched between dish 2311,
And be arranged on this optical detection dish 2511 bottom side with drive it to rotate the 5th driving assembly (accompanying drawing is not drawn
Go out), here, by manipulation control portion, control the 5th driving assembly startup work, the 5th drives assembly to drive
Optical detection dish 2511 rotates, and herein, this optical detection dish 2511 has heating function.Certainly, according to
Practical situation and real needs, in other embodiments of the invention, above-mentioned light-metering disc mechanism 251 can be also
Other version, the most uniquely limits.
In embodiments of the present invention, above-mentioned Full-automatic chemiluminescence immunoassay analysis meter also includes being arranged on frame 1
On process the collection system 26 of used reaction cup with collection, this collection system 26 can include for reaction cup
The throwing cup position 261 abandoned.Certainly, according to practical situation and real needs, in other embodiments of the present invention
In, above-mentioned Full-automatic chemiluminescence immunoassay analysis meter may also include other structures, is not further qualified.
Further, in an embodiment of the present invention, above-mentioned grasping mechanism 212 includes being arranged in frame 1
Crawl arm 2121, be arranged in frame 1 the 3rd driving to drive this crawl arm 2121 to rotate and lift
Assembly 2122, and it is arranged on the handgrip for capturing reaction cup of this crawl arm 2121 outer end (in accompanying drawing
It is not drawn into), herein, when the 3rd drives assembly 2122 to start, drive one end axial rotation of crawl arm 2121,
So, crawl arm 2121 other end synchronous axial system optionally rotation extremely above-mentioned cleaning disc mechanism 241
Cleaning dish 2411, light-metering disc mechanism 251, hatch disc mechanism 231, automatically enter grabbing of glass rotating disk 2113
Cup position b and the position of one of them throwing cup position 261 of above-mentioned collection system 26.When needs transfer is reacted
During cup, can be controlled the 3rd driving assembly 2122 started by manipulation control portion, the 3rd drives assembly 2122
Crawl arm 2121 is driven to rotate so that handgrip rotates with crawl arm 2121 and moves to specify position, afterwards, logical
Cross the 3rd driving assembly 2122 and lift crawl arm 2121 so that handgrip liter is down to suitable position to capture reaction
Cup.In the present embodiment, on handgrip movement locus, layout is the most successively: automatically enter a glass rotating disk
2113, hatch disc mechanism 231 hatches dish 2311, the optical detection dish 2511 of light-metering disc mechanism 251, clear
The cleaning dish 2411 of dishwashing mechanism 241, certainly, according to practical situation and real needs, at its of the present invention
In his embodiment, above-mentioned grasping mechanism 212 can be also other version, the most uniquely limits.
In the present embodiment, the movement locus of above-mentioned sample needle covers conventional sample bit 2213 (i.e. sample sample introduction
The position overlapped with sample needle movement locus on track 2211), emergency treatment sample bit 2212, hatch dish sample-adding
Position 23111 (hatching the position overlapped with sample needle movement locus on dish 2311), sample inhaled by two cleanout fluid
Position 2312 (hatching between dish 2311 and rotary case 2221), service sink a and rotary case 2221,
Can realize multiposition and inhale sample and multiposition stock layout, flexibility ratio is high；Herein, service sink a is distributed in and hatches dish
On movement locus between 2311 and rotary case 2221.In the motion hatched between dish 2311 and service sink a
On track, the position of one or two placement cleanout fluid is distributed；Sample needle is hatching two friendships of dish 2311
Vent is put and automatically enters the addition function that all can realize sample and reagent on the crossover location of glass rotating disk 2113.
