CN112816307A - Blood coagulation mixing device and incubation disc comprising same - Google Patents
Blood coagulation mixing device and incubation disc comprising same Download PDFInfo
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- CN112816307A CN112816307A CN202110044922.2A CN202110044922A CN112816307A CN 112816307 A CN112816307 A CN 112816307A CN 202110044922 A CN202110044922 A CN 202110044922A CN 112816307 A CN112816307 A CN 112816307A
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- reaction cup
- tray
- reaction
- iron beads
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
本发明公开了一种凝血混匀装置及包含其的孵育盘，所述凝血混匀装置是在反应杯内置入铁珠，并在反应杯外设置往复运动的磁铁，所述磁铁能够吸附反应杯内的铁珠，使铁珠在反应杯内同步进行往复运动；或，在反应杯内置入铁珠，设置运动机构，所述运动机构能够使反应杯以预定路径运动，在反应杯行进路径的两侧交替间隔设置数个磁铁，反应杯在沿预定路径运动时，所述磁铁能够交替吸附反应杯中的铁珠，使铁珠在反应杯内进行反复运动。本发明能够使凝血反应的样品与试剂通过铁珠往复摆动而混匀，不造成交叉污染，不产生气泡，提高了试验结果的准确性。
The invention discloses a coagulation mixing device and an incubation plate comprising the same. The coagulation mixing device has iron beads inside a reaction cup, and a reciprocating magnet is arranged outside the reaction cup, and the magnet can adsorb the reaction cup The iron beads inside make the iron balls reciprocate synchronously in the cuvette; or, the iron beads are built into the cuvette, and a motion mechanism is set up, and the motion mechanism can make the cuvette move in a predetermined path, and the cuvette travels in the path of the cuvette. Several magnets are alternately arranged on both sides. When the cuvette moves along a predetermined path, the magnets can alternately adsorb the iron beads in the cuvette, so that the iron beads move repeatedly in the cuvette. The invention can make the samples and reagents for coagulation reaction to be mixed evenly by the reciprocating swing of the iron beads, without causing cross-contamination and no bubbles, and improving the accuracy of the test results.
Description
Technical Field
The invention relates to the field of medical detection equipment, in particular to a blood coagulation blending device and an incubation disc comprising the same.
Background
At present, a blood coagulation blending device applied to blood coagulation reaction detection equipment mainly takes mechanical blending and sample adding needle sucking, beating and blending as main components. The mechanical blending mode is that a stirring rod is arranged and extends into the reaction cup to reciprocate, so as to achieve the purpose of blending; the sample adding needle is used for sucking, beating and uniformly mixing the sample and the reagent by repeatedly extracting and injecting the sample and the reagent through sample adding, so that the purpose of uniformly mixing is achieved. However, the two blending methods have obvious defects, cross contamination is easily caused by the stirring of the stirring rod, and bubbles are easily generated in the repeated extraction and injection process of the sample adding needle in the sucking and pumping blending method, so that the accuracy of the test result is affected.
Therefore, the above conventional coagulation mixing device still has inconvenience and disadvantages in structure and use, and further improvement is needed. How to create a new blood coagulation mixing device and an incubation disc containing the same, and actually belongs to one of the current important research and development issues.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a blood coagulation blending device, which achieves the blending purpose by the reciprocating swing of iron beads adsorbed by magnets, does not cause cross contamination, does not generate bubbles, and overcomes the defects of the existing blood coagulation blending device.
In order to solve the technical problem, the invention provides a coagulation reaction blending device, wherein iron beads are arranged in a reaction cup, a magnet which reciprocates is arranged outside the reaction cup, and the magnet can adsorb the iron beads in the reaction cup so that the iron beads synchronously reciprocate in the reaction cup;
or, iron beads are placed in the reaction cup, a movement mechanism is arranged, the movement mechanism can enable the reaction cup to move along a preset path, a plurality of magnets are alternately arranged on two sides of the moving path of the reaction cup at intervals, and when the reaction cup moves along the preset path, the magnets can alternately adsorb the iron beads in the reaction cup, so that the iron beads can repeatedly move in the reaction cup.
As a modification of the present invention, the magnet is a permanent magnet or an electromagnet.
Further, the axes of two adjacent magnets on two sides of the reaction cup traveling path are not coincident.
Further, the reaction cup travel path is in a straight line or annular track.
In addition, the invention also provides the incubation disc, so that cross contamination and air bubbles are not caused in the uniform mixing process, and the defects of the existing incubation disc are overcome.
