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CL2011001265A1 - Compuestos derivados de 2h-pirazolo[3,4-d]-pirimidin 4,6(5h,7h)- diona, inhibidores de fosfodiesterasa 1 (pde1); composicion farmaceutica; util en el tratamiento de enfermedades que involucran trastornos relacionados con dopamina d1, tales como parkinson, depresion, narcolepsia, esquizofrenia, entre otros. - Google Patents

Compuestos derivados de 2h-pirazolo[3,4-d]-pirimidin 4,6(5h,7h)- diona, inhibidores de fosfodiesterasa 1 (pde1); composicion farmaceutica; util en el tratamiento de enfermedades que involucran trastornos relacionados con dopamina d1, tales como parkinson, depresion, narcolepsia, esquizofrenia, entre otros.

Info

Publication number
CL2011001265A1
CL2011001265A1 CL2011001265A CL2011001265A CL2011001265A1 CL 2011001265 A1 CL2011001265 A1 CL 2011001265A1 CL 2011001265 A CL2011001265 A CL 2011001265A CL 2011001265 A CL2011001265 A CL 2011001265A CL 2011001265 A1 CL2011001265 A1 CL 2011001265A1
Authority
CL
Chile
Prior art keywords
pyrazolo
parkinson
depression
diseases
treatment
Prior art date
Application number
CL2011001265A
Other languages
English (en)
Inventor
Peng Wennogle Lawrence P Li
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42233536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011001265(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of CL2011001265A1 publication Critical patent/CL2011001265A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Compuestos derivados de 2h-pirazolo[3,4-d]pirimidina; composición farmacéutica; y uso en el tratamiento de enfermedades tales como Parkinson, Alzheimer, depresión, entre otros.
CL2011001265A 2008-12-06 2011-05-30 Compuestos derivados de 2h-pirazolo[3,4-d]-pirimidin 4,6(5h,7h)- diona, inhibidores de fosfodiesterasa 1 (pde1); composicion farmaceutica; util en el tratamiento de enfermedades que involucran trastornos relacionados con dopamina d1, tales como parkinson, depresion, narcolepsia, esquizofrenia, entre otros. CL2011001265A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12044408P 2008-12-06 2008-12-06

Publications (1)

Publication Number Publication Date
CL2011001265A1 true CL2011001265A1 (es) 2012-01-13

Family

ID=42233536

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011001265A CL2011001265A1 (es) 2008-12-06 2011-05-30 Compuestos derivados de 2h-pirazolo[3,4-d]-pirimidin 4,6(5h,7h)- diona, inhibidores de fosfodiesterasa 1 (pde1); composicion farmaceutica; util en el tratamiento de enfermedades que involucran trastornos relacionados con dopamina d1, tales como parkinson, depresion, narcolepsia, esquizofrenia, entre otros.

Country Status (22)

Country Link
US (2) US8859564B2 (es)
EP (1) EP2367430B1 (es)
JP (1) JP5813511B2 (es)
KR (1) KR20110098731A (es)
CN (1) CN102227167A (es)
AU (1) AU2009322904A1 (es)
BR (1) BRPI0922351A2 (es)
CA (1) CA2740396A1 (es)
CL (1) CL2011001265A1 (es)
CO (1) CO6390081A2 (es)
CR (1) CR20110309A (es)
DO (1) DOP2011000172A (es)
EA (1) EA201170772A1 (es)
EC (1) ECSP11011183A (es)
GE (1) GEP20146046B (es)
IL (1) IL213315A0 (es)
MA (1) MA32941B1 (es)
MX (1) MX2011005934A (es)
PE (1) PE20120120A1 (es)
SG (1) SG171777A1 (es)
WO (1) WO2010065152A1 (es)
ZA (1) ZA201103629B (es)

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CA2651519A1 (en) 2006-06-06 2007-12-13 Intra-Cellular Therapies, Inc. Organic compounds
EP2081431B1 (en) * 2006-11-13 2013-01-16 Intra-Cellular Therapies, Inc. Organic compounds
JP5837278B2 (ja) 2006-12-05 2015-12-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
JP5701608B2 (ja) * 2007-12-06 2015-04-15 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2009075784A1 (en) * 2007-12-06 2009-06-18 Intra-Cellular Therapies, Inc. Organic compounds
US8536159B2 (en) 2008-12-06 2013-09-17 Intra-Cellular Therapies, Inc. Organic compounds
BRPI0922700A2 (pt) 2008-12-06 2015-08-11 Intracellular Therapies Inc Compostos orgânicos
GEP20146046B (en) 2008-12-06 2014-02-25 Intracellular Therapies Inc Organic compounds
PE20110834A1 (es) 2008-12-06 2011-12-14 Intra Cellular Therapies Inc DERIVADOS DE PIRROL[3,4-d]PIRIMIDINA COMO INHIBIDORES DE FOSFODIESTERASA 1 (PDE1)
EP2358723B1 (en) 2008-12-06 2015-05-13 Intra-Cellular Therapies, Inc. 4,5,7,8-tetrahydro-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors
AU2009322900A1 (en) * 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
JP2012518685A (ja) * 2009-02-25 2012-08-16 イントラ−セルラー・セラピーズ・インコーポレイテッド 眼障害のためのｐｄｅ１阻害剤
WO2010132127A1 (en) 2009-05-13 2010-11-18 Intra-Cellular Therapies, Inc. Organic compounds
US8858911B2 (en) 2009-10-08 2014-10-14 Intra-Cellular Therapies, Inc. Phosphodiesterase 1-targeting tracers and methods
EP2590657A4 (en) 2010-05-31 2014-02-12 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
EP2576551A4 (en) 2010-05-31 2014-04-16 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
EP2575817A4 (en) 2010-05-31 2014-01-08 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
US10561656B2 (en) 2011-06-10 2020-02-18 Intra-Cellular Therapies, Inc. Organic compounds
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
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