In the present embodiment, the testing process of above-mentioned Full-automatic chemiluminescence immunoassay analysis meter is as follows:
Starting analyser, whole analysis process starts, and automatically enters the reaction cup transport unit 2112 of cup mechanism 211
What the reaction cup in reaction cup load store portion 2111 was fed to automatically to enter glass rotating disk 2113 enters cup position
21131, automatically enter glass rotating disk 2113 and be transported to reaction cup be loaded position 21132, by sample dispatcher
The motor driven systems of structure 221 controls sample and runs to conventional sample thereon on sample sample introduction track 2211
Position 2213, drives the motor driven systems of assembly to control rotary case 2221 by first and rotates with by Reagent Tube
Running to inhale reagent sites c, sample needle is drawn sample in the sample tube from conventional sample bit 2213 and adds
In reaction cup on sample-adding position 21132, sample needle draws reagent from the Reagent Tube inhaled reagent sites c
And add in the reaction cup on sample-adding position 21132, then, automatically enter glass rotating disk 2113 and rotate, and lead to
Cross the rotation concussion action of self, complete the reaction liquid in reaction cup is mixed.After having mixed,
Automatically entering glass rotating disk 2113 to be transported to reaction cup grab cup position b, the reaction cup grabbed on the b of cup position is grabbed by handgrip
Take and be transferred to hatch in dish 2311 and hatch.After having hatched, the reaction cup hatched is grabbed by handgrip
Take and transfer to cleaning dish 2411, carrying out three rank and clean adsorbing separation (after cleaning separation, also by grabbing
Reaction cup is grabbed from cleaning dish 2411 and hatches dish 2311 by hands, and then, sample needle is from rotary case 2221
Drawing reagent and add in the reaction cup hatching dish 2311, mixing, hatch, then, handgrip will have been hatched
The reaction cup become again captures and transfers to cleaning dish 2411 and carries out three rank cleaning adsorbing separation), then pass through
Substrate pipe on cleaning dish 2411 is toward filling substrate in the reaction cup cleaned after separating and mixes；Then,
Reaction cup is rotated to grabbing a glass position d by cleaning dish 2411, and the reaction cup after handgrip will add substrate and mixes is grabbed
Taking and transfer to optical detection dish 2511, carry out hatching, light-metering, after completing, handgrip is from optical detection dish 2511
On reaction cup captures and transfers to throw cup position 261, then will complete the reaction cup jettisoning of test, so far,
Whole testing process terminates.Whole testing process is automation mechanized operation, is prevented effectively from the individual of manual operation existence
Probabilistic problem such as body difference, human error, operation are lack of standardization, so, improves chemiluminescence and exempts from
The accuracy that epidemic disease is analyzed.
Embodiment described above, the only specific embodiment of the invention, but protection scope of the present invention not office
Being limited to this, any those familiar with the art, can be easily in the technical scope that the invention discloses
Expect the amendment of various equivalence, replace and improvement etc., these amendments, replace and improve and all should contain at this
Within the protection domain of invention.Therefore, protection scope of the present invention should be as the criterion with scope of the claims.
Claims (10)
1. Full-automatic chemiluminescence immunoassay analysis meter, it is characterised in that including: frame, is arranged at described machine
Analysis portion on frame, and for controlling the control portion that described analysis portion is run；Described analysis portion includes:
Transmit transfer system, including for deposit, screen and feeding reaction cup automatically enter cup mechanism, and
For transferring the grasping mechanism of described reaction cup, described automatically enter cup mechanism and be arranged in described frame, described
Grasping mechanism is movably set in described frame and is positioned at described automatically enter cup mechanism side and coordinate with it；
Sampling system, including the sample dispatcher for depositing and dispatch sample tube being arranged in described frame
Structure, be rotatably arranged in described frame and be positioned at described sample scheduling institution side for depositing and dispatching
The reagent disc mechanism of Reagent Tube, is movably arranged in described frame and is positioned at described reagent disc mechanism side
Model machine is added for what the reagent in the sample in described sample tube and described Reagent Tube was transferred load to described reaction cup
Structure, described sample scheduling institution enters between cup mechanism and described reagent disc mechanism automatically described, and described
Sample charging mechanism enters between cup mechanism, described sample scheduling institution and described reagent disc mechanism automatically described；
Incubation system, including the use being rotatably arranged in described frame and being positioned at described reagent disc mechanism side
Sample in being opposite to described reaction cup thereon carries out hatching the disc mechanism of hatching of operation, and is arranged at
Hatch in described frame and described in being positioned on the upside of disc mechanism for through described in hatch the institute after disc mechanism is hatched
State the sample in reaction cup and carry out the mixing mechanism of mixing operation；
Purging system, including the use being rotatably arranged in described frame and hatching described in being positioned at disc mechanism side
In to through described in hatch the sample in the described reaction cup after disc mechanism is hatched carry out three rank clean separate and to clearly
Wash the sample in the described reaction cup after separation and carry out the cleaning disc mechanism of substrate filling and mixing；
Systems for optical inspection, including be arranged at described cleaning disc mechanism and described hatch between disc mechanism for
Sample in described reaction cup after described cleaning disc mechanism cleans separation and substrate filling and mixing is carried out
The light-metering disc mechanism of optical detection, and it is arranged at the light collecting mechanism that described light-metering disc mechanism side coordinates with it；
Described control portion is arranged in described frame, and with described transmission transfer system, described sampling system,
Described incubation system, described purging system and the electrical connection of described Systems for optical inspection.
2. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 1, it is characterised in that described examination
Agent disc mechanism includes the rotary case carrying described Reagent Tube, encloses and is located at described rotary case periphery and can be to holding
The described Reagent Tube being loaded in described rotary case carries out the outer pot of cold preservation, is in transmission connection in the end of described rotary case
Side is to drive its first driving assembly rotated, and is arranged at the use between described outer pot and described rotary case
Rotate to carry out the tumbler of mixing operation in driving described Reagent Tube.
3. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 2, it is characterised in that described in adopt
Sample system also includes the bar code scanner being arranged in described frame, and is arranged at described sample dispatcher
Just the scanning window that can automatically heat after on structure and described rotary case and being scanned by described bar code scanner.
4. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 2, it is characterised in that described in add
Model machine structure includes being arranged in described frame and one end and optionally rotates to described sample scheduling institution, institute
State reagent disc mechanism and described hatch one of them sample arm of disc mechanism, being arranged in described frame to drive
Described sample arm rotates and the second driving assembly of lifting, and is arranged at the sample needle of described sample arm outer end.
5. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 4, it is characterised in that described sample
This scheduling institution includes the sample sample introduction track being arranged in described frame, and is arranged at described sample sample introduction
The emergency treatment sample bit of track side, one end of described sample arm is taken described sample needle and is can turn to described sample and enter
Sample track and described emergency treatment sample bit.
6. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 4, it is characterised in that described from
Move and include that the reaction cup loading for reaction cup described in load store being arranged in described frame is deposited into cup mechanism
Storage portion, is arranged at described side, reaction cup load store portion and interfaced for transmitting described reaction cup
Reaction cup transport unit, and butt up against described reaction cup transport unit outer end and rotating automatically enter a glass rotating disk.
7. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 6, it is characterised in that described in grab
Take mechanism to include being arranged in described frame and one end and optionally rotate to described cleaning disc mechanism, described
Light-metering disc mechanism, described in hatch disc mechanism and described automatically enter one of them crawl arm of glass rotating disk, arrange
To drive described crawl arm to rotate and the 3rd driving assembly of lifting in described frame, and it is arranged at described
The handgrip for capturing described reaction cup of crawl arm outer end.
8. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 6, it is characterised in that described in incubate
Educate disc mechanism and include hatching dish, and be in transmission connection in the described bottom side hatching dish with drive it to rotate the 4th
Drive assembly.
9. Full-automatic chemiluminescence immunoassay analysis meter as claimed in claim 8, it is characterised in that described survey
CD mechanism include rotatably being arranged in described frame and be positioned at described cleaning disc mechanism and described hatch dish it
Between optical detection dish, and be arranged at described optical detection try to get to the heart of a matter side with drive it to rotate the 5th driving assembly.
10. the Full-automatic chemiluminescence immunoassay analysis meter as described in any one of claim 1 to 9, its feature
Being, described Full-automatic chemiluminescence immunoassay analysis meter also includes being arranged at processing with collection in described frame to be made
The collection system of used described reaction cup, described collection system includes the throwing cup position abandoned for described reaction cup.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610131478.7A CN106199026B (en) | 2016-03-09 | 2016-03-09 | Full-automatic chemiluminescence immunoassay analysis meter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610131478.7A CN106199026B (en) | 2016-03-09 | 2016-03-09 | Full-automatic chemiluminescence immunoassay analysis meter |
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| Publication Number | Publication Date |
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| CN106199026A true CN106199026A (en) | 2016-12-07 |
| CN106199026B CN106199026B (en) | 2019-05-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610131478.7A Active CN106199026B (en) | 2016-03-09 | 2016-03-09 | Full-automatic chemiluminescence immunoassay analysis meter |
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