In order to solve the above technical problems, the present invention provides an incubation plate, comprising the above blood coagulation mixing device,
as a further improvement, the incubation plate comprises a heating plate, a reaction cup tray and a magnet, wherein:
the heating plate comprises an outer ring and an inner ring, and an annular gap is formed between the outer ring and the inner ring and used for placing the reaction cup tray;
the reaction cup tray and the heating disc are concentrically arranged, a plurality of reaction cup grooves are uniformly distributed in the circumferential direction of the reaction cup tray, and the reaction cup tray can rotate by taking the circle center as an axis;
the magnets are alternately arranged on the outer ring and the inner ring of the heating plate at intervals, so that when the reaction cup rotates along with the reaction cup tray, the iron beads swing in the reaction cup in a reciprocating manner.
Further, the length direction of each reaction cup groove on the reaction cup tray is the same as the radial direction of the reaction cup tray.
Furthermore, the reaction cup tray is connected with a driving disc through a bolt, and the driving disc is connected with an output shaft of the motor through a synchronous belt.
After adopting such design, the invention has at least the following advantages:
1. the iron beads are repeatedly swung in the reaction cup under the adsorption action of the magnets, so that the stirring purpose is achieved, and cross contamination can not be caused.
2. The iron beads do not generate bubbles when swinging, and the accuracy of the test result is improved.
Drawings
The foregoing is only an overview of the technical solutions of the present invention, and in order to make the technical solutions of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and the detailed description.
FIG. 1 is a schematic structural diagram of an incubation tray provided by the present invention.
FIG. 2 is a schematic view of the internal structure of the reaction cup tray without the incubation tray provided by the present invention.
Description of reference numerals: 1-heating a plate; 11-heating plate outer ring; 12-heating plate inner ring; 2-reaction cup tray; 21-reaction cup groove; 3-a magnet; 4-reaction cup; 5-drive plate.
Detailed Description
The invention provides a coagulation reaction blending device, which is characterized in that iron beads are placed in a reaction cup, a moving mechanism is arranged to enable the reaction cup to move along a preset path, a plurality of magnets are alternately arranged on two sides of the advancing path of the reaction cup at intervals, and when the reaction cup moves along the preset path, the magnets can alternately adsorb the iron beads in the reaction cup, so that the iron beads can repeatedly move in the reaction cup, and the purpose of blending is achieved.
Preferably, the reaction cup advancing path is a straight line or an annular track, and the axes of two adjacent magnets on two sides of the reaction cup advancing path are not coincident, so that the iron beads repeatedly swing in the reaction cup while the reaction cup advances.
Preferably, the magnet may be an electromagnet or a permanent magnet.
In other embodiments, the coagulation reaction blending device provided by the invention may further include a magnet arranged outside the reaction cup and moving back and forth, wherein the magnet moves back and forth to adsorb the iron beads and also move back and forth in the reaction cup, so as to achieve the purpose of blending.
Referring to fig. 1 and 2, the present invention provides an incubation disc, including the above coagulation reaction mixing device, the incubation disc includes a heating plate 1, a reaction cup tray 2, a magnet 3, and a driving plate 5. Heating plate 1 is used for heating reaction cup 4, and heating plate 1 includes heating plate outer loop 11 and heating plate inner ring 12, has annular space between heating plate outer loop 11 and the heating plate inner ring 12 for place reaction cup tray 2 in wherein. The reaction cup tray 2 and the heating plate 1 are arranged concentrically, and the reaction cup tray 2 is arranged in an annular gap of the heating plate 1 and can rotate in a horizontal plane relative to the heating plate 1. A circle of reaction cup grooves 21 are circumferentially arranged on the reaction cup tray 2, the reaction cup grooves 21 are rectangular, and the length direction of the reaction cup grooves 21 is the same as the radial direction of the reaction cup tray 2, so that the reaction cups 4 can be radially placed in the reaction cup grooves 4. Magnet 3 is installed on heating plate outer loop 11 and heating plate inner ring 12 at interval in turn to 3 axes of two adjacent magnets do not coincide, make at reaction cup 4 along with the in-process of reaction cup layer board 2 rotations, the magnet that is located on heating plate outer loop 11 and the heating plate inner ring 12 can adsorb the iron shot in turn, causes the reciprocal swing of iron shot, reaches the mixing purpose.
Preferably, the reaction cup tray 2 is connected with the driving plate 5 through a bolt, and the driving plate 5 is connected to an output shaft of the motor through a synchronous belt and is driven by the motor to rotate.
It should be noted that the incubation disc provided by the present invention can also be a structure in which the magnet reciprocates and the reaction cup is fixed in other embodiments.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.
