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DOP2020000100A - Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3 - Google Patents

Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3

Info

Publication number
DOP2020000100A
DOP2020000100A DO2020000100A DO2020000100A DOP2020000100A DO P2020000100 A DOP2020000100 A DO P2020000100A DO 2020000100 A DO2020000100 A DO 2020000100A DO 2020000100 A DO2020000100 A DO 2020000100A DO P2020000100 A DOP2020000100 A DO P2020000100A
Authority
DO
Dominican Republic
Prior art keywords
compounds
pirrolo
inhibitors
pyrimidine derivatives
novel pyrazolo
Prior art date
Application number
DO2020000100A
Other languages
English (en)
Inventor
Koppitz Marcus
Pook Elisabeth
Neuhaus Roland
Martin Fischer Oliver
Rotgeri Andrea
Bräuer Nico
Siebeneicher Holger
Nagel Jens
James Davenport Adam
Lindsay Carr James
James Townsend Robert
Connelly Ursinyova Nina
Anne Parrott Shelley
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of DOP2020000100A publication Critical patent/DOP2020000100A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención cubre compuestos de pirazolo-pirrolo-pirimidin-diona sustituidos (PPPD) de la fórmula general (I): (I) en la cual R1, R2 y R3 son como se los define en esta memoria, métodos de preparación de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos, y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento o la profilaxis de enfermedades, en particular de enfermedades neurogénicas, como agente único en combinación con otros principios activos.
DO2020000100A 2017-10-27 2020-06-01 Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3 DOP2020000100A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17198769 2017-10-27
PCT/EP2018/078567 WO2019081343A1 (en) 2017-10-27 2018-10-18 NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS

Publications (1)

Publication Number Publication Date
DOP2020000100A true DOP2020000100A (es) 2020-09-15

Family

ID=60190695

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2020000100A DOP2020000100A (es) 2017-10-27 2020-06-01 Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3

Country Status (26)

Country Link
US (1) US11319324B2 (es)
EP (1) EP3700907B1 (es)
JP (1) JP7250011B2 (es)
KR (1) KR20200078567A (es)
CN (1) CN111527090B (es)
AU (1) AU2018354777A1 (es)
BR (1) BR112020008122B1 (es)
CA (1) CA3080249A1 (es)
CL (1) CL2020001107A1 (es)
CO (1) CO2020005065A2 (es)
CR (1) CR20200174A (es)
CU (1) CU20200038A7 (es)
DK (1) DK3700907T3 (es)
DO (1) DOP2020000100A (es)
EA (1) EA202091003A1 (es)
EC (1) ECSP20023626A (es)
ES (1) ES2914377T3 (es)
IL (1) IL274036A (es)
JO (1) JOP20200100A1 (es)
MA (1) MA50439A (es)
MX (1) MX2020004981A (es)
NI (1) NI202000031A (es)
PE (1) PE20200932A1 (es)
PH (1) PH12020550494A1 (es)
SG (1) SG11202003662XA (es)
WO (1) WO2019081343A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112778311B (zh) * 2019-11-01 2024-06-04 上海翰森生物医药科技有限公司 含氮并环类衍生物抑制剂、其制备方法和应用
CN118894856A (zh) * 2019-12-10 2024-11-05 上海翰森生物医药科技有限公司 含吡唑多环类衍生物抑制剂、其制备方法和应用
WO2022175514A1 (en) * 2021-02-22 2022-08-25 Bayer Aktiengesellschaft N-(pyridin-2-yl)-acetamides as p2x3 inhibitors
CN117412974A (zh) * 2021-06-09 2024-01-16 上海翰森生物医药科技有限公司 含吡唑多环类衍生物的盐、晶型及其制备方法和应用
EP4387959A4 (en) * 2021-08-17 2025-07-02 Glaxosmithkline Intellectual Property No 3 Ltd PREPARATION OF A P2X3 ANTAGONIST
CN121127473A (zh) * 2023-05-17 2025-12-12 英矽智能科技知识产权有限公司 作为wrn抑制剂的螺环衍生物
US20250230168A1 (en) * 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3869789A (en) 1988-07-21 1990-02-19 Upjohn Company, The Pyrazolo-pyrrolo-pyrimidine-diones
AU707530B2 (en) * 1995-09-28 1999-07-15 Otsuka Pharmaceutical Factory, Inc. Analgesic composition
TR200201204T2 (tr) 1999-11-05 2002-08-21 Warner Lambert Company ACAT inhibitörleriyle plak rüptürünün engellenmesi.
AR061625A1 (es) 2006-06-23 2008-09-10 Incyte Corp Derivados de purinona como agonistas de hm74a
US20090099195A1 (en) 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
RU2638116C2 (ru) * 2011-08-12 2017-12-15 Ф. Хоффманн-Ля Рош Аг Пиразоло[3,4-с]пиридины и способы их применения
WO2013182519A1 (en) * 2012-06-04 2013-12-12 Universitaet Basel Combination of lysosomotropic or autophagy modulating agents and a gsk-3 inhibitor for treatment of cancer
US10314816B2 (en) 2012-06-08 2019-06-11 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
TW201441227A (zh) * 2013-01-16 2014-11-01 Signal Pharm Llc 經取代吡咯并嘧啶化合物、其組合物及其治療方法

Also Published As

Publication number Publication date
US11319324B2 (en) 2022-05-03
CN111527090A (zh) 2020-08-11
AU2018354777A1 (en) 2020-04-16
CL2020001107A1 (es) 2020-10-23
BR112020008122B1 (pt) 2022-11-01
EP3700907A1 (en) 2020-09-02
ES2914377T3 (es) 2022-06-10
CO2020005065A2 (es) 2020-05-29
JP2021500380A (ja) 2021-01-07
NI202000031A (es) 2020-08-28
JP7250011B2 (ja) 2023-03-31
DK3700907T3 (da) 2022-05-30
CU20200038A7 (es) 2021-03-11
MX2020004981A (es) 2020-08-24
EA202091003A1 (ru) 2020-09-11
CR20200174A (es) 2020-06-26
ECSP20023626A (es) 2020-06-30
CN111527090B (zh) 2023-05-26
EP3700907B1 (en) 2022-03-09
KR20200078567A (ko) 2020-07-01
MA50439A (fr) 2021-05-19
PE20200932A1 (es) 2020-09-17
PH12020550494A1 (en) 2021-01-11
JOP20200100A1 (ar) 2020-05-06
BR112020008122A2 (pt) 2020-11-03
SG11202003662XA (en) 2020-05-28
IL274036A (en) 2020-06-30
US20210317128A1 (en) 2021-10-14
CA3080249A1 (en) 2019-05-02
WO2019081343A1 (en) 2019-05-02

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