CL2014001562A1 - Compuestos derivados nucleosidos de purina y pirimidina, inhibidores de la replicacion del arn del vhc; composicion farmaceutica; y su uso para el tratamiento y profilaxis de la infeccion por el virus de la hepatitis c (vhc). - Google Patents
Compuestos derivados nucleosidos de purina y pirimidina, inhibidores de la replicacion del arn del vhc; composicion farmaceutica; y su uso para el tratamiento y profilaxis de la infeccion por el virus de la hepatitis c (vhc).Info
- Publication number
- CL2014001562A1 CL2014001562A1 CL2014001562A CL2014001562A CL2014001562A1 CL 2014001562 A1 CL2014001562 A1 CL 2014001562A1 CL 2014001562 A CL2014001562 A CL 2014001562A CL 2014001562 A CL2014001562 A CL 2014001562A CL 2014001562 A1 CL2014001562 A1 CL 2014001562A1
- Authority
- CL
- Chile
- Prior art keywords
- vhc
- arn
- purine
- prophylaxis
- hepatitis
- Prior art date
Links
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- -1 Nucleoside derivatives compounds Chemical class 0.000 title 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577707P | 2011-12-20 | 2011-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001562A1 true CL2014001562A1 (es) | 2014-11-14 |
Family
ID=47504913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001562A CL2014001562A1 (es) | 2011-12-20 | 2014-06-13 | Compuestos derivados nucleosidos de purina y pirimidina, inhibidores de la replicacion del arn del vhc; composicion farmaceutica; y su uso para el tratamiento y profilaxis de la infeccion por el virus de la hepatitis c (vhc). |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US9108999B2 (es) |
| EP (1) | EP2794629B1 (es) |
| JP (1) | JP5982007B2 (es) |
| KR (1) | KR101765997B1 (es) |
| CN (1) | CN104011061B (es) |
| AU (1) | AU2012357940B2 (es) |
| BR (1) | BR112014013661B1 (es) |
| CA (1) | CA2856179C (es) |
| CL (1) | CL2014001562A1 (es) |
| CO (1) | CO6960551A2 (es) |
| CR (1) | CR20140238A (es) |
| CY (1) | CY1119056T1 (es) |
| DK (1) | DK2794629T3 (es) |
| EA (1) | EA024297B1 (es) |
| ES (1) | ES2636448T3 (es) |
| HU (1) | HUE033727T2 (es) |
| IL (1) | IL232505B (es) |
| LT (1) | LT2794629T (es) |
| MA (1) | MA35750B1 (es) |
| MX (1) | MX350809B (es) |
| MY (1) | MY171577A (es) |
| PE (1) | PE20141423A1 (es) |
| PH (1) | PH12014501134B1 (es) |
| PL (1) | PL2794629T3 (es) |
| PT (1) | PT2794629T (es) |
| RS (1) | RS56212B1 (es) |
| SG (1) | SG11201403364PA (es) |
| SI (1) | SI2794629T1 (es) |
| UA (1) | UA111761C2 (es) |
| WO (1) | WO2013092481A1 (es) |
| ZA (1) | ZA201404273B (es) |
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| TW201408688A (zh) | 2012-05-25 | 2014-03-01 | Janssen R & D Ireland | 尿嘧啶基螺氧環丁烷（ｓｐｉｒｏｏｘｅｔａｎｅ）核苷類 |
| EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| AP2015008384A0 (en) | 2012-10-08 | 2015-04-30 | Univ Montpellier Ct Nat De La Rech Scient | 2'-Chloro nucleoside analogs for hcv infection |
| US9211300B2 (en) * | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
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| WO2011133871A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
| SG186831A1 (en) | 2010-07-19 | 2013-02-28 | Gilead Sciences Inc | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| EP2739154B1 (en) | 2011-08-01 | 2018-06-27 | MBC Pharma, Inc. | Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates |
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2012
- 2012-12-17 UA UAA201407326A patent/UA111761C2/uk unknown
- 2012-12-17 MY MYPI2014701642A patent/MY171577A/en unknown
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- 2012-12-17 EA EA201491179A patent/EA024297B1/ru not_active IP Right Cessation
- 2012-12-17 PE PE2014000991A patent/PE20141423A1/es active IP Right Grant
- 2012-12-17 EP EP12810206.8A patent/EP2794629B1/en active Active
- 2012-12-17 PL PL12810206T patent/PL2794629T3/pl unknown
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- 2012-12-17 JP JP2014547891A patent/JP5982007B2/ja active Active
- 2012-12-17 SI SI201231037T patent/SI2794629T1/sl unknown
- 2012-12-17 AU AU2012357940A patent/AU2012357940B2/en not_active Ceased
- 2012-12-17 RS RS20170808A patent/RS56212B1/sr unknown
- 2012-12-17 DK DK12810206.8T patent/DK2794629T3/en active
- 2012-12-17 ES ES12810206.8T patent/ES2636448T3/es active Active
- 2012-12-17 WO PCT/EP2012/075779 patent/WO2013092481A1/en not_active Ceased
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2014
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2017
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