Claims (8)
1. A coagulation reaction blending device is characterized in that iron beads are placed in a reaction cup, a magnet which moves back and forth is arranged outside the reaction cup, and the magnet can adsorb the iron beads in the reaction cup to enable the iron beads to synchronously move back and forth in the reaction cup;
or, iron beads are placed in the reaction cup, a movement mechanism is arranged, the movement mechanism can enable the reaction cup to move along a preset path, a plurality of magnets are alternately arranged on two sides of the moving path of the reaction cup at intervals, and when the reaction cup moves along the preset path, the magnets can alternately adsorb the iron beads in the reaction cup, so that the iron beads can repeatedly move in the reaction cup.
2. The coagulation reaction blending device of claim 1, wherein the magnet is a permanent magnet or an electromagnet.
3. The coagulation reaction mixing device according to claim 1, wherein the axes of two adjacent magnets on both sides of the reaction cup advancing path are not coincident.
4. The coagulation reaction blending device according to claim 1, wherein the reaction cup travel path is a linear or circular track.
5. An incubation plate comprising a coagulation reaction mixing device according to any one of claims 1 to 4.
6. The incubation tray of claim 5, comprising a heating tray, a reaction cup tray, a magnet, wherein:
the heating plate comprises an outer ring and an inner ring, and an annular gap is formed between the outer ring and the inner ring and used for placing the reaction cup tray;
the reaction cup tray and the heating disc are concentrically arranged, a plurality of reaction cup grooves are uniformly distributed in the circumferential direction of the reaction cup tray, and the reaction cup tray can rotate by taking the circle center as an axis;
the magnets are alternately arranged on the outer ring and the inner ring of the heating plate at intervals, so that when the reaction cup rotates along with the reaction cup tray, the iron beads swing in the reaction cup in a reciprocating manner.
7. The incubation tray of claim 5, wherein the length direction of each reaction cup groove on the reaction cup tray is the same as the radial direction of the reaction cup tray.
8. The incubation disc of claim 5, wherein the reaction cup tray is connected to a driving disc by a bolt, and the driving disc is connected to an output shaft of a motor by a timing belt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110044922.2A CN112816307A (en) | 2021-01-13 | 2021-01-13 | Blood coagulation mixing device and incubation disc comprising same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110044922.2A CN112816307A (en) | 2021-01-13 | 2021-01-13 | Blood coagulation mixing device and incubation disc comprising same |
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| Publication Number | Publication Date |
|---|---|
| CN112816307A true CN112816307A (en) | 2021-05-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110044922.2A Pending CN112816307A (en) | 2021-01-13 | 2021-01-13 | Blood coagulation mixing device and incubation disc comprising same |
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| CN (1) | CN112816307A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102279275A (en) * | 2011-06-22 | 2011-12-14 | 深圳市国赛生物技术有限公司 | Integrated apparatus for magnetic stirring, cleaning and separation |
| CN104237545A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay blending device |
| CN109406810A (en) * | 2017-08-16 | 2019-03-01 | 北京普利生仪器有限公司 | Sample analysis apparatus, sample incubation device and its control method |
| CN110501513A (en) * | 2019-09-19 | 2019-11-26 | 南京迪格诺斯生物技术有限公司 | A kind of chemiluminescence analyzer |
| CN209911387U (en) * | 2019-05-11 | 2020-01-07 | 南京岚煜生物科技有限公司 | Incubation reaction dish device |
| US20200355676A1 (en) * | 2018-02-08 | 2020-11-12 | Chengdu Shen Mindray Medical Electronics Technology Research Institute Co., Ltd. | Fully automated chemiluminescence immunoassay analyzer |
| CN214334455U (en) * | 2021-01-13 | 2021-10-01 | 北京罗特思创科技有限公司 | Blood coagulation mixing device and incubation disc comprising same |
-
2021
- 2021-01-13 CN CN202110044922.2A patent/CN112816307A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102279275A (en) * | 2011-06-22 | 2011-12-14 | 深圳市国赛生物技术有限公司 | Integrated apparatus for magnetic stirring, cleaning and separation |
| CN104237545A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay blending device |
| CN109406810A (en) * | 2017-08-16 | 2019-03-01 | 北京普利生仪器有限公司 | Sample analysis apparatus, sample incubation device and its control method |
| US20200355676A1 (en) * | 2018-02-08 | 2020-11-12 | Chengdu Shen Mindray Medical Electronics Technology Research Institute Co., Ltd. | Fully automated chemiluminescence immunoassay analyzer |
| CN209911387U (en) * | 2019-05-11 | 2020-01-07 | 南京岚煜生物科技有限公司 | Incubation reaction dish device |
| CN110501513A (en) * | 2019-09-19 | 2019-11-26 | 南京迪格诺斯生物技术有限公司 | A kind of chemiluminescence analyzer |
| CN214334455U (en) * | 2021-01-13 | 2021-10-01 | 北京罗特思创科技有限公司 | Blood coagulation mixing device and incubation disc comprising same |
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Application publication date: 20210518 |